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Nonalcoholic fat liver disease

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https://www.readbyqxmd.com/read/29325281/-value-of-hydrogen-proton-magnetic-resonance-spectroscopy-in-the-determination-of-liver-triglyceride-in-patients-with-fatty-liver-disease-and-its-influencing-factors
#1
H J Qu, L Wang, P H Jin, Q Gao, J X Zhou, Y Song, J Wang, Y M Jiang, L Gong, G Y Chen, J P Ding, J P Shi
Objective: To investigate the value of 1H-magnetic resonance spectroscopy ((1)H-MRS) in determining the content of liver triglyceride in patients with fatty liver disease (FLD), as well as its influencing factors. Methods: A total of 124 patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), or hepatitis B complicated by FLD who underwent liver biopsy in the Affiliated Hospital of Hangzhou Normal University were enrolled, and the clinical data, serological markers, FibroScan results, and (1)H-MRS results were collected...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29324774/activated-carbon-n-acetylcysteine-microcapsule-protects-against-nonalcoholic-fatty-liver-disease-in-young-rats-via-activating-telomerase-and-inhibiting-apoptosis
#2
Tingting Shi, Xingxin Yang, Hongping Zhou, Jianjun Xi, Jingjing Sun, Yunling Ke, Jiankang Zhang, Yidan Shao, Xiaojie Jiang, Xuwang Pan, Shourong Liu, Rangxiao Zhuang
Non-alcoholic fatty liver disease (NAFLD) is becoming one of the world's most common chronic liver diseases in childhood, yet no therapy is available that has been approved by the food and drug administration (FDA). Previous studies have reported that telomere and telomerase are involved the development and progression of NAFLD. This study was designed to investigate the potential beneficial effects of activated carbon N-acetylcysteine (ACNAC) microcapsules on the development of NAFLD in young rats as well as the underlying mechanism(s) involved...
2018: PloS One
https://www.readbyqxmd.com/read/29310441/dihydromyricetin-ameliorates-nonalcoholic-fatty-liver-disease-by-improving-mitochondrial-respiratory-capacity-and-redox-homeostasis-through-modulation-of-sirt3-signaling
#3
Xianglong Zeng, Jining Yang, Ou Hu, Juan Huang, Li Ran, Mengting Chen, Yu Zhang, Xi Zhou, Jundong Zhu, Qianyong Zhang, Long Yi, Mantian Mi
AIMS: Our previous clinical trial indicated that the flavonoid dihydromyricetin (DHM) could improve hepatic steatosis in patients with NAFLD, altough the potential mechanisms of these effects remained elusive. Here, we investigated the hepatoprotective role of DHM on high-fat diet (HFD)-induced NAFLD. RESULTS: DHM supplementation could effectively ameliorate the development of NAFLD by inhibiting hepatic lipids accumulation both in HFD-fed wild type mice and in palmitic acid (PA)-induced hepatocytes...
January 8, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29299759/translating-scientific-discovery-the-need-for-preclinical-models-of-nonalcoholic-steatohepatitis
#4
REVIEW
Abdul M Oseini, Banumathi K Cole, Danny Issa, Ryan E Feaver, Arun J Sanyal
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world, affecting about 1/3 of the US general population and remaining as a significant cause of morbidity and mortality. The hallmark of the disease is the excessive accumulation of fat within the liver cells (hepatocytes), which eventually paves the way to cellular stress, injury and apoptosis. NAFLD is strongly associated with components of the metabolic syndrome and is fast emerging as a leading cause of liver transplant in the USA...
January 3, 2018: Hepatology International
https://www.readbyqxmd.com/read/29299197/inhibition-of-5-lipoxygenase-inhibitor-zileuton-in-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-progression-model
#5
Kuifen Ma, Yihe Chen, Xingguang Liang, Jing Miao, Qingwei Zhao
Objectives: Arachidonic Acid/5-lipoxygenase (AA/5-LOX) pathway connects lipid metabolism and proinflammatory cytokine, which are both related to the development and progression of nonalcoholic fatty liver disease (NAFLD). Therefore, the present study was designed to investigate the role of AA/5-LOX pathway in progression of NAFLD, and the effect of zileuton, an inhibitor of 5-LOX, in this model. Materials and Methods: Animal model for progression of NAFLD was established via feeding high saturated fat diet (HFD)...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29298863/dual-regulation-of-hmgb1-by-combined-jnk1-2-atf2-axis-with-mir-200-family-in-nonalcoholic-steatohepatitis-in-mice
#6
Xin Chen, Yan Ling, Yanping Wei, Jing Tang, Yibing Ren, Baohua Zhang, Feng Jiang, Hengyu Li, Ruoyu Wang, Wen Wen, Guishuai Lv, Mengchao Wu, Lei Chen, Liang Li, Hongyang Wang
In the context of diabetes, obesity, and metabolic syndrome, the inflammatory signaling has critical roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), but the underlying mechanisms remain poorly delineated. Herein, early and persistently elevated, proinflammatory cytokine HMGB1 expression was detected in a high-fat diet (HFD)-induced NAFLD model in C57BL/6 mice. The expression and extracellular release of HMGB1 was rapidly and dramatically induced by saturated palmitic acid in vitro HFD-induced inflammatory response and liver function impairment were both mitigated after the inhibition of endogenous HMGB1 by neutralizing antibody in vivo The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429...
