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https://www.readbyqxmd.com/read/27909406/assessment-of-a-wearable-force-and-electromyography-device-and-comparison-of-the-related-signals-for-myocontrol
#1
Mathilde Connan, Eduardo Ruiz Ramírez, Bernhard Vodermayer, Claudio Castellini
In the frame of assistive robotics, multi-finger prosthetic hand/wrists have recently appeared, offering an increasing level of dexterity; however, in practice their control is limited to a few hand grips and still unreliable, with the effect that pattern recognition has not yet appeared in the clinical environment. According to the scientific community, one of the keys to improve the situation is multi-modal sensing, i.e., using diverse sensor modalities to interpret the subject's intent and improve the reliability and safety of the control system in daily life activities...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27881387/intrauterine-growth-restriction-influences-vascular-remodeling-and-stiffening-in-the-weanling-rat-more-than-sex-or-diet
#2
R Blair Dodson, Thomas A Miller, Kyle N Powers, Yueqin Yang, Baifeng Yu, Kurt H Albertine, Erin K Zinkhan
Intrauterine growth restriction (IUGR) increases the incidence of adult cardiovascular disease (CVD). The sex-specific developmental mechanisms for IUGR-induced and western high fat diet (HFD) modification of CVD remain poorly understood. We hypothesized a maternal HFD in the Sprague-Dawley rat would augment IUGR-induced CVD in the offspring through decreased cardiac function and increased extracellular matrix (ECM) remodeling and stiffness in a sex-specific manner. HFD or regular diet (Reg) was given from 5 weeks prior to mating through postnatal day 21 (PND21)...
November 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27861908/differences-in-trpc3-and-trpc6-channels-assembly-in-mesenteric-vascular-smooth-muscle-cells-in-essential-hypertension
#3
Inés Álvarez-Miguel, Pilar Cidad, M Teresa Pérez-García, José Ramón López-López
Increased vascular tone in essential hypertension involves a sustained rise in total peripheral resistance. A model has been proposed in which the combination of membrane depolarization and higher L-type Ca(2+) channel activity generates augmented Ca(2+) influx into vascular smooth muscle cells (VSMCs), contraction and vasoconstriction. The search for culprit ion channels responsible of membrane depolarization has provided several candidates, including members of the TRPC family. TRPC3 and TRPC6 are DAG-activated, non-selective cationic channels contributing to stretch- or agonist-induced depolarization...
November 12, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27843937/assessment-of-optimized-electrode-configuration-for-electrical-impedance-myography-using-genetic-algorithm-via-finite-element-model
#4
Somen Baidya, Mohammad A Ahad
Electrical Impedance Myography (EIM) is a noninvasive neurophysiologic technique to diagnose muscle health. Besides muscle properties, the EIM measurements vary significantly with the change of some other anatomic and nonanatomic factors such as skin fat thickness, shape and thickness of muscle, and electrode size and spacing due to its noninvasive nature of measurement. In this study, genetic algorithm was applied along with finite element model of EIM as an optimization tool in order to figure out an optimized EIM electrode setup, which is less affected by these factors, specifically muscle thickness variation, but does not compromise EIM's ability to detect muscle diseases...
2016: Journal of Medical Engineering
https://www.readbyqxmd.com/read/27829322/uterine-electrical-activity-at-labor-is-there-a-correlation-between-labor-stages
#5
Liran Hiersch, Liat Salzer, Amir Aviram, Eran Hadar, Yariv Yogev, Eran Ashwal
OBJECTIVE: To determine the association between the myometrial electrical activity in the active and second stages of labor at term using electrical uterine myography (EUM). METHODS: A prospective observational study of 47 singleton deliveries at term in a tertiary hospital. All women were assessed using non-invasive 9-channel surface electrodes of the EUM during labor. EUM index (EUMi) was calculated as the mean electrical activity during a-30 minute monitoring period and expressed as microjouls (MJ)...
