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https://www.readbyqxmd.com/read/28528301/selective-laser-sintering-scaffold-with-hierarchical-architecture-and-gradient-composition-for-osteochondral-repair-in-rabbits
#1
Yingying Du, Haoming Liu, Qin Yang, Shuai Wang, Jianglin Wang, Jun Ma, Insup Noh, Antonios G Mikos, Shengmin Zhang
Osteochondral defects cannot be adequately self-repaired due to the presence of the sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the major challenges remaining in this field is the structural design of a biomimetic scaffold that satisfies the specific requirements for osteochondral repair. To address this hurdle, a bio-inspired multilayer osteochondral scaffold that consisted of the poly(ε-caprolactone) (PCL) and the hydroxyapatite (HA)/PCL microspheres, was constructed via selective laser sintering (SLS) technique...
May 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28526996/improved-outcomes-with-arthroscopic-repair-of-partial-thickness-rotator-cuff-tears-a-systematic-review
#2
J Christoph Katthagen, Gabriella Bucci, Gilbert Moatshe, Dimitri S Tahal, Peter J Millett
PURPOSE: The optimum treatment strategy for the surgical management of partial-thickness rotator cuff tears (PTRCT) is evolving. In this study, two research questions were sought to be answered: "Does the repair technique for PTRCTs involving >50% of the tendon thickness have an effect on structural and functional outcomes of arthroscopic repair?" and "Is there a difference in outcomes of arthroscopically treated articular- and bursal-sided PTRCTs?". METHODS: A systematic review according to the PRISMA statement was conducted to identify all literature published reporting on outcomes of arthroscopic treatment of PTRCTs classified with the Ellman classification with minimum 2-year follow-up...
May 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28526995/two-cycles-of-plasma-rich-in-growth-factors-prgf-endoret-intra-articular-injections-improve-stiffness-and-activities-of-daily-living-but-not-pain-compared-to-one-cycle-on-patients-with-symptomatic-knee-osteoarthritis
#3
Víctor Vaquerizo, Sabino Padilla, José Javier Aguirre, Leire Begoña, Gorka Orive, Eduardo Anitua
PURPOSE: To assess the clinical efficacy and safety of a treatment based on one cycle versus two cycles of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) on patients with knee osteoarthritis (OA). METHODS: Ninety patients with knee OA were included and evaluated. A total of 48 patients received one cycle (OC group) (3 injections on a weekly basis), while 42 patients received two cycles of PRGF-Endoret (TC group) spaced 6 months between them...
May 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28526923/focal-articular-prosthetic-resurfacing-for-the-treatment-of-full-thickness-articular-cartilage-defects-in-the-knee-12-year-follow-up-of-two-cases-and-review-of-the-literature
#4
C Becher, E B Cantiller
INTRODUCTION: The rationale of focal articular prosthetic resurfacing used as a primary arthroplasty procedure in the treatment of articular cartilage defects is still under debate. Conflicting reports raise concern about high rates of re-operations and continued development of osteoarthritis, while others have reported good outcomes. The goal of this paper is to present the long-term results of two patients with a 12-year follow-up and to report the results of a literature review. MATERIALS AND METHODS: Two patients (male, 70 years; female 63 years) with a follow-up of 12 years were reviewed...
May 19, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28526287/functional-analyses-of-the-primate-upper-cervical-vertebral-column
#5
Thierra K Nalley, Neysa Grider-Potter
Recent work has highlighted functional correlations between direct measures of head and neck posture and primate cervical bony morphology. Primates with more horizontal necks exhibit middle and lower cervical vertebral features that indicate increased mechanical advantage for deep nuchal musculature and mechanisms for column curvature formation and maintenance. How features of the C1 and C2 reflect quantified measures of posture have yet to be examined. This study incorporates bony morphology from the upper cervical levels from 20 extant primate species in order to investigate further how posture correlates with cervical vertebrae morphology...
