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https://www.readbyqxmd.com/read/29227355/basic-calcium-phosphate-crystal-associated-musculoskeletal-syndromes-an-update
#1
Ann K Rosenthal
PURPOSE OF REVIEW: Basic calcium phosphate (BCP) crystals are associated with two important musculoskeletal syndromes. Deposition of BCP crystals in tendons, bursae, and other soft tissues around joints causes calcific periarthritis, whereas intra-articular BCP crystals contribute to osteoarthritis and cause the highly destructive arthritis known as Milwaukee Shoulder Syndrome. The epidemiology and natural history of these syndromes are poorly understood, and because the pathogenesis remains unclear, few targeted therapies are available...
December 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29226725/development-of-a-microcomputed-tomography-scoring-system-to-characterize-disease-progression-in-the-hartley-guinea-pig-model-of-spontaneous-osteoarthritis
#2
Lauren B Radakovich, Angela J Marolf, John P Shannon, Stephen C Pannone, Vanessa D Sherk, Kelly S Santangelo
AIM: There is potential discrepancy between human and laboratory animal studies of osteoarthritis (OA), as radiographic assessment is the hallmark of the former and histopathology the standard for the latter. This suggests a need to evaluate OA in animal models in a manner similar to that utilized in people. Our study aimed to develop a whole joint grading scheme for microcomputed tomography (microCT) images in Hartley guinea pigs, a strain that recapitulates joint changes highlighted in human spontaneous OA...
December 11, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29226204/single-cut-distal-femoral-varus-osteotomy-scfo-a-preliminary-study
#3
Reza Abdi, Ramin Hajzargarbashi, Mohammad H Ebrahimzadeh
Background: Genu valgum usually originates from a deformity of distal femur that is often corrected by distal femoral varus osteotomy. The osteotomy includes both components of angulationcorrection and translation because the site of osteotomy is not commonly at the apex of deformity. Improvement of patellar tracking not only depends on valgus correction, but also it may be partially due to centralization of the trochlear groove under the femoral anatomical axis (FAA).We asked whether we could accurately correct the deformities based on our preoperative goals for the correction of the mechanical axis and centralization of the trochlear groove under the FAA by using a single bone cut...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29226162/relationship-between-age-at-onset-of-symptoms-and-intraoperative-findings-in-hip-arthroscopic-surgery
#4
Carlos Suarez-Ahedo, Chengcheng Gui, Stephanie M Rabe, John P Walsh, Sivashankar Chandrasekaran, Benjamin G Domb
Background: Hip arthroscopic surgery is intended to treat multiple abnormalities in an effort to delay the progression to osteoarthritis, especially in young patients. However, the length of time in which patients experience joint pain before seeking a specialist for a diagnosis can delay hip preservation surgery and influence clinical outcomes. Purpose: To investigate the relationship between age at symptom onset and findings during hip arthroscopic surgery as well as outcomes after 2 years of clinical follow-up...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29225174/photopolymerized-maleilated-chitosan-methacrylated-silk-fibroin-micro-nanocomposite-hydrogels-as-potential-scaffolds-for-cartilage-tissue-engineering
#5
Yingshan Zhou, Kaili Liang, Shuyan Zhao, Can Zhang, Jun Li, Hongjun Yang, Xin Liu, Xianze Yin, Dongzhi Chen, Weilin Xu, Pu Xiao
Hydrogels composed of natural materials exhibit great application potential in artificial scaffolds for cartilage repair as they can resemble the extracellular matrices of cartilage tissues comprised of various glycosaminoglycan and collagen. Herein, the natural polymers with vinyl groups, i.e. maleilated chitosan (MCS) and methacrylated silk fibroin (MSF) micro/nanoparticles, were firstly synthesized. The chemical structures of MCS and MSF micro/nanoparticles were investigated using Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, and X-ray photoelectron spectroscopy (XPS)...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29225019/primary-versus-revision-anterior-cruciate-ligament-reconstruction-patient-demographics-radiographic-findings-and-associated-lesions
