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https://www.readbyqxmd.com/read/29473781/prediction-of-depression-and-anxiety-via-patient-assessed-tremor-severity-not-physician-reported-motor-symptom-severity-in-patients-with-parkinson-s-disease-or-essential-tremor-who-have-undergone-deep-brain-stimulation
#1
Rebecca L Achey, Erin Yamamoto, Daniel Sexton, Christine Hammer, Bryan S Lee, Robert S Butler, Nicolas R Thompson, Sean J Nagel, Andre G Machado, Darlene A Lobel
OBJECTIVE Deep brain stimulation (DBS) is an effective therapy for movement disorders such as idiopathic Parkinson's disease (PD) and essential tremor (ET). However, some patients who demonstrate benefit on objective motor function tests do not experience postoperative improvement in depression or anxiety, 2 important components of quality of life (QOL). Thus, to examine other possible explanations for the lack of a post-DBS correlation between improved objective motor function and decreased depression or anxiety, the authors investigated whether patient perceptions of motor symptom severity might contribute to disease-associated depression and anxiety...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29428214/the-effects-of-bilateral-continuous-and-chronic-deep-brain-stimulation-of-the-medial-forebrain-bundle-in-a-rodent-model-of-depression
#2
Stephanie Thiele, Luciano Furlanetti, Lisa-Marie Pfeiffer, Volker A Coenen, Máté D Döbrössy
BACKGROUND: Clinical trials of supra-lateral medial forebrain bundle (MFB) Deep Brain Stimulation (DBS) in treatment resistant major depressive patients have shown rapid and long-term benefits. OBJECTIVE/HYPOTHESIS: The study used Flinders Sensitive Line (FSL) rats with previously identified depressive-like phenotype to assess the range of behavior modification achieved by MFB DBS. METHODS: Male FSL and wild-type Sprague-Dawley rats as Controls were tested on mood/anxiety/exploration, cognitive and motor behaviors...
February 8, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29388475/massive-weight-loss-following-deep-brain-stimulation-of-the-nucleus-accumbens-in-a-depressed-woman
#3
Volker M Tronnier, Dirk Rasche, Veronika Thorns, Daniel Alvarez-Fischer, Thomas F Münte, Bartosz Zurowski
Obese individuals share behavioral characteristics with drug/alcohol addicts as well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used successfully in these disorders, thus warranting an evaluation in obesity. A woman with treatment-resistant depression as well as severe obesity was selected for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the primary and obesity being the secondary target of treatment. Compared to earlier bariatric surgery, the patient showed accelerated weight loss after DBS...
February 1, 2018: Neurocase
https://www.readbyqxmd.com/read/29371415/charting-the-road-forward-in-psychiatric-neurosurgery-proceedings-of-the-2016-american-society-for-stereotactic-and-functional-neurosurgery-workshop-on-neuromodulation-for-psychiatric-disorders
#4
Ausaf A Bari, Charles B Mikell, Aviva Abosch, Sharona Ben-Haim, Robert J Buchanan, Allen W Burton, Stephen Carcieri, G Rees Cosgrove, Pierre-Francois D'Haese, Zafiris Jeffrey Daskalakis, Emad N Eskandar, Jason L Gerrard, Wayne K Goodman, Benjamin David Greenberg, Robert E Gross, Clement Hamani, Zelma H T Kiss, Peter Konrad, Brian H Kopell, Lothar Krinke, Jean-Philippe Langevin, Andres M Lozano, Donald Malone, Helen S Mayberg, Jonathan P Miller, Parag G Patil, DeLea Peichel, Erika A Petersen, Ali R Rezai, R Mark Richardson, Patricio Riva-Posse, Tejas Sankar, Jason M Schwalb, Helen Blair Simpson, Konstantin Slavin, Paul H Stypulkowski, Tor Tosteson, Peter Warnke, Jon T Willie, Kareem A Zaghloul, Joseph S Neimat, Nader Pouratian, Sameer A Sheth
OBJECTIVE: Refractory psychiatric disease is a major cause of morbidity and mortality worldwide, and there is a great need for new treatments. In the last decade, investigators piloted novel deep brain stimulation (DBS)-based therapies for depression and obsessive-compulsive disorder (OCD). Results from recent pivotal trials of these therapies, however, did not demonstrate the degree of efficacy expected from previous smaller trials. To discuss next steps, neurosurgeons, neurologists, psychiatrists and representatives from industry convened a workshop sponsored by the American Society for Stereotactic and Functional Neurosurgery in Chicago, Illinois, in June of 2016...