June 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28525468/cortical-bone-trajectory-for-thoracic-pedicle-screws-a-technical-note
#6
Keitaro Matsukawa, Yoshiyuki Yato, Richard A Hynes, Hideaki Imabayashi, Naobumi Hosogane, Takashi Asazuma, Toshiyasu Matsui, Yasushi Kobayashi, Koichi Nemoto
STUDY DESIGN: A morphometric measurement of new thoracic pedicle screw trajectory using computed tomography and a biomechanical study on cadaveric thoracic vertebrae using insertional torque. OBJECTIVE: To introduce a new thoracic pedicle screw trajectory which maximizes engagement with denser bone. SUMMARY OF BACKGROUND DATA: Cortical bone trajectory (CBT) which maximizes the thread contact with cortical bone provides enhanced screw purchase...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525466/facet-preserving-technique-by-en-bloc-flavectomy-in-microscopic-posterior-decompression-surgery-for-lumbar-spinal-stenosis-semicircumferential-decompression-scd
#7
Yasushi Fujiwara, Hideki Manabe, Tadayoshi Sumida, Bunichiro Izumi, Kazuyoshi Nakanishi, Nobuhiro Tanaka, Nobuo Adachi
Posterior decompression surgery which enlarges the spinal canal in cases with lumbar spinal stenosis is the most fundamental technique in spine surgery, but controversy still remains for the exact technique. Because nerve roots run under the ventral side on the superior articular process (SAP), achieving both facet joint preservation and nerve root decompression is problematic. In conventional laminotomies or laminectomies, medial facetectomies are performed to decompress the nerve root, but it is ideal to preserve the facet joints completely for preserving joint stability...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28523634/are-blind-injections-of-gleno-humeral-joint-ghj-really-less-accurate-imaging-guided-injections-a-narrative-systematic-review-considering-multiple-anatomical-approaches
#8
Paolo Simoni, Marco Grumolato, Olivier Malaise, Marco Preziosi, Francoise Pasleau, Fréderic de Lemos Esteves
AIM: To perform a systematic review to establish whether blind injections of the gleno-humeral (GHJ) joint may be an accurate alternative to injections performed imaging guidance, considering multiple anatomical approaches. MATERIALS AND METHODS: Our search strategy yielded 478 articles for Scopus, 815 articles for MEDLINE, 128 articles for Cochrane Central Register of Controlled Trials and 555 articles for Embase until May 2016. One hundred and sixty-seven abstracts were retrieved after duplicates removal...
May 18, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28521989/synthesis-of-strontium-chondroitin-sulfate-and-the-evaluation-of-its-capability-to-attenuate-osteoarthritis
#9
F B Ma, N Liu, N Hu, C Y Wen, B Tang
Osteoarthritis (OA) is the most prevalent musculoskeletal disorder and the leading cause of joint disability in elderly patients. In this study, we fabricated strontium chondroitin sulfate (SrCS), a new polysaccharide-metal ion complex that is the combination of chondroitin sulfate and strontium, which are two widely adopted chemicals in OA clinical management. The structural, chemical compositions and morphology of as-fabricated SrCS were systematically investigated. Cell proliferation test, RT-PCR and preliminary animal studies were conducted to evaluate the clinical potential of SrCS on OA treatment...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28521277/the-spatio-temporal-mechanical-environment-of-healthy-and-injured-human-cartilage-during-sustained-activity-and-its-role-in-cartilage-damage
#10
Saeed Miramini, David W Smith, Lihai Zhang, Bruce S Gardiner
Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage...