#6
Justin J Mitchell, Mark E Cinque, Grant J Dornan, Lauren M Matheny, Chase S Dean, Brad Kruckeberg, Gilbert Moatshe, Jorge Chahla, Robert F LaPrade
PURPOSE: The purpose of this study was to evaluate the differences in intra-articular pathology, demographic characteristics, and radiographic characteristics of the knee associated with primary anterior cruciate ligament reconstruction (ACLR) versus revision ACLR at the time of initial presentation with either a native anterior cruciate ligament tear or an anterior cruciate ligament graft tear. Secondarily, we aimed to investigate risk factors for concomitant medial and lateral meniscal tears and cartilage injuries at the time of ACLR...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29225015/symptomatic-focal-knee-chondral-injuries-in-national-football-league-combine-players-are-associated-with-poorer-performance-and-less-volume-of-play
#7
Matthew T Provencher, Jorge Chahla, Mark E Cinque, George Sanchez, Nicholas I Kennedy, Daniel B Haber, Ashley J Tisosky, Brendin R Beaulieu-Jones, Mark D Price, James M Whalen, Gilbert Moatshe, Robert F LaPrade
PURPOSE: To (1) describe the magnetic resonance imaging (MRI) characteristics of knee chondral injuries identified at the National Football League (NFL) Combine and (2) assess in-game performance of prospective NFL players with previously untreated knee chondral injuries and compare it with matched controls. METHODS: All players with knee chondral injuries identified at the NFL Combine (2009-2015) were retrospectively reviewed. Players with prior knee surgery were excluded...
December 7, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29224971/biomechanical-effects-of-a-mandibular-advancement-device-on-the-temporomandibular-joint
#8
David S P Heidsieck, Jan Harm Koolstra, Maurits H T de Ruiter, Aarnoud Hoekema, Jan de Lange
PURPOSE: Mandibular advancement devices are commonly used in the treatment of patients with mild to moderate obstructive sleep apnea (OSA). Designed to maintain the mandible in forced protrusion while being worn, mandibular advancement devices (MADs) are intended to increase the upper airway during sleep, thereby reducing OSA symptoms. Depending on the extent of mandibular protrusion, side effects including temporomandibular joint dysfunction are frequently reported. These are likely to reduce overall treatment success by affecting therapeutic adherence...
November 22, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29223778/differences-in-trochlear-parameters-between-native-and-prosthetic-kinematically-or-mechanically-aligned-knees
#9
C Rivière, F Iranpour, S Harris, E Auvinet, A Aframian, S Parratte, J Cobb
INTRODUCTION: Kinematic (KA) and mechanical (MA) alignment techniques are two different philosophies of implant positioning that use the same TKA implants. This might generate differences in the resulting prosthetic trochlea parameters between the two techniques of alignment. Our study aim was to test the following hypotheses: 1) Mechanically or kinematically aligned femoral implant understuffs the native trochlear articular surface and poorly restores the native groove orientation, and 2) The orientation of the prosthetic trochlear groove and trochlear fill are different between MA and KA...
December 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29223659/complications-in-the-treatment-of-mandibular-condylar-fractures-surgical-versus-conservative-treatment
#10
REVIEW
Iván García-Guerrero, Juan M Ramírez, Rafael Gómez de Diego, José M Martínez-González, María S Poblador, José L Lancho
OBJECTIVES: In the present article, we aim to review the main intra- and post-operative complications associated with two different therapeutic approaches for treating mandibular condylar fractures: conservative (CTR) and surgical treatment (ORIF, Open Reduction and Internal Fixation). MATERIAL AND METHODS: We have carried out a retrospective, meta-analytic, observational study using literature review, covering the period between 2000- September 2017. The data obtained were processed using statistical software SPSS v...
