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Nonalcoholic fat liver disease

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https://www.readbyqxmd.com/read/29150932/high-fat-diet-induced-oxidative-stress-blocks-hepatocyte-nuclear-factor-4%C3%AE-and-leads-to-hepatic-steatosis-in-mice
#1
Dongsheng Yu, Gang Chen, Minglin Pan, Jia Zhang, Wenping He, Yang Liu, Xue Nian, Liang Sheng, Bin Xu
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease with manifestation of over-accumulation of fat in liver. Increasing evidences indicate that NAFLD may be in part caused by malfunction of very low density lipoprotein (VLDL) secretion. Hepatocyte nuclear factor 4α (HNF4α), a nuclear receptor protein, plays an important role in sustain hepatic lipid homeostasis via transcriptional regulation of genes involved in secretion of VLDL, such as apolipoprotein B (ApoB). However, the exact functional change of HNF4α in NAFLD remains to be elucidated...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29129819/nicotinic-acetylcholine-receptor-%C3%AE-7-subunit-improves-energy-homeostasis-and-inhibits-inflammation-in-nonalcoholic-fatty-liver-disease
#2
Dong-Jie Li, Jian Liu, Xia Hua, Hui Fu, Fang Huang, Yi-Bo Fei, Wen-Jie Lu, Fu-Ming Shen, Pei Wang
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide; yet, the pathogenesis of the disorder is not completely understood. The nicotinic acetylcholine receptor α7 subunit (α7nAChR) plays an indispensable role in the vagus nerve-regulated cholinergic anti-inflammatory pathway. METHODS: In the present study, we investigated the key role of α7nAChR in NAFLD development. Male wild-type (WT) and α7nAChR knockout (α7nAChR(-/-)) mice were fed a normal chow or a high-fat diet (HFD) for 16 weeks to induce NAFLD...
November 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29125642/genistein-ameliorates-fat-accumulation-through-ampk-activation-in-fatty-acid-induced-brl-cells
#3
Huijia Zhong, Huanhuan Liu, Zhuoqin Jiang
Genstein is the most abundant phytoestrogen in soybean that was reported to play positive roles in menopausal syndrome and metabolic syndrome. In the present study, we investigated the effects and potential mechanisms of genistein against progression of nonalcoholic fatty liver disease (NAFLD) in BRL cells treated with fatty acid mixture (oleate/palmitate, 2:1 ratio). Our data demonstrated that genistein remarkably improved fatty acid mixture-induced hepatocelluler fat accumulation, inhibited upregulation of genes expression related to fatty acid synthesis, and derepressed those associated with fatty acid oxidation...
November 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29124251/trail-deletion-prevents-liver-but-not-adipose-tissue-inflammation-during-murine-diet-induced-obesity
#4
Petra Hirsova, Peggy Weng, Warda Salim, Steven F Bronk, Thomas S Griffith, Samar H Ibrahim, Gregory J Gores
Background & Aim: TNF-related apoptosis-inducing ligand (TRAIL) and its cognate receptor(s) are upregulated in human and murine nonalcoholic steatohepatitis (NASH). However, the consequence of this enhanced expression on NASH pathogenesis remains unclear. TRAIL may either accentuate liver injury by promoting hepatic steatosis and inflammation, or it may mitigate the disease process by improving systemic insulin resistance and averting hepatic fibrosis. Herein, we investigated the role of TRAIL in an obesity-induced murine model of NASH...
September 2017: Hepatol Commun
https://www.readbyqxmd.com/read/29117763/pilose-antler-peptide-attenuates-high-fat-diet-induced-liver-injury
#5
Lixin Xu, Lijun Yan, Weiwei Tao
This study was performed to investigate the action of pilose antler peptide (PAP) on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats. Animals were randomly divided into five groups: control group, Model group receiving high-fat diet (HFD) group, Atorvastatin group receiving high-fat diet (HFD) + Atorvastatin (20 mg/kg), PAP-L group receiving HFD +PAP (50 mg/kg), PAP-H group receiving HFD+ DB (100 mg/kg). PAP administration significantly reduced the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), with improvement in liver histopathological examination...