May 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28521047/musculoskeletal-ultrasonography-for-psoriatic-arthritis-and-psoriasis-patients-a-systematic-literature-review
#11
Alen Zabotti, Francesca Bandinelli, Alberto Batticciotto, Carlo Alberto Scirè, Annamaria Iagnocco, Garifallia Sakellariou
Objective.: To systematically review the role of musculoskeletal US in patients suffering from PsA or psoriasis (Pso) in terms of prevalence, diagnosis, prognosis, monitoring and treatment. Methods.: A systematic literature review was conducted through medical databases (MEDLINE via PubMed, Embase) and the grey literature up to September 2015 to inform a new study of the Musculoskeletal Ultrasound Study Group of the Italian Society for Rheumatology. All articles reporting data on musculoskeletal US in PsA or Pso were included and extracted according to the underlying clinical question...
May 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28520463/a-preclinical-assessment-of-early-continuous-passive-motion-and-treadmill-therapeutic-exercises-for-generating-chondroprotective-effects-after-anterior-cruciate-ligament-rupture
#12
Nai-Jen Chang, Kuan-Wei Lee, Chih-Jou Chu, Ming-You Shie, Pei-Hsi Chou, Chih-Chan Lin, Peir-In Liang
BACKGROUND: Anterior cruciate ligament (ACL) injury is a well-known risk factor for the development of posttraumatic osteoarthritis (PTOA). However, whether using continuous passive motion (CPM) with or without additional treadmill exercise (TRE) in early ACL injury might provide chondroprotective effects and further decrease the risk of PTOA has yet to be determined. HYPOTHESIS: CPM may offer an enhanced chondroprotective effect, but TRE may attenuate that effect due to the mechanical stress on the joint and inflammatory cytokines in the joint...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28520086/activated-fgfr3-prevents-subchondral-bone-sclerosis-during-the-development-of-osteoarthritis-in-transgenic-mice-with-achondroplasia
#13
Toshiaki Okura, Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Taisuke Seki, Naoki Ishiguro, Hiroshi Kitoh
The purpose of this study is to investigate the morphometric changes of the subchondral bone during the development of osteoarthritis (OA) in transgenic mice with achondroplasia (Fgfr3(ach) ) carrying a heterozygous gain-of-function mutation in Fgfr3. Two OA models (spontaneously developed with age: the aging model, and surgically induced by destabilization of the medial meniscus: the DMM model) were established. Articular cartilage, epiphysis and metaphysis of the knee joint were histologically and morphometrically compared between wild-type mice and Fgfr3(ach) mice in both OA models...
May 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28518064/an-experimental-and-finite-element-protocol-to-investigate-the-transport-of-neutral-and-charged-solutes-across-articular-cartilage
#14
Vahid Arbabi, Behdad Pouran, Amir A Zadpoor, Harrie Weinans
Osteoarthritis (OA) is a debilitating disease that is associated with degeneration of articular cartilage and subchondral bone. Degeneration of articular cartilage impairs its load-bearing function substantially as it experiences tremendous chemical degradation, i.e. proteoglycan loss and collagen fibril disruption. One promising way to investigate chemical damage mechanisms during OA is to expose the cartilage specimens to an external solute and monitor the diffusion of the molecules. The degree of cartilage damage (i...
April 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516872/glucocorticoid-sparing-effect-of-first-year-anti-tnf%C3%AE-treatment-in-rheumatoid-arthritis-corpus-cohort
#15
Carole Duquenne, Daniel Wendling, Jean Sibilia, Chantal Job-Deslandre, Loic Guillevin, Jacques Benichou, René Marc Flipo, Francis Guillemin, Alain Saraux
OBJECTIVES: Anti-TNFα agents are indicated in selected patients with rheumatoid arthritis (RA) who respond inadequately to methotrexate and particularly when glucocorticoids are mandatory. We evaluated whether a glucocorticoid-sparing effect occurred during the first year of anti-TNF-α therapy. METHODS: Between 2007 and 2009, the French multicentre, longitudinal, prospective, observational, population-based CORPUS cohort included biologic-naive patients with inflammatory joint disease...
