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https://www.readbyqxmd.com/read/28922323/face-graft-scaffold-production-in-a-rat-model
#1
Jérôme Duisit, Hadrien Amiel, Giuseppe Orlando, Adeline Dedriche, Catherine Behets, Pierre Gianello, Benoît Lengelé
BACKGROUND: As a route towards face bioengineering, our group previously reported the production of a complete scaffold production by perfusion-decellularization of a porcine ear subunit graft and partial recellularization. In order to extend the scaffold to the whole face and to down-scale it, we applied our findings to a rodent hemi-facial graft model. METHODS: After euthanasia, seven full-thickness rat hemi-face grafts were harvested with the CCA and the EJV as pedicle, and cannulated...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28922191/acr-spr-str-practice-parameter-for-the-performance-of-cardiac-positron-emission-tomography-computed-tomography-pet-ct-imaging
#2
Rathan M Subramaniam, Warren R Janowitz, Geoffrey B Johnson, Martin A Lodge, Marguerite T Parisi, Mark R Ferguson, Jeffrey C Hellinger, Gregory W Gladish, Narainder K Gupta
This clinical practice parameter has been developed collaboratively by the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), and the Society of Thoracic Radiology (STR). This document is intended to act as a guide for physicians performing and interpreting positron emission tomography-computed tomography (PET/CT) of cardiac diseases in adults and children. The primary value of cardiac PET/CT imaging include evaluation of perfusion, function, viability, inflammation, anatomy, and risk stratification for cardiac-related events such as myocardial infarction and death...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28918335/modern-diagnosis-of-chronic-thromboembolic-pulmonary-hypertension
#3
Aileen Kharat, Anne-Lise Hachulla, Stéphane Noble, Frédéric Lador
Chronic thromboembolic pulmonary hypertension (CTEPH) should be suspected in patients presenting persistent dyspnea three months after a pulmonary embolism or in patients presenting with acute pulmonary embolism and suggestive images on the CT-scan. For these patients, a specific diagnostic work-up should be performed. First step consists of the ventilation/perfusion (V/Q) scan which is a good screening test due to its high sensitivity and high negative predictive value. Pulmonary angiography remains the gold standard approach for the confirmation of the diagnosis and pre-surgical evaluation of CTEPH...
September 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28917674/prognostic-value-of-risk-factors-calcium%C3%A2-score-coronary-cta-myocardial%C3%A2-perfusion-imaging-and-invasive%C3%A2-coronary-angiography-in-kidney%C3%A2-transplantation-candidates
#4
Simon Winther, My Svensson, Hanne Skou Jørgensen, Laust Dupont Rasmussen, Niels Ramsing Holm, Lars Christian Gormsen, Kirsten Bouchelouche, Hans Erik Bøtker, Per Ivarsen, Morten Bøttcher
OBJECTIVES: This study sought to perform a prospective head-to-head comparison of the predictive value of clinical risk factors and a variety of cardiac imaging modalities including coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), single-photon emission computed tomography (SPECT), and invasive coronary angiography (ICA) on major adverse cardiac events (MACE) and all-cause mortality in kidney transplantation candidates. BACKGROUND: Current guidelines recommend screening for coronary artery disease in kidney transplantation candidates...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28916603/phase-2a-clinical-trial-of-mitochondrial-protection-elamipretide-during-stent-revascularization-in-patients-with-atherosclerotic-renal-artery-stenosis
#5
Ahmed Saad, Sandra M S Herrmann, Alfonso Eirin, Christopher M Ferguson, James F Glockner, Haraldur Bjarnason, Michael A McKusick, Sanjay Misra, Lilach O Lerman, Stephen C Textor
BACKGROUND: Atherosclerotic renal artery stenosis reduces renal blood flow (RBF) and amplifies stenotic kidney hypoxia. Revascularization with percutaneous transluminal renal angioplasty (PTRA) and stenting often fails to recover renal function, possibly because of ischemia/reperfusion injury developing after PTRA. Elamipretide is a mitochondrial-targeted peptide that binds to cardiolipin and stabilizes mitochondrial function. We tested the hypothesis that elamipretide plus PTRA would improve renal function, oxygenation, and RBF in patients with atherosclerotic renal artery stenosis undergoing PTRA...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28916411/3d-fusion-of-coronary-ct-angiography-and-ct-myocardial-perfusion-imaging-intuitive-assessment-of-morphology-and-function
#6
Jochen von Spiczak, Robert Manka, Manoj Mannil, Sabrina Oebel, Sandra Hamada, Kai Higashigaito, Ernst Klotz, Frank Ruschitzka, Hatem Alkadhi
BACKGROUND: The objective of this work was to support three-dimensional fusion of coronary CT angiography (coronary CTA) and CT myocardial perfusion (CT-Perf) data visualizing coronary artery stenoses and corresponding stress-induced myocardial perfusion deficits for diagnostics of coronary artery disease. METHODS: Twelve patients undergoing coronary CTA/CT-Perf after heart transplantation were included (56 ± 12 years, all males). CT image quality was rated. Coronary diameter stenoses >50% were documented for coronary CTA...