November 8, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29113741/low-serum-ctrp3-levels-are-associated-with-nonalcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes-mellitus
#6
Junxia Zhang, Bilin Zhang, Yangyang Cheng, Jinxiu Xu
Nonalcoholic fatty liver disease (NAFLD) commonly occurs in patients with type 2 diabetes mellitus (T2DM). C1q/TNF-related protein-3 (CTRP3) levels are decreased in type 2 diabetic patients. However, to date, it is unknown whether low CTRP3 level are correlated with the incidence of NAFLD. The aim of this study was to observe this association in Chinese patients with T2DM. Overall, 175 newly diagnosed T2DM were recruited in this study. The subjects were divided into NAFLD group (n=93) and control group (n=82)...
November 4, 2017: Cytokine
https://www.readbyqxmd.com/read/29113135/nonalcoholic-fatty-liver-disease-is-exacerbated-in-high-fat-diet-fed-gnotobiotic-mice-by-colonization-with-the-gut-microbiota-from-patients-with-nonalcoholic-steatohepatitis
#7
Chien-Chao Chiu, Yung-Hao Ching, Yen-Peng Li, Ju-Yun Liu, Yen-Te Huang, Yi-Wen Huang, Sien-Sing Yang, Wen-Ching Huang, Hsiao-Li Chuang
Nonalcoholic fatty liver disease (NAFLD) is a serious liver disorder associated with the accumulation of fat and inflammation. The objective of this study was to determine the gut microbiota composition that might influence the progression of NAFLD. Germ-free mice were inoculated with feces from patients with nonalcoholic steatohepatitis (NASH) or from healthy persons (HL) and then fed a standard diet (STD) or high-fat diet (HFD). We found that the epididymal fat weight, hepatic steatosis, multifocal necrosis, and inflammatory cell infiltration significantly increased in the NASH-HFD group...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29113028/restoration-of-a-healthy-intestinal-microbiota-normalizes-portal-hypertension-in-a-rat-model-of-nonalcoholic-steatohepatitis
#8
Teresa García-Lezana, Imma Raurell, Miren Bravo, Manuel Torres-Arauz, María Teresa Salcedo, Alba Santiago, Andreu Schoenenberger, Chaysavanh Manichanh, Joan Genescà, María Martell, Salvador Augustin
Portal hypertension (PH) drives most of the clinical complications in chronic liver diseases. However, its progression in nonalcoholic steatohepatitis (NASH) and its association with the intestinal microbiota (IM) has been scarcely studied. Our aim was to investigate the role of IM in the mechanisms leading to PH in early NASH. The experimental design was divided in two stages: Stage 1: Sprague-Dawley rats were fed for 8 weeks with high-fat diet and high-glucose/fructose syrup (HFGFD) or control diet/water (CD)...
November 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29108123/optimal-threshold-of-controlled-attenuation-parameter-with-mri-pdff-as-the-gold-standard-for-the-detection-of-hepatic-steatosis
#9
Cyrielle Caussy, Mosab H Alquiraish, Phirum Nguyen, Carolyn Hernandez, Sandra Cepin, Lynda E Fortney, Veeral Ajmera, Ricki Bettencourt, Summer Collier, Jonathan Hooker, Ethan Sy, Emily Rizo, Lisa Richards, Claude B Sirlin, Rohit Loomba
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD). Magnetic resonance imaging proton-density-fat-fraction (MRI-PDFF) is an accurate and precise method to detect presence of hepatic steatosis and is better than CAP. Thus, the aim of this study was to evaluate the diagnostic accuracy and the optimal threshold of CAP for the detection of hepatic steatosis as defined by MRI-PDFF ≥ 5%...
