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https://www.readbyqxmd.com/read/27925228/a-mock-circulatory-system-incorporating-a-compliant-3d-printed-anatomical-model-to-investigate-pulmonary-hemodynamics
#1
Paul G M Knoops, Giovanni Biglino, Alun D Hughes, Kim H Parker, Linzhang Xu, Silvia Schievano, Ryo Torii
A realistic mock circulatory system (MCS) could be a valuable in vitro testbed to study human circulatory hemodynamics. The objective of this study was to design a MCS replicating the pulmonary arterial circulation, incorporating an anatomically representative arterial model suitable for testing clinically relevant scenarios. A second objective of the study was to ensure the system's compatibility with magnetic resonance imaging (MRI) for additional measurements. A latex pulmonary arterial model with two generations of bifurcations was manufactured starting from a 3D-printed mold reconstructed from patient data...
December 7, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27924985/creating-bhb-imprinted-magnetic-nanoparticles-with-multiple-binding-sites
#2
Yanxia Li, Yiting Chen, Lu Huang, BenYong Lou, Guonan Chen
A kind of protein imprinted over magnetic Fe3O4@Au multifunctional nanoparticles (NPs) with multiple binding sites was synthesized and investigated. Magnetic Fe3O4@Au NPs as carrier materials were modified with 4-mercaptophenylboronic acid (MPBA) and mercaptopropionic acid (MPA) to introduce boronic acids and carboxyl groups. Using Bovine Hemoglobin (BHb) as a template, a polydopamine(PDA)-based molecular imprinted film was fabricated to produce a kind of magnetic molecularly imprinted nanoparticle (MMIP), possessing multiple binding sites with benzene-diol, amino groups, boronic acids and carboxyl groups...
December 7, 2016: Analyst
https://www.readbyqxmd.com/read/27924728/synthesis-and-immunosuppressive-activity-of-new-mycophenolic-acid-derivatives
#3
Karina Pereira Barbieri, Lucas Dos Reis Ercolin, Thierry Louat, Marisa Campos Polesi, Chung Man Chin, Iracilda Carlos Zeppone, Jean Leandro Dos Santos
BACKGROUND: Immunosuppressive drugs are widely used to prevent and treat allograft rejection and autoimmune diseases. Mycophenolic acid (MPA) and its derivatives are currently one of the most prescribed immunosuppressive drugs; however, metabolic drawbacks and variable inter- and intrapatient responses limit its use. OBJECTIVE: In order to find out new safe and effective immunosuppressive compounds we report here the synthesis and pharmacological evaluation of hybrid MPA derivatives containing the thalidomide/phthalimide subunits...
December 7, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27921382/core-shell-silk-hydrogels-with-spatially-tuned-conformations-as-drug-delivery-system
#4
Le-Ping Yan, Joaquim M Oliveira, Ana L Oliveira, Rui L Reis
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status...
December 5, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27919708/early-interstitial-lung-disease-in-microscopic-polyangiitis-case-report-and-literature-review
#5
Marcos García-Nava, Heidegger Mateos-Toledo, Ana Patricia Georgina Guevara-Canseco, Cesar Eduardo Infante-González, Diego Alberto Reyes-Nava, Emilio Estrada-Castro
Microscopic polyangiitis (MPA) is a systemic disease included in the Chapel Hill 2012 Classification as necrotizing vasculitis affecting capillaries, venules and arterioles. It usually expresses antineutrophil cytoplasmic antibodies (ANCA) and has a perinuclear immunofluorescence pattern and correlation with anti-myeloperoxidase (MPO) antibodies. Capillaritis with alveolar hemorrhage is the most common manifestation of lung disease. Interstitial lung disease (ILD) is uncommon, with usual interstitial pneumonia being the predominant pattern...
