keyword
MENU ▼
Read by QxMD icon Read
search

Nonalcoholic fat liver disease

keyword
https://www.readbyqxmd.com/read/28081181/aronia-melanocarpa-extract-ameliorates-hepatic-lipid-metabolism-through-ppar%C3%AE-2-downregulation
#1
Chung-Hwa Park, Jung-Hee Kim, Eun Byul Lee, Wonhee Hur, Oh-Joo Kwon, Hyoung-Jin Park, Seung Kew Yoon
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis. Here, effects of Aronia melanocarpa (AM), known to be rich of anthocyanins, on hepatic lipid metabolism and adipogenic genes were determined. AM was treated to C57BL/6N mice fed with high fat diet (HFD) or to FL83B cells treated with free fatty acid (FFA). Changes in levels of lipids, enzymes and hormones were observed, and expressions of adipogenic genes involved in hepatic lipid metabolism were detected by PCR, Western blotting and luciferase assay...
2017: PloS One
https://www.readbyqxmd.com/read/28073414/-protective-effect-of-saccharomyces-boulardii-against-intestinal-mucosal-barrier-injury-in-rats-with-nonalcoholic-fatty-liver-disease
#2
Y T Liu, Y Q Li, Y Z Wang
Objective: To investigate the protective effect of Saccharomyces boulardii against intestinal mucosal barrier injury in rats with nonalcoholic fatty liver disease (NAFLD). Methods: A total of 36 healthy male Sprague-Dawley rats with a mean body weight of 180±20 g were randomly divided into control group, model group, and treatment group, with 12 rats in each group, after adaptive feeding for 1 week. The rats in the control group were given basic feed, and those in the model group and treatment group were given high-fat feed...
December 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28056552/soy-protein-isolate-inhibits-hepatic-tumor-promotion-in-mice-fed-a-high-fat-liquid-diet
#3
Kelly E Mercer, Casey F Pulliam, Kim B Pedersen, Leah Hennings, Martin Jj Ronis
Alcoholic and nonalcoholic fatty liver diseases are risk factors for development of hepatocellular carcinoma, but the underlying mechanisms are poorly understood. On the other hand, ingestion of soy-containing diets may oppose the development of certain cancers. We previously reported that replacing casein with a soy protein isolate reduced tumor promotion in the livers of mice with alcoholic liver disease after feeding a high fat ethanol liquid diet following initiation with diethylnitrosamine. Feeding soy protein isolate inhibited processes that may contribute to tumor promotion including inflammation, sphingolipid signaling, and Wnt/β-catenin signaling...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28033294/the-expression-of-thymosin-%C3%AE-4-in-chronic-hepatitis-b-combined-nonalcoholic-fatty-liver-disease
#4
Jing Liang, Wenjuan Cai, Tao Han, Li Jing, Zhe Ma, Yingtang Gao
The aim of the study was to detect the expression level of thymosin β4 (Tβ4) in serum and tissues of patients with chronic hepatitis B (CHB) combined nonalcoholic fatty liver disease (NAFLD). The effects of Tβ4 in hepatic steatosis, chronic inflammation, and fibrosis development in CHB combined NAFLD patients were also discussed. The study included 46 patients in the case group with CHB and NAFLD and 42 patients in the control group with CHB. ELISA was applied to detect serum Tβ4 and TNF-α level. Furthermore, the correlation analysis of Tβ4 levels with biochemical index, pathological index, and TNF-α level was performed...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030556/hepatocyte-hypoxia-inducible-factor-1-mediates-the-development-of-liver-fibrosis-in-a-mouse-model-of-nonalcoholic-fatty-liver-disease
#5
Omar A Mesarwi, Mi-Kyung Shin, Shannon Bevans-Fonti, Christina Schlesinger, Janet Shaw, Vsevolod Y Polotsky
BACKGROUND: Obstructive sleep apnea (OSA) is associated with the progression of non-alcoholic fatty liver disease (NAFLD) to steatohepatitis and fibrosis. This progression correlates with the severity of OSA-associated hypoxia. In mice with diet induced obesity, hepatic steatosis leads to liver tissue hypoxia, which worsens with exposure to intermittent hypoxia. Emerging data has implicated hepatocyte cell signaling as an important factor in hepatic fibrogenesis. We hypothesized that hepatocyte specific knockout of the oxygen sensing α subunit of hypoxia inducible factor-1 (HIF-1), a master regulator of the global response to hypoxia, may be protective against the development of liver fibrosis...