September 5, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28905995/leptomeningeal-collateral-status-predicts-outcome-after-middle-cerebral-artery-occlusion
#7
C F Madelung, C Ovesen, C Trampedach, A Christensen, I Havsteen, C K Hansen, H Christensen
OBJECTIVES: Perfusion through leptomeningeal collateral vessels is a likely pivotal factor in the outcome of stroke patients. We aimed to investigate the effect of collateral status on outcome in a cohort of unselected, consecutive stroke patients with middle cerebral artery occlusion undergoing reperfusion therapy. MATERIALS AND METHODS: This retrospectively planned analysis was passed on prospectively collected data from 187 consecutive patients with middle cerebral artery occlusion admitted within 4...
September 14, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28901610/low-dose-dynamic-myocardial-perfusion-ct-imaging-using-a-motion-adaptive-sparsity-prior
#8
Zhaoying Bian, Dong Zeng, Zhang Zhang, Changfei Gong, Xiumei Tian, Gang Yan, Jing Huang, Hong Guo, Bo Chen, Jing Zhang, Qianjin Feng, Wufan Chen, Jianhua Ma
PURPOSE: Dynamic myocardial perfusion computed tomography (DM-PCT) imaging offers benefits over quantitative assessment of myocardial blood flow (MBF) for diagnosis and risk stratification of coronary artery disease. However, one major drawback of DM-PCT imaging is that a high radiation level is imparted by repeated scanning. To address this issue, in this work, we developed a statistical iterative reconstruction algorithm based on the penalized weighted least-squares (PWLS) scheme by incorporating a motion adaptive sparsity prior (MASP) model to achieve high-quality DM-PCT imaging with low tube current dynamic data acquisition...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28899866/subacute-endovascular-recanalization-of-symptomatic-cerebral-artery-occlusion-a-propensity-score-matched-analysis
#9
Sang Hun Lee, Dae Chul Suh, Su Hee Cho, Jae Jon Sheen, Deok Hee Lee, Jong S Kim
BACKGROUND: The interval between the onset of cerebral vessel occlusion and recanalization has been shown to be an independent predictor of poor outcomes. However, endovascular recanalization of symptomatic cerebral vessel occlusion in the subacute period has not been well documented. We investigated the safety and efficacy of subacute recanalization of occluded cerebral vessels in patients with ischemic stroke or transient ischemic attacks (TIAs). METHODS: Between 2014 and 2015, 98 patients were admitted to the emergency room for ischemic stroke or TIA with a small infarct core, which was defined as modest early ischemic change on non-contrast CT or overt diffusion-perfusion mismatch...
September 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28898127/acute-pulmonary-embolism-retrospective-cohort-study-of-the-predictive-value-of-perfusion-defect-volume-measured-with-dual-energy-ct
#10
Dong Jin Im, Jin Hur, Kyung Hwa Han, Hye-Jeong Lee, Young Jin Kim, Woocheol Kwon, Byoung Wook Choi
OBJECTIVE: The purposes of this study were to investigate dual-energy CT findings predictive of clinical outcome and to determine the incremental risk stratification benefit of dual-energy CT findings compared with CT ventricular diameter ratio in patients with acute pulmonary embolism. MATERIALS AND METHODS: A retrospective evaluation was conducted of the cases of 172 patients with acute pulmonary embolism who underwent dual-energy CT. Ventricular diameter ratio and relative perfusion defect volume were measured...
