keyword
MENU ▼
Read by QxMD icon Read
search

Myography

keyword
https://www.readbyqxmd.com/read/28724979/impairment-of-coronary-endothelial-function-by-hypoxia-reoxygenation-involves-trpc3-inhibition-mediated-kca-channel-dysfunction-implication-in-ischemia-reperfusion-injury
#1
Xiang-Chong Wang, Wen-Tao Sun, Jie Fu, Jun-Hao Huang, Cheuk-Man Yu, Malcolm John Underwood, Guo-Wei He, Qin Yang
Despite increasing knowledge of the significance of calcium-activated potassium (KCa) and canonical transient receptor potential (TRPC) channels in endothelial physiology, no studies so far have investigated the link between these two distinct types of channels in the control of vascular tone in pathological conditions. We previously demonstrated that hypoxia-reoxygenation (H-R) inhibits endothelial KCa and TRPC3 channels in porcine coronary arteries (PCAs). The present study further investigated whether modulation of TRPC3 is involved in H-R-induced KCa channel inhibition and associated vasodilatory dysfunction using approaches of wire myography, whole-cell voltage-clamp, and coimmunoprecipitation...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28721951/recording-characteristics-of-electrical-impedance-myography-needle-electrodes
#2
Hyeuknam Kwon, Seward B Rutkove, Benjamin Sanchez
OBJECTIVE: The neurology and physiatry community need improved tools for the evaluation of skeletal muscle condition. Here, we evaluate needle electrical impedance myography (EIM), a new minimally invasive approach to determine muscle status that could ultimately become a bedside tool for the assessment of neuromuscular disorders. APPROACH: We design and study the recording characteristics of tetrapolar EIM needle electrodes combining theory and finite element model simulations...
July 19, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28686356/relaxing-responses-to-hydrogen-peroxide-and-nitric-oxide-in-human-pericardial-resistance-arteries-stimulated-with-endothelin-1
#3
Thomas M Leurgans, Maria Bloksgaard, Akhmadjon Irmukhamedov, Lars P Riber, Jo G R De Mey
In human pericardial resistance arteries, effects of the endothelium-dependent vasodilator bradykinin are mediated by NO during contraction induced by K(+) or the TxA2 analogue U46619 and by H2 O2 during contraction by endothelin-1 (ET-1), respectively. We tested the hypotheses that ET-1 reduces relaxing effects of NO and increases those of H2 O2 in resistance artery smooth muscle of patients with cardiovascular disease. Arterial segments, dissected from the parietal pericardium of 39 cardiothoracic surgery patients, were studied by myography during amplitude-matched contractions induced by K(+) , the TXA2 analogue U46619 or ET-1...
July 7, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28681979/trpv1-channels-in-human-skeletal-muscle-feed-arteries-implications-for-vascular-function
#4
Stephen J Ives, Song Young Park, Oh Sung Kwon, Jayson R Gifford, Robert H I Andtbacka, John R Hyngstrom, Russell S Richardson
To examine the role of transient receptor potential vanilloid type 1 (TRPV1 ) ion channel in the vascular function of human skeletal muscle feed arteries (SMFAs) and if activation of this heat-sensitive receptor could be involved in modulating vascular function, SMFAs from 16 humans (63 ± 5, 41-89 yrs) were studied using wire myography with capsaicin (TRPV1 agonist) and without (control). Specifically, phenylephrine (PE, α1 -adrenergic receptor agonist), dexemedetomidine (DEX, α2 -adrenergic receptor agonist), acetylcholine (ACh), and sodium nitroprusside (SNP) concentration response curves (CRCs) were performed to assess the role of TRPV1 channels in α-receptor-mediated vasocontraction as well as endothelium-dependent and independent vasorelaxation, respectively...
