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Nonalcoholic fat liver disease

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https://www.readbyqxmd.com/read/28814531/patients-with-nonalcoholic-fatty-liver-disease-have-a-low-response-rate-to-vitamin-d-supplementation
#1
Jaividhya Dasarathy, Rony Varghese, Abram Feldman, Amer Khiyami, Arthur J McCullough, Srinivasan Dasarathy
Background: Hypovitaminosis D is associated with an increased severity of nonalcoholic fatty liver disease (NAFLD), but reports on the response to cholecalciferol (vitamin D3) supplementation are conflicting.Objective: The objective of this study was to determine if standard vitamin D3 supplementation is effective in NAFLD with hypovitaminosis D.Methods: Sixty-five well-characterized adults [age (mean ± SD): 51.6 ± 12.3 y] with biopsy-proven NAFLD were screened. Forty-two patients (the ratio of men to women was 13:29) had hypovitaminosis D (plasma 25-hydroxyvitamin D [25(OH)D] <30 ng/mL)...
August 16, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28808418/emerging-roles-of-sirt1-in-fatty-liver-diseases
#2
REVIEW
Ren-Bo Ding, Jiaolin Bao, Chu-Xia Deng
Fatty liver diseases, which are commonly associated with high-fat/calorie diet, heavy alcohol consumption and/or other metabolic disorder causes, lead to serious medical concerns worldwide in recent years. It has been demonstrated that metabolic homeostasis disruption is most likely to be responsible for this global epidemic. Sirtuins are a group of conserved nicotinamide adenine dinucleotide (NAD(+)) dependent histone and/or protein deacetylases belonging to the silent information regulator 2 (Sir2) family...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28796993/oral-administration-of-cardioaid-and-lunasin-alleviates-liver-damage-in-a-high-fat-diet-nonalcoholic-steatohepatitis-model
#3
Ariel Drori, Dvorah Rotnemer-Golinkin, Lidya Zolotarov, Yaron Ilan
BACKGROUND: Several of the drugs in development for treatment of nonalcoholic steatohepatitis (NASH) target liver fibrosis or have side effects that prohibit their long-term use in patients with mild to moderate disease. Lunasin is a soy-derived peptide with anti-inflammatory properties. ADM's CardioAid™ is a plant sterol extract that exerts cholesterol- and triacylglycerol-lowering effects. AIM: To determine the immunomodulatory effects of CardioAid and lunasin in a high-fat diet (HFD) animal model of NASH...
August 11, 2017: Digestion
https://www.readbyqxmd.com/read/28796629/hepatic-lipid-accumulation-and-nrf2-expression-following-perinatal-and-peripubertal-exposure-to-bisphenol-a-in-a-mouse-model-of-nonalcoholic-liver-disease
#4
Prajakta C Shimpi, Vijay R More, Maneesha Paranjpe, Ajay C Donepudi, Jaclyn M Goodrich, Dana C Dolinoy, Beverly Rubin, Angela L Slitt
BACKGROUND: Exposure to chemicals during critical windows of development may re-program liver for increased risk of nonalcoholic fatty liver disease (NAFLD). Bisphenol A (BPA), a plastics component, has been described to impart adverse effects during gestational and lactational exposure. Our work has pointed to nuclear factor E2-related factor 2 (Nrf2) being a modulator of hepatic lipid accumulation in models of NAFLD. OBJECTIVES: To determine if chemical exposure can prime liver for steatosis via modulation of NRF2 and epigenetic mechanisms...
August 4, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28791556/the-clinical-implications-of-fatty-pancreas-a-concise-review
#5
REVIEW
Tawfik Khoury, Akwi W Asombang, Tyler M Berzin, Jonah Cohen, Douglas K Pleskow, Meir Mizrahi
Fatty pancreas is a newly recognized condition which is poorly investigated until today as compared to nonalcoholic fatty liver disease. It is characterized by pancreatic fat accumulation and subsequent development of pancreatic and metabolic complications. Association of fatty pancreas have been described with type 2 diabetes mellitus, acute and chronic pancreatitis and even pancreatic carcinoma. In this review article, we provide an update on clinical implications, pathogenesis, diagnosis, treatment and outcomes...