September 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28885205/reduced-microperfusion-due-to-portal-vein-thrombosis-impact-on-the-outcome-of-percutaneous-thermal-tumor-ablation
#11
B Pregler, L P Beyer, I Wiesinger, M Haimerl, C Stroszczynski, E M Jung, P Wiggermann
PURPOSE: To determine the influence of pre-interventionally existing portal vein thrombosis on the ablation success of percutaneous tumor ablation of HCC. MATERIALS AND METHODS: 15 patients with HCC and pre-existing portal vein thrombosis underwent thermal tumor ablation. We retrospectively analyzed the pre- and post-interventionally performed CT and MRI scans in terms of technical success as well as the complication rate. The portal vein thrombosis was classified into segmental, lobar and central thrombus...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28884300/what-every-radiologist-should-know-about-adnexal-torsion
#12
Guillaume Ssi-Yan-Kai, Anne-Laure Rivain, Caroline Trichot, Marie-Chantal Morcelet, Sophie Prevot, Xavier Deffieux, Jocelyne De Laveaucoupet
Adnexal torsion is the fifth most common gynecologic surgical emergency, requiring clinician and radiologist awareness. It involves the rotation of the ovarian tissue on its vascular pedicle leading to stromal edema, hemorrhagic infarction, and necrosis of the adnexal structures with the subsequent sequelae. Expedient diagnosis poses a difficult challenge because the clinical presentation is variable and often misleading. Adnexal torsion can mimic malignancy as it can take a subacute, intermittent, or chronic course, and thereby can be complicated to diagnose...
September 7, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28877656/longitudinal-evaluation-of-myocardial-fatty-acid-and-glucose-metabolism-in-fasted-and-nonfasted-spontaneously-hypertensive-rats-using-micropet-ct
#13
Jennifer S Huber, Andrew M Hernandez, Mustafa Janabi, James P O'Neil, Kathleen M Brennan, Stephanie T Murphy, Youngho Seo, Grant T Gullberg
Using longitudinal micro positron emission tomography (microPET)/computed tomography (CT) studies, we quantified changes in myocardial metabolism and perfusion in spontaneously hypertensive rats (SHRs), a model of left ventricular hypertrophy (LVH). Fatty acid and glucose metabolism were quantified in the hearts of SHRs and Wistar-Kyoto (WKY) normotensive rats using long-chain fatty acid analog (18)F-fluoro-6-thia heptadecanoic acid ((18)F-FTHA) and glucose analog (18)F-fluorodeoxyglucose ((18)F-FDG) under normal or fasting conditions...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28877524/selection-paradigms-for-large-vessel-occlusion-acute-ischemic-stroke-endovascular-therapy
#14
Mehdi Bouslama, Meredith T Bowen, Diogo C Haussen, Seena Dehkharghani, Jonathan A Grossberg, Letícia C Rebello, Srikant Rangaraju, Michael R Frankel, Raul G Nogueira
BACKGROUND: Optimal patient selection methods for thrombectomy in large vessel occlusion stroke (LVOS) are yet to be established. We sought to evaluate the ability of different selection paradigms to predict favorable outcomes. METHODS: Review of a prospectively collected database of endovascular patients with anterior circulation LVOS, adequate CT perfusion (CTP), National Institutes of Health Stroke Scale (NIHSS) ≥10 from September 2010 to March 2016. Patients were retrospectively assessed for thrombectomy eligibility by 4 mismatch criteria: Perfusion-Imaging Mismatch (PIM): between CTP-derived perfusion defect and ischemic core volumes; Clinical-Core Mismatch (CCM): between age-adjusted NIHSS and CTP core; Clinical-ASPECTS Mismatch (CAM-1): between age-adjusted NIHSS and ASPECTS; Clinical-ASPECTS Mismatch (CAM-2): between NIHSS and ASPECTS...
September 7, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28871423/an-application-study-of-low-dose-computed-tomography-perfusion-imaging-for-evaluation-of-the-efficacy-of-neoadjuvant-chemotherapy-for-advanced-gastric-adenocarcinoma
#15
Zongqiong Sun, Xiaofang Cheng, Yuxi Ge, Lin Shao, Yinghua Xuan, Gen Yan
BACKGROUND: This study used low-dose computed tomography (CT) perfusion imaging technology to evaluate the efficacy of neoadjuvant chemotherapy in patients with advanced gastric adenocarcinoma and to determine whether any of the perfusion parameters could predict tumor response to chemotherapy. METHODS: Forty patients with gastric adenocarcinoma (T3-4NxM0) received three cycles of neoadjuvant chemotherapy and low-dose spiral CT perfusion imaging prior to and after the first and third series of chemotherapy...