2016: PloS One
https://www.readbyqxmd.com/read/28029021/bile-acid-nuclear-receptor-farnesoid-x-receptor-therapeutic-target-for-nonalcoholic-fatty-liver-disease
#6
REVIEW
Sun Gi Kim, Byung Kwon Kim, Kyumin Kim, Sungsoon Fang
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries. NAFLD is a spectrum of pathology involving hepatic steatosis with/without inflammation and nonalcoholic steatohepatitis with accumulation of hepatocyte damage and hepatic fibrosis. Recent studies have revealed that NAFLD results in the progression of cryptogenic cirrhosis that leads to hepatocarcinoma and cardiovascular diseases such as heart failure...
December 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28027591/tm6sf2-rs58542926-impacts-lipid-processing-in-liver-and-small-intestine
#7
Elizabeth A O'Hare, Rongze Yang, Laura Yerges-Armstrong, Urmilla Sreenivasan, Rebecca McFarland, Carmen C Leitch, Meredith H Wilson, Shilpa Narina, Alexis Gorden, Kathy Ryan, Alan R Shuldiner, Steve A Farber, G Craig Wood, Christopher D Still, Glenn S Gerhard, Janet D Robishaw, Carole Sztalryd, Norann A Zaghloul
: The transmembrane 6 superfamily member 2 (TM6SF2) loss-of-function variant, rs58542926, is a genetic risk factor for nonalcoholic fatty liver disease and progression to fibrosis, but is paradoxically associated with lower levels of hepatic-derived triglyceride-rich lipoproteins (TRLs). TM6SF2 is expressed predominately in liver and small intestine, sites for triglyceride rich lipoprotein biogenesis and export. In light of this, we hypothesized that TM6SF2 may exhibit analogous effects on both liver and intestine lipid homeostasis...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28007783/early-pqq-supplementation-has-persistent-long-term-protective-effects-on-developmental-programming-of-hepatic-lipotoxicity-and-inflammation-in-obese-mice
#8
Karen R Jonscher, Michael S Stewart, Alba Alfonso-Garcia, Brian C DeFelice, Xiaoxin X Wang, Yuhuan Luo, Moshe Levi, Margaret J R Heerwagen, Rachel C Janssen, Becky A de la Houssaye, Ellen Wiitala, Garrett Florey, Raleigh L Jonscher, Eric O Potma, Oliver Fiehn, Jacob E Friedman
Nonalcoholic fatty liver disease (NAFLD) is widespread in adults and children. Early exposure to maternal obesity or Western-style diet (WD) increases steatosis and oxidative stress in fetal liver and is associated with lifetime disease risk in the offspring. Pyrroloquinoline quinone (PQQ) is a natural antioxidant found in soil, enriched in human breast milk, and essential for development in mammals. We investigated whether a supplemental dose of PQQ, provided prenatally in a mouse model of diet-induced obesity during pregnancy, could protect obese offspring from progression of NAFLD...
December 22, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28003715/high-fructose-intake-impairs-the-hepatic-hypolipidemic-effects-of-a-high-fat-fish-oil-diet-in-c57bl-6-mice
#9
Joshua S Wooten, Tayler N Nick, Andrew Seija, Kaylee E Poole, Kelsey B Stout
BACKGROUND: Overnutrition of saturated fats and fructose is one of the major factors for the development of nonalcoholic fatty liver disease. Because omega-3 polyunsaturated fatty acids (n-3fa) have established lipid lowering properties, we tested the hypothesis that n-3fa prevents high-fat and fructose-induced fatty liver disease in mice. METHODS: Male C57BL/6J mice were randomly assigned to one of the following diet groups for 14 weeks: normal diet (ND), high-fat lard-based diet (HFD), HFD with fructose (HFD + Fru), high-fat fish-oil diet (FOD), or FOD + Fru...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27999105/hepatic-dpp4-dna-methylation-associates-with-fatty-liver
#10
Christian Baumeier, Sophie Saussenthaler, Anne Kammel, Markus Jähnert, Luisa Schlüter, Deike Hesse, Mickaël Canouil, Stephane Lobbens, Robert Caiazzo, Violeta Raverdy, François Pattou, Emma Nilsson, Jussi Pihlajamäki, Charlotte Ling, Philippe Froguel, Annette Schürmann, Robert W Schwenk
Hepatic DPP4 expression is elevated in subjects with ectopic fat accumulation in the liver. However, whether increased dipeptidyl peptidase 4 (DPP4) is involved in the pathogenesis or is rather a consequence of metabolic disease is not known. We therefore studied the transcriptional regulation of hepatic Dpp4 in young mice prone to diet-induced obesity. Already at 6 weeks of age, expression of hepatic Dpp4 was increased in mice with high weight gain, independent of liver fat content. In the same animals, methylation of four intronic CpG sites was decreased, amplifying glucose-induced transcription of hepatic Dpp4 In older mice, hepatic triglyceride content was increased only in animals with elevated Dpp4 expression...
