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https://www.readbyqxmd.com/read/29786775/stormram-4-an-mr-safe-robotic-system-for-breast-biopsy
#1
Vincent Groenhuis, Françoise J Siepel, Jeroen Veltman, Jordy K van Zandwijk, Stefano Stramigioli
Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm. The Stormram 4 is driven by two linear and two curved pneumatic stepper motors. The linear motor is capable of exerting 63 N of force at a pressure of 0...
May 21, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29786415/tailoring-crystalline-morphology-by-high-efficiency-nucleating-fiber-towards-high-performance-poly-l-lactide-biocomposites
#2
Tao Gao, Zheng-Min Zhang, Le Li, Rui-Ying Bao, Zhengying Liu, Bang-Hu Xie, Ming-Bo Yang, Wei Yang
In this work, high melting point poly(L-lactide) fiber (hPLLA fiber) with high-efficiency nucleation activity was prepared and introduced into PLLA matrix to prepare fully biodegradable PLLA biocomposites. The highly active nucleating surfaces of hPLLA fiber induced chain ordering and lamellar organization, leading to preferable formation of well-organized PLLA transcrystallinity at the surface of hPLLA fiber in quiescent conditions. The construction of such compact transcrystallinity increased the crystallinity and enhanced the interfacial adhesion, which largely promoted the heat resistance, tensile strength, and barrier property of PLLA biocomposites at a low content of hPLLA fiber...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786042/early-immunosuppressive-exposure-of-enteric-coated-mycophenolate-sodium-plus-tacrolimus-associated-with-acute-rejection-in-expanded-criteria-donor-kidney-transplantation
#3
Chen-Guang Ding, Li-Zi Jiao, Feng Han, He-Li Xiang, Pu-Xun Tian, Xiao-Ming Ding, Xiao-Ming Pan, Xiao-Hui Tian, Yang Li, Jin Zheng, Wu-Jun Xue
Background: Immunosuppressive agents are still inefficient in preventing biopsy-proven acute rejection (BPAR) after expanded criteria donor (ECD) kidney transplantation. The aim of this study was to investigate the relationships between early immunosuppressive exposure and the development of BPAR. Methods: We performed a retrospective study of 58 recipients of ECD kidney transplantation treated with enteric-coated-mycophenolate sodium, tacrolimus (Tac), and prednisone...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785605/selection-of-inactivation-medium-for-fungal-spores-in-clinical-wastes-by-supercritical-carbon-dioxide
#4
Efaq Noman, Nik Norulaini Nik Ab Rahman, Adel Al-Gheethi, Hideyuki Nagao, Balkis A Talip, Omar Ab Kadir
The present study aimed to select the best medium for inactivation of Aspergillus fumigatus, Aspergillus spp. in section Nigri, A. niger, A. terreus var. terreus, A. tubingensis, Penicillium waksmanii, P. simplicissimum, and Aspergillus sp. strain no. 145 spores in clinical wastes by using supercritical carbon dioxide (SC-CO2 ). There were three types of solutions used including normal saline, seawater, distilled water, and physiological saline with 1% of methanol; each solution was tested at 5, 10, and 20 mL of the water contents...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29785178/functionally-graded-bone-and-tendon-like-polyurethane-for-rotator-cuff-repair
#5
Dai Fei Elmer Ker, Dan Wang, Anthony William Behn, Evelyna Tsi Hsin Wang, Xu Zhang, Benjamin Yamin Zhou, Ángel Enrique Mercado-Pagán, Sungwoo Kim, John Kleimeyer, Burhan Gharaibeh, Yaser Shanjani, Drew Nelson, Marc Safran, Emilie Cheung, Phil Campbell, Yunzhi Peter Yang
Critical considerations in engineering biomaterials for rotator cuff repair include bone-tendon-like mechanical properties to support physiological loading and biophysicochemical attributes that stabilize the repair site over the long-term. In this study, UV-crosslinkable polyurethane based on quadrol (Q), hexamethylene diisocyante (H), and methacrylic anhydride (M; QHM polymers), which are free of solvent, catalyst, and photoinitiator, is developed. Mechanical characterization studies demonstrate that QHM polymers possesses phototunable bone- and tendon-like tensile and compressive properties (12-74 MPa tensile strength, 0...