July 6, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28676786/alterations-in-localized-electrical-impedance-myography-of-biceps-brachii-muscles-paralyzed-by-spinal-cord-injury
#5
Le Li, Argyrios Stampas, Henry Shin, Xiaoyan Li, Ping Zhou
This study assessed electrical impedance myography (EIM) changes after spinal cord injury (SCI) with a localized multifrequency technology. The EIM measurement was performed on the biceps brachii muscle at rest condition of 17 cervical SCI subjects, and 23 neurologically intact subjects as control group. The results showed that there was a significant decrease in muscle reactance (X) and phase angle (θ) at selected frequencies (i.e., 50 and 100 kHz) in SCI compared to control. There was no significant difference in muscle resistance (R) between the two groups...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28673382/rational-use-of-dopamine-in-hypotensive-newborns-improving-our-understanding-of-the-effect-on-cerebral-autoregulation
#6
Vibeke Ramsgaard Eriksen
Hypotension in critically ill newborn infants is associated with higher mortality and higher risk of cerebral injuries. Yet treating hypotension has never been shown to improve outcomes. In fact, some studies have found that hypotensive newborn infants who were treated with dopamine fared worse than a comparable group of newborn infants who were not. Therefore, a concern has been raised that dopamine might cause the observed adverse outcomes. Cerebral autoregulation is a protective mechanism that maintains a fairly constant cerebral blood flow despite fluctuations in blood pressure...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28672931/resveratrol-enhances-vascular-reactivity-in-mice-following-lipopolysaccharide-challenge-via-the-rhoa-rock-mlcp-pathway
#7
Xu-Qing Wang, Yu-Ping Zhang, Li-Min Zhang, Niu-Niu Feng, Ming-Zhu Zhang, Zi-Gang Zhao, Chun-Yu Niu
The aim of the present study was to identify whether sepsis-induced vascular hyporeactivity is associated with microcirculation disturbance and multiple organ injuries. The current study assessed the impact of resveratrol (Res) treatment on lipopolysaccharide (LPS) challenge mediated vascular hyporeactivity. Effects of Res treatment (30 mg/kg; i.m.) at 1 h following LPS stimulation (5 mg/kg; i.v.) on the survival time, mean arterial pressure (MAP), and maximal difference of MAP (ΔMAP) to norepinephrine (NE; 4...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28672042/syncytiotrophoblast-extracellular-vesicles-impair-rat-uterine-vascular-function-via-the-lectin-like-oxidized-ldl-receptor-1
#8
Floor Spaans, Cindy K Kao, Jude S Morton, Anita L Quon, Tatsuya Sawamura, Dionne S Tannetta, Ian L Sargent, Sandra T Davidge
Syncytiotrophoblast extracellular vesicles (STBEVs) are placenta derived particles that are released into the maternal circulation during pregnancy. Abnormal levels of STBEVs have been proposed to affect maternal vascular function. The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a multi-ligand scavenger receptor. Increased LOX-1 expression and activation has been proposed to contribute to endothelial dysfunction. As LOX-1 has various ligands, we hypothesized that, being essentially packages of lipoproteins, STBEVs are able to activate the LOX-1 receptor thereby impairing vascular function via the production of superoxide and decreased nitric oxide bioavailability...
2017: PloS One
https://www.readbyqxmd.com/read/28651648/the-risk-of-oxygen-during-cardiac-surgery-rocs-trial-study-protocol-for-a-randomized-clinical-trial
#9
Marcos G Lopez, Mias Pretorius, Matthew S Shotwell, Robert Deegan, Susan S Eagle, Jeremy M Bennett, Bantayehu Sileshi, Yafen Liang, Brian J Gelfand, Adam J Kingeter, Kara K Siegrist, Frederick W Lombard, Tiffany M Richburg, Dane A Fornero, Andrew D Shaw, Antonio Hernandez, Frederic T Billings
BACKGROUND: Anesthesiologists administer excess supplemental oxygen (hyper-oxygenation) to patients during surgery to avoid hypoxia. Hyper-oxygenation, however, may increase the generation of reactive oxygen species and cause oxidative damage. In cardiac surgery, increased oxidative damage has been associated with postoperative kidney and brain injury. We hypothesize that maintenance of normoxia during cardiac surgery (physiologic oxygenation) decreases kidney injury and oxidative damage compared to hyper-oxygenation...
