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https://www.readbyqxmd.com/read/29234320/increasing-the-clinical-potential-and-applications-of-anti-hiv-antibodies
#1
REVIEW
Casey K Hua, Margaret E Ackerman
Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these recent studies include the selection of resistant viral populations, immunogenicity resulting in the development of antidrug (Ab) responses, and the potentially toxic elimination of reservoir cells in regeneration-limited tissues...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29229594/interim-results-of-brentuximab-vedotin-in-combination-with-nivolumab-in-patients-with-relapsed-or-refractory-hodgkin-lymphoma
#2
Alex F Herrera, Alison J Moskowitz, Nancy L Bartlett, Julie M Vose, Radhakrishnan Ramchandren, Tatyana A Feldman, Ann S LaCasce, Stephen M Ansell, Craig H Moskowitz, Keenan Fenton, Carol Anne Ogden, David Taft, Qu Zhang, Kazunobu Kato, Mary Campbell, Ranjana H Advani
In this phase 1/2 study, brentuximab vedotin (BV) and nivolumab (Nivo) administered in combination were evaluated as initial salvage therapy in patients with relapsed or refractory (R/R) classical Hodgkin lymphoma (HL) (ClinicalTrials.gov #NCT02572167). Patients received up to 4 cycles of combination treatment, with BV administered on Day 1 and Nivo on Day 8 of the first cycle. For Cycles 2-4, BV and Nivo were both administered on Day 1. Following study treatment, responses were evaluated by investigators per the 2014 Lugano classification, and patients could proceed to autologous stem cell transplantation (ASCT)...
December 11, 2017: Blood
https://www.readbyqxmd.com/read/29229365/repair-of-maxillary-cystic-bone-defects-with-mesenchymal-stem-cells-seeded-on-a-cross-linked-serum-scaffold
#3
Luis Miguel Redondo, Verónica García, Beatriz Peral, Alberto Verrier, José Becerra, Ana Sánchez, Javier García-Sancho
Tissue engineering combining cross-linked serum scaffolds with bone-derived mesenchymal stem cells has displayed excellent results for repair of maxillofacial bone defects in animal models, but it had not been tested in humans yet. We present here a pilot clinical trial using autologous bone-derived mesenchymal stem cells (H-MSV) grown in a serum cross-linked scaffold (BioMax) for treatment of maxillary cysts in 9 patients. Cells obtained from alveolar bone were seeded in the BioMax scaffold prepared from autologous serum, expanded under GMP conditions, and subjected to osteogenic differentiation for 3-4 weeks before application...
November 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29223373/adverse-prognostic-factors-for-morbidity-and-mortality-during-peripheral-blood-stem-cell-mobilization-in-patients-with-light-chain-amyloidosis
#4
Jason C Yeh, Brandon R Shank, Denái R Milton, Muzaffar H Qazilbash
Patients with immunoglobulin light chain (AL) amyloidosis undergoing peripheral blood hematopoietic stem cell (PBSC) mobilization for autologous hematopoietic stem cell transplantation (auto-HCT) can experience significant morbidity and mortality. The purpose of this study was to describe the adverse events and identify prognostic factors associated with the development of morbidity and mortality in patients with AL amyloidosis who had begun PBSC mobilization for auto-HCT. A retrospective study was performed in 101 consecutive patients with AL amyloidosis who underwent PBSC mobilization for auto-HCT between January 2006 and December 2013...
December 6, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29208211/plasma-firocoxib-concentrations-after-intra-articular-injection-of-autologous-conditioned-serum-prepared-from-firocoxib-positive-horses
#5
K F Ortved, M B Goodale, C Ober, G A Maylin, L A Fortier
Orthobiologics such as autologous conditioned serum (ACS) are often used to treat joint disease in horses. Because ACS is generated from the horse's own blood, any medication administered at the time of preparation would likely be present in stored ACS, which could lead to an inadvertent positive drug test following intra-articular (IA) injection. The main objective of this study was to determine if ACS prepared from firocoxib positive horses could result in detectable plasma concentrations of the drug following IA injection...