December 6, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29223595/modulation-of-cartilage-s-response-to-injury-can-chondrocyte-apoptosis-be-reversed
#11
REVIEW
Ippokratis Pountos, Peter V Giannoudis
Osteoarthritis is characterized by a chronic, progressive and irreversible degradation of the articular cartilage associated with joint inflammation and a reparative bone response. More than 100 million people are affected by this condition worldwide with significant health and welfare costs. Our available treatment options in osteoarthritis are extremely limited. Chondral or osteochondral grafts have shown some promising results but joint replacement surgery is by far the most common therapeutic approach. The difficulty lies on the limited regeneration capacity of the articular cartilage, poor blood supply and the paucity of resident progenitor stem cells...
December 2017: Injury
https://www.readbyqxmd.com/read/29223037/a-microfabricated-platform-for-the-study-of-chondrogenesis-under-different-compressive-loads
#12
Reza Kowsari-Esfahan, Azadeh Jahanbakhsh, Mohammad Said Saidi, Shahin Bonakdar
Microfluidic devices are beneficial in miniaturizing and multiplexing various cellular assays in a single platform. Chondrogenesis is known to pertain to chemical, topographical, and mechanical cues in the microenvironment. Mechanical cues themselves have numerous parameters such as strain magnitude, frequency, and stimulation time. Effects of different strain magnitudes on the chondrogenic differentiation of adult stem cells have not been explored thoroughly. Here, a new multilayer microdevice is presented for the unidirectional compressive stimulation of cells in a three-dimensional cell culture...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29221903/discrete-element-analysis-is-a-valid-method-for-computing-joint-contact-stress-in-the-hip-before-and-after-acetabular-fracture
#13
Kevin C Townsend, Holly D Thomas-Aitken, M James Rudert, Andrew M Kern, Michael C Willey, Donald D Anderson, Jessica E Goetz
Evaluation of abnormalities in joint contact stress that develop after inaccurate reduction of an acetabular fracture may provide a potential means for predicting the risk of developing post-traumatic osteoarthritis. Discrete element analysis (DEA) is a computational technique for calculating intra-articular contact stress distributions in a fraction of the time required to obtain the same information using the more commonly employed finite element analysis technique. The goal of this work was to validate the accuracy of DEA-computed contact stress against physical measurements of contact stress made in cadaveric hips using Tekscan sensors...
November 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29221665/effect-of-wrist-posture-rate-of-force-development-relaxation-and-isotonic-contractions-on-finger-force-independence
#14
Stephen E May, Peter J Keir
The multi-articular anatomy and inter-connections of the extrinsic finger muscles suggests that wrist posture may affect enslaved finger forces. The purpose of this study was to determine the effects of (i) wrist posture on enslaved finger forces during ramp and isotonic exertions, and (ii) the rate of force development on enslaved forces and error. Twelve men performed 3 repetitions of isometric finger flexion and extension force with index and ring fingers with the wrist in 30° flexion, neutral, and 30° extension...
December 2, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29220551/consensus-on-the-management-of-patients-with-psoriatic-arthritis-in-a-dermatology-setting
#15
P Gisondi, G Altomare, F Ayala, A Conti, P Dapavo, C De Simone, C Foti, L Idolazzi, E Lubrano, G Malara, A Marchesoni, I Olivieri, A Parodi, K Peris, S Piaserico, C Salvarani, R Scarpa, G Girolomoni
BACKGROUND: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis (PsO). Early diagnosis and prompt therapeutic intervention are crucial for limiting PsA progression and prevention of disability. Dermatologists are in a privileged position to detect early PsA. The management of patients with PsA in the dermatology setting is widely variable. OBJECTIVE: To provide practical recommendations for the management of patients with PsA in the dermatology setting including early diagnosis and treatment...