January 25, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29332085/deep-brain-stimulation-of-the-subthalamic-nucleus-and-globus-pallidus-for-parkinson-s-disease
#5
Philip S Lee, Donald J Crammond, R Mark Richardson
The concept of deep brain stimulation (DBS) for Parkinson's disease (PD) was introduced over 20 years ago, but our understanding of the nuances of this procedure continues to improve. The average motor outcomes of internal segment of the globus pallidus (GPi) and subthalamic nucleus (STN) DBS appear to be similar, although GPi DBS may allow greater recovery of verbal fluency and may provide greater relief of depression symptoms and improvement in the quality of life, and STN DBS appears more likely to result in decrease in levodopa equivalent doses...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29326002/prevalence-of-adult-pompe-disease-in-patients-with-proximal-myopathic-syndrome-and-undiagnosed-muscle-biopsy
#6
Amir Golsari, Arzoo Nasimzadah, Götz Thomalla, Sarah Keller, Christian Gerloff, Tim Magnus
We examined patients with limb-girdle muscle weakness and/or hyper-CKaemia and undiagnosed muscle biopsy for late onset Pompe disease (LOPD). Patients with an inconclusive limb-girdle muscle weakness who presented at our neuromuscular centre between 2005 and 2015 with undiagnosed muscle biopsies were examined by dry blood spot testing (DBS) including determination of the enzyme activity of acid alpha-glucosidase (GAA). In the case of depressed enzyme activity, additional gene testing of the GAA gene was carried out...
December 7, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29306976/deep-brain-stimulation-of-the-anterior-nucleus-of-the-thalamus-for-drug-resistant-epilepsy
#7
REVIEW
Tim A M Bouwens van der Vlis, Olaf E M G Schijns, Frédéric L W V J Schaper, Govert Hoogland, Pieter Kubben, Louis Wagner, Rob Rouhl, Yasin Temel, Linda Ackermans
Despite the use of first-choice anti-epileptic drugs and satisfactory seizure outcome rates after resective epilepsy surgery, a considerable percentage of patients do not become seizure free. ANT-DBS may provide for an alternative treatment option in these patients. This literature review discusses the rationale, mechanism of action, clinical efficacy, safety, and tolerability of ANT-DBS in drug-resistant epilepsy patients. A review using systematic methods of the available literature was performed using relevant databases including Medline, Embase, and the Cochrane Library pertaining to the different aspects ANT-DBS...
January 6, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29249683/before-and-after-the-veterans-affairs-cooperative-program-468-study-deep-brain-stimulator-target-selection-for-treatment-of-parkinson-s-disease
#8
Derek G Southwell, Martin J Rutkowski, Marta San Luciano, Caroline Racine, Jill Ostrem, Philip A Starr, Paul S Larson
INTRODUCTION: The Veterans Affairs Cooperative Study Program 468 study (CSP 468) produced significant findings regarding deep brain stimulation (DBS) target selection for Parkinson's Disease (PD) treatment, yet its impact on clinical practices has not been described. Here we assess how CSP 468 influenced target selection at a high-volume movement disorders treatment center. METHODS: We compared DBS target site selection between 4-year periods that immediately preceded and followed CSP 468 publication...
December 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29246748/impact-of-brain-shift-on-subcallosal-cingulate-deep-brain-stimulation
#9
Ki Sueng Choi, Angela M Noecker, Patricio Riva-Posse, Justin K Rajendra, Robert E Gross, Helen S Mayberg, Cameron C McIntyre
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is an emerging experimental therapy for treatment-resistant depression. New developments in SCC DBS surgical targeting are focused on identifying specific axonal pathways for stimulation that are estimated from preoperatively collected diffusion-weighted imaging (DWI) data. However, brain shift induced by opening burr holes in the skull may alter the position of the target pathways. OBJECTIVES: Quantify the effect of electrode location deviations on tractographic representations for stimulating the target pathways using longitudinal clinical imaging datasets...