August 8, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28790196/trif-dependent-toll-like-receptor-signaling-suppresses-scd1-transcription-in-hepatocytes-and-prevents-diet-induced-hepatic-steatosis
#6
Jing Chen, Jin Li, Jensen H C Yiu, Jenny K W Lam, Chi-Ming Wong, Bernhard Dorweiler, Aimin Xu, Connie W Woo
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that ranges in severity from hepatic steatosis to steatohepatitis, the latter of which is a major predisposing factor for liver cirrhosis and cancer. Toll-like receptor (TLR) signaling, which is critical for innate immunity, is generally believed to aggravate disease progression by inducing inflammation. Unexpectedly, we found that deficiency in TIR domain-containing adaptor-inducing interferon-β (TRIF), a cytosolic adaptor that transduces some TLR signals, worsened hepatic steatosis induced by a high-fat diet (HFD) and that such exacerbation was independent of myeloid cells...
August 8, 2017: Science Signaling
https://www.readbyqxmd.com/read/28789977/ablation-of-systemic-sirt1-activity-promotes-nonalcoholic-fatty-liver-disease-by-affecting-liver-mesenteric-adipose-tissue-fatty-acid-mobilization
#7
Junrui Cheng, Chun Liu, Kangquan Hu, Andrew Greenberg, Dayong Wu, Lynne M Ausman, Michael W McBurney, Xiang-Dong Wang
Sirtuin 1 (SIRT1) has been reported to protect against nonalcoholic fatty liver disease (NAFLD) development. The mechanism of how SIRT1 deacetylase activity affects NAFLD has not been well investigated. The current investigation addressed the causal effect of systemic SIRT1 activity on NAFLD development and the underlying mechanism involved in both liver and mesenteric adipose tissue (MAT). Both SIRT1 homozygous mice ablated the catalytic activity (sirt1(Y/Y)) and their corresponding wild type littermates (WT) were fed a high fat diet (HFD, 60% calories from fat) for 34weeks...
August 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#8
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28777296/serum-iron-ferritin-ratio-predicts-healthy-body-composition-and-reduced-risk-of-severe-fatty-liver-in-young-adult-women
#9
Nindy Sabrina, Chyi-Huey Bai, Chun-Chao Chang, Yi-Wen Chien, Jiun-Rong Chen, Jung-Su Chang
Dysregulated iron metabolism is associated with altered body composition and nonalcoholic fatty liver disease (NAFLD); however, mechanisms underlying this association remain undefined. We investigated this association in 117 women. Middle-aged women (≥45 years old (y)) were heavier and had lower serum iron, higher serum hepcidin, ferritin, and severe NAFLD incidence than young adult women (<45 y). Age-adjusted linear regression analysis revealed that young adult women with the highest serum iron:ferritin ratio (Tertile 3) had a 5...
August 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28774869/overactivation-of-intestinal-sterol-response-element-binding-protein-2-promotes-diet-induced-non-alcoholic-steatohepatitis
#10
Pooja Malhotra, Costica Aloman, Aparna Ankireddy, Hani Khadra, Kohtaro Ooka, Ravinder K Gill, Seema Saksena, Pradeep K Dudeja, Waddah A Alrefai
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver that may progress to hepatic fibrosis and nonalcoholic steatohepatitis (NASH). Mechanisms underlying NAFLD and NASH are not yet fully understood. Dietary cholesterol was recently shown to be a risk factor for the development of NASH suggesting a role for intestinal handling of cholesterol. One important regulator of cholesterol homeostasis is the Sterol Response Element Binding Protein SREBP2 transcription factor. We tested the hypothesis that the overactivation of intestinal SREBP2 increases the susceptibility to diet-induced NASH...