December 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29219780/anatomical-and-technical-factors-associated-with-superior-facet-joint-violation-in-lumbar-fusion
#16
Alisson R Teles, Michael Paci, Gabriel Gutman, Fahad H Abduljabbar, Jean A Ouellet, Michael H Weber, Jeff D Golan
OBJECTIVE The aim of this study was to evaluate the anatomical and surgical risk factors for screw-related facet joint violation at the superior level in lumbar fusion. METHODS The authors conducted a retrospective review of a consecutive series of posterior lumbar instrumented fusions performed by a single surgeon. Inclusion criteria were primary lumbar fusion of 1 or 2 levels for degenerative disorders. The following variables were analyzed as possible risk factors: surgical technique (percutaneous vs open screw placement), depth of surgical field, degree of anterior slippage of the superior level, pedicle and facet angle, and facet degeneration of the superior level...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29219025/the-effect-of-growth-hormone-on-chondral-defect-repair
#17
Natalie R Danna, Bryan G Beutel, Austin J Ramme, Thorsten Kirsch, Oran D Kennedy, Eric Strauss
Objective Focal chondral defects alter joint mechanics and cause pain and debilitation. Microfracture is a surgical technique used to treat such defects. This technique involves penetration of subchondral bone to release progenitor cells and growth factors from the marrow to promote cartilage regeneration. Often this results in fibrocartilage formation rather than structured hyaline cartilage. Some reports have suggested use of growth hormone (GH) with microfracture to augment cartilage regeneration. Our objective was to test whether intra-articular (IA) GH in conjunction with microfracture, improves cartilage repair in a rabbit chondral defect model...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219024/excess-maternal-thyroxine-alters-the-proliferative-activity-and-angiogenic-profile-of-growth-cartilage-of-rats-at-birth-and-weaning
#18
Lorena Gabriela Rocha Ribeiro, Juneo Freitas Silva, Natália de Melo Ocarino, Cíntia Almeida de Souza, Eliane Gonçalves de Melo, Rogéria Serakides
Objective The aim of this study was to unravel the mechanisms by which thyroxine affects skeletal growth by evaluating proliferative activity and angiogenic profile of growth cartilage of neonatal and weanling rats. Methods Sixteen adult Wistar rats were equally divided into 2 groups: control and treated with thyroxine during pregnancy and lactation. The weight, measurement of plasma free T4 and thyroids, femurs' histomorphometric analysis, and proliferative activity and angiogenic profile by immunohistochemical or real-time reverse transcriptase-polymerase chain reaction in growth cartilage was performed...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219023/tenascin-c-prevents-articular-cartilage-degeneration-in-murine-osteoarthritis-models
#19
Yuriyo Matsui, Masahiro Hasegawa, Takahiro Iino, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Akihiro Sudo
Objective The objective of this study was to determine whether intra-articular injections of tenascin-C (TNC) could prevent cartilage damage in murine models of osteoarthritis (OA). Design Fluorescently labeled TNC was injected into knee joints and its distribution was examined at 1 day, 4 days, 1 week, 2 weeks, and 4 weeks postinjection. To investigate the effects of TNC on cartilage degeneration after surgery to knee joints, articular spaces were filled with 100 μg/mL (group I), 10 μg/mL (group II) of TNC solution, or control (group III)...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29219022/effectiveness-of-radiofrequency-hyperthermia-for-treating-cartilage-in-guinea-pigs-with-primary-osteoarthritis
#20
Kenji Takahashi, Hiroshi Nakamura, Hitoshi Ozawa, Sanshiro Hashimoto, Norio Iijima, Shimpei Higo, Hiroshi Watanabe, Yusuke Mochizuki, Shinro Takai
Objective Autophagy was reported to be essential for maintaining chondrocyte function, and reduced autophagy leads to osteoarthritis (OA). Previous studies showed involvement of heat shock stress in the control of autophagy in cells. This study sought to investigate the effect of hyperthermia on the expression of autophagy-related proteins in articular cartilage and the progression of naturally occurring OA in Hartley guinea pigs. Design Radiofrequency pulses of 13.56 MHz were applied to the animals' knees for 20 minutes to induce hyperthermia...
January 2018: Cartilage
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