December 2, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27914669/effect-of-different-thermo-light-polymerization-on-flexural-strength-of-two-glass-ionomer-cements-and-a-glass-carbomer%C3%A2-cement
#6
Kristina Gorseta, Ali Borzabadi-Farahani, Alireza Moshaverinia, Domagoj Glavina, Edward Lynch
STATEMENT OF PROBLEM: Whether polymerization lights can be used for heating glass ionomer cements (GICs) or glass carbomer (GCP) to improve their mechanical properties is not well established. PURPOSE: The purpose of this in vitro study was to assess the effect of thermo-light polymerization on the flexural strength (FS) of 2 GICs (Fuji IX GP Fast, Ketac Molar) and a GCP. MATERIAL AND METHODS: Specimens (n=10) were prepared in stainless steel molds (2×2×25 mm), compressed, exposed to 3 polymerization lights (500, 1000, 1200 mW/cm(2)) for 2 cycles of 40 seconds on each side, and stored in petroleum jelly (37°C, 24 hours)...
November 30, 2016: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/27914179/ammonothermal-synthesis-of-novel-nitrides-case-study-on-cagasin3
#7
Jonas Häusler, Lukas Neudert, Mathias Mallmann, Robin Niklaus, Anna-Carina L Kimmel, Nicolas S A Alt, Eberhard Schlücker, Oliver Oeckler, Wolfgang Schnick
The first gallium-containing nitridosilicate CaGaSiN3 was synthesized in newly developed high-pressure autoclaves using supercritical ammonia as solvent and nitriding agent. The reaction was conducted in ammonobasic environment starting from intermetallic CaGaSi with NaN3 as mineralizer. At 770 K, intermediate compounds were obtained, which were subsequently converted to the crystalline nitride at temperatures up to 1070 K (70 - 150 MPa). The impact of other mineralizers (e. g. LiN3, KN3 and CsN3) on the product formation was investigated as well...
December 3, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27913330/ex-vivo-hifu-experiments-using-a-32-times-32-element-cmut-array
#8
Hyo-Seon Yoon, Chienliu Chang, Ji Hoon Jang, Anshuman Bhuyan, Jung Woo Choe, Amin Nikoozadeh, Ronald D Watkins, Douglas N Stephens, Kim Butts Pauly, Butrus T Khuri-Yakub
High-intensity focused ultrasound (HIFU) has been used as noninvasive treatment for various diseases. For these therapeutic applications, capacitive micromachined ultrasonic transducers (CMUTs) have advantages that make them potentially preferred transducers over traditional piezoelectric transducers. In this paper, we present the design and the fabrication process of an 8 ×8 -mm (2) 32 ×32 -element 2-D CMUT array for HIFU applications. To reduce the system complexity for addressing the 1024 transducer elements, we propose to group the CMUT array elements into eight HIFU channels based on the phase delay from the CMUT element to the targeted focal point...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27913328/subharmonic-response-of-polymer-contrast-agents-based-on-the-empirical-mode-decomposition
#9
Rintaro Hayashi, John S Allen, Parag V Chitnis, Jonathan Mamou, Jeffrey A Ketterling
The subharmonic threshold for ultrasound contrast agents has been defined as a 20-25 dB difference between the fundamental and subharmonic (2/1) spectral components of the backscatter signal. However, this Fourier-based criterion assumes a linear time-invariant signal. A more appropriate criterion for short cycle and frequency-modulated waveforms is proposed with an adaptive signal-processing approach based on the empirical mode decomposition (EMD) method. The signal is decomposed into an orthogonal basis known as intrinsic mode functions (IMFs) and a subharmonic threshold is defined with respect to the energy ratio of the subharmonic IMF component to that of the incident signal...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27911853/recurrence-of-cervical-cancer-and-its-resistance-to-progestin-therapy-in-a-mouse-model
#10
Fabiola F Mehta, Seunghan Baik, Sang-Hyuk Chung
Studies using K14E6/K14E7 transgenic mice expressing E6 and E7 oncoprotein of human papillomavirus type 16 (HPV16) have demonstrated that estrogen (E2) is required for the genesis and growth of cervical cancer. Our prior study using the same mouse model has showed that progestin drug medroxyprogesterone acetate (MPA) promotes regression of primary cervical cancer. In the present study, we use the same transgenic mouse model to determine whether the cancer recurs after MPA therapy. Cervical cancer recurred even if MPA treatment was continued...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27908716/self-healing-gelatin-ionogels
#11
REVIEW
Anshu Sharma, Kamla Rawat, Pratima R Solanki, H B Bohidar
We demonstrate room temperature (20°C) self-healing, and substantial recovery (68-96%) of gel rigidity of gelatin, a polypeptide, ionogels (made in 1-ethyl-3-methylimidazolium chloride ionic liquid (IL) solutions via thermal treatment, IL≤5% (w/v)) after they were cut using a surgical blade. The recovery process did not require any stimuli, and the complete healing under ambient condition required about 10h.The self-healing owed its origin to the reformation of network structures via imidazolium ion mediated charge quenching of deprotonated residues, and hydrophobic interaction between neighbouring alkyl tails of IL molecules...