January 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29295591/leonurus-japonicus-houtt-attenuates-nonalcoholic-fatty-liver-disease-in-free-fatty-acid-induced-hepg2-cells-and-mice-fed-a-high-fat-diet
#7
Mi-Ra Lee, Kwang Il Park, Jin Yeul Ma
We investigated the effects of a Leonurus japonicus ethanol extract (LJE) on nonalcoholic fatty liver disease (NAFLD). An in vitro model of hepatic steatosis was treated with 1 mM free fatty acid (FFA) in HepG2 cells. An in vivo NAFLD model was established using C57BL/6 mice fed a high-fat diet (HFD) and administered LJE (100 or 200 mg/kg) orally for 14 weeks. LJE treatment suppressed lipid accumulation and intracellular triglyceride levels significantly in a concentration-dependent manner in HepG2 cells. Moreover, LJE significantly reduced the expression of sterol regulatory element binding protein 1-c, and its downstream genes, which are associated with lipogenesis, in HepG2 cells...
December 25, 2017: Nutrients
https://www.readbyqxmd.com/read/29291351/the-deubiquitinating-enzyme-cylindromatosis-mitigates-nonalcoholic-steatohepatitis
#8
Yan-Xiao Ji, Zan Huang, Xia Yang, Xiaozhan Wang, Ling-Ping Zhao, Pi-Xiao Wang, Xiao-Jing Zhang, Michele Alves-Bezerra, Lin Cai, Peng Zhang, Yue-Xin Lu, Lan Bai, Mao-Mao Gao, Huan Zhao, Song Tian, Yong Wang, Zhi-Xiang Huang, Xue-Yong Zhu, Yan Zhang, Jun Gong, Zhi-Gang She, Feng Li, David E Cohen, Hongliang Li
Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. Lack of effective pharmacotherapies for NASH is largely attributable to an incomplete understanding of its pathogenesis. The deubiquitinase cylindromatosis (CYLD) plays key roles in inflammation and cancer. Here we identified CYLD as a suppressor of NASH in mice and in monkeys. CYLD is progressively degraded upon interaction with the E3 ligase TRIM47 in proportion to NASH severity. We observed that overexpression of Cyld in hepatocytes concomitantly inhibits lipid accumulation, insulin resistance, inflammation and fibrosis in mice with NASH induced in an experimental setting...
January 1, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29290620/pharmacological-stimulation-of-p53-with-low-dose-doxorubicin-ameliorates-diet-induced-nonalcoholic-steatosis-and-steatohepatitis
#9
Begoña Porteiro, Marcos F Fondevila, Xabier Buque, Maria J Gonzalez-Rellan, Uxia Fernandez, Alfonso Mora, Daniel Beiroa, Ana Senra, Rosalia Gallego, Johan Fernø, Miguel López, Guadalupe Sabio, Carlos Dieguez, Patricia Aspichueta, Rubén Nogueiras
OBJECTIVE: Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with low-dose doxorubicin, which is widely used to treat several types of cancer, may have beneficial effects on nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). METHODS: We used long-term pharmacological activation of p53 by i.p. or oral administration of low-dose doxorubicin in different animal models of NAFLD (high fat diet containing 45% and 60% kcal fat) and NASH (methionine- and choline-deficient diet and choline deficiency combined with high fat diet)...
