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https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#1
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK) and corneal epithelial defects (KED) were compared during first and last visit...
February 19, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29470317/the-effects-of-leukocyte-filtration-on-cell-salvaged-autologous-blood-transfusion-on-lung-function-and-lung-inflammatory-and-oxidative-stress-reactions-in-elderly-patients-undergoing-lumbar-spinal-surgery
#2
Lili Xu, Jianjun Shen, Jianliang Sun, Patrick M McQuillan, Zhiyong Hu
BACKGROUND: This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. MATERIALS AND METHODS: Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T0), immediately before blood transfusion (T1), and 1 (T2), 6 (T3), and 12 hours (T4) after end of blood transfusion...
February 21, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29467805/reduction-of-optic-disc-oedema-by-bortezomib-and-dexamethasone-followed-by-autologous-peripheral-blood-stem-cell-transplantation-in-patient-with-poems-syndrome
#3
Takehito Iwase, Hirotaka Yokouchi, Sonoko Misawa, Toshiyuki Oshitari, Takayuki Baba, Satoshi Kuwabara, Shuichi Yamamoto
The authors present findings in a 39-year-old man with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome with bilateral optic disc oedema. He was successfully treated with bortezomib and dexamethasone followed by autologous peripheral blood stem cell transplantation. The peripapillary retinal thickness was reduced in the optical coherence tomographic (OCT) images along with a decrease of the serum vascular endothelial growth factor (VEGF) levels. The authors recommend OCT to monitor the changes in the signs of POEMS syndrome after treatments...
February 2018: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29454565/investigation-of-the-biomechanical-and-histopathological-effects-of-autologous-conditioned-serum-on-healing-of-achilles-tendon
#4
Erdinç Genç, Ozan Beytemur, Serdar Yuksel, Yılmaz Eren, Aysel Çağlar, Bedri Onur Küçükyıldırım, Mehmet Akif Güleç
OBJECTIVE: The aim of this study to evaluate the effects of autologous conditioned serum (ACS) on the healing of transected rat Achilles tendons via the assessment of biomechanical and histological parameters. METHODS: The study was conducted on 45 male Sprague-Dawley rats. Five rats were used as donors for ACS preparation. Animals were randomly assigned to the experimental or control group. In both groups, the Achilles tendon was cut transversally and then sutured...
February 14, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29452623/currently-available-radiopharmaceuticals-for-imaging-infection-and-the-holy-grail
#5
REVIEW
Ebru Salmanoglu, Sung Kim, Mathew L Thakur
Infection is ubiquitous. However, its management is challenging for both the patients and the health-care providers. Scintigraphic imaging of infection dates back nearly half a century. The advances in our understanding of the pathophysiology of disease at cellular and molecular levels have paved the way to the development of a large number of radiopharmaceuticals for scintigraphic imaging of infection. These include radiolabeling of blood elements such as serum proteins, white blood cells (WBCs), and cytokines, to name a few...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29449098/quantification-of-human-complement-factor-h-binding-to-asexual-malaria-blood-stages-by-an-enzyme-linked-immunosorbent-assay
#6
Nina Simon, Oliver Friedrich, Barbara Kappes
The human complement system is the most effective defense mechanism of the human innate immune system. One major negative regulator of the alternative pathway in human blood is complement factor H (FH). It binds to autologous cells and thus, prevents complement attack against body-cells or tissues. Various pathogens are known to escape complement recognition by recruiting FH to provide protection against the host's immune system. This immune evasion mechanism was recently qualitatively reported for asexual malaria blood stages...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29442048/storage-stability-of-serum-formulations-containing-ofloxacin-for-autologous-serum-eardrop-therapy
#7
N Hashimoto, K Togami, K Endou, H Onodera, H Tanimoto, S Itagaki, S Chono
OBJECTIVE: The storage stability of serum formulations containing ofloxacin for autologous serum eardrop therapy was evaluated for microbiological quality and component stability. METHODS: Sterile serum formulations were prepared by mixing human serum and ofloxacin otic solution (1:1, v/v). To simulate eardrop contamination with external ear surface substances, prepared serum formulations were contaminated with a cotton swab that was rubbed sufficiently on the human external ear...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29434765/platelet-rich-plasma-has-beneficial-effects-in-mice-with-osteonecrosis-of-the-femoral-head-by-promoting-angiogenesis
#8
Shichao Tong, Jimin Yin, Ji Liu