November 9, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27825055/loss-of-electrical-anisotropy-is-an-unrecognized-feature-of-dystrophic-muscle-that-may-serve-as-a-convenient-index-of-disease-status
#6
Seward B Rutkove, Jim S Wu, Craig Zaidman, Kush Kapur, Sung Yim, Amy Pasternak, Lavanya Madabusi, Heather Szelag, Tim Harrington, Jia Li, Adam Pacheck, Basil T Darras
OBJECTIVE: We sought to understand the alteration in the anisotropic, or direction dependent, character of muscle as measured by electrical impedance myography (EIM) in subjects with Duchenne muscular dystrophy (DMD) and its potential to serve as a biomarker of disease status. METHODS: Thirty-six boys with DMD and 27 healthy controls were measured with EIM, with electrical current applied both parallel and perpendicular to the major muscle fiber direction. In addition, muscle extracted from 10 mdx and 10 wild-type mice were measured analogously...
December 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27812921/electrical-impedance-myography-and-its-applications-in-neuromuscular-disorders
#7
REVIEW
Benjamin Sanchez, Seward B Rutkove
Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among its advantages, the technique can be used noninvasively across a variety of disorders and requires limited subject cooperation and evaluator training to obtain accurate and repeatable data. Studies in both animals and human subjects support its potential utility as a primary diagnostic tool, as well as a biomarker for clinical trial or individual patient use...
November 3, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27784066/trpv2-channels-contribute-to-stretch-activated-cation-currents-and-myogenic-constriction-in-retinal-arterioles
#8
Mary K McGahon, José A Fernández, Durga P Dash, Jon McKee, David A Simpson, Alex V Zholos, J Graham McGeown, Tim M Curtis
Purpose: Activation of the transient receptor potential channels, TRPC6, TRPM4, and TRPP1 (PKD2), has been shown to contribute to the myogenic constriction of cerebral arteries. In the present study we sought to determine the potential role of various mechanosensitive TRP channels to myogenic signaling in arterioles of the rat retina. Methods: Rat retinal arterioles were isolated for RT-PCR, Fura-2 Ca2+ microfluorimetry, patch-clamp electrophysiology, and pressure myography studies...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27760732/maternal-vascular-responses-to-hypoxia-in-a-rat-model-of-intrauterine-growth-restriction
#9
Mais M Aljunaidy, Jude S Morton, Christy-Lynn Cooke, Sandra T Davidge
Intrauterine growth restriction (IUGR) is a common pregnancy complication and is a leading cause of fetal morbidity and mortality. Placental hypoxia contributes to adverse fetal consequences, such as IUGR. Exposing pregnant rats to hypoxia can lead to IUGR; however, assessment of maternal vascular function in a rat model of hypoxia, and the mechanisms that may contribute to adverse pregnancy outcomes, has not been extensively studied. We hypothesized that exposing pregnant rats to hypoxia will affect maternal systemic vascular function and increase the uterine artery resistance index (RI), which will be associated with IUGR...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27754257/os-36-08-a2a-receptor-mediated-activation-of-regulatory-t-cells-attenuates-hypertension-induced-cardiovascular-injury
#10
Lingran Kong, Chengchao Ruan, Pingjin Gao
OBJECTIVE: Inflammatory processes plays a pivotal role in pathogenesis of hypertension. Previous study have indicated that A2A receptor is closely related with immunogenic anti-inflammation process. The present study aimed to elucidate whether the activation of A2A receptor is involved in the regulation of hypertension-induced cardiovascular consequence via regulating immunoresponse. DESIGN AND METHOD: Deoxycorticosterone acetat (DOCA)-salt hypertensive mice were injected intraperitoneally with specific A2A receptor agonist (CGS21680) or antagonist (istradefylline) or PBS respectively...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754101/os-21-06-three-month-exposure-to-endothelin-1-overexpression-increases-blood-pressure-and-causes-small-artery-injury
#11