December 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29204944/comparison-of-culture-media-indicates-a-role-for-autologous-serum-in-enhancing-phenotypic-preservation-of-rabbit-limbal-stem-cells-in-explant-culture
#6
Mehmet Gürdal, Özlem Barut Selver, Kemal Baysal, İsmet Durak
In this study, we aimed to compare the effects of six different cell culture media and autologous serum (AS) on the phenotypic characteristics of rabbit limbal epithelial stem cells (LESC) cultivated on porous polyethylene terephthalate (PET) membranes. Limbal explants from rabbit corneas were grown on PET membrane inserts in five different media: DMEM-F12 with fetal bovine serum (FBS) (DMEM-F12-FBS), with pluripotin (DMEM-F12-pluripotin) and with autologous serum (DMEM-F12-AS), Epilife, Keratinocyte Serum Free Medium (KSFM) and Defined-Keratinocyte Serum Free Medium...
December 4, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29202975/diminished-ovarian-reserve-as-measured-by-means-of-baseline-follicle-stimulating-hormone-and-antral-follicle-count-is-not-associated-with-pregnancy-loss-in-younger-in%C3%A2-vitro-fertilization-patients
#7
Lauren A Bishop, Kevin S Richter, George Patounakis, Leslie Andriani, Kimberly Moon, Kate Devine
OBJECTIVE: To assess the relationship between diminished ovarian reserve and pregnancy outcomes in a large cohort of women achieving pregnancy through in vitro fertilization (IVF). We evaluated antral follicle count (AFC) and baseline FSH as a measure of ovarian reserve. Secondarily, we assessed whether diminished ovarian reserve was associated with aneuploidy among spontaneous abortions. DESIGN: Retrospective cohort study. SETTING: Multicenter private practice...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29172669/long-term-effect-of-injection-treatment-for-osteoarthritis-in-the-knee-by-orthokin-autologous-conditioned-serum
#8
Danial Zarringam, Joris E J Bekkers, Daniel B F Saris
Background Orthokin is an intra-articular autologous conditioned serum (ACS). Its use might have a beneficial biological effect on pain and function of osteoarthritis in the knee. However, earlier studies lack any consensus on its clinical application and disease modifying effect. Objective The aim of this study was to investigate the long-term effect of Orthokin injection treatment on prevention of surgical treatment for end-stage knee osteoarthritis. Study Design Prospective cohort study. Methods Patients of the previously published Orthokin cohort were contacted to determine whether any intra-articular surgical intervention or osteotomy of the study knee had taken place during the past decade...
November 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29151378/therapeutic-and-protective-effects-of-autologous-serum-in-amikacin-induced-ototoxicity
#9
I B Arslan, G G Aslan, G C Mercan, S Vatansever, I Cukurova, S Gokalp, A Aslan
OBJECTIVE: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacin-induced ototoxicity were investigated. METHODS: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method...
November 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29150105/for-survival-the-emergence-of-oligoclonal-bands-after-multiple-myeloma-treatment-is-less-important-than-achieving-complete-remission
#10
Luiza Soares Vieira da Silva, Edvan de Queiroz Crusoe, Lais Rocha Guimarães de Souza, Carlos Sérgio Chiattone, Vânia Tietsche de Moraes Hungria
BACKGROUND: The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, but their emergence has been associated with better prognosis. The aim of the present study was to determine the prevalence, clinical characteristics and prognostic impact of the presence of oligoclonal bands in multiple myeloma patients...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29146943/cryopreservation-of-human-mesenchymal-stem-cells-in-an-allogeneic-bioscaffold-based-on-platelet-rich-plasma-and-synovial-fluid
#11
Haritz Gurruchaga, Laura Saenz Del Burgo, Ane Garate, Diego Delgado, Pello Sanchez, Gorka Orive, Jesús Ciriza, Mikel Sanchez, Jose Luis Pedraz