December 15, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29286519/comparative-characteristics-of-hepatoprotectors-used-for-the-treatment-of-non-alcoholic-steatohepatitis-associated-with-herpesvirus-infection-in-sufferers-of-the-chornobyl-accident
#10
O V Gasanova, E O Sarkisova, A A Chumak, L M Ovsyannikova, O V Nosach, L M Alohina, V A Gasanov, V V Kryzhanivska
Objective of the study was to determine the effectiveness of various groups of hepatoprotectors in the treatment of patients with nonalcoholic steatohepatitis (NASH) sufferers of the accident at the Chornobyl NPP following the assessment of metabolic changes and control of persistent infections. MATERIALS AND METHODS: The study included 104 males with NASH, who were sufferers of the Chornobyl disaster and underwent examination and treatment in the conditions of the clinics of the National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29286302/microrna-27b-depletion-enhances-endotrophic-and-intravascular-lipid-accumulation-and-induces-adipocyte-hyperplasia-in-zebrafish
#11
Chia-Chun Hsu, Chi-Yu Lai, Chiu-Ya Lin, Kun-Yun Yeh, Guor Mour Her
miR-27b has emerged as a regulatory hub in cholesterol and lipid metabolism, and as a potential therapeutic target for treating atherosclerosis and obesity. However, the impact of miR-27b on lipid levels in vivo remains to be determined. Zebrafish lipids are normally stored as triacylglycerols (TGs) and their main storage sites are visceral, intramuscular, and subcutaneous lipid depots, and not blood vessels and liver. In this study, we applied microRNA-sponge (miR-SP) technology and generated zebrafish expressing transgenic miR-27b-SP (C27bSPs), which disrupted endogenous miR-27b activity and induced intravascular lipid accumulation (hyperlipidemia) and the early onset of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29280273/causal-relationship-of-hepatic-fat-with-liver-damage-and-insulin-resistance-in-nonalcoholic-fatty-liver
#12
P Dongiovanni, S Stender, A Pietrelli, R M Mancina, A Cespiati, S Petta, S Pelusi, P Pingitore, S Badiali, M Maggioni, V Mannisto, S Grimaudo, R M Pipitone, J Pihlajamaki, A Craxi, M Taube, L M S Carlsson, S Fargion, S Romeo, J Kozlitina, L Valenti
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease is epidemiologically associated with hepatic and metabolic disorders. The aim of this study was to examine whether hepatic fat accumulation has a causal role in determining liver damage and insulin resistance. METHODS: We performed a Mendelian randomization analysis using risk alleles in PNPLA3, TM6SF2, GCKR and MBOAT7, and a polygenic risk score for hepatic fat, as instruments. We evaluated complementary cohorts of at-risk individuals and individuals from the general population: 1515 from the liver biopsy cohort (LBC), 3329 from the Swedish Obese Subjects Study (SOS) and 4570 from the population-based Dallas Heart Study (DHS)...
December 27, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29278765/gd-eob-dtpa-enhanced-t1%C3%AF-imaging-vs-diffusion-metrics-for-assessment-liver-inflammation-and-early-stage-fibrosis-of-nonalcoholic-steatohepatitis-in-rabbits
#13
Yuanliang Xie, Hongfeng Zhang, Chaoling Jin, Xiang Wang, Xiaoqi Wang, Jingting Chen, Yikai Xu
To assess the value of T1ρ,T1ρ on hepatobiliary phase (HBP) and diffusion metrics in staging of Non-alcoholic fatty liver disease (NAFLD) activity scores, inflammation, fibrosis in NASH rabbits model. Non-alcoholic steatohepatitis (NASH) rabbits model was induced by feeding a varied duration of high-fat, high-cholesterol diet. T1ρ,T1ρ (HBP) 20min after administration of Gd-EOB-DTPA, and Intravoxel incoherent motion imaging (IVIM) diffusion-weighted imaging were performed on a 3.0T magnetic resonance (MR) imaging unit...
December 23, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29276215/deletion-of-both-p62-and-nrf2-spontaneously-results-in-the-development-of-nonalcoholic-steatohepatitis
#14
Kentaro Akiyama, Eiji Warabi, Kosuke Okada, Toru Yanagawa, Tetsuro Ishii, Katsumi Kose, Katsutoshi Tokushige, Kazunori Ishige, Yuji Mizokami, Kenji Yamagata, Kojiro Onizawa, Shun-Ichi Ariizumi, Masakazu Yamamoto, Junichi Shoda
Nonalcoholic steatohepatitis (NASH) is one of the leading causes of chronic liver disease worldwide. However, details of pathogenetic mechanisms remain unknown. Deletion of both p62/Sqstm1 and Nrf2 genes spontaneously led to the development of NASH in mice fed a normal chow and was associated with liver tumorigenesis. The pathogenetic mechanism(s) underlying the NASH development was investigated in p62:Nrf2 double-knockout (DKO) mice. DKO mice showed massive hepatomegaly and steatohepatitis with fat accumulation and had hyperphagia-induced obesity coupled with insulin resistance and adipokine imbalance...
