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https://www.readbyqxmd.com/read/29453775/effect-of-pparg-on-ages-induced-akt-mtor-signaling-associated-human-chondrocytes-autophagy
#1
Zhao-Jun Wang, Hai-Bin Zhang, Cheng Chen, Hao Huang, Jian-Xia Liang
Accumulation of advanced glycation end products (AGEs) in articular cartilage is thought to represent a major risk factor for osteoarthritis development. In this study we aimed to probe the role of AGEs in human chondrocytes and to determine the impact of the peroxisome proliferator-activated receptor-γ (PPARG) on AGEs-induced cell autophagy. Cell viability was measured after human chondrocytes were treated with different concentrations of AGEs with or without the PPARG inhibitor, T0070907, or agonist, pioglitazone...
February 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29453700/reliability-of-cartilage-digestion-and-fda-eb-fluorescence-staining-for-the-detection-of-chondrocyte-viability-in-osteochondral-grafts
#2
Jianhong Qi, Famin Cao, Yunning Han, Di Xie, Hongqiang Song, Bin Chen, Lu Zhou
The purpose of this study is to evaluate the reliability of cartilage digestion and fluorescein diacetate-ethidium bromide (FDA-EB) fluorescence staining for the detection of chondrocyte viability in osteochondral grafts. Sixteen fresh osteochondral grafts were harvested from pig knee condyles, and the articular cartilage tissue was preserved. Each cartilage graft was cut into two 70-µm thick pieces and randomly allocated to Group A or Group B. The cell viability of Group A was detected using FDA-EB fluorescence staining of the digested cartilage, and the viability of Group B was detected with FDA-EB fluorescence staining of cartilage sections...
February 16, 2018: Cell and Tissue Banking
https://www.readbyqxmd.com/read/29453480/limited-open-reduction-and-percutaneous-plate-osteosynthesis-alternative-option-to-minimally-invasive-plate-osteosynthesis-in-management-of-distal-tibia-fractures
#3
Shambhu Sah, Bikash Kc, Sailoj Jung Dangi, Rem Kumar Rai, Roshan Yadav
INTRODUCTION: The management of distal tibia fracture is challenging because of the limited soft tissue coverage and poor vascularity around the bone in that area. Minimally invasive percutaneous plate osteosynthesis is a novel technique in this regard but needs fluoroscopy. In unavailability of fluoroscopy or its technical malfunction, limited open reduction percutaneous plate osteosynthesis becomes useful. The aim of this study is to compare the outcomes of distal tibia fractures treated by LORPPO and MIPPO techniques in terms of duration of hospital stay, full weight bearing, union time and complications...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29452880/lucerne-cast-luca-functional-conservative-treatment-of-extra-articular-fractures-of-the-proximal-phalanges-of-the-fingers-with-video
#4
T Franz, Q Haxhosaj, U von Wartburg, U Hug
Most extra-articular fractures of the proximal phalanges (P1) of the triphalangeal fingers can be treated conservatively with good results. Prerequisites for successful fracture treatment are intact soft tissue without any lesions of the extensor hood and stable initial fracture reduction. The key to functional conservative treatment of P1 fractures is to immobilize the metacarpophalangeal joints in flexion, resulting in equilibrium of flexor and extensor forces across the fracture site, which converts these inherently unstable fractures into relatively stable fractures...
February 13, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29452423/anti-citrullinated-alpha-enolase-antibodies-interstitial-lung-disease-and-bone-erosion-in-rheumatoid-arthritis
#5
Alessia Alunno, Onelia Bistoni, Federico Pratesi, Giuliana Maria Concetta La Paglia, Ilaria Puxeddu, Paola Migliorini, Roberto Gerli
Objectives: RA is an articular chronic inflammatory disease that in a subgroup of patients can also present with extra-articular manifestations (EAMs). Despite intense investigation on this topic, reliable biomarkers for EAMs are lacking. In recent years several ACPAs, including those targeting anti-citrullinated alpha enolase peptide-1 (anti-CEP-1), have been identified in patients with RA. Data about the ability of anti-CEP-1 to predict the development of erosive disease are confliciting and no evidence concerning their possible association with EAMs in RA is currently available...
February 14, 2018: Rheumatology
https://www.readbyqxmd.com/read/29452304/the-chondrocyte-channelome-a-narrative-review
#6
Ali Mobasheri, Csaba Matta, Ilona Uzielienè, Emma Budd, Pablo Martín-Vasallo, Eiva Bernotiene
Chondrocytes are the main cells in the extracellular matrix of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29452203/morphology-of-the-elytral-base-sclerites
#7
Miwa Sugimoto, Naoki Ogawa, Kazunori Yoshizawa
The elytral base sclerites (= sclerites located at the articular region between the forewing and thorax in Coleoptera) of selected taxa were examined and homologized. Although the elytral base sclerites are highly modified compared to the wing base sclerites of the other neopterans, they can be homologized by using the conservative wing flapping and folding lines as landmarks. A reduction of the first axillary sclerite was identified as a general trend of the elytral base sclerites, although the sclerite usually has a very important function to mediate flight power from the notum to the wing...
