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https://www.readbyqxmd.com/read/29780326/effects-of-ginseng-supplementation-and-endurance-exercise-in-the-artery-specific-vascular-responsiveness-of-diabetic-and-sedentary-rats
#1
Juan M Murias, Mao Jiang, Tomasz Dzialoszynski, Earl G Noble
This study examined the effects of 12 weeks North-American ginseng supplementation, exercise training, and sedentary behavior on vascular responses in type I diabetic rats. The following hypotheses were tested: (1) ginseng supplementation would result in improved vascular responsiveness and sensitivity; (2) exercise training would result in further improvement in these vascular responses; (3) control rats with no access to exercise would show a depressed vascular response compared to control rats that were not exposed to a sedentary lifestyle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29778808/maternal-treatment-with-a-placental-targeted-antioxidant-mitoq-impacts-offspring-cardiovascular-function-in-a-rat-model-of-prenatal-hypoxia
#2
Mais M Aljunaidy, Jude S Morton, Raven Kirschenman, Tom Phillips, C Patrick Case, Christy-Lynn M Cooke, Sandra T Davidge
Intrauterine growth restriction, a common consequence of prenatal hypoxia, is a leading cause of fetal morbidity and mortality with a significant impact on population health. Hypoxia may increase placental oxidative stress and lead to an abnormal release of placental-derived factors, which are emerging as potential contributors to developmental programming. Nanoparticle-linked drugs are emerging as a novel method to deliver therapeutics targeted to the placenta and avoid risking direct exposure to the fetus...
May 17, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29777791/ticagrelor-protects-against-angii-induced-endothelial-dysfunction-by-alleviating-endoplasmic-reticulum-stress
#3
Xiaoyu Wang, Xuejie Han, Minghui Li, Yu Han, Yun Zhang, Shiqi Zhao, Yue Li
Ticagrelor has been reported to decrease cardiovascular mortality compared with clopidogrel. This benefit cannot be fully explained by the more efficient platelet inhibition. Many studies demonstrated that ticagrelor improved endothelial function, leaving the mechanism elusive though. The present study aims to investigate whether ticagrelor protects against endothelial dysfunction induced by angiotensinII (AngII) through alleviating endoplasmic reticulum (ER) stress. Male Sprague Dawley rats were infused with AngII or vehicle and administrated with ticagrelor or vehicle for 14 days...
May 16, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29758591/mineralocorticoid-receptor-antagonism-prevents-obesity-induced-cerebral-artery-remodeling-and-reduces-white-matter-injury-in-rats
#4
Paulo Wagner Pires, Jonathon Lee McClain, Sebastian F Hayoz, Anne McLaren Dorrance
Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF diet would show inward middle cerebral artery (MCA) remodeling that could be prevented by MR antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury...
May 14, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29753043/ska-31-an-activator-of-endothelial-ca-2-activated-k-channels-evokes-robust-vasodilation-in-rat-mesenteric-arteries
#5
Rayan Khaddaj-Mallat, Cini Mathew John, Andrew P Braun
It is now well recognized that endothelial KCa2.3 and KCa3.1 channel activities contribute to dilation of resistance arteries via endothelium-mediated hyperpolarization and vascular smooth muscle relaxation. In this study, we have investigated the functional effect of the KCa channel activator SKA-31 in third order rat mesenteric arteries using arterial pressure myography. Isolated arteries were cannulated, pressurized intraluminally to 70mmHg at 36°C and then constricted with 1μM phenylephrine. Acute bath exposure to SKA-31 evoked a robust and reversible inhibition of developed tone (IC50 = 0...