November 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27907100/patterns-of-fish-connectivity-between-a-marine-protected-area-and-surrounding-fished-areas
#12
Rita Sahyoun, Paolo Guidetti, Antonio Di Franco, Serge Planes
Patterns of connectivity and self-recruitment are recognized as key factors shaping the dynamics of marine populations. Connectivity is also essential for maintaining and restoring natural ecological processes with genetic diversity contributing to the adaptation and persistence of any species in the face of global disturbances. Estimates of connectivity are crucial to inform the design of both marine protected areas (MPAs) and MPA networks. Among several approaches, genetic structure is frequently used as a proxy for patterns of connectivity...
2016: PloS One
https://www.readbyqxmd.com/read/27907043/thermodynamic-simulation-of-carbonate-cements-water-carbon-dioxide-equilibrium-in-sandstone-for-prediction-of-precipitation-dissolution-of-carbonate-cements
#13
Yiping Duan, Mingshi Feng, Xinyan Zhong, Ruishu Shang, Lihong Huang
Carbonate cements, such as calcite, dolomite, ferrocalcite and ankerite, play important roles in the formation of pores in sandstones: precipitation of carbonate cements modifies pores and inhibits compaction, while dissolution creates secondary pores. This work proposed a precipitation-dissolution model for carbonate cements-CO2-H2O system by means of ion equilibrium concentration ([M2+], M = Ca, Mg, Fe or Mn) with different factors, such as temperature, depth, pH, [Formula: see text], variable rock composition and overpressure...
2016: PloS One
https://www.readbyqxmd.com/read/27906357/antiresonant-reflecting-guidance-mechanism-in-hollow-core-fiber-for-gas-pressure-sensing
#14
Maoxiang Hou, Feng Zhu, Ying Wang, Yiping Wang, Changrui Liao, Shen Liu, Peixiang Lu
A gas pressure sensor based on an antiresonant reflecting guidance mechanism in a hollow-core fiber (HCF) with an open microchannel is experimentally demonstrated for gas pressure sensing. The microchannel was created on the ring cladding of the HCF by femtosecond laser drilling to provide an air-core pressure equivalent to the external environment. The HCF cladding functions as an antiresonant reflecting waveguide, which induces sharp periodic lossy dips in the transmission spectrum. The proposed sensor exhibits a high pressure sensitivity of 3...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27905533/five-key-attributes-can-increase-marine-protected-areas-performance-for-small-scale-fisheries-management
#15
Antonio Di Franco, Pierre Thiriet, Giuseppe Di Carlo, Charalampos Dimitriadis, Patrice Francour, Nicolas L Gutiérrez, Alain Jeudy de Grissac, Drosos Koutsoubas, Marco Milazzo, María Del Mar Otero, Catherine Piante, Jeremiah Plass-Johnson, Susana Sainz-Trapaga, Luca Santarossa, Sergi Tudela, Paolo Guidetti
Marine protected areas (MPAs) have largely proven to be effective tools for conserving marine ecosystem, while socio-economic benefits generated by MPAs to fisheries are still under debate. Many MPAs embed a no-take zone, aiming to preserve natural populations and ecosystems, within a buffer zone where potentially sustainable activities are allowed. Small-scale fisheries (SSF) within buffer zones can be highly beneficial by promoting local socio-economies. However, guidelines to successfully manage SSFs within MPAs, ensuring both conservation and fisheries goals, and reaching a win-win scenario, are largely unavailable...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904203/daytime-changes-of-skin-biophysical-characteristics-a-study-of-hydration-transepidermal-water-loss-ph-sebum-elasticity-erythema-and-color-index-on-middle-eastern-skin
#16
Alireza Firooz, Hamed Zartab, Bardia Sadr, Leili Naraghi Bagherpour, Aidin Masoudi, Ferial Fanian, Yahya Dowlati, Amir Hooshang Ehsani, Aniseh Samadi