May 2018: Advanced Functional Materials
https://www.readbyqxmd.com/read/29785105/development-and-blood-compatibility-assessment-of-electrospun-polyvinyl-alcohol-blended-with-metallocene-polyethylene-and-plectranthus-amboinicus-pva-mpe-pa-for-bone-tissue-engineering
#6
Jie Qi, Huang Zhang, Yingzhou Wang, Mohan Prasath Mani, Saravana Kumar Jaganathan
Introduction: Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should not cause foreign body reactions. Materials and methods: In this study, the hybrid scaffold based on polyvinyl alcohol (PVA) blended with metallocene polyethylene (mPE) and plectranthus amboinicus (PA) was fabricated for bone tissue engineering via electrospinning...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29784921/the-significance-of-deformation-mechanisms-on-the-fracture-behavior-of-phase-reversion-induced-nanostructured-austenitic-stainless-steel
#7
R D K Misra, V S Y Injeti, M C Somani
We describe here the relationship between grain structure, deformation mechanism and fracture characteristics in an austenitic stainless steel. This was accomplished using the novel concept of phase reversion that enabled a wide range of grain size from nanograined/ultrafine grained (NG/UFG) to coarse-grained (CG) regime to be obtained in a single material through change in temperature-time annealing sequence. In the NG/UFG structure, a marked increase in abundance of stacking faults (SFs) and twin density with strain was observed that led to a decrease in the average spacing between adjacent SFs, thus converting stacking faults into twins...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784420/stable-carbon-isotope-ratios-for-sourcing-the-nerve-agent-precursor-methylphosphonic-dichloride-and-its-products
#8
James J Moran, Carlos G Fraga, Megan K Nims
The ability to connect a chemical threat agent to a specific batch of a synthetic precursor can provide a fingerprint to contribute to effective forensic investigations. Stable isotope analysis can leverage intrinsic, natural isotopic variability within the molecules of a threat agent to unlock embedded chemical fingerprints in the material. Methylphosphonic dichloride (DC) is a chemical precursor to the nerve agent sarin. DC is converted to methylphosphonic difluoride (DF) as part of the sarin synthesis process...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783693/microstructural-evolution-in-high-strain-rate-deformation-of-ti-5al-5mo-5v-1cr-1fe-alloy
#9
Chun Ran, Pengwan Chen, Zemin Sheng, Jingbo Li, Wangfeng Zhang
To study the microstructural evolution in high-strain-rate shear deformation of Ti-5Al-5Mo-5V-1Cr-1Fe (Ti-55511) alloy, a series of forced shear tests of hat-shaped specimens have been conducted using a split Hopkinson pressure bar combined with the "strain-frozen" technique. A localized shear band is induced in Ti-55511 alloy in these tests. The experimental results demonstrate that the flow stress in hat-shaped specimens remains constant (about 600 MPa) and is independent of punching depth. The width of the adiabatic shear band increases with increasing punching depth and tends to saturate at 30 μm, and the estimation of the adiabatic shear band (ASB) width in hat-shaped (HS) specimens has been modified...
May 18, 2018: Materials
https://www.readbyqxmd.com/read/29779887/pulmonary-capillary-hemorrhage-induced-by-diagnostic-ultrasound-in-ventilated-rats
#10
Douglas L Miller, Zhihong Dong, Chunyan Dou, Krishnan Raghavendran
Pulmonary capillary hemorrhage (PCH) can be induced by diagnostic ultrasound-a potential safety issue. Anesthetized rats were intubated for intermittent positive-pressure ventilation (IPPV) with 0 end-expiratory pressure, +4 cm H2 O end-expiratory pressure (PEEP) and -4 cm H2 O end-expiratory pressure (NEEP). Rats were imaged at 7.6 MHz with a Philips HDI 5000 ultrasound machine. The output was low (mechanical index [MI] = 0.22) for aiming and then was raised for 5 min in 20 different exposure groups with n = 8...
