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https://www.readbyqxmd.com/read/28454474/incidence-trends-in-high-grade-primary-brain-tumors-in-males-and-females
#1
Jonas Nilsson, Georg Holgersson, Tobias Carlsson, Roger Henriksson, Stefan Bergström, Michael Bergqvist
The focus of the present review is to investigate whether there is a variation in the incidence rates between male and female patients with high-grade primary brain tumors and if there are altered incidence rates associated with the time at which they were diagnosed. Previous studies identified in internationally peer-reviewed journals were identified using a systematic search of the PubMed database. Due to the difficulties in data interpretation, studies that exclusively included patient data classified prior to the 2nd edition of the World Health Organization histological classification system of brain tumors were excluded...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454457/detection-of-circulating-tumor-cells-in-patients-with-non-small-cell-lung-cancer-using-a-size-based-platform
#2
Chung-Hee Sonn, Jong Ho Cho, Jae-Won Kim, Moon Sung Kang, Jinseon Lee, Jhingook Kim
The detection of circulating tumor cells (CTCs) is limited by the rarity of these cells in the peripheral blood of patients with cancer. Understanding tumor biology may be useful in the development of novel therapeutic strategies for patients with lung cancer. The present study evaluated a novel size-based filtration platform for enriching CTCs from patients with lung cancer. Blood samples were obtained from 82 patients with lung cancer for CTC analysis. CTC enrichment by size-based filtration was performed on 5-ml blood samples...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454432/prognostic-and-predictive-role-of-cox-2-xrcc1-and-rassf1-expression-in-patients-with-esophageal-squamous-cell-carcinoma-receiving-radiotherapy
#3
Yaowen Zhang, Shangwen Dong, Ruiping Xu, Yanping Yang, Zhiyong Zheng, Xiaojing Wang, Runchuan Ren, Ronggang Sun, Ming Li, Haijun Yang, Yuting Huang, Fuyou Zhou, Anping Zheng
Identification of biomarkers for predicting radiosensitivity would be useful for administering individualized radiotherapy (RT) to patients with esophageal cancer. The aim of the present study was to evaluate the association between cyclooxygenase-2 (COX-2), X-ray repair cross complementing group 1 (XRCC1), ras association domain family 1 (RASSF1) protein expression, clinicopathological characteristics, radiosensitivity and survival rate in 76 patients with esophageal squamous cell carcinoma (ESCC) who were treated with RT...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454430/wt1-associated-protein-is-a-novel-prognostic-factor-in-pancreatic-ductal-adenocarcinoma
#4
Bing-Qi Li, Shuai Huang, Qian-Qian Shao, Jian Sun, Li Zhou, Lei You, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Yu-Pei Zhao
Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1-binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of WTAP on pancreatic ductal adenocarcinoma (PDAC) is still unknown. A total of 145 patients who underwent surgical treatment from 2004 to 2008 were enrolled in the present study. The cytoplasmic and nuclear expression of WTAP in tumor and adjacent normal tissues was examined by immunohistochemical analysis in order to investigate the relationship between WTAP and the clinicopathological factors and prognosis of patients with PDAC...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454384/new-applications-of-the-acridine-orange-fluorescence-staining-method-screening-for-circulating-tumor-cells
#5
Min Liu, Ruizhe Li, Yang Tang, Jiwu Chang, Rong Han, Shumin Zhang, Ning Jiang, Fuling Ma
The aim of the present study was to explore use of the acridine orange fluorescence (AO-F) staining method for screening of circulating tumor cells (CTCs) in renal cell carcinoma (RCC) patients. The AO-F positive staining rate of live and dead tumor cells was calculated. The positive staining rate in the live group was 93.4±3.0%, while the dead group failed to emit specific fluorescence. A known number of tumor cells were added to peripheral blood, and the detection sensitivity of the four groups (50, 100, 200 and 500 cells/tube) was 10...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454296/association-between-braf-v600e-mutation-and-the-clinicopathological-features-of-solitary-papillary-thyroid-microcarcinoma
#6
Hai-Zhen Lu, Tian Qiu, Jian-Ming Ying, Ning Lyn
The B-Raf proto-oncogene serine/threonine kinase (BRAF)(V600E) mutation is an important oncogene in the development of papillary thyroid carcinoma (PTC) and has been identified as a risk factor for poor prognosis in patients with PTC. However, whether the BRAF(V600E) mutation is a prognostic marker in patients with solitary papillary thyroid microcarcinoma (sPTMC) has not yet been established. The present study aimed to identify the association between BRAF(V600E) mutation and the clinicopathological features of patients with sPTMC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454193/-mental-stress-of-professionals-in-residential-care-for-children-and-adolescents
#7
Thea Rau, Jeannine Ohlert, Corinna Seidler, Jörg M Fegert, Marc Allroggen
An increasingly important issue is the mental strain of professionals in residential care for children and adolescents. However, only few studies investigate mental strain and overload of professionals in an educational context in general and even less in youth welfare institutions. The goal of this study was to examine mental strain experiences of professionals with the "Perceived Stress Questionnaire" (PSQ) in youth welfare institutions, as well as to investigate the relationship between age, duration of employment in this work environment and gender of participants...
