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https://www.readbyqxmd.com/read/29245171/effects-of-atorvastatin-on-autophagy-in-skeletal-muscles-of-diabetic-rats
#1
Bingquan Yang, Jie Sun, Yang Yuan, Zilin Sun
AIMS/INTRODUCTION: Atorvastatin is usually used to decrease the amount of fatty substances in individuals with type 2 diabetes mellitus. However, it can cause side effects, such as breakdown of skeletal muscle tissue. This study focuses on the effects of atorvastatin on autophagy of the skeletal muscles in diabetic rats. MATERIALS AND METHODS: Diabetes in rats in the diabetic (D) and atorvastatin (T) groups was induced using streptozotocin (65 mg/kg, intraperitoneal injection)...
December 15, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29245050/nanog-restores-the-impaired-myogenic-differentiation-potential-of-skeletal-myoblasts-after-multiple-population-doublings
#2
Aref Shahini, Debanik Choudhury, Mohammadnabi Asmani, Ruogang Zhao, Pedro Lei, Stelios T Andreadis
Adult skeletal muscle regeneration relies on the activity of satellite cells residing in the skeletal muscle niche. However, systemic and intrinsic factors decrease the myogenic differentiation potential of satellite cells thereby impairing muscle regeneration. Here we present data showing that late passage C2C12 myoblasts exhibited significantly impaired myogenic differentiation potential that was accompanied by impaired expression of myogenic regulatory factors (Myf5, MyoD, Myogenin, and MRF4) and members of myocyte enhancer factor 2 family...
December 2, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29244882/%C3%AE-ii-spectrin-in-t-cells-is-involved-in-the-regulation-of-cell-cell-contact-leading-to-immunological-synapse-formation
#3
Justyna M Meissner, Aleksander F Sikorski, Tomasz Nawara, Jakub Grzesiak, Krzysztof Marycz, Dżamila M Bogusławska, Izabela Michalczyk, Marie-Christine Lecomte, Beata Machnicka
T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation. This dynamic process involves reorganization of the actin cytoskeleton and signaling molecules at the cell membrane, leading to the formation of the Immunological Synapse (IS). The mechanisms regulating the formation of the IS are not completely understood. Nonerythroid spectrin is a membrane skeletal protein involved in the regulation of many cellular processes, including cell adhesion, signaling and actin cytoskeleton remodeling...
2017: PloS One
https://www.readbyqxmd.com/read/29244697/occipitocervical-fusion-for-severe-atlantoaxial-dislocation-in-an-underdeveloped-child-with-chondrodysplasia-punctata-a-case-report
#4
Yuki Tanaka, Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Keisuke Nagasaki, Toru Hirano
CASE: We present a case of brachytelephalangic chondrodysplasia punctata with a severe atlantoaxial dislocation in an underdeveloped child. The patient underwent halo jacket application using 10 halo pins with <1 lb/in of torque, followed by posterior occipitocervical fusion with onlay rib and iliac autografts. After bone grafts and replacement of the halo ring multiple times, successful osseous fusion had been achieved by the 2-year follow-up. CONCLUSION: Although simple bone-grafting with a halo jacket is useful in underdeveloped patients with skeletal dysplasia, the complications related to halo fixation, including cranial bone perforation, and the patient's neurological status must be carefully monitored...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244680/irreducible-ankle-fracture-from-an-interposed-chaput-fragment-a-case-report
#5
Chihua Lee, Thomas J Douglas
CASE: A 23-year-old active-duty military service member sustained an unusual irreducible fracture-dislocation of the ankle joint. Preoperative computed tomography showed an anterolateral tibial (Chaput) fragment entrapped within the distal syndesmosis, preventing adequate reduction. An open reduction of the fragment was performed in the operating room, which allowed near-anatomic reduction and internal fixation of the tibiotalar joint. At the 21-month follow-up visit, the patient remained on active duty in the Navy without limitations...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29243896/diagnostics-and-current-care-of-myasthenia-gravis
#6
Sari Atula, Kathrin Pfau, Tapani Salmi, Eero Sihvo, Mikko Haapio, Mika Saarela, Mari Auranen
Myasthenia gravis (MG) is the most common neuromuscular transmission disorder, causing weakness of skeletal muscles on exertion. The course of the disease is highly variable, symptoms and signs may change rapidly due to infection or pregnancy. MG is classified using serological, electrophysiological and pharmaceutical tools. A precise diagnosis allows for the choice of right treatment, predicts the course of disease and hence helps with the follow-up. In this review we present Finnish guidelines for diagnostics, treatment and follow-up of MG patients...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243488/comparison-and-optimisation-of-imaging-techniques-in-suspected-physical-abuse-paediatric-radiography
#7
Jodie R Hampel, Ana Pascoal
OBJECTIVE: This study compares protocols in clinical use for paediatric Suspected Physical Abuse (SPA) radiographic imaging across four NHS Trusts in the UK. The patient dose delivered from a SPA skeletal survey was compared between two sites using different imaging technology. Additionally, the technique in use for the abdomen Anterior-Posterior (AP) radiographic projection was optimised at one of the participant sites. METHODS: Retrospective data collection was performed to compare SPA protocols...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29243310/coriolus-versicolor-aqueous-extract-ameliorates-insulin-resistance-with-pi3k-akt-and-p38-mapk-signaling-pathways-involved-in-diabetic-skeletal-muscle
#8
Hui-Min Xian, Hui Che, Ying Qin, Fan Yang, Song-Yan Meng, Xiao-Guang Li, Yun-Long Bai, Li-Hong Wang
Patients with type 2 diabetes mellitus (T2DM) are usually with poor immunity and easier to suffer from cancer and microbial infections. Herein, we report an efficient anti-diabetic medicinal mushroom, Coriolus versicolor (CV). This study aimed to investigate the anti-diabetic and anti-insulin-resistance effects of CV aqueous extract in myoblasts (L6 cells) and skeletal muscle of T2DM rat. Our results showed that CV extract treatment significantly reduced blood glucose levels of T2DM rats, whereas CV extract increased glucose consumption in insulin resistant L6 cells...