Platelet-rich plasma (PRP) is autologous and multifunctional. Platelet concentrate from blood contains highly concentrated platelets and various types of cells, including growth factors. PRP promotes the recovery of cell proliferation and differentiation. Osteonecrosis of the femoral head is a disease caused by femoral head damage or an insufficient blood supply, which leads to the death of bone cells and abnormal bone marrow composition. The subsequent repair of bone cells may result in changes to the structure of femoral head, femoral head collapse and joint dysfunction...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434608/a-case-of-type-2-hypersensitivity-to-rasburicase-diagnosed-with-a-natural-killer-cell-activation-assay
#9
Sébastien Viel, Rémi Pescarmona, Alexandre Belot, Audrey Nosbaum, Christine Lombard, Thierry Walzer, Frédéric Bérard
Drug hypersensitivity reactions can lead to different clinical pictures depending on the underlying immunological mechanism. Diagnosis tests are already available to assess the most frequent drugs hypersensitivity reactions, which are mediated by specific IgE or T cells. However, it remains challenging to diagnose type 2 hypersensitivity reactions (T2HR), which can lead to severe cytopenia and liver failure. Here, we describe a case of T2HR to rasburicase, an uricolytic agent used to prevent tumor lysis syndrome...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29428575/s-adenosylmethionine-attenuates-bile-duct-early-warm-ischemia-reperfusion-injury-after-rat-liver-transplantation
#10
Yong Tang, Hongpeng Chu, Guojun Cao, Xiaolong Du, Xiaobo Min, Chidan Wan
Warm ischemia reperfusion injury (IRI) plays a key role in biliary complication, which is a substantial vulnerability of liver transplantation. The early pathophysiological changes of IRI are characterized by an excessive inflammatory response. S-Adenosylmethionine (SAM) is an important metabolic intermediate that modulates inflammatory reactions; however, its role in bile duct warm IRI is not known. In this study, male rats were treated with or without SAM (170 μmol/kg body weight) after orthotopic autologous liver transplantation...
February 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29426040/neutrophils-from-both-susceptible-and-resistant-mice-efficiently-kill-opsonized-listeria-monocytogenes
#11
Michelle G Pitts, Travis A Combs, Sarah E F D'Orazio
Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (PMN) were particularly important for clearance in the liver, but the ability of PMN from susceptible and resistant mice to directly kill L. monocytogenes has not been examined. In this study, we showed that PMN infiltrated the livers of BALB/c/By/J (BALB/c) and C57BL/6 (B6) mice in similar numbers and both cell types readily migrated towards leukotriene B4 in an in vitro chemotaxis assay...
February 5, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29417735/fetal-bovine-serum-can-reduce-toxicity-of-indocyanine-green-brilliant-blue-g-and-trypan-blue-in-arpe-19-cellular-model-that-suggests-new-surgical-staining-protocols-for-internal-limiting-membrane-peeling-procedure
#12
Yu-Yi Lin, Jorn-Hon Liu, Yin Chang
BACKGROUND: To investigate and compare the cytotoxicity of indocyanine green (ICG), brilliant blue G (BBG) and trypan blue (TB) using ARPE-19 cells that have been pre-treated/post- treated with balanced salt solution (BSS) or fetal bovine serum (FBS). METHODS: The cultured human retina pigment epithelium (RPE) ARPE-19 cells were pre-treated/post-treated with BSS or FBS (represent the autologous serum in clinic) in parallel with cells being soaked with various concentrations of ICG, BBG, and TB...
February 8, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29415117/attenuated-macrophage-infiltration-in-glomeruli-of-aged-mice-resulting-in-ameliorated-kidney-injury-in-nephrotoxic-serum-nephritis
#13
Yoshikatsu Kaneko, Takamasa Cho, Yuya Sato, Kei Goto, Suguru Yamamoto, Shin Goto, Michael P Madaio, Ichiei Narita
Senescent cells have deleterious effects on the tissue microenvironment through proinflammatory senescence-associated secretory phenotypes; meanwhile, the onset of glomerulonephritis is predominant in younger adults. To clarify the influence of aging on the onset and development of glomerulonephritis, we used a murine model of antibody-mediated nephritis. Sheep nephrotoxic serum was administered in C57BL/6J mice at 12 weeks (adult) or 18 months old (aged) after pre-immunization with sheep IgG. Depositions of sheep IgG and autologous mouse IgG along the glomerular basement membrane and the serum titer of anti-sheep IgG-specific mouse IgG were similar between adult and aged mice...
February 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29408047/phenotypic-and-functional-modulations-of-porcine-macrophages-by-interferons-and-interleukin-4
#14
Carmen A Sautter, Gaël Auray, Sylvie Python, Artur Summerfield
Considering that macrophage functions are strongly impacted by the local tissue environment and the type of immune response, the aim of this study was to carefully set the methodological baseline for phenotype and functions of polarized porcine monocyte-derived macrophages. To this end, macrophages were generated in autologous serum alone or with colony-stimulating factor (CSF)-1 or CSF-2, and subsequently polarized with interferon (IFN)γ, interleukin-4 or IFNβ. IFNγ promoted expression of MHC class I, MHC class II, CD11a, and CD40 as well as LPS-induced IL-6 and IL-12...