Transplantation of mesenchymal stem cells (MSCs) has emerged as an alternative strategy to treat knee osteoarthritis. In this context, MSCs derived from synovial fluid could provide higher chondrogenic and cartilage regeneration, presenting synovial fluid as an appropriate MSCs source. An allogeneic and biomimetic bioscaffold composed of Platelet Rich Plasma and synovial fluid that preserve and mimics the natural environment of MSCs isolated from knee has also been developed. We have optimized the cryopreservation of knee-isolated MSCs embedded within the aforementioned biomimetic scaffold, in order to create a reserve of young autologous embedded knee MSCs for future clinical applications...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136724/-expert-consensus-for-the-diagnosis-and-treatment-of-patients-with-renal-impairment-of-multiple-myeloma
#12
(no author information available yet)
Renal impairment (RI) is a common complication of multiple myeloma (MM), which is presented as chronic kidney disease (CKD) or acute kidney injury (AKI). The typical pathological feature is cast nephropathy. Presently international system staging (ISS) is used in evaluating MM. Although the classic Durie-Salmon staging system could be still used in clinical practice, it may miss out some patients with renal impairment. For evaluations of RI in MM patients with CKD, it's recommended to assess the estimated glomerular filtration rate (eGFR) by creatinine based formula CKD-epidemiology collaboration (EPI) or modification of diet in renal disease(MDRD) and to stage the renal injuries according to 2013 Kidney Disease Improving Global Outcomes (KDIGO) CKD guidelines...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29130488/crp-is-linked-to-disease-activity-impact-and-response-to-treatment-in-patients-with-chronic-spontaneous-urticaria
#13
Pavel Kolkhir, Sabine Altrichter, Tomasz Hawro, Marcus Maurer
BACKGROUND: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria. Here, we retrospectively analyzed data from 1,253 CSU patients from two centers to answer the following questions: 1) What is the prevalence of elevated levels of CRP in CSU? 2) Why do CSU patients show elevated levels of CRP? 3) Are elevated CRP levels relevant? METHODS: Serum levels of CRP were measured by the nephelometric method...
November 12, 2017: Allergy
https://www.readbyqxmd.com/read/29111123/prognostic-and-added-value-of-two-dimensional-global-longitudinal-strain-for-prediction-of-survival-in-patients-with-light-chain-amyloidosis-undergoing-autologous-hematopoietic-cell%C3%A2-transplantation
#14
Shawn C Pun, Heather J Landau, Elyn R Riedel, Jonathan Jordan, Anthony F Yu, Hani Hassoun, Carol L Chen, Richard M Steingart, Jennifer E Liu
BACKGROUND: Autologous hematopoietic cell transplantation (HCT) is a first-line therapy for prolonging survival in patients with light-chain (AL) amyloidosis. Cardiac involvement is the most important determinant of survival. However, patients with advanced cardiac involvement have often been excluded from HCT because of high risk for transplantation-related mortality and poor overall survival. Whether baseline left ventricular global longitudinal strain (GLS) can provide additional risk stratification and predict survival after HCT in this high-risk population remains unclear...
October 27, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29105864/study-of-bone-metabolism-and-angiogenesis-in-patients-undergoing-high-dose-chemotherapy-autologous-hematopoietic-stem-cell-transplantation
#15
Georgios Boutsikas, Evangelos Terpos, Athanasios Papatheodorou, Pantelis Tsirkinidis, Panayiotis Tsirigotis, Anastasia Meletiou, Eleni Lalou, Vasileios Telonis, Anna Zannou, Alexander Kanellopoulos, Zacharoula Galani, Angeliki Stefanou, Panayiotis Tsaftaridis, Nora-Athina Viniou, Panayiotis Panayiotidis, Marie-Christine Kyrtsonis, John Meletis, Theodoros P Vassilakopoulos, Maria K Angelopoulou
OBJECTIVES: Since the interaction between Hematopoietic Stem Cells (HSCs) and endosteal and endothelial niches in HSCs homing is essential, we aimed to study bone turnover and angiogenesis in 29 patients with lymphoma/multiple myeloma undergoing Hematopoietic Stem Cell Transplantation (HSCT). METHODS: Serum samples were collected before High Dose Chemotherapy (HDT), at the end of HDT, after HSC infusion, at the nadir of myelotoxicity and at engraftment. Bone metabolism (CTX, TRACP-5b, bALP, OC, DKK1, RANKL, OPG) and angiogenesis (Ang1, Ang2) markers were measured...
