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crohn hypercoagulability

Hajime Ikenouchi, Naoto Sugeno, Takaaki Nakamura, Junpei Kobayashi, Ryuji Oshima, Hiroshi Kuroda, Masashi Aoki
Development of paradoxical cerebral embolism requires both unstable venous thrombosis and right-to-left shunt (RLS). Gastrointestinal endoscopy (GE) has the potential to affect intrathoracic and abdominal venous thrombi and to enhance RLS because the procedure alters intrathoracic and abdominal pressure. We describe a patient with Crohn's disease who developed paradoxical cerebral embolism after GE. Both an unstable venous thrombus in the superior vena cava and RLS through patent foramen ovale were thought to be responsible for the stroke...
February 28, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Camila C Simoes, Yezaz A Ghouri, Shehzad N Merwat, Heather L Stevenson
Budd-Chiari syndrome (BCS) is characterised by obstruction of hepatic venous outflow and may be triggered by the prothrombotic state associated with inflammatory bowel disease (IBD). We reported a case of Crohn's disease (CD) that presented with anasarca, ascites, symptomatic hepatomegaly, elevated liver enzymes, increased prothrombin time and low albumin. Oesophagogastroduodenoscopy and colonoscopy confirmed active CD. Abdominal CT showed hepatic vein thrombosis. Liver biopsy revealed severe perivenular sinusoidal dilation with areas of hepatocyte dropout, bands of hepatocyte atrophy and centrizonal fibrosis, suggestive of BCS...
January 17, 2018: BMJ Case Reports
Janet Martin, Vidhya Nair, Allison Edgecombe
A 27-year-old male, admitted to hospital for a psoas muscle abscess secondary to Crohn's disease, suddenly died while in hospital. A medicolegal autopsy showed coronary sinus thrombosis. Coronary sinus thrombosis is rare and is usually associated with invasive cardiac procedures. Coronary sinus thrombosis associated with Crohn's disease has not been reported. Autopsy examination of the coronary sinus is advocated, especially in individuals with hypercoagulable states.
January 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Ravi Rasalingam, Ibrahim M Saeed, Pamela K Woodard, Julio E Pérez
Crohn's disease results in a hypercoagulable state increasing the risk of venous or arterial thromboembolism. Cardiac involvement has not been routinely identified. Two cases are presented to illustrate that patients with Crohn's disease may represent an exception to the rule that left ventricular apical thrombus should be associated with an underlying wall motion abnormality and reduction in left ventricular ejection fraction.
January 2016: Echocardiography
Inha Kim, Kyung-Hyun Min, Minju Yeo, Ji Seon Kim, Sung Hyun Lee, Sang Soo Lee, Kyeong Seob Shin, Sei Jin Youn, Dong Ick Shin
The development of cerebral venous thrombosis (CVT) as a secondary complication of Crohn's disease (CD) seems to be rare, but it is generally accepted that the disease activity of CD contributes to the establishment of a hypercoagulable state. Here, we describe a case of CVT that developed outside the active phase of CD. A 17-year-old male visited the emergency room because of a sudden onset of right-sided weakness and right-sided hypesthesia. He had been diagnosed with CD 1 year before and was on a maintenance regimen of mesalazine and azathioprine...
May 2015: Case Reports in Neurology
Imen Kraiem, Samira Hadhri, Mohamed Ben Rejeb, Lamia Ifa, Ali Jmaa, Salem Ajmi, Hadef Skouri
The hypercoagulable state accompanying inflammatory bowel diseases (IBDs) is still poorly understood. The aim of this study was to assess antiphospholipid antibodies (APAs) and a large panel of inherited and acquired thrombotic markers simultaneously in a sample of Tunisian patients with IBD. In total, 89 consecutive patients with IBD (mean age 38 ± 15 years; 48 with Crohn disease and 41 with ulcerative colitis) and 129 controls were prospectively evaluated for immunoglobulin (Ig) G, IgM, and IgA antibodies against cardiolipin (aCL), β2glycoprotein I (aβ2GPI), and prothrombin (aPT); IgG and IgM antibodies against phosphatidic acid (aPA), phosphatidylinositol (aPI), and annexin V (aAnnV); lupus anticoagulant (LA); coagulation factors; natural inhibitors; and thrombotic genetic polymorphisms...