January 30, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29392757/chronic-spontaneous-urticaria-in-children-a-systematic-review-on-interventions-and-comorbidities
#15
Hélène Cornillier, Bruno Giraudeau, Stéphane Munck, Florence Hacard, Annie-Pierre Jonville-Bera, Gwenaëlle d'Acremont, Bach-Nga Pham, Annabel Maruani
BACKGROUND: Chronic spontaneous urticaria (CSU) is not frequent in children. Management guidelines have been developed for adults and randomized controlled trials (RCTs) included teenagers aged 12 to 18, but data for children under age 12 are limited. We performed a systematic review to assess comorbidities in children < 12 years old with CSU and the efficacy and safety of treatments. METHODS: We searched for original articles of epidemiologic and treatment data in children < 12 years old with CSU that were published from 2005 to July 2016 in MEDLINE, EMBASE, CENTRAL and LILACS...
February 2, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29355985/identification-of-t-cell-epitopes-from-benzylpenicillin-conjugated-to-human-serum-albumin-and-implication-in-penicillin-allergy
#16
Marie Eliane Azoury, Lucia Filì, Rami Bechara, Noémie Scornet, Luc de Chaisemartin, Richard J Weaver, Nancy Claude, Bernard Maillere, Paola Parronchi, Delphine Joseph, Marc Pallardy
BACKGROUND: There is in vitro evidence that T-cells from allergic patients react to benzylpenicillin-human serum albumin (BP-HSA) bioconjugates. Our group has recently shown the existence of naïve CD4+ T lymphocytes recognizing BP-HSA in healthy donors. However, BP-haptenated peptides from HSA participating in the immunization of allergic patients have never been identified. The purpose of the present study is to identify immunodominant BP-haptenated peptides from HSA involved in immunization of patients to BP and to refine the frequency calculation of naïve CD4+ T-cells recognizing BP...
January 22, 2018: Allergy
https://www.readbyqxmd.com/read/29354952/-effects-of-autologous-blood-injection-at-zusanli-st-36-on-ovarian-function-in-patients-with-primary-ovarian-insufficiency
#17
Renjian Jiang, Yu Zou
OBJECTIVE: To observe the effects of autologous blood injection and 0.9% NaCl at Zusanli (ST 36) on ovarian function in patients with primary ovarian insufficiency. METHODS: Sixty patients with primary ovarian insufficiency were randomly divided into an observation group and a control group, 30 cases in each one. The patients in the observation group were treated with injection of autologous blood at Zusanli (ST 36); the patients in the control group were treated with 0...
November 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29350016/biomarkers-of-treatment-efficacy-in-patients-with-chronic-spontaneous-urticaria
#18
M Sánchez-Borges, A Capriles-Hulett, F Caballero-Fonseca, L González-Aveledo
Background. Currently there are no biomarkers useful to predict the future evolution and the therapeutic response in patients with chronic spontaneous urticaria (CSU). Objective. To review the available information on biomarkers that might be applied for the follow up of the response to guideline recommended therapies for CSU. Methods. A review of the medical literature on CSU potential clinical and laboratory biomarkers in PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria, antihistamines (AHs), omalizumab (OMA), cyclosporine (CyA), and treatment...
January 2018: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29339636/successful-treatment-of-autoimmune-urticaria-with-low-dose-prednisolone-therapy-administered-for-a-few-months-a-case-series-of-42-patients
#19
Krisztina Vas, Anita Altmayer, Lilla Mihályi, Edina Garaczi, Ágnes Kinyó, Eszter Jakobicz, Sándor Husz, Lajos Kemény, Zsuzsanna Bata-Csörgő
BACKGROUND: Chronic spontaneous urticaria (CSU) is defined as symptoms of urticaria persisting for 6 weeks or more without obvious cause. Autologous serum skin test (ASST) positivity in patients with CSU is considered to be associated with autoimmune urticaria (AIU). METHODS: In this retrospective study we retrieved the medical records of 1,073 urticaria patients seen at the Department of Dermatology and Allergology of Szeged University between January 2005 and February 2014...
January 17, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29337067/the-impact-of-growth-factors-on-human-induced-pluripotent-stem-cells-differentiation-into-cardiomyocytes
#20
Marianne E Yassa, Iman A Mansour, Nadia I Sewelam, Hala Hamza, Taghrid Gaafar
Human induced pluripotent stem cells (hiPSCs) act as a promising therapeutic alternative for cardiovascular diseases. They yield a large number of functional cardiomyocytes (CMs) from autologous cell sources without ethical or immunological problems. However, significant limitations still remain in terms of line-to-line variability in CM yield and reproducibility. AIM: To efficiently enhance NP0040 hiPSCs differentiation into CMs. MAIN METHODS: Following a standard cardiac differentiation protocol using small molecules targeting the canonical Wnt signaling, growth factors (BMP4 and FGF2) and ascorbic acid were added further in order to increase the cardiac differentiation efficiency...
January 11, 2018: Life Sciences
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