September 4, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28870377/cardiac-imaging-in-the-diagnosis-of-coronary-artery-disease
#16
Ashvarya Mangla, Estefania Oliveros, Kim Allan Williams, Dinesh K Kalra
Coronary artery disease (CAD) continues to be a leading cause of morbidity and mortality worldwide. Although invasive coronary angiography has previously been the gold standard in establishing the diagnosis of CAD, there is a growing shift to more appropriately use the cardiac catheterization laboratory to perform interventional procedures once a diagnosis of CAD has been established by noninvasive imaging modalities rather than using it primarily as a diagnostic facility to confirm or refute CAD. With ongoing technological advancements, noninvasive imaging plays a pre-eminent role in not only diagnosing CAD but also informing the choice of appropriate therapies, establishing prognosis, all while containing costs and providing value-based care...
October 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28869670/pulmonary-embolism-in-pregnant-patients-assessing-organ-dose-to-pregnant-phantom-and-its-fetus-during-lung-imaging
#17
Laleh Rafat Motavalli, Elie Hoseinian Azghadi, Hashem Miri Hakimabad, Parisa Akhlaghi
PURPOSE: To provide updated radiation dose from diagnostic exams performed for pregnant patients suspected of pulmonary embolism (PE) using the recently developed BREP phantoms of pregnant woman and the fetus. Also to challenge the validity of current recommendations suggest that ventilation/perfusion (V/Q) single photon emission computed tomography (SPECT) vs. computed tomography pulmonary angiography (CTPA) should be considered for diagnosis of PE in radiosensitive groups such as pregnant women...
September 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28868318/complete-shrinkage-of-the-obliterated-false-lumen-after-open-and-endovascular-chronic-aortic-dissection-stanford-type-a-repair
#18
George Samanidis, Meletios Kanakis, Constantinos Ieromonachos, George Stavridis
A 48-year-old man was admitted to our hospital with chronic aortic dissection Stanford Type A. His diagnosis was confirmed by chest multi-detector computed tomography (CT). The patient underwent combined (i.e., hybrid) open and endovascular repair (frozen elephant trunk) in a one-stage operation with moderate hypothermic circulatory arrest and antegrade cerebral perfusion. His postoperative course was uneventful, and he was discharged home on postoperative day 9. At 2-year follow-up, chest CT angiography revealed complete shrinkage of the obliterated false lumen in the distal aortic arch and descending thoracic aorta...
April 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/28866488/radiation-dose-reduction-in-ct-myocardial-perfusion-imaging-using-smart-recon
#19
Yinsheng Li, Michael A Speidel, Christopher J Francois, Guang-Hong Chen
In this work, a newly developed statistical model based image reconstruction (referred to as Simultaneous Multiple Artifacts Reduction in Tomographic RECONstruction (SMARTRECON) [1]) is applied to low dose computer tomography (CT) myocardial perfusion imaging (CT-MPI). This method uses the nuclear norm of the spatial-temporal image matrix of the CTMPI images as a regularizer, rather than a conventional spatial regularizer that incorporates image smoothness, edge preservation, or spatial sparsity into the reconstruction...
August 30, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28865944/false-ischaemic-penumbras-in-ct-perfusion-in-patients-with-carotid-artery-stenosis-and-changes-following-angioplasty-and-stenting
#20
A J Mosqueira, J M Pumar, S Arias, M Rodríguez-Yáñez, M Blanco Ulla, F Vázquez Herrero, J Castillo
INTRODUCTION: Carotid artery stenosis influences CT perfusion (CTP) studies, sometimes manifesting as a false ischaemic penumbra (FIP). This study aims to estimate the incidence of FIP in patients with carotid artery stenosis, establish their relationship with the degree of stenosis, and measure quantitative and qualitative changes in CTP after carotid angioplasty and stenting (CAS). METHODS: Between October 2013 and June 2015, we prospectively selected 26 patients with carotid stenosis who underwent CAS, with CTP being performed 2-10 days before and after CAS...
August 30, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
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