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https://www.readbyqxmd.com/read/28076894/electrical-impedance-myography-for-assessment-of-duchenne-muscular-dystrophy
#1
Seward B Rutkove, Kush Kapur, Craig Zaidman, Jim S Wu, Amy Pasternak, Lavanya Madabusi, Sung Yim, Adam Pacheck, Heather Szelag, Tim Harrington, Basil T Darras
OBJECTIVE: Sensitive, objective and easily applied methods for evaluating disease progression and response to therapy are needed for clinical trials in Duchenne muscular dystrophy (DMD). In this study, we evaluated whether electrical impedance myography (EIM) could serve this purpose. METHODS: In this non-blinded study, 36 boys with DMD and 29 age-similar healthy boys underwent multifrequency EIM measurements for up to 2 years on 6 muscles unilaterally along with functional assessments...
January 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28074232/vasoactive-actions-of-nitroxyl-hno-are-preserved-in-resistance-arteries-in-diabetes
#2
Marianne Tare, Rushita S R Kalidindi, Kristen J Bubb, Helena C Parkington, Wee-Ming Boon, Xiang Li, Christopher G Sobey, Grant R Drummond, Rebecca H Ritchie, Barbara K Kemp-Harper
Endothelial dysfunction is a major risk factor for the vascular complications of diabetes. Increased reactive oxygen species (ROS) generation, a hallmark of diabetes, reduces the bioavailability of endothelial vasodilators, including nitric oxide (NO·). The vascular endothelium also produces the one electron reduced and protonated form of NO·, nitroxyl (HNO). Unlike NO·, HNO is resistant to scavenging by superoxide anions (·O2(─)). The fate of HNO in resistance arteries in diabetes is unknown. We tested the hypothesis that the vasodilator actions of endogenous and exogenous HNO are preserved in resistance arteries in diabetes...
January 10, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28062507/brown-adipose-tissue-regulates-small-artery-function-through-nadph-oxidase-4-derived-hydrogen-peroxide-and-redox-sensitive-protein-kinase-g-1%C3%AE
#3
Malou Friederich-Persson, Aurelie Nguyen Dinh Cat, Patrik Persson, Augusto C Montezano, Rhian M Touyz
OBJECTIVE: Biomedical interest in brown adipose tissue (BAT) has increased since the discovery of functionally active BAT in adult humans. Although white adipose tissue (WAT) influences vascular function, vascular effects of BAT are elusive. Thus, we investigated the regulatory role and putative vasoprotective effects of BAT, focusing on hydrogen peroxide, nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4), and redox-sensitive signaling. APPROACH AND RESULTS: Vascular reactivity was assessed in wild-type and Nox4-knockout mice (Nox4(-/-)) by wire myography in the absence and presence of perivascular adipose tissue of different phenotypes from various adipose depots: (1) mixed WAT/BAT (inguinal adipose tissue) and (2) WAT (epididymal visceral fat) and BAT (intrascapular fat)...
December 22, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28056494/sensitivity-distribution-simulations-of-surface-electrode-configurations-for-electrical-impedance-myography
#4
Seward Rutkove, Adam Pacheck, Benjamin Sanchez
OBJECTIVE: Surface-based electrical impedance myography (EIM) is sensitive to muscle condition in neuromuscular disorders. However, the specific contribution of muscle to the obtained EIM values is unknown. METHODS: We combined theory and the finite element method to calculate the electrical current distribution in a three-dimensional model using different electrode array designs and subcutaneous fat thicknesses (SFT). Through a sensitivity analysis, we decoupled the contribution of muscle from other surrounding tissues in the measured surface impedance values...
January 5, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28056487/non-invasive-assessment-of-muscle-injury-in-healthy-and-dystrophic-animals-with-electrical-impedance-myography
#5
Benjamin Sanchez, Shama R Iyer, Jia Li, Kush Kapur, Su Xu, Seward Rutkove, Richard M Lovering
INTRODUCTION: Dystrophic muscle is particularly susceptible to eccentric contraction-induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal-force lengthening contractions. METHODS: We induced injury in the quadriceps of wild type (WT) and dystrophic (mdx) mice with eccentric contractions using an established model. RESULTS: mdx quadriceps had significantly larger losses in peak twitch and tetany compared to losses in WT quadriceps...
