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https://www.readbyqxmd.com/read/28213819/conditional-knockout-of-activin-like-kinase-1-alk-1-leads-to-heart-failure-without-maladaptive-remodeling
#1
Kevin J Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J Aronovitz, Emily E Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M Blanton, Richard H Karas, S Paul Oh, Navin K Kapur
Activin like kinase-1 (AlK-1) mediates signaling via the transforming growth factor beta (TGFβ) family of ligands. AlK-1 activity promotes endothelial proliferation and migration. Reduced AlK-1 activity is associated with arteriovenous malformations. No studies have examined the effect of global AlK-1 deletion on indices of cardiac remodeling. We hypothesized that reduced levels of AlK-1 promote maladaptive cardiac remodeling. To test this hypothesis, we employed AlK-1 conditional knockout mice (cKO) harboring the ROSA26-CreER knock-in allele, whereby a single dose of intraperitoneal tamoxifen triggered ubiquitous Cre recombinase-mediated excision of floxed AlK-1 alleles...
February 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28203368/a-nationwide-survey-of-anthelmintic-treatment-failure-on-sheep-farms-in-ireland
#2
Jason D Keegan, Orla M Keane, Barbara Good, Theo De Waal, Marian Denny, James P Hanrahan, William Fitzgerald, Maresa Sheehan
BACKGROUND: Between 2013 and 2015 the Department of Agriculture, Food and the Marine (DAFM) administered a sheep technology adoption programme (STAP), with the aim of increasing profitability on Irish sheep farms by encouraging the adoption of best management practices. One of the options available to STAP participants was to test the efficacy of the anthelmintic treatment (benzimadazole, levamisole or macrocyclic lactone) used in their flocks by means of a drench test, which is a modification of the faecal egg count reduction test; individual faecal samples were collected from the same group of lambs before and after anthelmintic treatment, the number of eggs present pre and post treatment was subsequently determined from a pooled sample...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28201783/long-term-outcomes-with-planned-multistage-reduced-dose-repeat-stereotactic-radiosurgery-for-treatment-of-inoperable-high-grade-arteriovenous-malformations-an-observational-retrospective-cohort-study
#3
Ariel E Marciscano, Judy Huang, Rafael J Tamargo, Chen Hu, Mohamed H Khattab, Sameer Aggarwal, Michael Lim, Kristin J Redmond, Daniele Rigamonti, Lawrence R Kleinberg
No abstract text is available yet for this article.
February 14, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28194399/the-role-of-permissive-and-induced-hypotension-in-current-neuroanesthesia-practice
#4
Suren Soghomonyan, Nicoleta Stoicea, Gurneet S Sandhu, Jeffrey J Pasternak, Sergio D Bergese
BACKGROUND: Induced hypotension (IH) had been used for decades in neurosurgery to reduce the risk for intraoperative blood loss and decrease blood replacement. More recently, this method fell out of favor because of concerns for cerebral and other end-organ ischemia and worse treatment outcomes. Other contributing factors to the decline in its popularity include improvements in microsurgical technique, widespread use of endovascular procedures, and advances in blood conservation and transfusion protocols...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28179198/cesarean-scar-ectopic-pregnancy-laparoscopic-resection-and-total-scar-dehiscence-repair-a-case-report
#5
Sara Mahgoub, Victor Gabriele, Emilie Faller, Bruno Langer, Arnaud Wattiez, Lise Lecointre, Cherif Akladios
STUDY OBJECTIVE: Illustrate laparoscopic technique for resection of cesarean scar ectopic pregnancy, associated with isthmocele repair. DESIGN: Case report SETTING: Tertiary referral centre in Strasbourg, France. The study was approved by the local IRB. BACKGROUND: Cesarean scar pregnancy is a rare form of ectopic pregnancy. The major risk of this type of pregnancy is the early uterine rupture with massive bleeding and maternal life-threatening...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28175493/306%C3%A2-worse-stereotactic-radiosurgery-outcomes-for-intracranial-arteriovenous-malformations-after-repeat-vs-initial-treatment-a-matched-cohort-study
#6
Dale Ding, Zhiyuan Xu, Han-Hsun Shih, Robert M Starke, Chun-Po Yen, Or Cohen-Inbar, Jason P Sheehan
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175486/359%C3%A2-delayed-treatment-of-ruptured-arteriovenous-malformations-is-it-ok-to-wait
#7
Jeffrey S Beecher, Awais Vance, Kristopher Allen Lyon, Vin Shen Ban, Cameron Michael McDougall, Louis A Whitworth, Jonathan A White, Duke S Samson, H Hunt Batjer, Babu Guai Welch