August 3, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28770225/pegylated-curcumin-derivative-attenuates-hepatic-steatosis-via-creb-ppar-%C3%AE-cd36-pathway
#11
Yu Liu, Fei Cheng, Yuxuan Luo, Zhu Zhan, Peng Hu, Hong Ren, Huadong Tang, Mingli Peng
Curcumin has the potential to cure dyslipidemia and nonalcoholic fatty liver disease (NAFLD). However, its therapeutic effects are curbed by poor bioavailability. Our previous work has shown that modification of curcumin with polyethylene glycol (PEG) improves blood concentration and tissue distribution. This study sought to investigate the role of a novel PEGylated curcumin derivative (Curc-mPEG454) in regulating hepatic lipid metabolism and to elucidate the underlying molecular mechanism in a high-fat-diet- (HFD-) fed C57BL/6J mouse model...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28768719/the-specialized-pro-resolving-lipid-mediator-maresin-1-protects-hepatocytes-from-lipotoxic-and-hypoxia-induced-endoplasmic-reticulum-stress
#12
Bibiana Rius, Marta Duran-Güell, Roger Flores-Costa, Cristina López-Vicario, Aritz Lopategi, José Alcaraz-Quiles, Mireia Casulleras, Juan José Lozano, Esther Titos, Joan Clària
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) are hallmarks of nonalcoholic fatty liver disease (NAFLD), which is the hepatic manifestation of the metabolic syndrome associated with obesity. The specialized pro-resolving lipid mediator maresin 1 (MaR1) preserves tissue homeostasis by exerting cytoprotective actions, dampening inflammation, and expediting its timely resolution. Here, we explored whether MaR1 protects liver cells from lipotoxic and hypoxia-induced ER stress...
August 2, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28763845/-sivelestat-alleviates-nonalcoholic-steatohepatitis-in-mice-through-inhibiting-activation-of-kupffer-cells
#13
S F Zang, X J Ma, L Wang, G L Zhu, W J Yang, Y L Liu, J Yan, Y Luo, Z J Zhuang, J Y Chen, Y H Xun, J P Shi
Objective: To investigate the role of neutrophil elastase inhibitor, sivelestat, in preventing and treating nonalcoholic steatohepatitis (NASH) and its underling mechanisms. Methods: A total of forty 4-week-old male C57BL/6J ApoE-/-mice were equally divided into the following four groups: standard chow (SC)+isotonic saline; SC+sivelestat; high-fat, high-cholesterol (HFHC) diet+isotonic saline; and HFHC+sivelestat. These mice were treated with above methods for 12 weeks. Blood and liver tissue samples were collected to measure biochemical parameters, hepatic steatosis and non-alcoholic fatty liver disease (NAFLD) activity score (inflammation) were evaluated by oil red O staining and HE staining, respectively...
May 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28759727/the-beneficial-effects-of-resveratrol-on-the-steatosis-and-mitochondrial-oxidative-stress-in-hepg2-cells
#14
Magdalena Izdebska, Iwona Piątkowska-Chmiel, Agnieszka Korolczuk, Mariola Herbet, Monika Gawrońska-Grzywacz, Renata Gieroba, Marcin Sysa, Klaudia Czajkowska-Bania, Marcelina Cygal, Agnieszka Korga, Jarosław Dudka
Nonalcoholic fatty liver disease (NAFLD) is currently one of the most common chronic liver diseases, especially in developed countries. One group of substances with a potential use in the treatment of NAFLD are plant polyphenols, represented by resveratrol. The aim of this study was to evaluate the effect of resveratrol on steatosis and oxidative stress in HepG2 cells. The steatosis of cells was carried out using free fatty acids: oleic or palmitic acid and their mixtures. Steatosis was visualized using the intracellular lipid staining by Nile Red dye with a fluorescence microscope...
July 31, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28759276/biochemical-and-histopathological-evidence-on-beneficial-effects-of-standardized-extract-from-tragopogon-graminifolius-as-a-dietary-supplement-in-fatty-liver-role-of-oxidative-stress
#15
Atena Sadeghi, Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Hosein Farzaei, Fatemeh Farzaei, Zahra Minoosh Siavosh Haghighi, Mohammad Abdollahi
Nonalcoholic fatty liver disease (FLD) is a worldwide common liver disorder. Tragopogon graminifolius is used as a dietary supplement for liver disorders. This study aimed to assess the beneficial effects of a standardized preparation from T. graminifolius extract (TGE) in animal model of FLD induced by high-fat diet (HFD). The standardization of TGE based on phenolic compounds was performed using high-performance liquid chromatography (HPLC) analysis. The HFD induced metabolic and hepatic damages. TGE significantly reduced the elevations of serum triglyceride, cholesterol, low-density lipoprotein (LDL), and hepatic enzymes (p =...