May 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516738/intrinsic-fluorescence-and-mechanical-testing-of-articular-cartilage-in-human-patients-with-osteoarthritis
#16
Juan Pablo Padilla-Martinez, William Lewis, Antonio Ortega-Martinez, Walfre Franco
The degeneration of articular cartilage is the main cause of osteoarthritis (OA), a common cause of disability among elderly patients. The aim of this study is to understand the correlation between intrinsic fluorescence of articular cartilage and its biomechanical properties in patients with osteoarthritis. Cylindrical samples of articular cartilage 6 mm in diameter were extracted via biopsy punch from the femoral condyles of 6 patients with advanced OA undergoing knee replacement surgery. The mechanical stiffness and fluorescence of each cartilage plug were measured by indentation test and spectrofluorometry...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28516048/image-interpolation-improves-the-zonal-analysis-of-cartilage-t2-relaxation-in-mri
#17
Farid Badar, Yang Xia
BACKGROUND: This project aimed to investigate the improvement in the detection of osteoarthritis (OA) in cartilage by the interpolation of T2 images, in the situation when the native MRI resolution is insufficient to resolve the depth-dependent T2 characteristics in articular cartilage (AC). METHODS: Eighteen intact canine knee joints that were healthy or had mild (contralateral) or severe OA were T2-imaged in a 7T/20 cm MRI system at 200 µm/pixel resolution (macro-MRI)...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28515594/radiofrequency-ablation-of-osteoid-osteoma-in-common-and-technically-challenging-locations-in-pediatric-population
#18
Shaileshkumar Garge, Shyamkumar N Keshava, Vinu Moses, George K Chiramel, Munawwar Ahmed, Suraj Mammen, Vrisha Madhuri
CONTEXT: Percutaneous radiofrequency ablation (RFA) of osteoid osteoma has a high technical and clinical success rate. However, there is limited data on its use in the pediatric population, especially in technically challenging locations. OBJECTIVE: To assess the safety and efficacy of computed tomography (CT)-guided percutaneous RFA of osteoid osteoma in pediatric population. PATIENTS AND METHODS: From June 2009 to May 2014, 30 patients with osteoid osteoma were treated with CT-guided RFA in common (25 cases) and technically challenging (five cases: four near articular surface and one in sacrum) locations...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28515465/gender-specific-differential-expression-of-exosomal-mirna-in-synovial-fluid-of-patients-with-osteoarthritis
#19
Ravindra Kolhe, Monte Hunter, Siyang Liu, Ravirajsinh N Jadeja, Chetan Pundkar, Ashis K Mondal, Bharati Mendhe, Michelle Drewry, Mumtaz V Rojiani, Yutao Liu, Carlos M Isales, Robert E Guldberg, Mark W Hamrick, Sadanand Fulzele
The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches are limited to preventing progression of the disease. Recent studies have shown that exosomes play a vital role in cell-to-cell communication, and pathogenesis of many age-related diseases. Molecular profiling of synovial fluid derived exosomal miRNAs may increase our understanding of OA progression and may lead to the discovery of novel biomarkers and therapeutic targets. In this article we report the first characterization of exosomes miRNAs from human synovial fluid...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515058/tissue-engineered-cartilage-constructed-by-a-biotin-conjugated-anti-cd44-avidin-binding-technique-for-the-repairing-of-cartilage-defects-in-the-weight-bearing-area-of-knee-joints-in-pigs
#20
H Lin, J Zhou, L Cao, H R Wang, J Dong, Z R Chen
OBJECTIVES: The lack of effective treatment for cartilage defects has prompted investigations using tissue engineering techniques for their regeneration and repair. The success of tissue-engineered repair of cartilage may depend on the rapid and efficient adhesion of transplanted cells to a scaffold. Our aim in this study was to repair full-thickness defects in articular cartilage in the weight-bearing area of a porcine model, and to investigate whether the CD44 monoclonal antibody biotin-avidin (CBA) binding technique could provide satisfactory tissue-engineered cartilage...
May 2017: Bone & Joint Research
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