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175479/204%C3%A2-pediatrics-arteriovenous-malformations-treatment-with-stereotactic-radiosurgery-gamma-knife-our-institutional-experience
#8
Jody Filippo Capitanio, Alberto Luigi Gallotti, Pietro Panni, Silvia Snider, Francesco Scomazzoni, Pietro Mortini
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28165436/management-of-acute-spontaneous-thoracic-spinal-epidural-hematoma-causing-paraplegia
#9
Fahrudin Alić, Hakija Bečulić, Aldin Jusić, Rasim Skomorac, Mirza Moranjkić, Lejla Hrvat, Lejla Tandir
Aim To emphasize the importance of early recognition, diagnostic processing and emergent surgical treatment of spontaneous spinal epidural hematoma (SSEH). Methods A 39-year-old female presented with sudden onset of severe pain between the shoulder blades followed by paraparesis and alerted sensibility in the lower extremities. An hour later she developed paraplegia with sensory deficits below ThIV level, absence of patellar reflex, ankle jerk reflex and sphincter dysfunction. Results Magnetic resonance imaging (MRI) demonstrated acute extensive epidural mass of thoracic spinal segments (ThI-ThIII)...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28163810/eruption-of-blood-arteriovenous-malformation-of-the-penile-urethra
#10
Joshua T White, Richard J Baverstock
While arteriovenous malformations (AVMs) are a common congenital or post-traumatic abnormality, male genital AVMs are rare and have been described in the scrotum or penis in pediatric patients.1,2 We describe a 34-year-old male presenting with recurrent spontaneous penile urethral bleeding found to have an AVM of the penile urethra. While angiography has traditionally been helpful, magnetic resonance imaging (MRI) can aid in the diagnosis and characterization of these lesions.3 Each case of male genital AVM provides a unique challenge to manage depending on the presenting complaint, as there are no guidelines to direct treatment...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28157750/management-of-unruptured-intracranial-aneurysms-and-cerebrovascular-malformations
#11
Kelly D Flemming, Giuseppe Lanzino
PURPOSE OF REVIEW: Unruptured intracranial aneurysms and vascular malformations are detected more frequently because of the increased use and availability of brain imaging. Management of these entities requires knowledge of which patients are at high risk for hemorrhage and what treatment options are available. This article summarizes the epidemiology, natural history, and management strategies for unruptured intracranial aneurysms, arteriovenous malformations, cavernous malformations, developmental venous anomalies, and capillary telangiectasias...
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28141624/dilated-superior-ophthalmic-vein-clinical-and-radiographic-features-of-113-cases
#12
Christopher R Adam, Carol L Shields, Justin Gutman, H Joon Kim, Brent Hayek, John W Shore, Alexandra Braunstein, Flora Levin, Bryan J Winn, Ivan Vrcek, Ronald Mancini, Craig Linden, Christina Choe, Mithra Gonzalez, David Altschul, Santiago Ortega-Gutierrez, Srinivasan Paramasivam, Johanna T Fifi, Alejandro Berenstein, Vikram Durairaj, Roman Shinder
PURPOSE: Dilated superior ophthalmic vein (SOV) is an uncommon radiographic finding. The authors review the presentation, etiology, radiography, and visual implications of 113 patients with dilated SOV. METHODS: An observational case series and multicenter retrospective chart review were conducted. There were 113 patients with a dilated SOV. Outcome measures included patient demographics, clinical features, radiographic findings, diagnosis, and treatment, and treatment outcomes were assessed...
January 30, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28132749/persistence-in-coil-embolized-pulmonary-arteriovenous-malformations-with-feeding-artery-diameters-of-3-mm-or-less-a-retrospective-single-center-observational-study
#13
Elliot J Stein, Jesse L Chittams, Mary Miller, Scott O Trerotola
PURPOSE: To assess persistence in coil-embolized pulmonary arteriovenous malformations (PAVMs) with feeding artery diameters ≤ 3 mm. MATERIALS AND METHODS: Fifty-eight patients (21 male, 37 female; mean age, 43 y; range, 13-71 y) with 141 simple-type PAVMs treated from 2004 to 2014 were analyzed retrospectively. Inclusion criteria were one or more PAVMs with feeding artery diameters ≤ 3 mm ("small PAVMs"), treatment with coil embolization, and presence of a follow-up chest computed tomographic (CT) angiogram at approximately 6 months...