January 5, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28045780/cardiovascular-responsiveness-to-vasopressin-and-%C3%AE-1-adrenergic-receptor-agonists-after-burn-injury
#6
Ann E Evans, P Geoff Vana, Heather M LaPorte, Richard H Kennedy, Richard L Gamelli, Matthias Majetschak
The effects of burn injury on cardiovascular responsiveness to vasoactive agents are not well understood. The aims of this study were to determine whether burn injury alters cardiovascular reactivity to vasoactive drugs in vivo and intrinsic function of isolated mesenteric resistance arteries. Anesthetized Sprague-Dawley rats were subjected to sham procedure or 30% TBSA dorsal scald burn, followed by crystalloid resuscitation (Parkland Formula). At 24, 72, 96, and 168 hours post burn, rats were reanesthetized, and the mean arterial blood pressure (MAP) responses to various doses of the α1-adrenergic receptor agonist phenylephrine and arginine vasopressin were tested...
December 30, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28028193/smooth-muscle-endothelin-b-receptors-regulate-blood-pressure-but-not-vascular-function-or-neointimal-remodeling
#7
Eileen Miller, Alicja Czopek, Karolina M Duthie, Nicholas S Kirkby, Elisabeth E Fransen van de Putte, Sibylle Christen, Robert A Kimmitt, Rebecca Moorhouse, Raphael F P Castellan, Yuri V Kotelevtsev, Rhoda E Kuc, Anthony P Davenport, Neeraj Dhaun, David J Webb, Patrick W F Hadoke
The role of smooth muscle endothelinB (ETB) receptors in regulating vascular function, blood pressure (BP), and neointimal remodeling has not been established. Selective knockout mice were generated to address the hypothesis that loss of smooth muscle ETB receptors would reduce BP, alter vascular contractility, and inhibit neointimal remodeling. ETB receptors were selectively deleted from smooth muscle by crossing floxed ETB mice with those expressing cre-recombinase controlled by the transgelin promoter. Functional consequences of ETB deletion were assessed using myography...
December 27, 2016: Hypertension
https://www.readbyqxmd.com/read/27998289/effects-of-low-doses-of-esmolol-on-cardiac-and-vascular-function-in-experimental-septic-shock
#8
Chaojie Wei, Huguette Louis, Margaux Schmitt, Eliane Albuisson, Sophie Orlowski, Bruno Levy, Antoine Kimmoun
BACKGROUND: Administration of a selective β1-blocker, such as esmolol, in human septic shock has demonstrated cardiovascular protective effects related to heart rate reduction. Certain experimental data also indicate that esmolol exerts systemic anti-inflammatory and beneficial effects on vascular tone. Thus, the present study aimed to determine whether a non-chronotropic dose of esmolol maintains its protective cardiovascular and anti-inflammatory effects in experimental septic shock...
December 21, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27940046/electrical-impedance-myography-for-discriminating-traumatic-peripheral-nerve-injury-in-the-upper-extremity
#9
Zhao Li, Dong Tian, Lingfen Chen, Xiaoqing Wang, Lijuan Jiang, Yude Yu
OBJECTIVE: To evaluate the potential of electrical impedance myography (EIM), which is sensitive to the changes in muscle structure and physiology, in discriminating traumatic peripheral nerve injury (TPNI) in the upper extremity. To identify factors that primarily influence muscle atrophy secondary to nerve injury. METHODS: Thirty-nine patients with TPNI underwent EIM measurement and standard electromyography tests for multiple muscles in the upper extremity. The side-to-side differences in EIM parameters were calculated for each subject and compared with the compound motor action potential (CMAP) amplitude, which is a measure of injury severity, and the time since injury...
