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https://www.readbyqxmd.com/read/28644130/mmp-3-gene-polymorphisms-are-associated-with-increased-risk-of-osteoarthritis-in-chinese-men
#1
Wen Guo, Pengcheng Xu, Tianbo Jin, Jihong Wang, Dongsheng Fan, Zengtao Hao, Yuntao Ji, Shangfei Jing, Chaoqian Han, Jieli Du, Dong Jiang, Shuzheng Wen, Jianzhong Wang
Osteoarthritis (OA) is the most common late-onset degenerative joint disease., It is characterized by progressive degradation of articular cartilage. We investigated the association between OA occurrence and single nucleotide polymorphisms (SNPs) in the matrix metalloproteinase-3 (MMP-3)gene involved in the breakdown of extra-cellular matrix proteins. The study included 100 male OA patients and 197 healthy men from the north area of China. Eight MMP-3 SNPs were genotyped. Odds ratios (ORs) with 95% confidence intervals (95%CIs) and multivariate logistic regression analysis were used to assess the association...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644116/axillary-intraneural-ganglion-cysts
#2
Kartik G Krishnan, Nikhil K Prasad, Kimberly K Amrami, Paul J Kurtin, Robert J Spinner
Aside from affecting the stability of the glenohumeral joint, tears in the joint capsule can give rise to extraneural (paralabral) and, very rarely, intraneural ganglion cysts. This report presents the first two cases of axillary intraneural ganglion cysts in the literature with magnetic resonance imaging. Both cases were incidentally noted to have coexisting lesions (lymphadenopathy from an undifferentiated malignancy and suprascapular nerve entrapment, respectively). This report reinforces the applicability of the articular theory for intraneural ganglion cysts at a novel site...
2017: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/28643827/anti-oxidant-and-immune-modulatory-properties-of-sulfated-alginate-derivatives-on-human-chondrocytes-and-macrophages
#3
Anne Kerschenmeyer, Øystein Arlov, Vera Malheiro, Matthias Steinwachs, Markus Rottmar, Katharina Maniura-Weber, Gemma Palazzolo, Marcy Zenobi-Wong
Degeneration of articular cartilage represents one of the most common causes of pain and disability in our aging society. Current treatments only address the symptoms of joint disease, but not their underlying causes which include oxidative stress and inflammation in cartilage and surrounding tissues. Sulfated biopolymers that mimic aspects of the native extracellular environment of cartilage are recently gaining interest as a means to slow the inflammatory events responsible for tissue degeneration. Here we show that the natural polysaccharide alginate and particularly its sulfated derivatives have potent anti-oxidant, anti-inflammatory and anti-immunogenic properties in vitro...
June 23, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28643466/anemonin-attenuates-osteoarthritis-progression-through-inhibiting-the-activation-of-il-1%C3%AE-nf-%C3%AE%C2%BAb-pathway
#4
Zuqiang Wang, Junlan Huang, Siru Zhou, Fengtao Luo, Wei Xu, Quan Wang, Qiaoyan Tan, Liang Chen, Jun Wang, Hangang Chen, Lin Chen, Yangli Xie, Xiaolan Du
The osteoarthritis (OA) progression is now considered to be related to inflammation. Anemonin (ANE) is a small natural molecule extracted from various kinds of Chinese traditional herbs and has been shown to inhibiting inflammation response. In this study, we examined whether ANE could attenuate the progression of OA via suppression of IL-1β/NF-κB pathway activation. Destabilization of the medial meniscus (DMM) was performed in 10-week-old male C57BL/6J mice. ANE was then intra-articularly injected into joint capsule for 8 and 12 weeks...
June 23, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28642867/evaluation-of-the-effect-of-a-single-intra-articular-injection-of-allogeneic-neonatal-mesenchymal-stromal-cells-compared-to-oral-non-steroidal-anti-inflammatory-treatment-on-the-postoperative-musculoskeletal-status-and-gait-of-dogs-over-a-6-month-period-after
#5
Mathieu Taroni, Quentin Cabon, Marine Fèbre, Thibaut Cachon, Nathalie Saulnier, Claude Carozzo, Stéphane Maddens, Fabrice Labadie, Clément Robert, Eric Viguier
OBJECTIVE: Compare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs). STUDY DESIGN: Prospective, double-blinded, randomized, controlled, monocentric clinical study...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28642243/anti-inflammatory-and-anti-osteoarthritis-effects-of-tectorigenin
#6
Cheng-Long Wang, De Li, Chuan-Dong Wang, Fei Xiao, Jun-Feng Zhu, Chao Shen, Bin Zuo, Yi-Min Cui, Hui Wang, Yuan Gao, Guo-Li Hu, Xiao-Ling Zhang, Xiao-Dong Chen
Osteoarthritis (OA) is a common and dynamic joint disease, including the articular cartilage, underlying bones, and synovium. In particular, OA is considered as the degeneration of the cartilage. Tectorigenin (Tec) can affect many biological processes. However, its effect on articular chondrocytes remains unclear. This study aimed to assess the role of Tec in articular cartilage. In vitro, Tec inhibited the expression levels of type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3, and MMP-13 gene but enhanced those of Runx1, type II collagen, and aggrecan in the presence of IL-1β...