January 26, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28132013/new-predictive-model-for-microsurgical-outcome-of-intracranial-arteriovenous-malformations-study-protocol
#14
Xianzeng Tong, Jun Wu, Yong Cao, Yuanli Zhao, Shuo Wang
INTRODUCTION: Although microsurgical resection is currently the first-line treatment modality for arteriovenous malformations (AVMs), microsurgery of these lesions is complicated due to the fact that they are very heterogeneous vascular anomalies. The Spetzler-Martin grading system and the supplementary grading system have demonstrated excellent performances in predicting the risk of AVM surgery. However, there are currently no predictive models based on multimodal MRI techniques. The purpose of this study is to propose a predictive model based on multimodal MRI techniques to assess the microsurgical risk of intracranial AVMs...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28131776/novel-use-of-thalidomide-in-recurrent-gastrointestinal-tract-bleeding-in-patients-with-left-ventricular-assist-devices-a-case-series
#15
Laura Lihua Chan, Choon Pin Lim, Chong Hee Lim, Teing Ee Tan, David Sim, Cumaraswamy Sivathasan
BACKGROUND: Bleeding is an important and common complication of left ventricular assist devices (LVADs). One of the common causes of gastrointestinal bleeding is arteriovenous malformations. However, the source of bleeding is often hard to identify. Thalidomide is efficacious in treatment of gastrointestinal (GI) bleeding in non-LVAD patients. We report our experience of the use of thalidomide in the treatment of GI bleeding in four patients with LVAD. METHOD AND RESULTS: Four patients who had recurrent GI bleeding from May 2009 to December 2014 were started on thalidomide...
December 23, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28128692/volume-staged-versus-dose-staged-stereotactic-radiosurgery-outcomes-for-large-brain-arteriovenous-malformations-a-systematic-review
#16
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Davis G Taylor, Shayan Moosa, Cheng-Chia Lee, Or Cohen-Inbar, Jason P Sheehan
OBJECTIVE Several recent studies have improved our understanding of the outcomes of volume-staged (VS) and dose-staged (DS) stereotactic radiosurgery (SRS) for the treatment of large (volume > 10 cm(3)) brain arteriovenous malformations (AVMs). In light of these recent additions to the literature, the aim of this systematic review is to provide an updated comparison of VS-SRS and DS-SRS for large AVMs. METHODS A systematic review of the literature was performed using PubMed to identify cohorts of 5 or more patients with large AVMs who had been treated with VS-SRS or DS-SRS...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28127723/obstructive-hydrocephalus-caused-by-an-unruptured-arteriovenous-malformation-successfully-treated-by-endoscopic-third-ventriculostomy-after-shunt-dysfunction
#17
Charles Champeaux, Céline Botella, Etienne Lefevre, Bertrand Devaux
The authors report on a patient harbouring an unruptured cortical arteriovenous malformation (AVM), who had presented with obstructive hydrocephalus due to compression of the cerebral aqueduct by a large venous varix. A ventriculoperitoneal (VP) shunt was inserted in emergency. Due to its large volume, the AVM was not referred for treatment and a follow-up policy was chosen. After the second VP shunt dysfunction, endoscopic third ventriculostomy was performed under neuronavigation. The procedure went uneventfully and the patient recovered well...
December 22, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28126751/application-of-time-resolved-3d-digital-subtraction-angiography-to-plan-cerebral-arteriovenous-malformation-radiosurgery
#18
K-K Chen, W-Y Guo, H-C Yang, C-J Lin, C-H F Wu, S Gehrisch, M Kowarschik, Y-T Wu, W-Y Chung
BACKGROUND AND PURPOSE: Time-resolved 3D-DSA (4D-DSA) enables viewing vasculature from any desired angle and time frame. We investigated whether these advantages may facilitate treatment planning and the feasibility of using 4D-DSA as a single imaging technique in AVM/dural arteriovenous fistula radiosurgery. MATERIALS AND METHODS: Twenty consecutive patients (8 dural arteriovenous fistulas and 12 AVMs; 13 men and 7 women; mean age, 45 years; range, 18-64 years) who were scheduled for gamma knife radiosurgery were recruited (November 2014 to October 2015)...
January 26, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28124740/trigeminal-neuralgia-caused-by-a-dilated-superior-cerebellar-artery-and-a-draining-vein-of-cerebellar-arteriovenous-malformations-a-case-report-and-review-of-the-literature
#19
Zi-Yi Li, Jian-Tao Liang, Hong-Qi Zhang, Yu-Hai Bao, Feng Ling
Trigeminal neuralgia (TN) secondary to arterivenous malformations (AVMs) is relatively rare. We here report on a case of TN caused by cerebellar AVMs that was successfully treated by total AVMs resection in conjunction with microvasecular decompression (MVD) in one stage. In addition, we perform a review of the literature about the treatment of TN caused by cerebellar AVMs.
January 26, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28117260/linear-accelerator-radiosurgery-for-arteriovenous-malformations-updated-literature-review
#20
S Yahya, G Heyes, P Nightingale, S Lamin, S Chavda, I Geh, D Spooner, G Cruickshank, P Sanghera
Arteriovenous malformations (AVMs) are the leading causing of intra-cerebral haemorrhage. Stereotactic radiosurgery (SRS) is an established treatment for arteriovenous malformations (AVM) and commonly delivered using Gamma Knife within dedicated radiosurgery units. Linear accelerator (LINAC) SRS is increasingly available however debate remains over whether it offers an equivalent outcome. The aim of this project is to evaluate the outcomes using LINAC SRS for AVMs used within a UK neurosciences unit and review the literature to aid decision making across various SRS platforms...
January 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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