December 25, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29274380/the-nox1-isoform-of-nadph-oxidase-is-involved-in-dysfunction-of-liver-sinusoids-in-nonalcoholic-fatty-liver-disease
#15
Misaki Matsumoto, Jia Zhang, Xueqing Zhang, Junjie Liu, Joy X Jiang, Kanji Yamaguchi, Akiyuki Taruno, Masato Katsuyama, Kazumi Iwata, Masakazu Ibi, Wenhao Cui, Kuniharu Matsuno, Yoshinori Marunaka, Yoshito Itoh, Natalie J Torok, Chihiro Yabe-Nishimura
The increased production of reactive oxygen species (ROS) has been postulated to play a key role in the progression of nonalcoholic fatty liver disease (NAFLD). However, the source of ROS and mechanisms underlying the development of NAFLD have yet to be established. We observed a significant up-regulation of a minor isoform of NADPH oxidase, NOX1, in the liver of nonalcoholic steatohepatitis (NASH) patients as well as of mice fed a high-fat and high-cholesterol (HFC) diet for 8 weeks. In mice deficient in Nox1 (Nox1KO), increased levels of serum alanine aminotransferase and hepatic cleaved caspase-3 demonstrated in HFC diet-fed wild-type mice (WT) were significantly attenuated...
December 20, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29262266/effect-of-a-short-term-physical-activity-intervention-on-liver-fat-content-in-obese-children
#16
Dong-Woo Kang, Ji-Hye Park, Mi Kyung Lee, YoonMyung Kim, In Deok Kong, Choon Hee Chung, Young Hee Lee, Justin Y Jeon
Nonalcoholic fatty liver disease is the most common chronic liver disease and can present with advanced fibrosis or nonalcoholic steatohepatitis. The purpose of this study is to investigate the effect of a 7-day intense physical activity intervention on liver fat content in children with obesity. Fifty-seven obese children (Mean BMI: 26.5±3.2 kg/m2; Mean age: 12.0±0.8 y) participated in a 7-day physical activity program. All participants were housed together and their food intake and energy expenditure were strictly controlled...
December 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29249967/psoralea-corylifolia-l-attenuates-nonalcoholic-steatohepatitis-in-juvenile-mouse
#17
Lishan Zhou, Jianqiao Tang, Xiaoli Xiong, Hui Dong, Juan Huang, Shunchang Zhou, Lingling Zhang, Huan Qin, Suqi Yan
Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Recent studies have shown its liver protection and anti-oxidative effects. The aim of this study was to explore the effect and mechanism of PC on nonalcoholic steatohepatitis in juvenile mice. The juvenile mouse model of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) was established by being fed a high-fat diet in maternal-offspring manner. PC granules were prepared and the quality was assessed...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29249184/caffeine-affects-hfd-induced-hepatic-steatosis-by-multifactorial-intervention
#18
M G Helal, S E Ayoub, W F Elkashefand, T M Ibrahim
The incidence of nonalcoholic fatty liver disease (NAFLD) is considered a risk factor for hepatic fibrosis. Therefore, there is critical need to develop novel cheap and effective therapeutic approaches to prevent and reverse NAFLD. Caffeine is commonly consumed beverage and has antioxidant and anti-inflammatory activities. This study examined whether caffeine can ameliorate liver injury induced by high-fat diet (HFD) feeding. Four groups of rats were used and treated for 16 weeks as follows: control group, rats were fed a standard diet; HFD group, rats were fed HFD; and caffeine 20 and caffeine 30 groups, rats were fed HFD for 16 weeks in addition to different doses of caffeine (20 or 30 mg/kg, respectively) for last 8 weeks...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29247356/current-and-future-pharmacological-therapies-for-nafld-nash
#19
REVIEW
Yoshio Sumida, Masashi Yoneda
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide, and there is no approved pharmacotherapy. The efficacy of vitamin E and pioglitazone has been established in nonalcoholic steatohepatitis (NASH), a progressive form of NAFLD. GLP-1RA and SGLT2 inhibitors, which are currently approved for use in diabetes, have shown early efficacy in NASH, and also have beneficial cardiovascular or renal effects. Innovative NASH therapies include four main pathways. The first approach is targeting hepatic fat accumulation...
December 16, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29234195/simple-anthropometric-indices-are-useful-for-predicting-non-alcoholic-fatty-liver-disease-nafld-in-asian-indians
#20
Ayaskanta Singh, Sasmita Parida, Jimmy Narayan, Preetam Nath, Pradeep K Padhi, Girish K Pati, Prasanta K Parida, Chudamani Meher, Omprakash Agrawal, Shivaram P Singh
Background and aims: With the rising prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder in both developed and developing nations. Several studies on NAFLD have described waist circumference, a surrogate marker of visceral fat accumulation and waist height ratio as a better screening tool for NAFLD and metabolic syndrome than body mass index (BMI). We conducted this study to assess simple abdominal obesity indices as a predictor of NAFLD and determine the appropriate cut-off levels with reference to NAFLD...
December 2017: Journal of Clinical and Experimental Hepatology
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