December 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29243280/mixed-histiocytosis-a-case-report-and-published-work-review
#9
Zhongtao Li, Yun Li, Weiping Liu, Jinfan Li, Lin Wang
Histiocytoses are a group of heterogeneous diseases that encompass Langerhans cell histiocytosis and non-Langerhans cell histiocytosis. Cutaneous plane xanthoma is a non-Langerhans cell histiocytic disorder characterized by the presence of yellow-orange plaques on the face, neck, upper trunk and extremities. It can appear in association with several systemic diseases (including dyslipidemias, paraproteinemias, cardiovascular diseases and lymphoproliferative disorders), but is rarely connected with Langerhans cell histiocytoses...
December 15, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29243276/the-influence-of-shc-proteins-and-high-fat-diet-on-energy-metabolism-of-mice
#10
W A Baldassini, J J Ramsey, K Hagopian, D P D Lanna
The purpose of this study was to determine if Shc proteins influence the metabolic response to acute (7 days) feeding of a high-fat diet (HFD). To this end, whole animal energy expenditure (EE) and substrate oxidation were measured in the Shc knockout (ShcKO) and wild-type (WT) mice fed a control or HFD. The activities of enzymes of glycolysis, the citric acid cycle, electron transport chain (ETC), and β-oxidation were also investigated in liver and skeletal muscle of ShcKO and WT animals. The study showed that ShcKO increases (P < ...
December 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29243234/equine-gestational-length-and-location-is-there-more-that-the-research-could-be-telling-us
#11
REVIEW
J Clothier, G Hinch, W Brown, A Small
Clear definitions of 'normal' equine gestation length (GL) are elusive, with GL being subject to a considerable number of internal and external variables that have confounded interpretation and estimation of GL for over 50 years. Consequently, the mean GL of 340 days first established by Rossdale in 1967 for Thoroughbred horses in northern Europe continues to be the benchmark value referenced by veterinarians, breeders and researchers worldwide. Application of a 95% confidence limit to reported GL range values indicates a possible connection between geographic location and GL...
December 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29243143/highlights-of-the-44th-annual-scientific-congress-of-the-international-skeletal-society-iss-2017-new-york-new-york
#12
Miriam A Bredella
This paper summarizes the highlights of the Special Scientific Sessions of the 44th Annual Scientific Meeting of the International Skeletal Society (ISS), which was hosted in New York, NY, in August 2017.
December 14, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29243067/translational-regulation-in-the-anoxic-turtle-trachemys-scripta-elegans
#13
Kama E Szereszewski, Kenneth B Storey
The red-eared slider turtle (Trachemys scripta elegans), has developed remarkable adaptive mechanisms for coping with decreased oxygen availability during winter when lakes and ponds become covered with ice. Strategies for enduring anoxia tolerance include an increase in fermentable fuel reserves to support anaerobic glycolysis, the buffering of end products to minimize acidosis, altered expression in crucial survival genes, and strong metabolic rate suppression to minimize ATP-expensive metabolic processes such as protein synthesis...
December 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29243057/decreased-muscle-mass-is-independently-associated-with-knee-pain-in-female-patients-with-radiographically-mild-osteoarthritis-a-nationwide-cross-sectional-study-knhanes-2010-2011
#14
Hee Min Park, Ho Jae Kim, Byeori Lee, Minkyoung Kwon, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
To evaluate the association between muscle mass and knee pain in relation to radiographic severity of knee osteoarthritis. We consulted nationwide health examination and survey records collected from 2010 to 2011 and extracted data regarding female patients aged > 50 years and diagnosed with knee osteoarthritis. Radiographic severity was assessed on plain radiographs using the Kellgren-Lawrence system, whereas appendicular skeletal mass was obtained from dual-energy X-ray absorptiometry data. We performed multivariate logistic regression to evaluate the association between knee pain and muscle mass index (appendicular skeletal muscle mass divided by body weight in percentile) in patient groups stratified by radiographic severity of knee osteoarthritis...