May 9, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29725306/muscle-performance-investigated-with-a-novel-smart-compression-garment-based-on-pressure-sensor-force-myography-and-its-validation-against-emg
#6
Aaron Belbasis, Franz Konstantin Fuss
Muscle activity and fatigue performance parameters were obtained and compared between both a smart compression garment and the gold-standard, a surface electromyography (EMG) system during high-speed cycling in seven participants. The smart compression garment, based on force myography (FMG), comprised of integrated pressure sensors that were sandwiched between skin and garment, located on five thigh muscles. The muscle activity was assessed by means of crank cycle diagrams (polar plots) that displayed the muscle activity relative to the crank cycle...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29694711/the-involvement-of-phosphorylation-of-myosin-phosphatase-targeting-subunit1-mypt1-and-mypt1-isoform-expression-in-no-cgmp-mediated-differential-vasoregulation-of-cerebral-arteries-compared-to-systemic-arteries
#7
Lubomir T Lubomirov, Symeon Papadopoulos, Dilyana Filipova, Sufian Baransi, Daniel Todorović, Philipp Lake, Doris Metzler, Silvia Hilsdorf, Rudolf Schubert, Mechthild M Schroeter, Gabriele Pfitzer
AIM: Constitutive release of NO blunts intrinsic and stimulated contractile activity in cerebral arteries (CA). Here, we explored the involvement of phosphorylation and expression levels of the PKG sensitive, leucine zipper positive (LZ+ ) splice variants of the regulatory subunit of myosin phosphatase (MYPT1) and whether its expression is associated with higher cGMP sensitivity. METHODS: Vascular contractility was investigated by wire-myography. Phosphorylation of MYPT1 was determined by western blotting...
April 25, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29690532/a-wearable-gait-phase-detection-system-based-on-force-myography-techniques
#8
Xianta Jiang, Kelvin H T Chu, Mahta Khoshnam, Carlo Menon
(1) Background: Quantitative evaluation of gait parameters can provide useful information for constructing individuals’ gait profile, diagnosing gait abnormalities, and better planning of rehabilitation schemes to restore normal gait pattern. Objective determination of gait phases in a gait cycle is a key requirement in gait analysis applications; (2) Methods: In this study, the feasibility of using a force myography-based technique for a wearable gait phase detection system is explored. In this regard, a force myography band is developed and tested with nine participants walking on a treadmill...
April 21, 2018: Sensors
https://www.readbyqxmd.com/read/29686000/angiotensin-ii-promotes-k-v-7-4-channels-degradation-through-reduced-interaction-with-hsp90-heat-shock-protein-90
#9
Vincenzo Barrese, Jennifer B Stott, Hericka B Figueiredo, Aisah A Aubdool, Adrian J Hobbs, Thomas A Jepps, Alister J McNeish, Iain A Greenwood
Voltage-gated Kv 7.4 channels have been implicated in vascular smooth muscle cells' activity because they modulate basal arterial contractility, mediate responses to endogenous vasorelaxants, and are downregulated in several arterial beds in different models of hypertension. Angiotensin II (Ang II) is a key player in hypertension that affects the expression of several classes of ion channels. In this study, we evaluated the effects of Ang II on the expression and function of vascular Kv 7.4. Western blot and quantitative polymerase chain reaction revealed that in whole rat mesenteric artery, Ang II incubation for 1 to 7 hours decreased Kv 7...
April 23, 2018: Hypertension
https://www.readbyqxmd.com/read/29683445/assessing-collagen-and-elastin-pressure-dependent-microarchitectures-in-live-human-resistance-arteries-by-label-free-fluorescence-microscopy
#10
Maria Bloksgaard, Bjarne Thorsted, Jonathan R Brewer, Jo G R De Mey
The pathogenic contribution of resistance artery remodeling is documented in essential hypertension, diabetes and the metabolic syndrome. Investigations and development of microstructurally motivated mathematical models for understanding the mechanical properties of human resistance arteries in health and disease have the potential to aid understanding how disease and medical treatments affect the human microcirculation. To develop these mathematical models, it is essential to decipher the relationship between the mechanical and microarchitectural properties of the microvascular wall...
