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Gulen Hatemi, Emire Seyahi, Izzet Fresko, Rosaria Talarico, Vedat Hamuryudan
Several articles highlighting the epidemiology, pathogenesis, clinical features, treatment modalities and disease assessment of Behçet's syndrome (BS) have been published during the last year. Clinical and radiological features of lower extremity deep vein thrombosis due to BS can be quite different than those found in thrombosis due to other causes; additionally, frequency of post-thrombotic syndrome is significantly increased in BS. Some clinical and colonoscopic features are useful in differentiating BS from Crohn's disease...
September 2016: Clinical and Experimental Rheumatology
Cary C Cotton, Donna Baird, Robert S Sandler, Millie D Long
BACKGROUND: Persons with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism. We sought to examine whether the self-report of hormonal contraception (HC), as a proxy for exposure to estrogen-based contraception, was less common for women with multiple risk factors for venous thromboembolism. METHODS: We examined the prevalence of personal use of hormonal birth control in a large internet-based cohort of patients with IBD. To determine whether HC was less common among patients with IBD with increased risk of thrombosis, we estimated unadjusted and adjusted prevalence ratios (PRs) for the use of HC...
July 2016: Inflammatory Bowel Diseases
Adriano Alatri, Alain Schoepfer, Nicolas Fournier, Rolf Peter Engelberger, Ekaterina Safroneeva, Stephan Vavricka, Luc Biedermann, Luca Calanca, Lucia Mazzolai
OBJECTIVE: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with the occurrence of venous thromboembolism (VTE) such as deep vein thrombosis (DVT) and pulmonary embolism (PE). We aimed to assess the prevalence and associated risk factors for VTE in a large national cohort of IBD patients. MATERIAL AND METHODS: Data from patients of the Swiss IBD Cohort Study (SIBDCS) enrolled between 2006 and 2013 were analyzed...
October 2016: Scandinavian Journal of Gastroenterology
Elżbieta Krzesiek, Urszula Zaleska-Dorobisz, Barbara Iwańczak, Andrzej T Dorobisz
BACKGROUND: Inflammatory bowel disease includes ulcerative colitis and Crohn's disease. CASE REPORT: This case report presents a patient with ulcerative colitis, with thrombotic complication of the left common iliac vein that occurred at the age of 11, two years after diagnosis. After a year of anticoagulation and compression therapy, although exacerbations of underlying disease occurred in the first 6 months of treatment, there was no recurrence of deep venous thrombosis, partial recanalization within affected venous system has been achieved and the patient is remission of ulcerative colitis for the last six months...
2016: Polish Journal of Radiology
Lize Bollen, Niels Vande Casteele, Vera Ballet, Gert van Assche, Marc Ferrante, Séverine Vermeire, Ann Gils
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a higher risk of developing thromboembolic events (TE) compared with the healthy population. AIM: This study aimed to describe a cohort of IBD patients with a history of TE focusing on recurrence of TE, disease activity and IBD medication at the time of TE and surgery before TE. MATERIALS AND METHODS: In a retrospective monocentric cohort study, we included IBD patients in whom an arterial and/or venous TE occurred...
January 2016: European Journal of Gastroenterology & Hepatology
Marcin Włodarczyk, Aleksandra Sobolewska, Jakub Fichna, Maria Wiśniewska-Jarosińska
Crohn's disease and ulcerative colitis belong to a group of inflammatory bowel diseases (IBD). IBD are characterized by a chronic character of inflammatory process and overlapping immunological abnormalities, which, along with therapeutic strategies are currently available, underlie an increased risk of venous thromboembolic events (VTE). The most common sites of VTE in IBD patients are deep venous thrombosis (DVT) and pulmonary embolism (PE). These complications are particularly important in clinical practice due to a very high mortality rate...
2015: Current Drug Targets
Nathalie Bleau, Valerie Patenaude, Haim A Abenhaim
OBJECTIVE: The objective of this study is to evaluate the effect of autoimmune disease on the risk of venous thromboembolism (VTE) including deep vein thrombosis (DVT) and pulmonary embolism (PE) in pregnant women. METHODS: Using the Health Care Cost and Utilization Project, Nationwide Inpatient Sample database from 2003 to 2011, the risk of developing DVT, PE, and VTE among pregnant patients with selected autoimmune diseases was estimated using unconditional logistic regression analysis...