November 2016: Clinical and Applied Thrombosis/hemostasis
Xiaobing Wang, Ge Wang, Jinghui Wang, Shi Liu, Rui Zhou, Liping Chen, Ting Wu, Meifang Huang, Jin Li, Lu Song, Bing Xia
BACKGROUND: Growing evidence has shown that coagulation processes play an important role in disease pathogenesis and/or disease progression in patients with inflammatory bowel disease. However, no study has ever focused on the possible influence of infliximab (IFX) therapy on the coagulation status in patients with Crohn's disease (CD). OBJECTIVE: To investigate the difference in the coagulation biomarkers between the CD patients and the control participants, and evaluate the impact of IFX usage on the coagulation status of CD patients...
September 2014: European Journal of Gastroenterology & Hepatology
Inimioara Mihaela Cojocaru, M Cojocaru, Violeta Sapira, Andreea Ionescu, Natalia Tacu
UNLABELLED: Cerebrovascular complications in 9 patients with inflammatory bowel disease (IBD) are presented, 6 with Crohn's disease (CD) and 3 with ulcerative colitis (UC), 7 men and 2 women, mean age 36.5 +/- 3.5 years, 4 of them during acute disease. Cerebrovascular complications were: cerebral venous thrombosis (CVT)--7 cases (5 CD and 2 UC) and ischemic stroke--2 cases (1 CD and 1 UC). Out of 7 cases with CVT 5 were superior sagittal sinus thrombosis (SSS), 2 SSS and transverse and sigmoid sinus thrombosis...
January 2014: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Darina Kohoutova, Miroslav Pecka, Michal Cihak, Jiri Cyrany, Jaroslav Maly, Jan Bures
OBJECTIVE. Inflammatory bowel disease (IBD) can be associated with hypercoagulable disorders. Aim of this single-center, prospective study was an in-depth evaluation of acquired hypercoagulable states in IBD patients. METHODS. A total of 110 patients with Crohn's disease (CD) (aged 19-69; mean 40.5, median 38.5 years), 43 with ulcerative colitis (UC) (aged 17-72; mean 42, median 36 years), and 30 controls were enrolled. Full blood count, serum C-reactive protein (CRP), proteins C and S, activated protein C (APC) resistance, thrombin-antithrombin complex (TAT), F1+F2 fragments, tissue factor pathway inhibitor (TFPI) total and truncated, TFPI-factor Xa, tissue plasminogen activator (tPA) and PAI-I antigen were investigated in peripheral blood samples...
March 2014: Scandinavian Journal of Gastroenterology
Sébastien Richard, Gioia Mione, Julien Perrin, Marie Toussaint-Hacquard, Jean-Christophe Lacour, Xavier Ducrocq
Increased ischemic stroke risk is observed in patients with inflammatory bowel disease (IBD). Causes and physiopathological aspects of cerebral infarct, in this specific population, are less often described. There is little information to provide guidelines for the best curative and preventive treatment. We report 2 cases of ischemic strokes due to internal carotid thrombus in patients during active phase of IBD. Ulceration of early atherosclerotic plaques activated by a hypercoagulation state may cause a thrombus...
February 7, 2013: World Journal of Gastroenterology: WJG
J R Korzenik
: In recent years, heparin has emerged as a possible therapy for inflammatory bowel disease (IBD). Several recent, strongly positive, open-labeled series of heparin in both ulcerative colitis (UC) and Crohn's disease (CD) reinforce the work of Gaffney and co-workers that suggested a benefit of heparin in UC. Although counterintuitive as a therapy for a disorder characterized by bleeding, heparin is intriguing also for implications with regard to the pathophysiology of UC and CD. Although the thromboembolic complications and hypercoagulable state associating flares of both UC and CD suggest that heparin may produce a benefit by treating microthrombi in the intestinal circulation, recent IBD research suggests that a broader endothelial dysfunction in regulation of coagulation, inflammation, and vascular repair may be important events in the pathogenesis of IBD...
1997: Inflammatory Bowel Diseases
Cade M Nylund, Anthony Goudie, Jose M Garza, Gary Crouch, Lee A Denson
BACKGROUND: Adults with inflammatory bowel disease (IBD) have an increased risk of venous thrombotic events (TEs). We sought to evaluate the risk for TE in children and adolescents with IBD using a large population database. METHODS: The triennial Healthcare Cost and Utilization Project Kids' Inpatient Database was used in a retrospective cohort study of hospitalized children in the United States across 1997, 2000, 2003, 2006, and 2009. Billing codes were used to identify discharges with Crohn disease, ulcerative colitis, pulmonary embolism, deep vein thrombosis, thrombophlebitis, thrombosis of intracranial venous sinus, Budd-Chiari syndrome, and portal vein thrombosis...
