Cláudia E V Rocha, Monique F Silva, Andressa C B Guedes, Thaynara P Carvalho, Camila Eckstein, Noelly Q Ribeiro, Daniel A Santos, Marilia M Melo, Marcio S S Araújo, Olindo A Martins-Filho, Renato L Santos, Tatiane A Paixão
Listeria monocytogenes is a cause of infectious food-borne disease in humans, characterized by neurological manifestations, abortion, and neonatal septicemia. It is intracellular bacterium, which limits the development of protective inactivated vacines. Adjuvants capable of stimulating cellular immune response are important tools for developing novel vaccines against intracellular bacteria. The aim of this study was to evaluate the vaccine potential of L. monocytogenes inactivated by gamma irradiation (KLM-γ) encapsulated in alginate microcapsules associated or not with chitosan against listeriosis in the murine model...
February 10, 2021: International Journal of Biological Macromolecules