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methotrexate pneumonitis

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https://www.readbyqxmd.com/read/29503065/methotrexate-pneumonitis-in-crohn-s-disease-a-rare-case-report-and-review-of-literature
#1
Arantza Sánchez, Patricia Ramírez de la Piscina, Ileana Duca, Silvia Estrada, Rosario Calderón, Marta Salvador, Elvira Delgado, Francisco García Campos
No abstract text is available yet for this article.
March 1, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29341936/rheumatic-manifestations-among-cancer-patients-treated-with-immune-checkpoint-inhibitors
#2
Merav Lidar, Eitan Giat, Daniela Garelick, Yuval Horowitz, Howard Amital, Yael Steinberg-Silman, Jacob Schachter, Ronnie Shapira-Frommer, Gal Markel
BACKGROUND: The use of immune checkpoint inhibitors (ICI) has grown incessantly since they were first approved in 2014. These monoclonal antibodies inhibit T cell activation, yielding a dramatic tumor response with improved survival. However, immunotherapy is frequently hampered by immune adverse events (iAE) such as hypophysitis, colitis, hepatitis, pneumonitis and rash. Until recently, rheumatic side effects were only infrequently reported. AIM: To describe the rheumatic manifestations encountered among patients treated with ICIs in a large tertiary cancer center in Israel METHODS: The cancer center's patient registry was screened for patients who had ever been treated with ipilimumab, pembrolizumab and/or nivolumab with relevant data gathered from clinical charts...
March 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29173689/esophageal-abnormalities-in-juvenile-localized-scleroderma-is-it-associated-with-other-extracutaneous-manifestations
#3
Clarissa C M Valões, Glaucia V Novak, Juliana B Brunelli, Katia T Kozu, Ricardo K Toma, Clovis A Silva
OBJECTIVE: To assess esophageal involvement (EI) in juvenile localized scleroderma (JLS) population and the possible association between this gastrointestinal manifestation and demographic data, clinical features, laboratory exams, treatments and outcomes. METHODS: For a period of 30 years, 5881 patients with rheumatic diseases were followed in our Pediatric Rheumatology Division. EI was defined by the presence of symptoms (solid/liquid dysphagia, heartburn, esophageal regurgitation, nausea/vomiting and epigastralgia) and confirmed by at least one EI exam abnormality: barium contrast radiography, upper gastrointestinal endoscopy and 24-hour esophageal pH-monitoring...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29055135/treatment-of-prurigo-with-methotrexate-a-multicentre-retrospective-study-of-39-cases
#4
T Klejtman, M Beylot-Barry, P Joly, M A Richard, S Debarbieux, L Misery, P Wolkenstein, O Chosidow, S Ingen-Housz-Oro
BACKGROUND: Prurigo is a common primary pruritic condition. Treatment is challenging. Methotrexate (MTX) is effective for the treatment of pruriginous dermatoses, but its use in prurigo has been little studied. OBJECTIVES: To investigate the efficacy and safety of MTX in the treatment of difficult-to-treat prurigo. METHODS: Patients from six university dermatology departments treated with MTX between 2006 and 2016 for difficult-to-treat prurigo (i...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28655345/methotrexate-induced-hypersensitivity-pneumonitis-appearing-after-30%C3%A2-years-of-use-a-case-report
#5
Mashal Salehi, Robertha Miller, Myint Khaing
BACKGROUND: Methotrexate has been implicated in a variety of lung complications, one of which is hypersensitivity pneumonitis. Hypersensitivity pneumonitis most often occurs within the first year of starting low-dose orally administered methotrexate. We present a case of methotrexate-induced hypersensitivity pneumonitis after 30 years of methotrexate use, which is the first case to be reported so far. CASE PRESENTATION: A 77-year-old African American woman with a history of rheumatoid arthritis presented with progressively worsening shortness of breath and nonproductive cough...
June 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28500058/response-to-hla-a-31-01-is-not-associated-with-the-development-of-methotrexate-pneumonitis-in-the-uk-population-results-from-a-genome-wide-association-study-by-bluett-et-al
#6
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Naoyuki Tsuchiya, Shigeto Tohma
No abstract text is available yet for this article.
May 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28349012/low-dose-methotrexate-induced-acute-interstitial-pneumonitis-report-of-two-cases-from-south-india-and-review-of-literature
#7
Ramya Iyyadurai, Ronald Albert Benton Carey, Sowmya Satyendra
Methotrexate (MTX) is an antimetabolite used as a disease-modifying agent for various rheumatological conditions. We report two patients who were treated with daily low-dose MTX and developed acute interstitial pneumonitis requiring hospital admission. MTX-induced pneumonitis is a rare life-threatening side effect, high index of clinical suspicion is required, treatment is mainly withdrawal of MTX, supportive therapy, and adjunctive steroids, outcome is good if condition is recognized early, and appropriate treatment is given...