May 2013: Journal of Pediatric Gastroenterology and Nutrition
Kuldeep Singh, Sean A Marco, Ming-Li Wang, Luca Milone, Jonathan S Deitch
Isolated arterial thrombi complicating inflammatory bowel disease occurs rarely. We encountered a case of a 28-year-old man with Crohn disease who presented with abdominal pain and severe claudication and was found to have an isolated aortoiliac thrombus. Bilateral aortoiliac thromboembolectomies were performed with successful restoration of femoral blood flow. Long-term anticoagulation therapy was instituted after an extensive hypercoagulable workup, which failed to reveal an etiology for the patient's coagulopathy...
November 2012: Annals of Vascular Surgery
Danuta Owczarek, Dorota Cibor, Kinga Sałapa, Andrzej Cieśla, Mikołaj K Głowacki, Halina Pocztar, Tomasz H Mach
INTRODUCTION: In patients with inflammatory bowel disease (IBD), disbalance between procoagulant, anticoagulant, and fibrinolytic factors has been shown. The hemostatic system is an indispensable component of the inflammatory process. Deficiencies in the protein C (PC) pathway components not only promote thrombosis, but also exacerbate inflammation. OBJECTIVES: The aim of the study was to assess the components of the PC system and their correlations with disease activity in patients with IBD...
2012: Polskie Archiwum Medycyny Wewnętrznej
Giovanni Maconi, Elena Bolzacchini, Alessandra Dell'Era, Umberto Russo, Sandro Ardizzone, Roberto de Franchis
BACKGROUND AND METHODS: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission...
April 2012: Journal of Crohn's & Colitis
Uri Kopylov, Marianne M Amitai, Aharon Lubetsky, Rami Eliakim, Yehuda Chowers, Shomron Ben-Horin
BACKGROUND: Mesenteric vein thrombosis (MVT) is a rare and frequently underdiagnosed complication of Crohn's disease (CD). This study describes the clinical and radiological characteristics of CD /patients with superior mesenteric vein thrombosis (MVT) diagnosed by CT/MRI. PATIENTS AND METHODS: The database of Crohn's disease patients treated in Sheba Medical Center between 2005-2010 was searched for MVT diagnosis. Imaging studies of identified patients were retrieved and reviewed by an experienced abdominal radiologist...
June 2012: Journal of Crohn's & Colitis
Riyazuddin S Ansari, Fatima M Domfu, Basem Felemban, Wael H Mutair
Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the gastrointestinal tract. There is a well-known risk of thrombosis in patients with IBD with an overall incidence of 1.3-7.5%. Cerebral venous sinus thrombosis (CVST) has been reported as an uncommon complication of IBD. It is suspected to be a consequence of genetic predisposition and the hypercoagulable state occurring during periods of increased activity. There are a few cases of Crohn`s disease in the literature associated with CVST...
January 2012: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Huseyin Alkim, Selime Ayaz, Canan Alkim, Aysel Ulker, Burhan Sahin
This study was planned for searching possible changes of the total coagulation and fibrinolysis system in inflammatory bowel disease (IBD) in order to obtain some clues for explaining the relation between IBD and hypercoagulability. A total of 24 patients with ulcerative colitis, 12 patients with Crohn disease, and 20 healthy controls were studied. Platelets; prothrombin time (PT); partial thromboplastin time (PTT); fibrinogen; D-dimer; fibrinogen degradation products; protein C; protein S; antithrombin; thrombin time; von Willebrand factor; coagulation factors V, VII, VIII, IX, XI, and XIII; plasminogen; antiplasmin; tissue plasminogen activator; plasminogen activator inhibitor 1; and prothrombin fragments 1 + 2 were studied...
November 2011: Clinical and Applied Thrombosis/hemostasis
Tarun Rustagi, Shounak Majumder
No abstract text is available yet for this article.
April 2011: Journal of Digestive Diseases
Heike Bernhard, Andrea Deutschmann, Bettina Leschnik, Sabrina Schweintzger, Michael Novak, Almuthe Hauer, Wolfgang Muntean
BACKGROUND: Patients with inflammatory bowel disease (IBD) have an increased risk of thromboembolic complications. The pathogenesis of IBD is not really clear and a high thrombin activity might contribute to the pathogenesis. We measured thrombin generation by means of calibrated automated thrombography (CAT), a new tool better reflecting overall hemostasis, in children with Crohn's disease (CD) during active and inactive disease and compared it to conventional markers of activity. We wanted to see whether children with CD have a higher potential for thrombin generation and if there is a correlation between hypercoagulability and disease activity...
November 2011: Inflammatory Bowel Diseases
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