April 28, 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28454051/no-association-between-slc6a2-slc6a3-drd2-polymorphisms-and-schizophrenia-in-the-han-chinese-population
#8
Yan Bi, Xiaoye Huang, Weibo Niu, Shiqing Chen, Xi Wu, Yanfei Cao, Rui Zhang, Fengping Yang, Lu Wang, Weidong Li, Yifeng Xu, Lin He, Tao Yu, Guang He
This study was intended to ascertain whether SNPs in dopaminergic and serotoninergic pathway genes SLC6A2, SLC6A3 and DRD2 are associated with schizophrenia in Han Chinese people. We conducted a case-control study by genotyping 7 SNPs of the three genes in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls despite one positive haplotype (rs1362621-rs2242446-rs5564). Stratified analysis of gender and gene-gene interaction analysis showed no positive results...
February 27, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28453993/sexual-violence-interventions-considerations-for-humanitarian-settings
#9
David Wells
Sexual and gender based violence may result in a range of destructive consequences to the individual, their family and the wider community. Addressing such violence and its immediate aftermath in circumstances of civil turmoil requires a timely, planned and coordinated multidisciplinary response. Such interventions need to be cognisant of, and address a range of challenges which might include economic barriers, religious and cultural divides, a dearth of respect for human rights and limited access or capacity of medical, policing and legal services...
April 14, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28453951/are-biodegradable-plates-applicable-in-endoscope-assisted-open-reduction-and-internal-fixation-of-mandibular-subcondyle-fractures
#10
Jang-Ho Son, Jinhee Ha, Yeong-Cheol Cho, Iel-Yong Sung
PURPOSE: To investigate whether biodegradable plates are applicable in endoscope-assisted open reduction and internal fixation (EAORIF) of mandibular subcondyle fractures. MATERIALS AND METHODS: This retrospective case-series study included patients with mandibular subcondyle fractures treated with EAORIF using an unsintered hydroxyapatite particles/poly-l-lactide biodegradable plate system, with at least 6 months of clinical follow-up data available. The outcome variables were fracture healing with postoperative stability and postoperative complications...
April 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453950/histological-assessment-of-the-carotid-sheath-in-patients-with-oral-squamous-cell-carcinoma
#11
Manjari Palliyalil, Venkatesh Anehosur, Abhijit Joshi, Swetha Acharya
PURPOSE: During surgical management of the neck using various types of neck dissection, the carotid sheath is removed, in particular, the part adjacent to the jugular lymph node chain, with the intention of preventing recurrence from the lymphatics present in it. The role of the carotid sheath as a potential origin for nodal recurrence has not been proved thus far. Working in a tissue plane between the carotid sheath and the neurovascular structures of the neck can lead to a greater chance of damage to these structures...
April 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453897/clinical-outcome-of-childhood-chronic-immune-thrombocytopenia-a-38-year-experience-from-a-single-tertiary-center-in-thailand
#12
Thirachit Chotsampancharoen, Pornpun Sripornsawan, Sarapee Duangchoo, Malai Wongchanchailert, Edward McNeil
BACKGROUND: There is limited information on long-term follow-up and prognostic factors for remission among children diagnosed with chronic immune thrombocytopenia (ITP). The aim of this study was to determine clinical outcomes and factors influencing remission in childhood chronic ITP. STUDY DESIGN: The hospital records of children aged 0-15 years diagnosed with chronic ITP were retrospectively reviewed. Kaplan-Meier curves were fit to estimate the median time to complete remission with 95% confidence intervals (CIs)...
April 28, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28453860/different-tales-the-role-of-gender-in-the-oral-narrative-reading-link-among-african-american-children
#13
Nicole Gardner-Neblett, John Sideris
Evidence suggests that oral narrative skills are a linguistic strength for African American children, yet few studies have examined how these skills are associated with reading for African American boys and girls. The current study uses longitudinal data of a sample of 72 African American 4-year-olds to examine how preschool oral narrative skills predict reading from first through sixth grades and explores differences by gender. Findings indicate that although girls demonstrated stronger narrative skills, their narrative skills did not moderate change in reading...