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28120731/-serious-complications-during-treatment-with-methotrexate-also-in-chronic-low-dosage-use
#8
R J Rodenburg, M J H Wijnands, P L Rensma
Methotrexate is a frequently prescribed drug and is considered to be safe at a low dosage. However, serious complications may occur during treatment. In this article we describe a 78-year-old male who used low-dose methotrexate for psoriatic arthritis. He died of multi-organ failure caused by sepsis and methotrexate intoxication as a result of deteriorating renal function. The second patient was a 56-year-old male who used low-dose methotrexate for rheumatoid arthritis. This patient developed pancytopenia and methotrexate pneumonitis during treatment with methotrexate...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28031829/summer-type-hypersensitivity-pneumonitis-in-a-patient-with-rheumatoid-arthritis-on-methotrexate-and-tacrolimus
#9
Hirotsugu Ohkubo, Minami Okayama, Kensuke Fukumitsu, Akio Niimi
A 59-year-old woman receiving methotrexate and tacrolimus for rheumatoid arthritis (RA) was referred to our hospital following bilateral ground-glass opacity observed in her chest X-ray and elevated serum KL-6. After methotrexate and tacrolimus cessation, shortness of breath developed and ground-glass opacity observed in the chest computed tomography rapidly worsened. Bronchoalveolar lavage showed increased lymphocytes, and trans-bronchial lung biopsy confirmed lymphocytic alveolitis. In addition, the patient had serum antibodies against Trichosporon asahii, a fungal pathogen...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28001499/effectiveness-and-safety-of-methotrexate-in-psoriasis-an-eight-year-experience-with-218-patients
#10
Camila Cabello Zurita, Mercè Grau Pérez, Carlos Pelayo Hernández Fernández, Alicia González Quesada, Pedro Valerón Almazán, Jaime Vilar Alejo, Gregorio Carretero Hernández
BACKGROUND: Methotrexate (MTX), a traditional antipsoriatic drug, is very frequently used either as monotherapy or in combination with other systemic drugs. OBJECTIVES: To assess the effectiveness and safety of MTX in psoriasis in usual clinical practice. METHODS: We conducted a retrospective study. We performed an electronic and manual chart review of patients treated with MTX in the Psoriasis Unit of our Hospital from January 2007 to December 2014...
August 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27693175/esophageal-abnormalities-in-juvenile-localized-scleroderma-is-it-associated-with-other-extracutaneous-manifestations
#11
Clarissa C M Valões, Glaucia V Novak, Juliana B Brunelli, Katia T Kozu, Ricardo K Toma, Clovis A Silva
OBJECTIVE: To assess esophageal involvement (EI) in juvenile localized scleroderma (JLS) population and the possible association between this gastrointestinal manifestation and demographic data, clinical features, laboratory exams, treatments and outcomes. METHODS: For a period of 31 years, 5,881 patients with rheumatic diseases were followed in our Pediatric Rheumatology Division. EI was defined by the presence of symptoms (solid/liquid dysphagia, heartburn, esophageal regurgitation, nausea/vomiting and epigastralgia) and confirmed by at least one EI exam abnormality: barium contrast radiography, upper gastrointestinal endoscopy and 24-hour esophageal pH-monitoring...
September 17, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27307501/inflammatory-arthritis-and-sicca-syndrome-induced-by-nivolumab-and-ipilimumab
#12
Laura C Cappelli, Anna Kristina Gutierrez, Alan N Baer, Jemima Albayda, Rebecca L Manno, Uzma Haque, Evan J Lipson, Karen B Bleich, Ami A Shah, Jarushka Naidoo, Julie R Brahmer, Dung Le, Clifton O Bingham
OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) pathways have demonstrated survival improvements in multiple advanced cancers, but also cause immune-related adverse events (IRAEs). IRAEs with clinical features similar to rheumatic diseases have not been well described. We report patients with inflammatory arthritis and sicca syndrome secondary to ICIs. METHODS: We report patients evaluated in the Johns Hopkins Rheumatology clinics from 2012 to 2016 identified as having new rheumatological symptoms in the context of treatment with ipilimumab (anti-CTLA-4) and/or nivolumab (anti-PD-1) for solid tumours...
January 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/26602361/acute-pneumonitis-in-a-patient-with-adult-onset-disease-after-toclizumab-treatment-with-good-response-to-anakinra
#13
Clara Sangüesa Gómez, Bryan Josué Flores Robles, Beatriz Jara Chinarro, María Espinosa Malpartida, Carmen Barbadillo Mateos
Pulmonary involvement in the form of acute pneumonitis in adult-onset Still's disease (AOSD) is an uncommon manifestation, with few cases reported in the literature. We report the case of a 61-year-old male with 3 years of AOSD evolution, treated with methotrexate (MTX) and half-dose corticosteroids, which debuted with symptoms of fever, dyspnea and dry cough after 3 weeks of receiving the first dose of tocilizumab (TCZ). In the follow-up study showed leukocytosis with left shift, elevated serum ferritin and C-reactive protein standard...