July 31, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28751548/comparison-of-ipragliflozin-and-pioglitazone-effects-on-nonalcoholic-fatty-liver-disease-in-patients-with-type-2-diabetes-a-randomized-24-week-open-label-active-controlled-trial
#16
Daisuke Ito, Satoshi Shimizu, Kazuyuki Inoue, Daigo Saito, Morifumi Yanagisawa, Kouichi Inukai, Yuji Akiyama, Yoshihiro Morimoto, Mitsuhiko Noda, Akira Shimada
OBJECTIVE: To compare the efficacy of ipragliflozin versus pioglitazone in patients with type 2 diabetes complicated by nonalcoholic fatty liver disease (NAFLD). RESEARCH DESIGN AND METHODS: In this open-label, randomized, active-controlled trial, we randomly assigned 66 patients with type 2 diabetes and NAFLD to receive ipragliflozin 50 mg (n = 32) or pioglitazone 15-30 mg (n = 34) orally once daily. The primary outcome was a change from baseline in the liver-to-spleen attenuation ratio (L/S ratio) on computed tomography at week 24...
July 27, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28741270/involvement-of-porphyromonas-gingivalis-in-the-progression-of-non-alcoholic-fatty-liver-disease
#17
Takashi Nakahara, Hideyuki Hyogo, Atsushi Ono, Yuko Nagaoki, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Nobuhiko Hiraga, Clair Nelson Hayes, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Hiromi Abe-Chayama, Hisako Furusho, Tomoaki Shintani, Hidemi Kurihara, Mutsumi Miyauchi, Takashi Takata, Koji Arihiro, Kazuaki Chayama
BACKGROUND AND AIMS: The risk factors in the progression of nonalcoholic fatty liver disease (NAFLD) have not been fully clarified. Porphyromonas gingivalis (P.g) has been considered to be a confounding risk factor for systemic diseases. We aimed to evaluate the effect of P.g infection on risk of progression to NASH. METHODS: (1) Serum IgG antibody titers against P.g fimbriae (fimA) in 200 biopsy-proven NAFLD patients were measured by ELISA and compared with histological findings...
July 24, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28739056/supplementation-with-vitis-vinifera-l-skin-extract-improves-insulin-resistance-and-prevents-hepatic-lipid-accumulation-and-steatosis-in-high-fat-diet-fed-mice
#18
Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Ana Paula Machado da Rocha, Gisele França da Costa, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende
Nonalcoholic fatty liver disease is one of the most common complications of obesity. The Vitis vinifera L. grape skin extract (ACH09) is an important source of polyphenols, which are related to its antioxidant and antihyperglycemic activities. We hypothesized that ACH09 could also exert beneficial effects on metabolic disorders associated with obesity and evaluated ACH09's influence on high-fat (HF) diet-induced hepatic steatosis and insulin resistance in C57BL/6 mice. The animals were fed a standard diet (10% fat, control) or an HF diet (60% fat, HF) with or without ACH09 (200mg/[kg d]) for 12weeks...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28737568/systematic-review-nutrition-and-physical-activity-in-the-management-of-paediatric-nonalcoholic-fatty-liver-disease
#19
Philippa S Gibson, Sarah Lang, Anil Dhawan, Emer Fitzpatrick, Michelle L Blumfield, Helen Truby, Kathryn H Hart, J Bernadette Moore
OBJECTIVES: The aim of the study was to evaluate efficacy of nutrition and physical activity interventions in the clinical management of paediatric nonalcoholic fatty liver disease. The prevalence of paediatric nonalcoholic fatty liver disease continues to rise alongside childhood obesity. Weight loss through lifestyle modification is currently first-line treatment, although supplementation of specific dietary components may be beneficial. METHODS: Medline, CINAHL, EMBASE, Scopus, and Cochrane Libraries were systematically searched to identify randomized controlled trials assessing nutritional and physical activity interventions...
August 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28736228/dbz-is-a-putative-ppar%C3%AE-agonist-that-prevents-high-fat-diet-induced-obesity-insulin-resistance-and-gut-dysbiosis
#20
Pengfei Xu, Fan Hong, Jialin Wang, Jing Wang, Xia Zhao, Sheng Wang, Tingting Xue, Jingwei Xu, Xiaohui Zheng, Yonggong Zhai
BACKGROUND: The nuclear receptor PPARγ is an effective pharmacological target for some types of metabolic syndrome, including obesity, diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. However, the current PPARγ-targeting thiazolidinedione drugs have undesirable side effects. Danshensu Bingpian Zhi (DBZ), also known as tanshinol borneol ester derived from Salvia miltiorrhiza, is a synthetic derivative of natural compounds used in traditional Chinese medicine for its anti-inflammatory activity...
July 20, 2017: Biochimica et Biophysica Acta
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