November 6, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29101724/adjunctive-role-of-self-retained-cryopreserved-amniotic-membrane-in-treating-immune-related-dry-eye-disease
#16
Anny M S Cheng, Sean Tighe, Hosam Sheha, Scheffer C G Tseng
PURPOSE: To present a case of successful treatment of immune-related severe dry eye disease (DED) by self-retained cryopreserved amniotic membrane (CAM) in conjunction with conventional and systemic immunotherapy. OBSERVATIONS: A 48-year-old female with a 10-year history of rheumatoid arthritis under systemic immunomodulation developed non-resolved severe ocular dryness, pain, photophobia and blurred vision due to corneal epithelial keratopathy OD much worse than OS despite topical artificial tears, steroids, cyclosporine, autologous serum drops, punctal plugs and scleral lens for the last 3 years...
November 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29067881/autologous-cytokine-induced-killer-cell-immunotherapy-may-improve-overall-survival-in-advanced-malignant-melanoma-patients
#17
Yong Zhang, Yu'nan Zhu, Erjiang Zhao, Xiaolei He, Lingdi Zhao, Zibing Wang, Xiaomin Fu, Yalong Qi, Baozhen Ma, Yongping Song, Quanli Gao
AIMS: Our study was conducted to explore the efficacy of autologous cytokine-induced killer (CIK) cells in patients with advanced malignant melanoma. Materials & Methods: Here we reviewed 113 stage IV malignant melanoma patients among which 68 patients received CIK cell immunotherapy alone, while 45 patients accepted CIK cell therapy combined with chemotherapy. Results: We found that the median survival time in CIK cell group was longer than the combined therapy group (21 vs 15 months, p = 0...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29066741/peripheral-cd19hi-b-cells-exhibit-activated-phenotype-and-functionality-in-promoting-igg-and-igm-production-in-human-autoimmune-diseases
#18
Zhicui Liu, Weihong Zeng, Xiangyang Huang, Shujun Wang, Jie Zheng, Meng Pan, Ying Wang
Systemic Lupus Erythematosus (SLE) and pemphigus are two representative autoimmune diseases driven by pathogenic autoantibody systemically and organ-specifically, respectively. Given the involvement of antibody in the pathogenesis, B cells are inclined to differentiate and function in an abnormal activation model. Here we defined a unique CD19hi B cell population existing in the periphery of SLE and pemphigus patients as well as in human tonsils. CD19hi B cells could be induced in vitro after co-culturing fully activated CD4+ T cells with autologous B cells...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29050213/serum-protein-fingerprinting-by-pea-immunoassay-coupled-with-a-pattern-recognition-algorithms-distinguishes-mgus-and-multiple-myeloma
#19
Petra Schneiderova, Tomas Pika, Petr Gajdos, Regina Fillerova, Pavel Kromer, Milos Kudelka, Jiri Minarik, Tomas Papajik, Vlastimil Scudla, Eva Kriegova
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored. Using highly-sensitive Proximity Extension ImmunoAssay on 92 cancer biomarkers (Proseek Multiplex, Olink), enhanced serum levels of Adrenomedullin (ADM, Pcorr= .0004), Growth differentiation factor 15 (GDF15, Pcorr= .003), and soluble Major histocompatibility complex class I-related chain A (sMICA, Pcorr= .023), all prosurvival and chemoprotective factors for myeloma cells, were detected in MM comparing to MGUS...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044680/effects-of-three-blood-derived-products-on-equine-corneal-cells-an-in-vitro-study
#20
J O Rushton, E Kammergruber, A Tichy, M Egerbacher, B Nell, S Gabner
BACKGROUND: Despite advances in therapy of corneal ulcerative diseases in horses, a vast number of cases require surgical intervention, due to poor response to treatment. Topical application of serum has been used for many years, based on its anti-collagenolytic properties and the presence of growth factors promoting corneal wound healing. However, although other blood derived products i.e. platelet rich plasma (PRP), plasma rich in growth factors (PRGF) have been widely used in equine orthopaedics and in human ophthalmology, no reports of the effects of these blood derived products exist in equine ophthalmology...
October 16, 2017: Equine Veterinary Journal
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