BACKGROUND: The exposure of skin to ultraviolet radiation and temperature differs significantly during the day. It is reasonable that biophysical parameters of human skin have periodic daily fluctuation. The objective of this study was to study the fluctuations of various biophysical characteristics of Middle Eastern skin in standardized experimental conditions. MATERIALS AND METHODS: Seven biophysical parameters of skin including stratum corneum hydration, transepidermal water loss, pH, sebum, elasticity, skin color, and erythema index were measured at three time points (8 a...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27904087/push-out-bond-strength-of-a-new-post-system-after-various-post-space-treatments
#17
Melek Akman, Ayçe Unverdi Eldeniz, Selen Ince, Mehmet Burak Guneser
To assess the effect of post-space treatment with chelating agents on the push-out bond-strength of a glass fiber post-system. Fortyeight human teeth were decoronated. The roots were prepared to size 40 and obturated. The post-spaces were prepared with PeesoReamer drills. The post-spaces were irrigated with (i) NaOCl and EDTA with chlorhexidine (QMix), (ii) NaOCl and EDTA, (iii) NaOCl and Citric acid, (iv) NaOCl and saline as a control group. i-TFC glass fiber posts were then luted with i-TFC bond system. The samples were horizontally sectioned...
2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27903450/low-energy-impact-of-human-cartilage-predictors-for-microcracking-the-network-of-collagen
#18
B Kaleem, F Maier, H Drissi, D M Pierce
OBJECTIVE: We aimed to determine the minimum mechanical impact to cause microstructural damage in the network of collagen (microcracking) within human cartilage and hypothesized that energies below 0.1 J or 1 mJ/mm(3) would suffice. DESIGN: We completed 108 low-energy impact tests (0.05, 0.07, or 0.09 J; 0.75 or 1.0 m/s(2)) using healthy cartilage specimens from six male donors (30.2 ± 8.8 yrs old). Before and after impact we acquired, imaging the second harmonic generation (SHG), ten images from each specimen (50 μm depth, 5 μm step size), resulting in 2160 images...
November 27, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27903394/-correlation-between-epicardial-adipose-tissue-thickness-and-slow-flow-of-non-obstructive-coronary-artery
#19
Q Wu, B Yang
Objective: To investigate the correlation between epicardial adipose thickness and slow flow of non-obstructive coronary artery. Methods: Clinical data of patients with coronary angiography examination evidenced stenosis<50% in our department from May 2014 to May 2015 were retrospectively analyzed.According to the level of TIMI in angiography, patients were divided into slow blood flow group (TIMI Ⅰ-Ⅱ, n=16) and normal blood flow group (TIMI Ⅲ, n=127). All epicardial adipose thickness was determined by echocardiography and data of biochemical data (fibrinogen, whole blood viscosity at high shear rate, erythrocyte aggregation index, platelet count, and platelet aggregation rate) were also analyzed...
November 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27903231/new-analogues-of-mycophenolic-acid
#20
Agnieszka Głowacka, Michal Prejs, Grzegorz Cholewinski, Krystyna Dzierzbicka
Mycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH) [1,2]. This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection [3]. Until now clinically have been used two derivatives of MPA: mycophenolate mofetil (MMF, CellCept) and mycophenolate sodium (MPS, Myfortic). They cause, similar to MPA, although at lower degree, the side effects such as vomiting, abdominal pain, diarrhea, nausea, gastrointestinal, urogenital tract, blood or nervous system disorders...
November 29, 2016: Mini Reviews in Medicinal Chemistry
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