April 9, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29650545/regulation-of-blood-pressure-by-targeting-ca-v-1-2-galectin-1-protein-interaction
#11
Zhenyu Hu, Guang Li, Jiong-Wei Wang, Suet Yen Chong, Dejie Yu, Xiaoyuan Wang, Jia Lin Soon, Mui Cheng Liang, Yuk Peng Wong, Na Huang, Henry M Colecraft, Ping Liao, Tuck Wah Soong
Background -L-type CaV 1.2 channels play crucial roles in regulation of blood pressure. Galectin-1 (Gal-1), has been reported to bind to the I-II loop of CaV 1.2 channels to reduce their current density. However, the mechanistic understanding for the down-regulation of CaV 1.2 channels by Gal-1, and whether Gal-1 plays a direct role in blood pressure regulation remain unclear. Methods - In vitro experiments involving co-IP, western blot, patch-clamp recordings, immunohistochemistry and pressure myography were used to evaluate the molecular mechanisms by which Gal-1 down-regulates CaV 1...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29628894/insulin-receptor-substrate-2-controls-insulin-mediated-vasoreactivity-and-perivascular-adipose-tissue-function-in-muscle
#12
Alexander H Turaihi, Wineke Bakker, Victor W M van Hinsbergh, Erik H Serné, Yvo M Smulders, Hans W M Niessen, Etto C Eringa
Introduction: Insulin signaling in adipose tissue has been shown to regulate insulin's effects in muscle. In muscle, perivascular adipose tissue (PVAT) and vascular insulin signaling regulate muscle perfusion. Insulin receptor substrate (IRS) 2 has been shown to control adipose tissue function and glucose metabolism, and here we tested the hypothesis that IRS2 mediates insulin's actions on the vessel wall as well as the vasoactive properties of PVAT. Methods: We studied PVAT and muscle resistance arteries (RA) from littermate IRS2+/+ and IRS2-/- mice and vasoreactivity by pressure myography, vascular insulin signaling, adipokine expression, and release and PVAT morphology...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29623045/relaxin-deficiency-leads-to-uterine-artery-dysfunction-during-pregnancy-in-mice
#13
Sarah A Marshall, Sevvandi N Senadheera, Maria Jelinic, Kelly O'Sullivan, Laura J Parry, Marianne Tare
The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnancy through a reduction in myogenic tone and an increase in flow-mediated vasodilation. Little is known however about the influence of endogenous relaxin on the uterine artery during pregnancy...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29604087/uteroplacental-insufficiency-temporally-exacerbates-salt-induced-hypertension-associated-with-a-reduced-natriuretic-response-in-male-rat-offspring
#14
Linda A Gallo, Sarah L Walton, Marc Q Mazzuca, Marianne Tare, Helena C Parkington, Mary E Wlodek, Karen M Moritz
Intrauterine growth restriction increases the risk of developing chronic diseases in adulthood. Lifestyle factors, such as poor dietary choices, may elevate this risk. We determined whether being born small increases the sensitivity to a dietary salt challenge, in the context of hypertension, kidney disease and arterial stiffness. Bilateral uterine vessel ligation or sham surgery (offspring termed Restricted and Control, respectively) was performed on 18-day pregnant WKY rats. Male offspring were allocated to receive a diet high in salt (8% sodium chloride) or remain on standard rat chow (0...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29574460/the-unexpected-role-of-calcium-activated-potassium-channels-limitation-of-no-induced-arterial-relaxation
#15
Johannes Schmid, Bettina Müller, David Heppeler, Dina Gaynullina, Mario Kassmann, Hristo Gagov, Mitko Mladenov, Maik Gollasch, Rudolf Schubert
BACKGROUND: Multiple studies have shown that an NO-induced activation of vascular smooth muscle BK channels contributes to the NO-evoked dilation in many blood vessels. In vivo, NO is released continuously. NO attenuates vessel constrictions and, therefore, exerts an anticontractile effect. It is unknown whether the anticontractile effect of continuously present NO is mediated by BK channels. METHODS AND RESULTS: This study tested the hypothesis that BK channels mediate the vasodilatory effect of continuously present NO...