December 6, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29161674/deep-brain-stimulation-of-the-subcallosal-cingulate-gyrus-in-patients-with-treatment-resistant-depression-a-double-blinded-randomized-controlled-study-and-long-term-follow-up-in-eight-patients
#10
Angela Merkl, Sabine Aust, Gerd-Helge Schneider, Veerle Visser-Vandewalle, Andreas Horn, Andrea A Kühn, Jens Kuhn, Malek Bajbouj
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Short-term results of efficacy in DBS are incongruent and studies investigating long-term effects are warranted. METHODS: We assessed efficacy of SCG-DBS in eight patients randomized into a delayed-onset group (sham-DBS four weeks) and a non-delayed-onset group. The primary outcome measure was improvement on the Hamilton Depression Rating-Scale (HAMD-24-item-version)...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29152502/target-specific-deep-brain-stimulation-of-the-ventral-capsule-ventral-striatum-for-the-treatment-of-neuropsychiatric-disease
#11
Chencheng Zhang, Dianyou Li, Haiyan Jin, Kristina Zeljic, Bomin Sun
Deep brain stimulation (DBS) is a well-established therapy for Parkinson's disease and other movement disorders. An accumulating body of evidence supports the extension of DBS application for the treatment of refractory psychiatric disorders. The ventral capsule/ventral striatum (VC/VS) is the most common anatomical target for obsessive-compulsive disorder (OCD), addiction, and depression. However, no specific electrode is available for the clinical targeting of these areas for DBS. According to the anatomical features of the VC/VS, a novel electrode was developed for simultaneous and independently programmed stimulation of the nucleus accumbens (NAc) and the anterior limb of the internal capsule (ALIC)...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29146474/a-systematic-review-and-meta-analysis-of-deep-brain-stimulation-in-treatment-resistant-depression
#12
Chanjuan Zhou, Hanping Zhang, Yinhua Qin, Tian Tian, Bing Xu, Jianjun Chen, Xinyu Zhou, Li Zeng, Liang Fang, Xunzhong Qi, Bin Lian, Haiyang Wang, Zicheng Hu, Peng Xie
BACKGROUND: Deep brain stimulation (DBS) has been applied in treatment-resistant depression (TRD) as a putative intervention targeting different brain regions. However, the antidepressant effects of DBS for TRD in recent clinical trials remain controversial. METHODS: We searched Scopus, EMBASE, the Cochrane Library, PubMed, and PsycINFO for all published studies investigating the efficacy of DBS in TRD up to Feb 2017. Hamilton depression rating scale (HDRS) scores and Montgomery-Asberg depression rating scale (MARDS) scores were compared between baseline levels and those after DBS using the standardized mean difference (SMD) with 95% confidence intervals (CIs)...
March 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29142796/impact-of-depression-on-hospitalization-and-related-outcomes-for-parkinson-s-disease-patients-a-nationwide-inpatient-sample-based-retrospective-study
#13
Rikinkumar S Patel, Ramkrishna Makani, Zeeshan Mansuri, Upenkumar Patel, Rupak Desai, Amit Chopra
Background Major Depressive Disorder (MDD) is a common comorbidity that significantly affects the quality of life and disease outcomes in Parkinson's disease (PD) patients. No studies have been conducted to our knowledge to address the health care utilization and its outcomes in these patients. The aim of this study is to analyze and discern the differences in the hospitalization outcomes, comorbid conditions, and utilization of procedures in PD patients versus patients with comorbid MDD. Methods We used the Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project from year's 2010-2014...
September 3, 2017: Curēus
https://www.readbyqxmd.com/read/29115994/exploring-venlafaxine-pharmacokinetic-variability-with-a-phenotyping-approach-a-multicentric-french-swiss-study-marvel-study
#14
Célia Lloret-Linares, Youssef Daali, Sylvie Chevret, Isabelle Nieto, Fanny Molière, Philippe Courtet, Florence Galtier, Raphaëlle-Marie Richieri, Sophie Morange, Pierre-Michel Llorca, Wissam El-Hage, Thomas Desmidt, Frédéric Haesebaert, Philippe Vignaud, Jerôme Holtzmann, Jean-Luc Cracowski, Marion Leboyer, Antoine Yrondi, Fabienne Calvas, Liova Yon, Philippe Le Corvoisier, Olivier Doumy, Kyle Heron, Damien Montange, Siamak Davani, Julien Déglon, Marie Besson, Jules Desmeules, Emmanuel Haffen, Frank Bellivier
BACKGROUND: It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The development of a personalized medicine in psychiatry may reduce treatment failure, intolerance or resistance, and hence the burden and costs of mood depressive disorders. The Geneva Cocktail Phenotypic approach presents several advantages including the "in vivo" measure of different cytochromes and transporter P-gp activities, their simultaneous determination in a single test, avoiding the influence of variability over time on phenotyping results, the administration of low dose substrates, a limited sampling strategy with an analytical method developed on DBS analysis...