November 25, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27927648/renin-angiotensin-system-transgenic-mouse-model-recapitulates-pathophysiology-similar-to-human-preeclampsia-with-renal-injury-that-may-be-mediated-through-vegf
#10
J Morgan Denney, Cynthia E Bird, Annette Gendron-Fitzpatrick, Emmanuel Sampene, Ian M Bird, Dinesh M Shah
Using a transgenic cross, we evaluated features of preeclampsia, renal injury and the sFlt1/VEGF changes. Transgenic hAGT and hREN, or wild type (WT) C57Bl/6 mice were cross-bred: ♀hAGT x ♂hREN for preeclampsia (PRE) model and ♀WT x ♂WT for pregnant controls (WTP). Samples were collected for plasma VEGF, sFlt1 and urine albumin. Blood pressures (BP) were monitored by telemetry. Vascular reactivity was investigated by wire myography. Kidneys and placenta were immunostained for sFlt1 and VEGF. Eleven PRE and 9 WTP mice were compared...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27909406/assessment-of-a-wearable-force-and-electromyography-device-and-comparison-of-the-related-signals-for-myocontrol
#11
Mathilde Connan, Eduardo Ruiz Ramírez, Bernhard Vodermayer, Claudio Castellini
In the frame of assistive robotics, multi-finger prosthetic hand/wrists have recently appeared, offering an increasing level of dexterity; however, in practice their control is limited to a few hand grips and still unreliable, with the effect that pattern recognition has not yet appeared in the clinical environment. According to the scientific community, one of the keys to improve the situation is multi-modal sensing, i.e., using diverse sensor modalities to interpret the subject's intent and improve the reliability and safety of the control system in daily life activities...
2016: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/27881387/intrauterine-growth-restriction-influences-vascular-remodeling-and-stiffening-in-the-weanling-rat-more-than-sex-or-diet
#12
R Blair Dodson, Thomas A Miller, Kyle N Powers, Yueqin Yang, Baifeng Yu, Kurt H Albertine, Erin K Zinkhan
Intrauterine growth restriction (IUGR) increases the incidence of adult cardiovascular disease (CVD). The sex-specific developmental mechanisms for IUGR-induced and western high fat diet (HFD) modification of CVD remain poorly understood. We hypothesized a maternal HFD in the Sprague-Dawley rat would augment IUGR-induced CVD in the offspring through decreased cardiac function and increased extracellular matrix (ECM) remodeling and stiffness in a sex-specific manner. HFD or regular diet (Reg) was given from 5 weeks prior to mating through postnatal day 21 (PND21)...
November 23, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27861908/differences-in-trpc3-and-trpc6-channels-assembly-in-mesenteric-vascular-smooth-muscle-cells-in-essential-hypertension
#13
Inés Álvarez-Miguel, Pilar Cidad, M Teresa Pérez-García, José Ramón López-López
KEY POINTS: Canonical transient receptor potential (TRPC)3 and TRPC6 channels of vascular smooth muscle cells (VSMCs) mediate stretch- or agonist-induced cationic fluxes, contributing to membrane potential and vascular tone. Native TRPC3/C6 channels can form homo- or heterotetrameric complexes, which can hinder individual TRPC channel properties. The possibility that the differences in their association pattern may change their contribution to vascular tone in hypertension is unexplored...
November 12, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27843937/assessment-of-optimized-electrode-configuration-for-electrical-impedance-myography-using-genetic-algorithm-via-finite-element-model
#14
Somen Baidya, Mohammad A Ahad
Electrical Impedance Myography (EIM) is a noninvasive neurophysiologic technique to diagnose muscle health. Besides muscle properties, the EIM measurements vary significantly with the change of some other anatomic and nonanatomic factors such as skin fat thickness, shape and thickness of muscle, and electrode size and spacing due to its noninvasive nature of measurement. In this study, genetic algorithm was applied along with finite element model of EIM as an optimization tool in order to figure out an optimized EIM electrode setup, which is less affected by these factors, specifically muscle thickness variation, but does not compromise EIM's ability to detect muscle diseases...
2016: Journal of Medical Engineering
https://www.readbyqxmd.com/read/27829322/uterine-electrical-activity-at-labor-is-there-a-correlation-between-labor-stages
#15
Liran Hiersch, Liat Salzer, Amir Aviram, Eran Hadar, Yariv Yogev, Eran Ashwal
OBJECTIVE: To determine the association between the myometrial electrical activity in the active and second stages of labor at term using electrical uterine myography (EUM). METHODS: A prospective observational study of 47 singleton deliveries at term in a tertiary hospital. All women were assessed using non-invasive 9-channel surface electrodes of the EUM during labor. EUM index (EUMi) was calculated as the mean electrical activity during a-30 minute monitoring period and expressed as microjouls (MJ)...