November 6, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29107687/mir-150-deficiency-ameliorated-hepatosteatosis-and-insulin-resistance-in-nonalcoholic-fatty-liver-disease-via-targeting-casp8-and-fadd-like-apoptosis-regulator
#10
Baozhong Zhuge, Guohong Li
The prevalence of Non-alcoholic fatty liver diseases (NAFLD) increased rapidly in the world. However, the pathogenesis of is still unclear. Hepatic steatosis and insulin resistance are considered to be central to the pathophysiology of NAFLD. MicroRNAs are short non-coding RNAs and has been reported to be involved in pathogenesis of NAFLD and related metabolic diseases. Here, we investigated the mechanisms by which miR-150 regulate hepatic steatosis and insulin resistance in high fat diet (HFD) induced NAFLD model...
October 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29106945/activation-of-the-sting-irf3-pathway-promotes-hepatocyte-inflammation-apoptosis-and-induces-metabolic-disorders-in-nonalcoholic-fatty-liver-disease
#11
J T Qiao, C Cui, L Qing, L S Wang, T Y He, F Yan, F Q Liu, Y H Shen, X G Hou, L Chen
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a common result of obesity and metabolic syndrome. Hepatocyte injury and metabolic disorders are hallmarks of NAFLD. Stimulator of interferon genes (STING) and its downstream factor interferon regulatory factor 3 (IRF3) trigger inflammatory reaction in response to the presence of cytosolic DNA. STING has recently been shown to play an important role in early alcoholic liver disease. However, little is known about the role of STING-IRF3 pathway in hepatocyte injury...
October 26, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29106426/effect-of-a-novel-potential-probiotic-lactobacillus-paracasei-jlus66-isolated-from-fermented-milk-on-nonalcoholic-fatty-liver-in-rats
#12
Haiqing Ye, Qian Li, Zhengzhe Zhang, Maocheng Sun, Changhui Zhao, Tiehua Zhang
Nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Previous evidence indicates that probiotics can be applied as a therapeutic agent for NAFLD. In this study, the potential probiotic strain Lactobacillus paracasei Jlus66 was isolated from natural fermented milk by a culture-dependent method, and its probiotic potentials were tested by established in vitro tests. In addition, the protective effect of Lactobacillus paracasei Jlus66 against NAFLD was evaluated in rat models...
November 6, 2017: Food & Function
https://www.readbyqxmd.com/read/29091299/hepatic-leukocyte-immunoglobulin-like-receptor-b4-lilrb4-attenuates-nonalcoholic-fatty-liver-disease-via-shp1-traf6-pathway
#13
Yao Lu, Zhou Jiang, Haijiang Dai, Rujia Miao, Jingxian Shu, Haotian Gu, Xing Liu, Zhijun Huang, Guoping Yang, Alex F Chen, Hong Yuan, Ying Li, Jingjing Cai
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent liver pathology marked by hepatic steatosis and commonly accompanied by systematic inflammation and metabolic disorder. Despite an accumulating number of studies, no pharmacological strategy is available to treat this condition in the clinic. The current work applied extensive gain- and loss-of-function approaches to identify the key immune factor leukocyte immunoglobulin-like receptor B4 (LILRB4) as a negative regulator of NAFLD. The hepatocyte-specific knockout of LILRB4 (LILRB4-HKO) significantly exacerbated high-fat diet (HFD)-induced insulin resistance, glucose metabolic imbalance, hepatic lipid accumulation, and systematic inflammation in mice, whereas LILRB4 overexpression in hepatocytes showed a completely opposite phenotype relative to that of LILRB4-HKO mice when compared to their corresponding controls...
November 1, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29090980/dolichos-lablab-protects-against-nonalcoholic-fatty-liver-disease-in-mice-fed-high-fat-diets
#14
A-Rang Im, Yun Hee Kim, Young Hwa Kim, Won-Kyung Yang, Seung Hyung Kim, Kwang Hoon Song
Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we, thus, aimed at clarifying the hepatoprotective effects of DLL-Ex in a high-fat diet-induced in vivo animal NAFLD model, as well as at elucidating underlying mechanisms of identified effects...