January 2017: Diabetes
https://www.readbyqxmd.com/read/27997977/regulation-of-hepatocellular-fatty-acid-uptake-in-mouse-models-of-fatty-liver-disease-with-and-without-functional-leptin-signaling-roles-of-nfkb-and-srebp-1c-and-the-effects-of-spexin
#11
Jasmine F Ge, J L Walewski, D Anglade, P D Berk
The processes causing increased hepatic triglycerides (TGs) in mouse models of hepatic steatosis (HS) due to high fat diet (HFD)-induced obesity (DIO), EtOH consumption, or obesity mutations (ob/ob, db/db) are uncertain. This report summarizes two studies. Study 1 focused on regulation by five transcription factors (TFs) (NfKb, Srebp-lc, AMPK, PPARα, PPARγ) of seven, much-studied hepatic long-chain fatty acid (LCFA) transporters (FABPpm, CD36, FATPl, FATP2, FATP4, FATP5, & Caveolin-1 [CAV-1]), and expression of genes for enzymes of LCFA synthesis (SCD-1, FASN) in mice with HS from various causes...
September 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/27989689/cd40-signaling-and-hepatic-steatosis-unanticipated-links
#12
Sébastien Lepreux, Julien Villeneuve, Antoine Dewitte, Annie M Bérard, Alexis Desmoulière, Jean Ripoche
Obesity predisposes to an increased risk of nonalcoholic fatty liver disease (NAFLD). Hepatic steatosis is the key pathological feature of NAFLD and has emerged as a metabolic disorder in which innate and adaptive arms of the immune response play a central role in disease pathogenesis. Recent studies have revealed unexpected relationships between CD40 signaling and hepatic steatosis in high fat diet rodent models. CD154, the ligand of CD40, is a mediator of inflammation and controls several critical events of innate and adaptive immune responses...
December 15, 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/27988847/calcium-and-vitamin-d3-combinations-improve-fatty-liver-disease-through-ampk-independent-mechanisms
#13
Sara Shojaei Zarghani, Hamid Soraya, Mohammad Alizadeh
PURPOSE: Some research findings suggest that calcium plus vitamin D (VitD) might have a preventive effect on nonalcoholic fatty liver disease development. Moreover, contradictory evidence also exists regarding calcium and VitD deficient diets. This study aimed to evaluate the effect of four different dietary calcium and VitD3 (cholecalciferol) levels on the development of high-fat, high-fructose (HFHFr) diet-induced nonalcoholic fatty liver disease and AMP-activated protein kinase (AMPK) phosphorylation...
December 17, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27986169/hepatic-steatosis-etiology-patterns-and-quantification
#14
Ilkay S Idilman, Ilknur Ozdeniz, Musturay Karcaaltincaba
Hepatic steatosis can occur because of nonalcoholic fatty liver disease (NAFLD), alcoholism, chemotherapy, and metabolic, toxic, and infectious causes. Pediatric hepatic steatosis is also becoming more frequent and can have distinctive features. The most common pattern is diffuse form; however, it can present in heterogenous, focal, multinodular, perilesional, perivascular, subcapsular, and lobar forms. Focal steatosis and fat sparing can occur because of the presence of veins of Sappey, pancreaticoduodenal vein, and aberrant right and left gastric veins, which drain into the liver as third inflow...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27979751/parp1-mediated-ppar%C3%AE-poly-adp-ribosyl-ation-suppresses-fatty-acid-oxidation-in-non-alcoholic-fatty-liver-disease
#15
Kun Huang, Meng Du, Xin Tan, Ling Yang, Xiangrao Li, Yuhan Jiang, Cheng Wang, Fengxiao Zhang, Feng Zhu, Min Cheng, Qinglin Yang, Liqing Yu, Lin Wang, Dan Huang, Kai Huang
BACKGROUND & AIMS: PARP1 is a key mediator of cellular stress responses and critically in multiple physiological and pathophysiological processes of cells.However, whether it is involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains elusive. METHODS: We detect PARP1 activity in liver of mice on high fat diet (HFD), and sample from NAFLD patients. Gain- or loss-of-function approaches are used to investigate the roles and mechanisms of hepatic PARP1 in the pathogenesis of NAFLD...