May 17, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29779413/tailoring-tacrolimus-therapy-in-kidney-transplantation
#11
Thomas Jouve, Johan Noble, Lionel Rostaing, Paolo Malvezzi
BACKGROUND: The prevalence of end-stage renal disease is increasing worldwide. The best treatment is kidney transplantation, although life-long immunosuppressive therapy is then mandatory. Currently, the cornerstone immunosuppressive therapy relies on tacrolimus, a calcineurin inhibitor that is nephrotoxic but whose exposition can be minimized in a delicate balance. Area covered: We addressed whether, in the setting of kidney transplantation, tacrolimus-based therapy can be tailored to medical needs: to achieve this, we searched for suitable articles in PubMed...
May 19, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29779078/effects-of-elevated-pressure-on-pseudanabaena-galeata-b%C3%A3-cher-in-varying-light-and-dark-environments
#12
Helayaye Damitha Lakmali Abeynayaka, Takashi Asaeda, M Harun Rashid
To understand the effect of the hydrostatic pressure on Pseudanabaena galeata Böcher cells in both stratified and frequently mixed lakes, separate laboratory-scale models were developed. The pressure conditions in the stratified and mixed lakes were simulated in those models, and the variations of the cell and chlorophyll-a (Chl-a) concentration were analyzed. It was observed that an increase in pressure and darkness significantly reduced the cell concentration and pigmentation in P. galeata (p < 0...
May 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29778988/synthesis-microstructure-and-mechanical-behaviour-of-a-unique-porous-phbv-scaffold-manufactured-using-selective-laser-sintering
#13
Sven H Diermann, Mingyuan Lu, Yitian Zhao, Luigi-Jules Vandi, Matthew Dargusch, Han Huang
Selective Laser Sintering (SLS) is a promising technique for manufacturing bio-polymer scaffolds used in bone tissue engineering applications. Conventional scaffolds made using SLS have complex engineered architectures to introduce adequate porosity and pore interconnectivity. This study presents an alternative approach to manufacture scaffolds via SLS without using pre-designed architectures. In this work, a SLS process was developed for fabricating interconnected porous biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffolds with large surface areas and relative porosities of up to 80%...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29778880/cellulose-hydrogel-with-tunable-shape-and-mechanical-properties-from-rigid-cylinder-to-soft-scaffold
#14
Noriyuki Isobe, Takehiro Komamiya, Satoshi Kimura, Ung-Jin Kim, Masahisa Wada
Cellulose hydrogel from aqueous solution of lithium bromide demonstrated excellent tunability of mechanical property and shape. A series of compression tests showed that cellulose hydrogel covered a wide range of mechanical property, where the compressive Young's modulus was controllable from 30 kPa to 1.3 MPa by changing the initial concentration of cellulose solution. Meanwhile, the diameter of the building block of gel, namely nano-fibrous cellulose, was constant at 15-20 nm irrelevant of the initial concentration of cellulose solution...
May 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29778666/mycophenolate-mofetil-for-induction-and-maintenance-of-remission-in-na%C3%A3-ve-patients-with-granulomatosis-with-polyangiitis-without-renal-involvement
#15
Yasser Emad, Yasser Ragab, Johannes J Rasker
Antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides include granulomatosis with polyangiitis (GPA, previously called Wegener's), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss). In this report we used mycophenolate mofetil (MMF) and steroids to induce and maintain remission in two newly diagnosed cases with c-ANCA associated GPA. The two patients' maintained remission with no disease relapses during one year follow-up...