February 13, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29451955/relationship-between-subchondral-bone-microstructure-and-articular-cartilage-in-the-osteoarthritic-knee-using-3t-mri
#8
Chenglei Liu, Chang Liu, Liping Si, Hao Shen, Qian Wang, Weiwu Yao
BACKGROUND: The importance of subchondral bone in the pathogenesis of osteoarthritis (OA) has drawn interest. PURPOSE: To investigate subregional trabecular bone microstructural features and to determine the relationship between cartilage and trabecular bone in the osteoarthritic human knee. STUDY TYPE: Prospective study. SUBJECTS: In all, 92 knees were enrolled and divided into three groups: without OA, mild OA, and severe OA...
February 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29451403/assessment-of-mri-findings-and-clinical-symptoms-in-patients-with-temporomandibular-joint-disorders
#9
Risa Matsubara, Yoshinobu Yanagi, Kazuhiro Oki, Miki Hisatomi, Karina Cp Santos, Babatunde O Bamgbose, Mariko Fujita, Shunsuke Okada, Shogo Minagi, Junichi Asaumi
OBJECTIVES: To investigate the correlations among various temporomandibular joint (TMJ) findings on MRI and the relationships between MRI findings and symptoms. METHODS: 425 patients (850 TMJs) with temporomandibular joint disorders (TMDs) who underwent MRI were enrolled. Oblique sagittal proton density-weighted and T 2 weighted images in open- and closed-mouth positions were evaluated. MRI findings included disc configuration, disc position, condylar morphology, bone marrow pattern, and joint effusion...
February 16, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29450729/physical-activity-and-mediterranean-diet-based-on-olive-tree-phenolic-compounds-from-two-different-geographical-areas-have-protective-effects-on-early-osteoarthritis-muscle-atrophy-and-hepatic-steatosis
#10
Marta Anna Szychlinska, Paola Castrogiovanni, Francesca Maria Trovato, Houda Nsir, Mokhtar Zarrouk, Debora Lo Furno, Michelino Di Rosa, Rosa Imbesi, Giuseppe Musumeci
PURPOSE: Osteoarthitis (OA) leads to progressive loss of articular cartilage, pain and joint disability. An acute injury constitutes an important risk factor for early OA, determining an inflammatory process responsible of cartilage degeneration and muscle atrophy, due to the joint pain and immobility. The study aims to assess the effects of conjugation of physical activity and diet enriched by olive tree compounds [extra virgin olive oil (EVOO) and olive leaf extract (OLE)], on the musculoskeletal system in OA rat model...
February 15, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29450563/-surgical-treatment-of-extra-articular-femorocetabular-impingment
#11
EDITORIAL
O Rühmann
No abstract text is available yet for this article.
February 15, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29450562/-which-typical-foot-fractures-should-the-radiologist-know
#12
REVIEW
G Bratke, V Neuhaus, K Slebocki, S Haneder, R Rau
CLINICAL/METHODICAL ISSUE: Due to mechanical loading and the number of joints involved, fractures of the foot are among the most common fractures. STANDARD RADIOLOGICAL METHODS: X-ray is basis for diagnostic workup of all foot fractures. METHODICAL INNOVATIONS: For stress fractures, the additional use of magnetic resonance imaging (MRI) is indicated. Computed tomography (CT) can be used for preoperative imaging of intraarticular tarsal fractures...
February 15, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29450207/fixation-of-traumatic-chondral-only-fragments-of-the-knee-in-pediatric-and-adolescent-athletes-a-retrospective-multicenter-report
#13
Peter D Fabricant, Yi-Meng Yen, Dennis E Kramer, Mininder S Kocher, Lyle J Micheli, J Todd R Lawrence, Theodore J Ganley, Benton E Heyworth
Background: While traditional biological principles have suggested that fragments consisting of cartilage alone cannot be reaffixed to bone with expectable long-term healing, case reports of successful healing after fixation in younger patients indicate that this concept remains incompletely explored. Purpose: To evaluate the presenting features, techniques, healing rates, and clinical and radiological results in a cohort of pediatric and adolescent athletes who underwent fixation of traumatic chondral-only fragments in the knee...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29450205/revision-surgery-after-cartilage-repair-data-from-the-german-cartilage-registry-knorpelregister-dgou
#14
Jan M Pestka, Nam H Luu, Norbert P Südkamp, Peter Angele, Gunther Spahn, Wolfgang Zinser, Philipp Niemeyer
Background: Various operative strategies have been introduced to restore the integrity of articular cartilage when injured. The frequency of revision surgery after cartilage regenerative surgery remains incompletely understood. Purpose/Hypothesis: The purpose of this study was to identify the reasons for revision surgery after cartilage regenerative surgery of the knee. We hypothesized that in a large patient cohort, revision rates would differ from those in the current literature...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29449966/raman-spectroscopic-imaging-for-quantification-of-depth-dependent-and-local-heterogeneities-in-native-and-engineered-cartilage
#15
M B Albro, M S Bergholt, J P St-Pierre, A Vinals Guitart, H M Zlotnick, E G Evita, M M Stevens
Articular cartilage possesses a remarkable, mechanically-robust extracellular matrix (ECM) that is organized and distributed throughout the tissue to resist physiologic strains and provide low friction during articulation. The ability to characterize the make-up and distribution of the cartilage ECM is critical to both understand the process by which articular cartilage undergoes disease-related degeneration and to develop novel tissue repair strategies to restore tissue functionality. However, the ability to quantitatively measure the spatial distribution of cartilage ECM constituents throughout the tissue has remained a major challenge...