June 22, 2017: Biology Open
https://www.readbyqxmd.com/read/28641954/interventional-rheumatology-the-competence-of-brazilian-rheumatologists
#7
Aline Teixeira de Landa, Jamil Natour, Rita Nely Vilar Furtado
OBJECTIVES: Describe Brazilian rheumatologists's competence in interventional rheumatology; assess the association between this ability and demographic and training variables. METHODS: A cross-sectional study with 500 Brazilian rheumatologists. Participants were assessed by self-administered questionnaire consisting of demographics, training, practice in office and knowledge in interventional rheumatology data. RESULTS: 463 participants had their data analyzed...
June 19, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#8
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639551/facet-joint-injections-for-people-with-persistent-non-specific-low-back-pain-facet-injection-study-a-feasibility-study-for-a-randomised-controlled-trial
#9
David R Ellard, Martin Underwood, Felix Achana, James Hl Antrobus, Shyam Balasubramanian, Sally Brown, Melinda Cairns, James Griffin, Frances Griffiths, Kirstie Haywood, Charles Hutchinson, Ranjit Lall, Stavros Petrou, Nigel Stallard, Colin Tysall, David A Walsh, Harbinder Sandhu
BACKGROUND: The National Institute for Health and Care Excellence (NICE) 2009 guidelines for persistent low back pain (LBP) do not recommend the injection of therapeutic substances into the back as a treatment for LBP because of the absence of evidence for their effectiveness. This feasibility study aimed to provide a stable platform that could be used to evaluate a randomised controlled trial (RCT) on the clinical effectiveness and cost-effectiveness of intra-articular facet joint injections (FJIs) when added to normal care...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28639458/use-of-computed-tomography-to-define-a-sacral-safe-corridor-for-placement-of-2-7-mm-cortical-screws-in-feline-sacroiliac-luxation
#10
Helen Philp, Alexane Durand, Felipe De Vicente
Objectives This study aimed to define a safe corridor for 2.7 mm cortical sacroiliac screw insertion in the dorsal plane (craniocaudal direction) using radiography and CT, and in the transverse plane (dorsoventral direction) using CT in feline cadavers. A further aim was to compare the values obtained by CT with those previously reported by radiography in the transverse plane. Methods Thirteen pelvises were retrieved from feline cadavers and dissected to expose one of the articular surfaces of the sacrum. A 2...
June 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28638931/-operative-techniques-and-results-of-tibial-pilon-fractures
#11
REVIEW
R Rotter, P Gierer
BACKGROUND: The anatomical reconstruction of tibial pilon fractures is a major challenge with respect to preoperative planning, time management and the intraoperative procedure. OBJECTIVE: Presentation of the various surgical procedures available and the clinical outcome. MATERIAL AND METHODS: The established open reduction and internal plate fixation procedures form the basis for new minimally invasive treatment concepts. The current results of comparative studies and basic literature are discussed...
June 21, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28638889/reduction-of-intra-articular-adhesion-by-topical-application-of-daidzein-following-knee-surgery-in-rabbits
#12
Xiangchun Liu, Heng Jia, Hongsheng Xia
BACKGROUND: Intra-articular adhesion is the commonest complication that is faced by orthopedic surgeons after knee surgery. Thus, the present investigation evaluates the effect of daidzein on intra-articular adhesion in rabbits. MATERIAL AND METHODS: All the rabbits were separated in to four different groups each group carries ten rabbits. Cancellous bone was exposed in each rabbit by removing cortical bone from both side of the femoral condyle. Following daidzein (2...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638881/aristolochia-bracteolate-retz-attenuates-hyperuricemia-in-a-metabolic-arthritis-rat-model
#13
Yun-Peng Li, Shuang Wu, Afou Ran, Da-Yong Xu, Jing-Mei Wei, Zi-Long Zhao
BACKGROUND: The leaves of Aristolochia bracteolata Retz. has been documented in the folk medicine literature for its anti-arthritic activity. The target of the research envisaged was to elucidate the activity of A. bracteolata extract on hyperuricemic condition in arthritis rat model. MATERIALS AND METHODS: Dried and powdered plant leaves were extracted using ether and chloroform. Potassium oxonate was injected intra-articularly to produce arthritis. The hyperuricemic effect, of A...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638693/management-of-the-temporomandibular-joint-in-inflammatory-arthritis-involvement-of-surgical-procedures
#14
REVIEW
Rory C O'Connor, Fiona Fawthrop, Rami Salha, Andrew J Sidebottom