December 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29242789/giant-cell-tumor-of-metacarpal-in-the-skeletally-immature-patient-and-free-osteoarticular-metatarsal-transfer-review-of-literature-with-case-report
#15
Pankaj Kumar Mishra, Yash Agarwal, Prakhar Singhal, Kripa Shankar Mishra
Introduction: In the customary wisdom, it is conceded that giant-cell tumor (GCT) is a pathology of fused epiphysis, but there are literatures available to depict that even though rare bit, but it occurs in the skeletally immature patients. Here, we are presenting a rare case of GCT of the fifth metacarpal in the skeletally immature patient. Case Report: It is a case report of a 13-year-old girl with the history of swelling over her right hand for 5 months. X-ray revealed that there was an osteolytic fusiform expansible lesion...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242729/altered-biodistribution-of-99mtc-dpd-on-bone-scan-after-intravenous-iron-supplement
#16
Eonwoo Shin, Minyoung Oh, Changhwan Sung, Ki-Hun Kim, Jin-Sook Ryu
We report a case with altered biodistribution of 99mTc-dicarboxypropane diphosphonate (99mTc-DPD) on whole body bone scan after intravenous iron supplement therapy. A 47-year-old male patient who had recently been detected with a hepatic mass suggestive of hepatocellular carcinoma underwent bone scan as staging work-up before surgery. Bone scan images at 3 h after injection of 99mTc-DPD demonstrated unusually increased blood pool activities in the heart, liver, and spleen with usual skeletal uptakes. The patient had been treated for severe anemia from hemorrhoid with two intravenous administration of ferric hydroxide carboxymaltose complex at approximately 22 h and 2 h prior to the 99mTc-DPD injection, which we consider as the most probable cause of altered biodistribution of 99mTc-DPD...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242624/plant-derived-compounds-strigolactone-gr24-and-pinosylvin-activate-sirt1-and-enhance-glucose-uptake-in-rat-skeletal-muscle-cells
#17
Shalem Modi, Nagendra Yaluri, Tarja Kokkola, Markku Laakso
Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue. We hypothesised that the novel plant-derived compounds, strigolactone and pinosylvin, beneficially enhance SIRT1 function, insulin signalling, glucose uptake, and mitochondrial biogenesis in skeletal muscle cells...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242563/ck2-modulates-adipocyte-insulin-signaling-and-is-up-regulated-in-human-obesity
#18
Christian Borgo, Gabriella Milan, Francesca Favaretto, Fabio Stasi, Roberto Fabris, Valentina Salizzato, Luca Cesaro, Anna Belligoli, Marta Sanna, Mirto Foletto, Luca Prevedello, Vincenzo Vindigni, Romeo Bardini, Arianna Donella-Deana, Roberto Vettor
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on insulin-signaling in adipose tissue, liver and skeletal muscle and its acute inhibition impairs glucose tolerance...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242526/percentiles-for-skeletal-muscle-index-area-and-radiation-attenuation-based-on-computed-tomography-imaging-in-a-healthy-caucasian-population
#19
A van der Werf, J A E Langius, M A E de van der Schueren, S A Nurmohamed, K A M I van der Pant, S Blauwhoff-Buskermolen, N J Wierdsma
BACKGROUND/OBJECTIVES: Muscle mass is a key determinant of nutritional status and associated with outcomes in several patient groups. Computed tomography (CT) analysis is increasingly used to assess skeletal muscle area (SMA), skeletal muscle index (SMI) and muscle radiation attenuation (MRA). However, interpretation of these muscle parameters is difficult since values in a healthy population are lacking. The aim of this study was to provide sex specific percentiles for SMA, SMA and MRA in a healthy Caucasian population and to examine the association with age and BMI in order to define age- and BMI specific percentiles...
December 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29242452/taxonomic-and-morphological-revision-of-butterfly-rays-of-the-i-gymnura-i-i-micrura-i-bloch-amp-schneider-1801-species-complex-with-the-description-of-two-new-species-myliobatiformes-gymnuridae
#20
Leandro Yokota, Marcelo Rodrigues DE Carvalho
An extensive taxonomic revision of Gymnura micrura based on external and internal morphology, and considering specimens from its entire geographical distribution in the Atlantic Ocean, is presented. Gymnura micrura is redescribed and a neotype is designated; its distributional range is limited to the Southwestern Atlantic. Two new species of butterfly rays are described: Gymnura lessae, sp. nov., occurring in the North and Central Western Atlantic, and Gymnura sereti, sp. nov., found in the Eastern Central Atlantic...
October 12, 2017: Zootaxa
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