Pierre Paradis, Suellen C Coelho, Sofiane Ouerd, Júlio C Fraulob-Aquino, Stefan Offermanns, Ernesto L Schiffrin
OBJECTIVE: The mechanisms of blood pressure (BP) regulation by endothelin (ET)-1 produced by endothelial cells are complex and remain unclear. Recently, we developed a transgenic mouse with tamoxifen-inducible endothelium-restricted human ET-1 overexpression (ieET-1) using Cre/loxP technology. ieET-1 mice exhibited a BP increase after three weeks of induction in an ET type A receptor-dependent manner, in absence of evident vascular injury. It is unknown whether long-term exposure to ET-1 overexpression results in persistent BP elevation and vascular injury...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754098/os-21-03-effects-of-the-trpm7-kinase-domain-in-vascular-dysfunction-and-cardiac-fibrosis-induced-by-aldosterone-and-salt
#12
Francisco J Rios, Katie Y Hood, A Karvey, Karla B Neves, Panagiota Anyfanti, Ryszard Nosalski, Livia L Camargo Ll, Augusto C Montezano, Rhian M Touyz
OBJECTIVE: TRPM7 is cation channel with intrinsic kinase activity important for cellular Mg homeostasis. We recently showed that TRPM7-kinase plays a role in aldosterone-mediated vascular effects and inflammation. Here we explored the putative role of TRPM7-kinase in cardiac fibrosis and vascular function in aldosterone-induced hypertension in mice. DESIGN AND METHOD: Wild-type (WT) or heterozygote TRPM7-kinase domain (TRPM7+/-) mice were treated with infused aldosterone (600 μg/Kg/day) and NaCl 1% in drinking water (aldo/salt) for 4 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754096/os-21-01-nox1-or-nox4-deletion-prevents-type-1-diabetes-induced-endothelial-dysfunction
#13
Pierre Paradis, Sofiane Ouerd, Noureddine Idris-Khodja, Michelle Trindade, Suellen C Coelho, Karin A Jandeleit-Dahm, Ernesto L Schiffrin
OBJECTIVE: The prognosis of type-1 diabetes remains poor and is primarily related to the increased risk of vascular complications. Overproduction of reactive oxygen species by NADPH oxidase (NOX) is believed to play an important role in diabetes-related vascular injury. NOX1 may play a role in the macrovascular disease, whereas NOX4 may have protective actions. Nevertheless, their role in diabetic microangiopathy is less well understood. We hypothesized that deletion of Nox1 would prevent diabetes-induced endothelial dysfunction and vascular remodeling of small arteries whereas Nox4 would exaggerate vascular injury...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754054/os-15-02-matrix-metalloproteinase-2-knockout-protects-from-angiotensin-ii-induced-vascular-injury-in-part-via-inhibition-of-egfr-and-erk1-2-activation
#14
Pierre Paradis, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Julio C Fraulob-Aquino, Asia Rehman, Nourredine Idris-Khodja, Ernesto L Schiffrin
OBJECTIVE: Matrix metalloproteinase 2 (MMP2) is involved in cardiovascular disease. Whether MMP2 plays a role in hypertension and vascular damage is unknown. We hypothesized that Mmp2 knockout will prevent angiotensin (Ang) II-induced hypertension and vascular injury. DESIGN AND METHOD: Mmp2 knockout (Mmp2) and wild-type (WT) mice were infused with Ang II (1000 ng/kg/min, SC) for 14 days. Systolic blood pressure (SBP) was measured by telemetry, and mesenteric artery (MA) endothelial function and vascular remodeling by pressurized myography...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754034/yia-03-10-endothelial-kruppel-like-factor-15-a-novel-target-for-the-treatment-of-pulmonary-hypertension
#15
Deepesh Pandey, Daijiro Tori, Yohei Nomura, Dan Berkowitz, Lewis Romer
OBJECTIVE: Kruppel Like Factor 15 (KLF15) has recently been shown to be critical for activation of proinflammatory processes in vascular smooth muscle and atherogenesis. Although KLF15 is abundantly expressed in vascular endothelium there is a significant lack of knowledge regarding the role of KLF15 in the regulation of vascular endothelial function. Here we tested the hypothesis that KLF15 is a critical regulator of Arg2 transcription in hypoxia exposed human pulmonary microvascular endothelial cells (HPMEC) and that it plays critical role in pathogenesis of pulmonary hypertension (PHTN)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754033/yia-03-09-noradrenergic-receptor-function-in-healthy-and-obese-perivascular-adipose-tissue