November 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/26600985/-cervical-aspergillosis-with-dissemination-to-the-central-nervous-system-case-reports-and-review-of-the-literature
#14
Guillermo Enrique Vergara, Natalia Roura, Marcelo Del Castillo, Andrea Mora, Santiago Condomi Alcorta, Rubén Mormandi, Andrés Cervio, Jorge Salvat
BACKGROUND: Invasive aspergillosis (IA) of the central nervous system (CNS) is an uncommon condition that usually occurs in immunocompromised patients. This illness can manifest as meningitis, or as a micotic aneurism, stroke or abscess. The infection affects the CNS either primarily or, more often, secondarily via blood dissemination from a distant focus, and has a poor prognosis. We present a patient with IA primarily affecting the cervical bones, with later spread into the brain. CASE DESCRIPTION: A 25-year old male was receiving chemotherapy for acute lymphocytic leukemia when he developed pneumonitis secondary to methotrexate and was started on corticosteroids...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/26592712/hyperacute-methotrexate-pneumonitis-in-a-patient-with-crohn-s-disease
#15
Itishree Trivedi, Rishi Raj, Stephen Hanauer
No abstract text is available yet for this article.
March 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26526669/the-development-of-a-questionnaire-to-evaluate-rheumatoid-arthritis-patient-s-knowledge-about-methotrexate
#16
Françoise Fayet, Carine Savel, Malory Rodere, Bruno Pereira, Dihya Abdi, Sylvain Mathieu, Anne Tournadre, Martin Soubrier, Jean-Jacques Dubost
AIMS AND OBJECTIVES: Assess knowledge concerning methotrexate in rheumatoid arthritis patients by means of a questionnaire. BACKGROUND: Methotrexate is the standard drug for rheumatoid arthritis treatment. It has potentially serious side effects that can be largely prevented by making sure that patients are well informed and comply with prescription guidelines. DESIGN: Cross-sectional survey. METHODS: A questionnaire on methotrexate (mode of action, administration, drug interactions), side effects, monitoring and lifestyle implications was offered to all the rheumatoid arthritis patients treated with the drug seen between March and September 2013 in a large hospital in France...
March 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/26312671/combined-acute-interstitial-pneumonitis-and-pancytopenia-induced-by-low-dose-methotrexate-in-a-hemodialysis-patient-treated-for-bullous-pemphigoid
#17
Haibo Liu, Fang Liu, Min Zhang, Wenliang Yan, Hong Sang
Methotrexate has been widely used for many years in the treatment of a variety of diseases. Acute pneumonitis and bone marrow suppression are very serious side effects in methotrexate treatment. A 48-year-old man with end-stage renal disease undergoing chronic hemodialysis developed combined acute pneumonitis and pancytopenia after a cumulative dose of 20 mg methotrexate for bullous pemphigoid. Continuous renal replacement therapy (CRRT) can efficiently decrease serum methotrexate concentration. A rapid improvement of clinical symptoms and resolution of pulmonary opacification were found after CRRT...
May 2015: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/26199244/-transplant-related-mortality-following-allogeneic-hematopoietic-stem-cell-transplantation-using-fludarabine-busulfan-based-reduced-intensity-conditioning-a-retrospective-analysis-in-a-single-institution
#18
Takashi Yoshida, Shigeru Kusumoto, Arisa Masuda, Haruhito Totani, Tomoko Narita, Ayako Masaki, Asahi Ito, Masaki Ri, Takashi Ishida, Hirokazu Komatsu, Shinsuke Iida
Reduced-intensity conditioning (RIC) has been shown to facilitate allogeneichematopoieticstem cell transplantation (allo-HSCT) for patients with comorbidities and the elderly. However, there are some concerns about transplant-related mortality (TRM). We retrospectively analyzed 37 consecutive patients who received allo-HSCT using RIC from January 2005 to December 2012 in our hospital. All patients received fludarabine(FLU), 180 mg/m2, and intravenous busulfan(BU), 6.4 mg/ kg (or oral BU 8 mg/kg), with or without TBI (2 or 4 Gy)...
June 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26069917/-rheumatoid-arthritis-and-lung-more-than-a-minor-aspect-of-the-disease
#19
Christoph Fiehn
Although rheumatoid arthritis (RA) mainly manifests as polyarthritis, there is growing evidence that the initiation of the pathological immune reaction against citrullinated peptides takes place in the lung. However, in spite of this important role of the lung in pathophysiology, clinically manifest lung involvement has been demonstrated only in about 2-5 % of the patients with RA, and therefore is relatively rare. In particular the severe interstitial lung involvement with histological pattern of usual interstitial pneumonia has a bad prognosis and an increased mortality...
June 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25819619/treatment-for-metastatic-penile-cancer-after-first-line-chemotherapy-failure-analysis-of-response-and-survival-outcomes
#20
Jennifer Wang, Curtis A Pettaway, Lance C Pagliaro
OBJECTIVE: To retrospectively estimate the efficacy of various treatments used in men with metastatic penile cancer that progresses after first-line chemotherapy. METHODS: Patients were from a 30-patient cohort with stage TxN2-3M0 penile squamous cell carcinoma treated with neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy before planned lymphadenectomy. Nineteen patients (63.3%) had tumor progression or recurrence, and we evaluated the response to subsequent treatment and survival...
May 2015: Urology
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