November 7, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29077140/-deep-brain-stimulation-in-psychiatry
#15
M Figee, C Bervoets, D Denys
BACKGROUND: Deep brain stimulation (DBS) is now used regularly to treat therapy-refractory obsessive-compulsive disorders, and is being applied experimentally for refractory depression, Tourette syndrome, addiction, eating disorders, post-traumatic stress disorder, autism and schizophrenia. AIM: To review the effects and mechanisms of dbs and to consider the future opportunities for this type of treatment in psychiatry. METHOD: We reviewed the literature using PubMed...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29074339/effect-of-deep-brain-stimulation-of-the-ventromedial-prefrontal-cortex-on-the-noradrenergic-system-in-rats
#16
Sonia Torres-Sanchez, Laura Perez-Caballero, Juan A Mico, Pau Celada, Esther Berrocoso
BACKGROUND: Deep Brain Stimulation (DBS) of the subgenual cingulate cortex (SCC) is a promising therapeutic alternative to treat resistant major depressive disorder. In preclinical studies, DBS of the ventromedial prefrontal cortex (vmPFC, the rodent SCC correlate) provokes an antidepressant-like effect, along with changes in noradrenaline levels at the site of stimulation. Hence, DBS appears to activate the noradrenergic-locus coeruleus (LC) system. OBJECTIVE/HYPOTHESIS: The aim of this study was to evaluate the effect of vmPFC DBS on the electrical activity of noradrenergic LC neurons, cortical oscillations and coherence between both brain areas in male rats...
October 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29034243/improving-surgical-outcome-using-diffusion-tensor-imaging-techniques-in-deep-brain-stimulation
#17
REVIEW
Angela An Qi See, Nicolas Kon Kam King
INTRODUCTION: Recent advances in surgical imaging include the use of diffusion tensor imaging (DTI) in deep brain stimulation (DBS) and provide a detailed view of the white matter tracts and their connections which are not seen with conventional magnetic resonance imaging. Given that the efficacy of DBS depends on the precise and accurate targeting of these circuits, better surgical planning using information obtained from DTI may lead to improved surgical outcome. We aim to review the available literature to evaluate the efficacy of such a strategy...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/29032294/one-year-double-blind-study-of-high-vs-low-frequency-subcallosal-cingulate-stimulation-for-depression
#18
Renana Eitan, Denys Fontaine, Michel Benoît, Caroline Giordana, Nelly Darmon, Zvi Israel, Eduard Linesky, David Arkadir, Shiri Ben-Naim, Moshe Iserlles, Hagai Bergman, Natasha Hulse, Mohamed Abdelghani, Peter McGuffin, Anne Farmer, Peichel DeLea, Keyoumars Ashkan, Bernard Lerer
Subcallosal Brodmann's Area 25 (Cg25) Deep Brain Stimulation (DBS) is a new promising therapy for treatment resistant major depressive disorder (TR-MDD). While different DBS stimulating parameters may have an impact on the efficacy and safety of the therapy, there is no data to support a protocol for optimal stimulation parameters for depression. Here we present a prospective multi-center double-blind randomized crossed-over 13-month study that evaluated the effects of High (130 Hz) vs Low (20 Hz) frequency Cg25 stimulation for nine patients with TR-MDD...
October 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29018554/psychiatric-neurosurgery-in-the-21st-century-overview-and-the-growth-of-deep-brain-stimulation
#19
REVIEW
Kenneth Barrett
Ambulatory deep brain stimulation (DBS) became possible in the late 1980s and was initially used to treat people with movement disorders. Trials of DBS in people with treatment-resistant psychiatric disorder began in the late 1990s, initially focusing on obsessive-compulsive disorder, major depressive disorder and Tourette syndrome. Despite methodological issues, including small participant numbers and lack of consensus over brain targets, DBS is now being trialled in a wide range of psychiatric conditions...
October 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29017175/body-weight-changes-after-deep-brain-stimulation-for-obsessive-compulsive-disorder-or-depression
#20
Rosalie S N Linssen, Marloes S Oudijn, Mariska Mantione, Pepijn van den Munckhof, Damiaan Denys, P Richard Schuurman
BACKGROUND: In 2010, we published an often-cited case report describing smoking cessation and substantial weight loss after deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) in an obese patient. To test whether this single observation was also observed in the treated population at large, the weight changes of a larger cohort of patients who underwent DBS for OCD or major depressive disorder (MDD) were studied. RESULTS: Data were available for 46 patients (30 OCD and 16 MDD patients; mean age 46...
2017: Stereotactic and Functional Neurosurgery
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