#16
Sophie Saxton, Sarah Withers, Jacqueline Ohanian, Anthony Heagerty
OBJECTIVE: Perivascular adipose tissue (PVAT) exerts an anti-contractile effect vital to regulating blood pressure. Evidence suggests that the sympathetic nervous stimulation of PVAT triggers the release of anti-contractile factors via activation of β3-adrenoceptors. Therefore it was decided to examine β3-adrenoceptor function in obesity. DESIGN AND METHOD: Electrical field stimulation (EFS) of healthy and obese mouse mesenteric arteries (<200 μm, +/-PVAT) were characterised using wire myography (0...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753908/os-02-08-microvascular-tone-of-skeletal-muscle-resistance-arteries-the-regulatory-role-of-perivascular-adipose-tissue-and-insulin
#17
Ben Clark, Sarah Withers, Anthony Heagerty
OBJECTIVE: Resistance arteries significantly contribute to peripheral vascular resistance, and also determine insulin-sensitivity by controlling blood flow to skeletal muscle. Increased microvascular tone therefore facilitates the development of hypertension and insulin-resistance. Surrounding most blood vessels, perivascular adipose tissue (PVAT) exerts a vasorelaxant 'anti-contractile' effect. Few studies on skeletal muscle resistance arteries have investigated this vasorelaxant effect and the role of insulin...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753901/os-02-01-role-of-aldosterone-and-nadph-oxidase-1-in-hypertension-associated-vascular-aging
#18
Adam P Harvey, Augusto Montezano, Khai C Wong, Katie Y Hood, Rheure Alves-Lopes, Graziela S Ceravolo, Chihiro Yabe-Nishimura, Delyth Graham, Rhian M Touyz
OBJECTIVE: In hypertension, the vasculature undergoes alterations that resemble those seen in aging. The involvement of aldosterone and Noxs in the mechanisms underlying age-associated vascular damage is unclear. We postulated that aging-like changes in the vasculature is amplified in hypertension due to increased aldosterone-induced Nox-redox signalling. DESIGN AND METHOD: We assessed vascular aging in arteries from adult WKY (18 weeks), aged WKY (52 weeks) and adult stroke-prone spontaneously hypertensive (SHRSP) rats...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27739590/n-acetylcysteine-a-glutathione-precursor-reverts-vascular-dysfunction-and-endothelial-epigenetic-programming-in-intrauterine-growth-restricted-guinea-pigs
#19
Emilio A Herrera, Francisca Cifuentes-Zúñiga, Esteban Figueroa, Cristian Villanueva, Cherie Hernández, René Alegría, Viviana Arroyo-Jousse, Estefania Peñaloza, Marcelo Farías, Ricardo Uauy, Paola Casanello, Bernardo J Krause
KEY POINTS: Intrauterine growth restriction (IUGR) is associated with vascular dysfunction, oxidative stress and signs of endothelial epigenetic programming of the umbilical vessels. There is no evidence that this epigenetic programming is occurring on systemic fetal arteries. In IUGR guinea pigs we studied the functional and epigenetic programming of endothelial nitric oxide synthase (eNOS) (Nos3 gene) in umbilical and systemic fetal arteries, addressing the role of oxidative stress in this process by maternal treatment with N-acetylcysteine (NAC) during the second half of gestation...
October 14, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27725162/the-calcilytics-calhex-231-and-nps-2143-and-the-calcimimetic-calindol-reduce-vascular-reactivity-via-inhibition-of-voltage-gated-ca-2-channels
#20
Harry Z E Greenberg, Kazi S Jahan, Jian Shi, W-S Vanessa Ho, Anthony P Albert
The present study investigates the effect of commonly used negative and positive allosteric modulators of the calcium-sensing receptor (CaSR) on vascular reactivity. In wire myography studies, increasing [Ca(2+)]o from 1mM to 6mM induced concentration-dependent relaxations of methoxamine-induced pre-contracted rabbit mesenteric arteries, with 6mM [Ca(2+)]o producing almost complete relaxation. [Ca(2+)]o-induced relaxations were attenuated in the presence of the calcilytics Calhex-231 and NPS 2143, and abolished by the removal of the endothelium...
November 15, 2016: European Journal of Pharmacology
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