April 2016: Clinical and Applied Thrombosis/hemostasis
SreyRam Kuy, Anahita Dua, Rohit Chappidi, Gary Seabrook, Kellie R Brown, Brian Lewis, Peter J Rossi, Cheong J Lee
BACKGROUND: We performed a national population-based study examining the incidence of both venous and arterial thromboembolic events in patients hospitalized with inflammatory bowel disease over the past decade. METHODS: A retrospective cross-sectional analysis using the Nationwide Inpatient Sample Database was performed. Patients hospitalized with Crohn's disease and ulcerative colitis were identified using ICD-9 codes. The incidence of clinically relevant venous thromboembolic events and arterial thromboembolic events including myocardial infarction, visceral ischemia, cerebrovascular accidents, and peripheral arterial events was examined...
June 2015: Vascular
A Ri Shin, Chang Kyun Lee, Hyo Jong Kim, Jae-Jun Shim, Jae Young Jang, Seok Ho Dong, Byung Ho Kim, Young Woon Chang
Thrombophlebitis of the portal venous system (PVS) with superimposed bacterial infection (septic pylephlebitis) is an extremely rare complication of Crohn's disease (CD), and therefore diagnosis of septic pylephlebitis is difficult without high clinical suspicion. A 16-year old male patient who was diagnosed with CD 3 months earlier was admitted with recurrent fever and abdominal pain. CD activity had been well controlled with conventional medical treatment during a follow-up period. Abdominal contrast-enhanced computed tomography showed massive thrombosis in the PVS without evidence of intra-abdominal infection, and blood cultures were positive for Streptococcus viridians...
April 2013: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Simone Saibeni, Maria J Etchevers, Dolors Tassies, Julián Panés, Joan C Reverter, Silvio Danese, Josep M Piqué, Savino Bruno, Maurizio Vecchi, Antonio Gasbarrini, Miquel Sans
PURPOSE: In inflammatory bowel diseases (IBD), risk of thrombosis and production of antibodies are increased. In autoimmune and inflammatory disorders, a role of anti-prothrombin (aPT) antibodies in developing thrombosis has been hypothesised. The aim of the study is to evaluate the prevalence of aPT antibodies in IBD patients, with and without thrombosis. METHODS: Thirty-three IBD patients with thrombosis, 33 IBD patients without thrombosis matched for sex, age, diagnosis and disease activity and 66 sex- and age-matched healthy controls were enrolled...
September 2013: International Journal of Colorectal Disease
Melissa Gianos, Abraham Abdemur, Samuel Szomstein, Raul Rosenthal
BACKGROUND: Laparoscopic sleeve gastrectomy is a relatively new treatment modality implemented in the surgical management for morbid obesity. It has been well documented that obesity is not only associated with an increased risk of malignancies but is also consistent with a higher incidence of surgical complications related to its definitive management. In spite of the weight loss experienced by patients with malignancy due to a catabolic state, bariatric surgery might be considered as a step procedure allowing for a more efficient and suitable surgical approach to treat early stage malignancies, thereby decreasing the procedure-related morbidity and mortality...
September 2013: Obesity Surgery
Woohyeon Kim, Borami Kang, Byung-Wook Kim, Joon Sung Kim, Hae-Mi Lee, Eun-Joo Lim, Jong In Kim, Bong-Koo Kang, Jeong-Seon Ji, Bo-In Lee, Hwang Choi
Extraintestinal manifestations are not uncommon in Crohn's disease, and a thromboembolic event is a disastrous potential complication. Deep vein thrombosis is the most common manifestation of a thromboembolic event and typically occurs in association with active inflammatory disease. Peripheral neuropathy in Crohn's disease has rarely been reported and is considered an adverse effect of metronidazole therapy. Here, we describe a patient who was initially diagnosed with Crohn's disease complicated with deep vein thrombosis and ulnar neuropathy without metronidazole exposure...
March 2013: Gut and Liver
H Yuhara, C Steinmaus, D Corley, J Koike, M Igarashi, T Suzuki, T Mine
BACKGROUND: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism (VTE). AIM: To provide a quantitative assessment of the association of IBD with venous thromboembolism risk and to explore the possible sources of heterogeneity in the current literature, a meta-analysis of case-control and cohort studies was conducted...