May 16, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29778477/the-effects-of-microfluidization-on-the-physical-microbial-chemical-and-coagulation-properties-of-milk
#16
A J Bucci, D L Van Hekken, M H Tunick, J A Renye, P M Tomasula
This work examines the use of mild heat treatments in conjunction with 2-pass microfluidization to generate cheese milk for potential use in soft cheeses, such as Queso Fresco. Raw, thermized, and high temperature, short time pasteurized milk samples, standardized to the 3% (wt/wt) fat content used in cheesemaking, were processed at 4 inlet temperature and pressure conditions: 42°C/75 MPa, 42°C/125 MPa, 54°C/125 MPa, and 54°C/170 MPa. Processing-induced changes in the physical, chemical, and microbial properties resulting from the intense pressure, shear, and cavitation that milk experiences as it is microfluidized were compared with nonmicrofluidized controls...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29777960/utility-of-cement-injection-to-stabilize-split-depression-tibial-plateau-fracture-by-minimally-invasive-methods-a-finite-element-analysis
#17
D Belaid, T Vendeuvre, A Bouchoucha, F Brémand, C Brèque, P Rigoard, A Germaneau
BACKGROUND: Treatment for fractures of the tibial plateau is in most cases carried out by stable fixation in order to allow early mobilization. Minimally invasive technologies such as tibioplasty or stabilization by locking plate, bone augmentation and cement filling (CF) have recently been used to treat this type of fracture. The aim of this paper was to determine the mechanical behavior of the tibial plateau by numerically modeling and by quantifying the mechanical effects on the tibia mechanical properties from injury healing...
May 8, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29777394/biomechanical-impact-of-wrong-positioning-of-a-dedicated-stent-for-coronary-bifurcations-a-virtual-bench-testing-study
#18
Claudio Chiastra, Maik J Grundeken, Carlos Collet, Wei Wu, Joanna J Wykrzykowska, Giancarlo Pennati, Gabriele Dubini, Francesco Migliavacca
The treatment of coronary bifurcations is challenging for interventional cardiologists. The Tryton stent (Tryton Medical, Inc., USA) is one of the few devices specifically designed for coronary bifurcations that underwent large clinical trials. Although the manufacturer provides specific recommendations to position the stent in the bifurcation side branch (SB) according to four radio-opaque markers under angiographic guidance, wrong device positioning may accidentally occur. In this study, the virtual bench testing approach was used to investigate the impact of wrong positioning of the Tryton stent in coronary bifurcations in terms of geometrical and biomechanical criteria...
May 17, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29774924/fluorescence-resonance-energy-transfer-fret-based-nanoparticles-composed-of-aie-luminogens-and-nir-dyes-with-enhanced-three-photon-near-infrared-emission-for-in-vivo-brain-angiography
#19
Wen Liu, Yalun Wang, Xiao Han, Ping Lu, Liang Zhu, Chaowei Sun, Jun Qian, Sailing He
Near-infrared (NIR) fluorescence is very important for high-contrast biological imaging of high-scattering tissues such as brain tissue. Unfortunately, commercial NIR dyes are excited usually by visible light, and their multi-photon absorption (MPA) cross-sections are small. Here, we design new co-encapsulated NIR nanoparticles (NPs) with a large three-photon (3PA) absorption cross-section. A form of aggregation-induced emission (AIE) luminogen (AIEgen), 2,3-bis(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl) fumaronitrile (TPATCN), is introduced as the donor, and a form of NIR dye, silicon 2,3-naphthalocyanine bis-(trihexylsilyloxide) (NIR775), is adopted as the acceptor...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29773402/hydroxypropylmethyl-cellulose-hpmc-crosslinked-chitosan-ch-based-scaffolds-containing-bioactive-glass-bg-and-zinc-oxide-zno-for-alveolar-bone-repair
#20
Rabia Zeeshan, Zeeshan Mutahir, Haffsah Iqbal, Moazzam Ali, Farasat Iqbal, Kashif Ijaz, Faiza Sharif, Asma Tufail Shah, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur-Rehman
The success of a dental implant relies on the presence of an optimal alveolar ridge. The aim of this study was to fabricate HPMC crosslinked chitosan based scaffolds for alveolar bone repair. Our results indicated that HPMC crosslinked CH/BG foams presented better morphological structure (132-90.5 μm) and mechanical responses (0.451 MPa with 100 mg BG) as confirmed by SEM analysis and fatigue testing respectively. Cytotoxicity analysis at day 2, 4 and 8 demonstrated that all composites were non-toxic and supported cellular viability...
August 1, 2018: Carbohydrate Polymers
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