Many conditions may affect the temporomandibular joint (TMJ), but its incidence in individual joint diseases is low. However, inflammatory arthropathies, particularly rheumatoid and psoriatic arthritis and ankylosing spondylitis, appear to have a propensity for affecting the joint. Symptoms include pain, restriction in mouth opening, locking, and noises, which together can lead to significant impairment. Jaw rest, a soft diet, a bite splint, and medical therapy, including disease-modifying antirheumatic drugs (DMARDs) and simple analgesia, are the bedrock of initial treatment and will improve most symptoms in most patients...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638679/decrease-of-serum-biomarker-of-type-ii-collagen-degradation-coll2-1-by-intra-articular-injection-of-an-autologous-plasma-rich-platelet-in-patients-with-unilateral-primary-knee-osteoarthritis
#15
Rasha Mohamed Fawzy, Nashwa Ismail Hashaad, Amira Ibrahim Mansour
OBJECTIVE: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. MATERIAL AND METHODS: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group I): including patients with KL grade < 3 and (Group II): including patients with KL grade ≥3...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638670/arthroscopic-treatment-of-2-consecutive-cases-of-dysplasia-epiphysealis-hemimelica-of-the-ankle-a-5-year-follow-up-report
#16
Cosma Calderaro, Carlo Iorio, Francesco Turturro, Federico Morelli, Luca Labianca, Antonello Montanaro, Andrea Ferretti
The dysplasia epiphysealis hemimelica (DEH) is a rare disease of unknown etiology consisting in an abnormal osteocartilaginous growth at the epiphysis, usually hemimelic with histological findings similar to benign osteochondroma. In this case series, we described the results of the arthroscopic treatment of 2 consecutive cases of intra-articular ankle localization of DEH in 2 patients aged 9 and 10 years. The good result obtained, persistent at the 5-year follow-up, leads us to consider the arthroscopic approach as a reliable treatment in patient affected by intra-articular ankle DEH...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28638116/laser-ultrasonic-delivery-of-agents-into-articular-cartilage
#17
Heikki J Nieminen, Gonçalo Barreto, Mikko A Finnilä, Alejandro García-Pérez, Ari Salmi, Sanjeev Ranjan, Kari K Eklund, Kenneth P H Pritzker, Simo Saarakkala, Edward Hæggström
Research is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigates the capability of laser ultrasound (laser-induced plasma sound source) to deliver agents (methylene blue, MB, in PBS) into bovine AC. Treatment samples (n = 10) were immersed in MB solution simultaneously with LU exposure, while adjacent control 1 tissue (n = 10) was pre-treated with LU followed by immersion in MB and adjacent control 2 tissue (n = 10) was only immersed in MB...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637998/reinvestigation-of-the-morphological-characteristics-of-the-lateral-ulnar-collateral-ligament-in-humans
#18
Karen Tokunaga, Kotaro Sato, Goro Tajima, Jun Yan, Yoshikuni Mimata, Katsumi Tajima, Yuki Kikuchi, Minoru Doita
To clarify the cause of posterolateral rotatory instability after damage to the lateral ulnar collateral ligament (LUCL), the morphological characteristics of the LUCL were reinvestigated and three-dimensional (3D) image of the ligament was reconstructed using 35 human elbows. The results were as follows: 1) the insertion point of the LUCL on the humerus was almost at the center of the capitellum, and its width was 2.61 ± 1.02 mm. The insertion point of the LUCL on the ulna was located from the lesser sigmoid notch to the supinator crest and had a width of 9...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/28634835/impact-of-mechanical-stimulation-on-the-chondrogenic-processes-in-human-bone-marrow-aspirates-modified-to-overexpress-sox9-via-raav-vectors
#19
Jagadeesh K Venkatesan, Janina Frisch, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini
BACKGROUND: Evaluation of gene-based approaches to target human bone marrow aspirates in conditions of mechanical stimulation that aim at reproducing the natural joint environment may allow to develop improved treatments for articular cartilage injuries. In the present study, we investigated the potential of rAAV-mediated sox9 gene transfer to enhance the chondrogenic differentiation processes in human bone marrow aspirates under established hydrodynamic conditions compared with the more commonly employed static culture conditions...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28634743/comminuted-olecranon-fractures-biomechanical-testing-of-locked-versus-minifragment-non-locked-plate-fixation
#20
David S Wellman, Scott M Tucker, Josh R Baxter, Nadine C Pardee, Lionel E Lazaro, Christopher S Smith, Dean G Lorich, David L Helfet
INTRODUCTION: Open reduction and internal fixation has long been accepted as optimal treatment for displaced olecranon fractures based on poor results seen with conservative management. With the presence of comminution, tension-band wiring constructs are contraindicated due to tendency to compress through fragments, thereby shortening the articular segment. Therefore, plate fixation is typically employed. Our hypothesis was that in a comminuted fracture model, 2.7 mm reconstruction plating without locking screws will perform equally to 3...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
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