March 24, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29566737/murine-breast-cancer-feed-arteries-are-thin-walled-with-reduced-%C3%AE-1a-adrenoceptor-expression-and-attenuated-sympathetic-vasocontraction
#16
Anne Sofie Froelunde, Marit Ohlenbusch, Kristoffer B Hansen, Nicolai Jessen, Sukhan Kim, Ebbe Boedtkjer
BACKGROUND: Perfusion of breast cancer tissue limits oxygen availability and metabolism but angiogenesis inhibitors have hitherto been unsuccessful for breast cancer therapy. In order to identify abnormalities and possible therapeutic targets in mature cancer arteries, we here characterize the structure and function of cancer feed arteries and corresponding control arteries from female FVB/N mice with ErbB2-induced breast cancer. METHODS: We investigated the contractile function of breast cancer feed arteries and matched control arteries by isometric myography and evaluated membrane potentials and intracellular [Ca2+ ] using sharp electrodes and fluorescence microscopy, respectively...
March 22, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29559676/obesity-induced-endothelial-dysfunction-is-prevented-by-neutrophil-extracellular-trap-inhibition
#17
Hui Wang, Qian Wang, Jessica Venugopal, Jintao Wang, Kyle Kleiman, Chiao Guo, Daniel T Eitzman
Endothelial dysfunction precedes atherosclerosis and may constitute a critical link between obesity-related inflammation and cardiovascular disease. Neutrophil extracellular traps (NETs) have been shown to promote vascular damage in murine models of autoimmune disease and atherosclerosis. The impact of NETs towards endothelial dysfunction associated with obesity is unknown. Using a diet-induced obesity (DIO) mouse model, this study investigated whether the inhibition or degradation of NETs could reduce the endothelial dysfunction observed in DIO mice...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29544083/an-investigation-of-the-accuracy-and-reliability-of-body-composition-assessed-with-a-handheld-electrical-impedance-myography-device
#18
Cherilyn N Mclester, Alex D Dewitt, Rasmus Rooks, John R Mclester
The purpose of this study was to compare the body fat per cent (BF%) assessed with a unique handheld electrical impedance myography (EIM) device, along with other popular methods, to dual-energy X-ray absorptiometry (DXA). Participants included 33 males (aged 24.3 ± 4.6 years) and 38 females (aged 25.3 ± 8.9 years) who completed 2 visits separated by 24-72 h. The assessments included DXA, bioelectrical impedance analysis (BIA), skinfold measures (SKF), and three separate EIM measurements. No significant differences in BF% (P > 0...
March 15, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29543984/electrical-impedance-myography-in-facioscapulohumeral-muscular-dystrophy-a-1-year-follow-up-study
#19
Karlien Mul, Chad Heatwole, Katy Eichinger, Nuran Dilek, William B Martens, Baziel G M Van Engelen, Rabi Tawil, Jeffrey M Statland
INTRODUCTION: Electrical impedance myography (EIM) is a noninvasive technique for measuring muscle composition and a potential physiological biomarker for facioscapulohumeral muscular dystrophy (FSHD). METHODS: Thirty-two participants with genetically confirmed and clinically affected FSHD underwent EIM in 7 muscles bilaterally. Correlations between EIM and baseline clinical measures were used to select EIM variables of interest in FSHD, and EIM and clinical measures were followed for 1 year...
March 15, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29513744/acute-radiation-impacts-contractility-of-guinea-pig-bladder-strips-affecting-mucosal-detrusor-interactions
#20
Bronagh M McDonnell, Paul J Buchanan, Kevin M Prise, Karen D McCloskey
Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue. This study aimed to investigate the acute impact of ionizing radiation on the contractility of bladder strips and identify the radiation-sensitivity of the mucosa vs the detrusor. Guinea-pig bladder strips (intact or mucosa-free) received ex vivo sham or 20Gy irradiation and were studied with in vitro myography, electrical field stimulation and Ca2+-fluorescence imaging...
2018: PloS One
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