December 12, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27976696/phospholipase-d1-deficiency-in-mice-causes-nonalcoholic-fatty-liver-disease-via-an-autophagy-defect
#16
Jang Ho Hur, Shi-Young Park, Claudia Dall'Armi, Jae Sung Lee, Gilbert Di Paolo, Hui-Young Lee, Mee-Sup Yoon, Do Sik Min, Cheol Soo Choi
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of triglycerides (TG) as lipid droplets in the liver. Although lipid-metabolizing enzymes are considered important in NAFLD, the involvement of phospholipase D1 (PLD1) has not yet been studied. Here, we show that the genetic ablation of PLD1 in mice induces NAFLD due to an autophagy defect. PLD1 expression was decreased in high-fat diet-induced NAFLD. Subsequently, PLD1 deficiency led to an increase in hepatic TGs and liver weight...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27959408/involvement-of-xanthine-oxidase-and-paraoxonase-1-in-the-process-of-oxidative-stress-in-nonalcoholic-fatty-liver-disease
#17
Bing Wang, Rui-Ning Yang, Yue-Rong Zhu, Ji-Cheng Xing, Xiao-Wei Lou, Yu-Jie He, Qi-Long Ding, Ming-Yue Zhang, Hong Qiu
Xanthine oxidase (XOD) and paraoxonase 1 (PON1) are important enzymes in redox reactions in vivo, and are predominantly synthesized by the liver. The aim of the present study was to investigate the redox state in nonalcoholic fatty liver disease, and determine the association between the activities of XOD and PON1 and the severity of NAFLD. Sprague‑Dawley rats were randomly divided into control, model and α‑lipoic acid (high and low dose) groups. The rats in the NAFLD model were induced by feeding a high fat diet for 12 weeks and the in vitro cell model of hepatocyte steatosis was induced by treating L‑02 cells with oleic acid for 24 h...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27956794/galectin-3-and-il-33-st2-axis-roles-and-interplay-in-diet-induced-steatohepatitis
#18
REVIEW
Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
Immune reactivity and chronic low-grade inflammation (metaflammation) play an important role in the pathogenesis of obesity-associated metabolic disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), a spectrum of diseases that include liver steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Increased adiposity and insulin resistance contribute to the progression from hepatic steatosis to NASH and fibrosis through the development of proinflammatory and profibrotic processes in the liver, including increased hepatic infiltration of innate and adaptive immune cells, altered balance of cytokines and chemokines, increased reactive oxygen species generation and hepatocellular death...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27941355/managing-nonalcoholic-fatty-liver-disease-in-patients-living-with-hiv
#19
Zaid H Tafesh, Elizabeth C Verna
PURPOSE OF REVIEW: Nonalcoholic fatty liver disease (NAFLD) is common among patients living with HIV and may lead to liver-related morbidity and mortality. RECENT FINDINGS: The prevalence of NAFLD among patients with HIV is increasingly well described due to new noninvasive techniques to quantify hepatic steatosis and fibrosis. Patients with HIV may be at increased risk of disease progression, though high-quality natural history studies are not available. The high rates of metabolic syndrome, dyslipidemia and insulin resistance may partially account for this excess risk, though the impact of HIV itself, antiretroviral medications and dysregulation of the gut-liver axis likely play important roles...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27935258/polyphenols-from-lonicera-caerulea-l-berry-attenuate-experimental-nonalcoholic-steatohepatitis-by-inhibiting-proinflammatory-cytokines-productions-and-lipid-peroxidation
#20
Shusong Wu, Satoshi Yano, Ayami Hisanaga, Xi He, Jianhua He, Kozue Sakao, De-Xing Hou
SCOPE: Nonalcoholic steatohepatitis (NASH) is a common disease that closely associated with inflammation and oxidative stress, and Lonicera caerulea L. polyphenols (LCP) are reported to possess both antioxidant and anti-inflammatory properties. This study aimed to study the protective effects and mechanisms of LCP on NASH in a high fat diet (HFD) plus carbon tetrachloride (CCL4 )-induced mouse model. METHODS AND RESULTS: Mice were fed with HFD containing LCP (0...
December 9, 2016: Molecular Nutrition & Food Research
keyword
keyword
40191
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"