November 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29083323/dimethylguanidino-valeric-acid-is-a-marker-of-liver-fat-and-predicts-diabetes
#15
John F O'Sullivan, Jordan E Morningstar, Qiong Yang, Baohui Zheng, Yan Gao, Sarah Jeanfavre, Justin Scott, Celine Fernandez, Hui Zheng, Sean O'Connor, Paul Cohen, Ramachandran S Vasan, Michelle T Long, James G Wilson, Olle Melander, Thomas J Wang, Caroline Fox, Randall T Peterson, Clary B Clish, Kathleen E Corey, Robert E Gerszten
Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology...
October 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29081885/dietary-flaxseed-oil-prevents-western-type-diet-induced-nonalcoholic-fatty-liver-disease-in-apolipoprotein-e-knockout-mice
#16
Hao Han, Fubin Qiu, Haifeng Zhao, Haiying Tang, Xiuhua Li, Dongxing Shi
The prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased globally during recent decades. Intake of n-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3), is believed to be beneficial to the development of NAFLD. However, little information is available with regard to the effect of flaxseed oil rich in α-linolenic acid (ALA, C18:3n-3), a plant-derived n-3 PUFA, in improving NAFLD. This study was to gain the effect of flaxseed oil on NAFLD and further investigate the underlying mechanisms...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29077769/the-relationship-between-visceral-obesity-and-hepatic-steatosis-measured-by-controlled-attenuation-parameter
#17
Hye Won Lee, Kwang Joon Kim, Kyu Sik Jung, Young Eun Chon, Ji Hye Huh, Kyeong Hye Park, Jae Bock Chung, Chang Oh Kim, Kwang-Hyub Han, Jun Yong Park
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/29056000/-the-progress-of-studying-the-mechanisms-of-immune-cells-in-the-regulation-of-non-alcoholic-fatty-liver-diseases
#18
Y Bao
Non-alcoholic fatty liver diseases (NAFLD) are liver diseases which are strongly associated with obesity. The incidence of NAFLD has been gradually increased in recent years. According to different pathology of the liver, NAFLD include three disease states: simple fatty liver, hepatitis (nonalcoholic steatohepatitis, NASH) and fatty liver cirrhosis. The accumulations of fat around the internal organs, which secrete a wide range of adipokines, such as interleukin-6, contribute the development and progress of NAFLD in obesity...
July 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29045180/quantitative-liver-mri-biopsy-correlation-in-pediatric-and-young-adult-patients-with-nonalcoholic-fatty-liver-disease-can-one-be-used-to-predict-the-other
#19
Jonathan R Dillman, Andrew T Trout, Emma N Costello, Suraj D Serai, Kristin S Bramlage, Rohit Kohli, Stavra A Xanthakos
OBJECTIVE: The purpose of this study is to determine the relationships between quantitative liver MRI measurements and liver biopsy findings in pediatric and young adult patients with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: Data were obtained from a registry that prospectively enrolls pediatric and young adult patients with biopsy-confirmed NAFLD at our tertiary medical center with parent or guardian and subject informed consent, as appropriate...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29038049/inhibition-of-egfr-attenuates-fibrosis-and-stellate-cell-activation-in-diet-induced-model-of-nonalcoholic-fatty-liver-disease
#20
Dandan Liang, Hongjin Chen, Leping Zhao, Wenxin Zhang, Jie Hu, Zhiguo Liu, Peng Zhong, Wei Wang, Jingying Wang, Guang Liang
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. NAFLD begins with steatosis and advances to nonalcoholic steatohepatitis (NASH) and cirrhosis. The molecular mechanisms involved in NAFLD progression are not understood. Based on recent studies showing dysregulation of epidermal growth factor receptor (EGFR) in animal models of liver injury, we sought to determine if inhibition of EGFR mitigates liver fibrosis and HSC activation in NAFLD. We utilized the high fat diet (HFD)-induced murine model of liver injury to study the role of EGFR in NAFLD...
October 13, 2017: Biochimica et Biophysica Acta
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