2018: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29449195/neutrophil-microvesicles-from-healthy-control-and-rheumatoid-arthritis-patients-prevent-the-inflammatory-activation-of-macrophages
#16
Hefin I Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V Norling, Mauro Perretti
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage. MVs were generated in response to tumour necrosis factor-α, from healthy control neutrophils or those from rheumatoid arthritis patients. MVs were used to stimulate human monocyte-derived macrophages in vitro, or administered intra-articularly in the K/BxN mouse model of arthritis...
February 7, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29448865/diagnostic-accuracy-of-three-screening-questions-3q-tmd-in-relation-to-the-dc-tmd-in-a-specialized-orofacial-pain-clinic
#17
Anna Lövgren, Hasti Parvaneh, Frank Lobbezoo, Birgitta Häggman-Henrikson, Anders Wänman, Corine Mirjam Visscher
OBJECTIVE: To determine the diagnostic accuracy of three screening questions (3Q/TMD) in relation to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), in a specialized clinic. MATERIAL AND METHODS: Consecutive patients, >18 years, referred with a possible TMD complaint to the Orofacial Pain and Dysfunction clinic, Academic Centre for Dentistry Amsterdam, the Netherlands, were included in the study. All patients (n = 449; mean age 44 years; 72% females), answered the 3Q/TMD and the DC/TMD questionnaire before a DC/TMD examination...
February 15, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29448817/treating-severe-knee-osteoarthritis-with-combination-of-intra-osseous-and-intra-articular-infiltrations-of-platelet-rich-plasma-an-observational-study
#18
Mikel Sánchez, Diego Delgado, Orlando Pompei, Juan Carlos Pérez, Pello Sánchez, Ane Garate, Ane Miren Bilbao, Nicolás Fiz, Sabino Padilla
Objective Assessing the therapeutic effects of a combination of intra-articular and intra-osseous infiltrations of platelet-rich plasma (PRP) to treat severe knee osteoarthritis (KOA) using intra-articular injections of PRP as the control group. Design In this observational study, 60 patients suffering from severe KOA were treated with intra-articular infiltrations of PRP (IA group) or with a combination of intra-osseous and intra-articular infiltrations of PRP (IO group). Both groups were matched for sex, age, body mass index, and radiographic severity (III and IV degree according to Ahlbäck scale)...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29448816/using-cartilage-mri-t2-mapping-to-analyze-early-cartilage-degeneration-in-the-knee-joint-of-young-professional-soccer-players
#19
Leonie Waldenmeier, Christoph Evers, Michael Uder, Rolf Janka, Frank Friedrich Hennig, Milena Liese Pachowsky, Götz Hannes Welsch
Objective To evaluate and characterize the appearance of articular cartilage in the tibiofemoral joint of young professional soccer players using T2-relaxation time evaluation on magnetic resonance imaging (MRI). Design In this study, we included 57 male adolescents from the youth academy of a professional soccer team. The MRI scans were acquired of the knee joint of the supporting leg. An "early unloading" (minute 0) and "late unloading" (minute 28) T2-sequence was included in the set of images...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29447948/roles-of-ihh-signaling-in-chondroprogenitor-function-in-postnatal-condylar-cartilage
#20
Naito Kurio, Cheri Saunders, Till E Bechtold, Imad Salhab, Hyun-Duck Nah, Sayantani Sinha, Paul C Billings, Maurizio Pacifici, Eiki Koyama
Condylar articular cartilage in mouse temporomandibular joint develops from progenitor cells near the articulating surface that proliferate, undergo chondrogenesis and mature into hypertrophic chondrocytes. However, it remains unclear how these processes are regulated, particularly postnatally. Here we focused on the apical polymorphic layer rich in progenitors and asked whether the phenotype and fate of the cells require signaling by Indian hedgehog (Ihh) previously studied in developing long bones. In condyles in newborn mice, the apical polymorphic/progenitor cell layer was ~10 cell layer-thick and expressed the articular matrix marker Tenascin-C (Tn-C), and the underlying thick cell layer expressed Tn-C as well as the chondrogenic master regulator Sox9...
February 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
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