November 9, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27825055/loss-of-electrical-anisotropy-is-an-unrecognized-feature-of-dystrophic-muscle-that-may-serve-as-a-convenient-index-of-disease-status
#16
Seward B Rutkove, Jim S Wu, Craig Zaidman, Kush Kapur, Sung Yim, Amy Pasternak, Lavanya Madabusi, Heather Szelag, Tim Harrington, Jia Li, Adam Pacheck, Basil T Darras
OBJECTIVE: We sought to understand the alteration in the anisotropic, or direction dependent, character of muscle as measured by electrical impedance myography (EIM) in subjects with Duchenne muscular dystrophy (DMD) and its potential to serve as a biomarker of disease status. METHODS: Thirty-six boys with DMD and 27 healthy controls were measured with EIM, with electrical current applied both parallel and perpendicular to the major muscle fiber direction. In addition, muscle extracted from 10 mdx and 10 wild-type mice were measured analogously...
December 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27812921/electrical-impedance-myography-and-its-applications-in-neuromuscular-disorders
#17
REVIEW
Benjamin Sanchez, Seward B Rutkove
Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among its advantages, the technique can be used noninvasively across a variety of disorders and requires limited subject cooperation and evaluator training to obtain accurate and repeatable data. Studies in both animals and human subjects support its potential utility as a primary diagnostic tool, as well as a biomarker for clinical trial or individual patient use...
November 3, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27784066/trpv2-channels-contribute-to-stretch-activated-cation-currents-and-myogenic-constriction-in-retinal-arterioles
#18
Mary K McGahon, José A Fernández, Durga P Dash, Jon McKee, David A Simpson, Alex V Zholos, J Graham McGeown, Tim M Curtis
Purpose: Activation of the transient receptor potential channels, TRPC6, TRPM4, and TRPP1 (PKD2), has been shown to contribute to the myogenic constriction of cerebral arteries. In the present study we sought to determine the potential role of various mechanosensitive TRP channels to myogenic signaling in arterioles of the rat retina. Methods: Rat retinal arterioles were isolated for RT-PCR, Fura-2 Ca2+ microfluorimetry, patch-clamp electrophysiology, and pressure myography studies...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27760732/maternal-vascular-responses-to-hypoxia-in-a-rat-model-of-intrauterine-growth-restriction
#19
Mais M Aljunaidy, Jude S Morton, Christy-Lynn Cooke, Sandra T Davidge
Intrauterine growth restriction (IUGR) is a common pregnancy complication and is a leading cause of fetal morbidity and mortality. Placental hypoxia contributes to adverse fetal consequences, such as IUGR. Exposing pregnant rats to hypoxia can lead to IUGR; however, assessment of maternal vascular function in a rat model of hypoxia, and the mechanisms that may contribute to adverse pregnancy outcomes, has not been extensively studied. We hypothesized that exposing pregnant rats to hypoxia will affect maternal systemic vascular function and increase the uterine artery resistance index (RI), which will be associated with IUGR...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27754257/os-36-08-a2a-receptor-mediated-activation-of-regulatory-t-cells-attenuates-hypertension-induced-cardiovascular-injury
#20
Lingran Kong, Chengchao Ruan, Pingjin Gao
OBJECTIVE: Inflammatory processes plays a pivotal role in pathogenesis of hypertension. Previous study have indicated that A2A receptor is closely related with immunogenic anti-inflammation process. The present study aimed to elucidate whether the activation of A2A receptor is involved in the regulation of hypertension-induced cardiovascular consequence via regulating immunoresponse. DESIGN AND METHOD: Deoxycorticosterone acetat (DOCA)-salt hypertensive mice were injected intraperitoneally with specific A2A receptor agonist (CGS21680) or antagonist (istradefylline) or PBS respectively...
September 2016: Journal of Hypertension
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