June 26, 2017: Trials
https://www.readbyqxmd.com/read/28603637/t-type-voltage-gated-ca-2-channels-do-not-contribute-to-the-negative-feedback-regulation-of-myogenic-tone-in-murine-superior-epigastric-arteries
#10
Brendan Mullan, Jessica Pettis, William F Jackson
T-type voltage-gated Ca(2+) channels (CaV3.2 VGCC) have been hypothesized to control spontaneous transient outward currents (STOCs) through large-conductance Ca(2+)-activated K(+) channels (BKCa), and contribute to the negative-feedback regulation of myogenic tone. We tested this hypothesis in superior epigastric arteries (SEAs) isolated from male C57BL/6 mice. SEAs were isolated and enzymatically dissociated to obtain single smooth muscle cells (SMCs) for whole-cell recording of paxilline-sensitive (PAX, 1 μmol/L) STOCs at -30 mV, or cannulated and studied by pressure myography (80 cm H2O, 37°C)...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28596957/heterogeneous-vascular-bed-responses-to-pulmonary-titanium-dioxide-nanoparticle-exposure
#11
Alaeddin B Abukabda, Phoebe A Stapleton, Carroll R McBride, Jinghai Yi, Timothy R Nurkiewicz
A growing body of research links engineered nanomaterial (ENM) exposure to adverse cardiovascular endpoints. The purpose of this study was to evaluate the impact of ENM exposure on vascular reactivity in discrete segments so that we may determine the most sensitive levels of the vasculature where these negative cardiovascular effects are manifest. We hypothesized that acute nano-TiO2 exposure differentially affects reactivity with a more robust impairment in the microcirculation. Sprague-Dawley rats (8-10 weeks) were exposed to nano-TiO2via intratracheal instillation (20, 100, or 200 µg suspended per 250 µL of vehicle) 24 h prior to vascular assessments...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28596832/mechanical-and-vasomotor-properties-of-piglet-isolated-middle-cerebral-artery
#12
Vibeke R Eriksen, Bahareh Abdolalizadeh, Simon Trautner, Gorm Greisen, Majid Sheykhzade
Piglets are often used as experimental models for studying cerebrovascular responses in newborn infants. However, the mechanical characteristics of piglets' middle cerebral arteries (MCA) are not well characterized. Additionally, the vessels' response to dopamine, the most commonly used vasopressor in newborns, is not characterized in piglets' MCA. Finally, the influence of preterm birth on the dopamine response is not known. The aim of this current was to compare by wire myography the active and passive mechanical characteristics and dopamine concentration-response relations of MCAs isolated from preterm and term newborn piglets...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28582263/counting-grasping-action-using-force-myography-an-exploratory-study-with-healthy-individuals
#13
Zhen Gang Xiao, Carlo Menon
BACKGROUND: Functional arm movements generally require grasping an object. The possibility of detecting and counting the action of grasping is believed to be of importance for individual with motor function deficits of the arm, as it could be an indication of the number of the functional arm movements performed by the individuals during rehabilitation. In this exploratory work, the feasibility of using armbands recording radial displacements of forearm muscles and tendons (ie, force myography, FMG) to estimate hand grasping with healthy individuals was investigated...
May 16, 2017: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/28574361/electrical-impedance-myography-for-evaluating-paretic-muscle-changes-after-stroke
#14
Xiaoyan Li, Le Li, Henry Shin, Sheng Li, Ping Zhou
Electrical impedance myography (EIM) was used to assess the paretic muscle intrinsic electrical properties post stroke. Twenty-seven stroke survivors with chronic hemiparesis participated in the study. Muscle impedance was measured by applying high-frequency, low-intensity alternating current to subjects' biceps brachii muscles. Major EIM parameters including resistance (R), reactance (X), phase angle (θ), and electrical anisotropy ratios (AR) of the three parameters were examined at 50 kHz. Statistical analysis demonstrated significant reduction of reactance, phase angle, AR of resistance and AR of reactance in the paretic muscle compared with the contralateral side (Paretic X: 6...
