Hyoung Jin Kang, Hee Young Shin, Jun Eun Park, Nak Gyun Chung, Bin Cho, Hack Ki Kim, Sun Young Kim, Young Ho Lee, Young Tak Lim, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Ho Joon Im, Jong Jin Seo, Sang Kyu Park, Hyo Seop Ahn
Antithymocyte globulin (ATG) has been used in severe aplastic anemia (SAA) as part of the conditioning regimen. Among the many kinds of ATG preparations, thymoglobulin had been found to be more effective for preventing graft-versus-host disease (GVHD) and the rejection of organ transplants. After the promising results of our preliminary study, we conducted a phase II prospective multicenter clinical trial using a fludarabine (Flu), cyclophosphamide (Cy), and thymoglobulin conditioning regimen to allow good engraftment in patients who underwent unrelated transplantation for SAA...
November 2010: Biology of Blood and Marrow Transplantation