May 2013: Alimentary Pharmacology & Therapeutics
Geoffrey C Nguyen, Harry Wu, Aliya Gulamhusein, Morgan Rosenberg, Reka Thanabalan, Erik L Yeo, Charles N Bernstein, A Hillary Steinhart, Myles Margolis
BACKGROUND: Asymptomatic deep vein thrombosis (DVT) occurs in up to 11% of medical inpatients. The incidence of asymptomatic DVT among patients with inflammatory bowel disease (IBD) is unknown but may be even higher. D-dimer is effective for DVT screening, but its utility has not been studied in the IBD population. METHODS: Hospitalized and ambulatory patients with IBD during flares were recruited between 2009 and 2011. Those with clinical symptoms of venous thromboembolism or previous venous thromboembolism were excluded...
April 2013: Inflammatory Bowel Diseases
Cade M Nylund, Anthony Goudie, Jose M Garza, Gary Crouch, Lee A Denson
BACKGROUND: Adults with inflammatory bowel disease (IBD) have an increased risk of venous thrombotic events (TEs). We sought to evaluate the risk for TE in children and adolescents with IBD using a large population database. METHODS: The triennial Healthcare Cost and Utilization Project Kids' Inpatient Database was used in a retrospective cohort study of hospitalized children in the United States across 1997, 2000, 2003, 2006, and 2009. Billing codes were used to identify discharges with Crohn disease, ulcerative colitis, pulmonary embolism, deep vein thrombosis, thrombophlebitis, thrombosis of intracranial venous sinus, Budd-Chiari syndrome, and portal vein thrombosis...
May 2013: Journal of Pediatric Gastroenterology and Nutrition
A H Lim, R Grafton, D J Hetzel, J M Andrews
BACKGROUND: Acute severe colitis (ASC) is a serious condition with possible outcomes of emergency colectomy and mortality. Validated guidelines exist to help avoid these. AIMS: To examine local adherence to guidelines and identify (a) opportunities to improve care and (b) possible barriers to adherence. METHODS: Retrospective, hospital-wide audit of all patients with ASC during a 2-year period (2009-2010) at a major metropolitan hospital. Cases were identified by an electronic search of all discharges with International Classification of Diseases-10 codes for colitis, colectomy, ulcerative colitis or Crohn disease...
July 2013: Internal Medicine Journal
Jessica B Wallaert, Randall R De Martino, Priscilla S Marsicovetere, Philip P Goodney, Sam R G Finlayson, John J Murray, Stefan D Holubar
BACKGROUND: Although it is commonly reported that IBD patients are at increased risk for venous thromboembolic events, little real-world data exist regarding their postoperative incidence and related outcomes in everyday practice. OBJECTIVE: We aimed to identify the rate of venous thromboembolism and modifiable risk factors within a large cohort of surgical IBD patients. DESIGN: We performed a retrospective review of IBD patients who underwent colorectal procedures...
November 2012: Diseases of the Colon and Rectum
Cristina Suárez Ferrer, María Isabel Vera Mendoza, Leticia Amo San Román, Yago González Lama, Marta Calvo Moya, Mercedes García Casas, Luis Abreu García
INTRODUCTION: Inflammatory bowel disease (IBD) is an independent risk factor for thromboembolic phenomena (TEP). We evaluated the prevalence and the possible risk factors associated with developing TEP in patients with IBD in our center. MATERIAL AND METHODS: Data were retrospectively collected from January 1995 to December 2011 from 23 patients. A total of 61% were diagnosed with Crohn's disease (CD) and 39% with ulcerative colitis (UC) according to routine criteria...
November 2012: Gastroenterología y Hepatología
Stefan Jacobson
OBJECTIVE: The effect of preoperative total parenteral nutrition (TPN) on the rate of early (within 30 days) postoperative complications in patients with moderate to severe Crohn's disease (CD) was examined. MATERIAL AND METHODS: A series of 15 consecutive patients with CD (mean CD activity index score, 270) given preoperative TPN for 18-90 days (mean, 46 days) and undergoing bowel resection and primary anastomosis was compared with matching controls (105 patients) consecutively selected from all CD patients operated in Stockholm County during a preceding 20-year period without preoperative TPN...
February 2012: Scandinavian Journal of Gastroenterology
Lei Lian, K V Narayanan Menon, Bo Shen, Feza Remzi, Ravi P Kiran
BACKGROUND: The pattern and severity of postoperative complications after colectomy and total proctocolectomy with ileoanal pouch for patients with IBD with liver cirrhosis from primary sclerosing cholangitis have not been well characterized. OBJECTIVE: This study aimed to evaluate the immediate and long-term outcomes for patients with cirrhosis from primary sclerosing cholangitis undergoing colectomy for IBD. DESIGN: This is a retrospective study...
January 2012: Diseases of the Colon and Rectum
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