May 26, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28560541/differential-inhibitory-response-to-telcagepant-on-%C3%AE-cgrp-induced-vasorelaxation-and-intracellular-ca-2-levels-in-the-perfused-and-non-perfused-isolated-rat-middle-cerebral-artery
#15
André Erdling, Majid Sheykhzade, Lars Edvinsson
BACKGROUND: Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilators identified to date. The present study elucidates the differential interaction of CGRP, its receptor and the effect of the CGRP-receptor antagonist telcagepant on intracellular Ca(2+) -levels and tension in rat middle cerebral arteries (MCA) by pressurized arteriography, FURA-2/wire myography and immunohistochemistry. METHODS: A pressurized arteriograph system was used to evaluate changes in MCA tension when subjected to CGRP and/or telcagepant...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28550176/mechanical-behavior-and-matrisome-gene-expression-in-aneurysm-prone-thoracic-aorta-of-newborn-lysyl-oxidase-knockout-mice
#16
Marius Catalin Staiculescu, Jungsil Kim, Robert P Mecham, Jessica Wagenseil
Mutations in lysyl oxidase (LOX) are associated with thoracic aortic aneurysm and dissection (TAAD). Mice that do not express Lox (Lox(-/-)) die soon after birth and have 60% and 40% reductions in elastin- and collagen-specific crosslinks, respectively. LOX inactivation could also change the expression of secreted factors, structural matrix, and matrix-associated proteins that constitute the aortic matrisome. We hypothesize that the absence of Lox will change the mechanical behavior of the aortic wall due to reduced elastin and collagen crosslinking and alter the expression levels of matrisome and smooth muscle cell (SMC) genes in a vascular location-specific manner...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28513236/enhanced-gap-junctional-channel-activity-between-vascular-smooth-muscle-cells-in-cerebral-artery-of-spontaneously-hypertensive-rats
#17
Li-Jie Wang, Ke-Tao Ma, Wen-Yan Shi, Ying-Zi Wang, Lei Zhao, Xin-Yan Chen, Xin-Zhi Li, Xue-Wei Jiang, Zhong-Shuang Zhang, Li Li, Jun-Qiang Si
The aim of the present study is to investigate the effects of hypertension on the gap junctions between vascular smooth muscle cells (VSMCs) in the cerebral arteries (CAs) of spontaneously hypertensive rats (SHRs). The functions of gap junctions in the CAs of VSMCs in SHRs and control normotensive Wistar-Kyoto (WKY) rats were studied using whole-cell patch clamp recordings and pressure myography, and the expression levels of connexins were analyzed using reverse transcription-quantitative polymerase chain reaction and Western blot analyses...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28511661/a-preliminary-investigation-on-the-utility-of-temporal-features-of-force-myography-in-the-two-class-problem-of-grasp-vs-no-grasp-in-the-presence-of-upper-extremity-movements
#18
Gautam P Sadarangani, Carlo Menon
BACKGROUND: In upper-extremity stroke rehabilitation applications, the potential use of Force Myography (FMG) for detecting grasping is especially relevant, as the presence of grasping may be indicative of functional activity, which is a key goal of rehabilitation. To date, most FMG research has focused on the classification of the raw FMG signal (i.e. instantaneous FMG samples) in order to determine the state of the hand. However, given the temporal nature of force generation during grasping, the use of temporal feature extraction techniques may yield increased accuracy...
May 16, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28490016/backup-mechanisms-maintain-pacap-vip-induced-arterial-relaxations-in-pituitary-adenylate-cyclase-activating-polypeptide-deficient-mice
#19
Ivan Ivic, Balazs D Fulop, Tamas Juhasz, Dora Reglodi, Gabor Toth, Hitoshi Hashimoto, Andrea Tamas, Akos Koller
BACKGROUND: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide in the VIP/secretin/glucagon peptide superfamily. Two active forms, PACAP1-38 and PACAP1-27, act through G protein-coupled receptors, the PAC1 and VPAC1/2 receptors. Effects of PACAP include potent vasomotor activity. Vasomotor activity and organ-specific vasomotor effects of PACAP-deficient mice have not yet been investigated; thus, the assessment of its physiological importance in vasomotor functions is still missing...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28432059/increased-amplitude-of-inward-rectifier-k-currents-with-advanced-age-in-smooth-muscle-cells-of-murine-superior-epigastric-arteries
#20
Sebastien Hayoz, Jessica Pettis, Vanessa Bradley, Steven S Segal, William F Jackson
Inward rectifier K(+) channels (KIR) may contribute to skeletal muscle blood flow regulation and adapt to advanced age. Using mouse abdominal wall superior epigastric arteries (SEAs) from either young (3-6 months) or old (24-26 months) male C57BL/6 mice, we investigated whether SEA smooth muscle cells (SMCs) express functional KIR, and how aging may affect KIR function. Freshly dissected SEAs were either enzymatically dissociated to isolate SMCs for electrophysiological recording (perforated patch) and mRNA expression, or used intact for pressure myography...
April 21, 2017: American Journal of Physiology. Heart and Circulatory Physiology
keyword
keyword
40192
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"