April 28, 2017: Child Development
https://www.readbyqxmd.com/read/28453802/propensity-matched-comparison-of-extrapleural-pneumonectomy-and-pleurectomy-decortication-for-mesothelioma-patients%C3%A2
#14
Arthur Kostron, Martina Friess, Ilhan Inci, Sven Hillinger, Didier Schneiter, Hans Gelpke, Rolf Stahel, Burkhardt Seifert, Walter Weder, Isabelle Opitz
OBJECTIVES: The objective of this retrospective study was to assess perioperative outcomes, overall survival and freedom from recurrence after induction chemotherapy followed by extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D) in patients with mesothelioma in a propensity score matched analysis. METHODS: Between September 1999 and August 2015, 167 patients received multimodality treatment (platinum-based chemotherapy followed by EPP [ n =  141] or P/D [ n =  26])...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453793/impact-of-gender-on-long-term-outcomes-after-surgical-repair-for-acute-stanford-a-aortic-dissection-a-propensity-score-matched-analysis%C3%A2
#15
Anton Sabashnikov, Stephanie Heinen, Antje Christin Deppe, Mohamed Zeriouh, Alexander Weymann, Ingo Slottosch, Kaveh Eghbalzadeh, Aron-Frederik Popov, Oliver Liakopoulos, Parwis B Rahmanian, Navid Madershahian, Axel Kroener, Yeong-Hoon Choi, Ferdinand Kuhn-Régnier, André R Simon, Thorsten Wahlers, Jens Wippermann
OBJECTIVES: Previous research suggests that female gender is associated with increased mortality rates after surgery for Stanford A acute aortic dissection (AAD). However, women with AAD usually present with different clinical symptoms that may bias outcomes. Moreover, there is a lack of long-term results regarding overall mortality and freedom from major cerebrovascular events. We analysed the impact of gender on long-term outcomes after surgery for Stanford A AAD by comparing genders with similar risk profiles using propensity score matching...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453773/increased-cerebrospinal-fluid-levels-of-gaba-testosterone-and-estradiol-in-women-with-polycystic-ovary-syndrome
#16
Jennifer F Kawwass, Kristen M Sanders, Tammy L Loucks, Lisa Cencia Rohan, Sarah L Berga
STUDY QUESTION: Do cerebrospinal fluid (CSF) concentrations of gamma-aminobutyric acid (GABA), testosterone (T) and estradiol (E2) differ in women with polycystic ovary syndrome (PCOS) as compared to eumenorrheic, ovulatory women (EW)? SUMMARY ANSWER: Women with PCOS displayed higher CSF levels of GABA and E2, and possibly T, than EW. WHAT IS KNOWN ALREADY: The chronic anovulation characteristic of PCOS has been attributed to increased central GnRH drive and resulting gonadotropin aberrations...
April 27, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28453756/malignancies-in-patients-with-inflammatory-bowel-disease-results-from-20-years-of-follow-up-in-the-ibsen-study
#17
Øistein Hovde, Marte Lie Høivik, Magne Henriksen, Inger Camilla Solberg, Milada Cvancarova Småstuen, Bjørn A Moum
Background and Aims: Whether patients with inflammatory bowel diseases [IBDs] have increased risk of developing cancer has been debated. The aims of the study were to determine the prevalence of intestinal/extraintestinal cancers in an IBD cohort 20 years after diagnosis and to assess whether these patients had an increased cancer-specific risk compared with a matched control population. Methods: Patients with ulcerative colitis [UC] and Crohn's disease [CD] diagnosed 1990-1993 have been prospectively followed up for 20 years...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453749/an-independently-validated-nomogram-for-individualized-estimation-of-survival-among-patients-with-newly-diagnosed-glioblastoma-nrg-oncology-rtog-0525-and-0825
#18
Haley Gittleman, Daniel Lim, Michael W Kattan, Arnab Chakravarti, Mark R Gilbert, Andrew B Lassman, Simon S Lo, Mitchell Machtay, Andrew E Sloan, Erik P Sulman, Devin Tian, Michael A Vogelbaum, Tony J C Wang, Marta Penas-Prado, Emad Youssef, Deborah T Blumenthal, Peixin Zhang, Minesh P Mehta, Jill S Barnholtz-Sloan
Background.: Glioblastoma (GBM) is the most common primary malignant brain tumor. Nomograms are often used for individualized estimation of prognosis. This study aimed to build and independently validate a nomogram to estimate individualized survival probabilities for patients with newly diagnosed GBM, using data from 2 independent NRG Oncology Radiation Therapy Oncology Group (RTOG) clinical trials. Methods.: This analysis included information on 799 (RTOG 0525) and 555 (RTOG 0825) eligible and randomized patients with newly diagnosed GBM and contained the following variables: age at diagnosis, race, gender, Karnofsky performance status (KPS), extent of resection, O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and survival (in months)...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453710/prescription-of-antibiotics-to-pre-school-children-from-2005-to-2014-in-japan-a-retrospective-claims-database-study
#19
Satomi Yoshida, Masato Takeuchi, Koji Kawakami
Background: Antibiotics are the most frequently prescribed medications for children but inappropriate antibiotic prescribing is prevalent. The purpose of our study was to access the nationwide trend in antibiotic prescriptions, and to ascertain inappropriate prescribing for upper respiratory infections (URIs) in pre-school children in Japan. Methods: Data from the administrative claims database from 2005 January to 2014 September in Japan were examined. We identified outpatient antibiotic prescription claims and described prescription patterns of subjects who were followed from birth to 6 years of age...
April 27, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28453689/periodontal-disease-edentulism-and-pancreatic-cancer-a-meta-analysis
#20
P Maisonneuve, S Amar, A B Lowenfels
Background: Periodontal disease (PD), now our commonest infectious disorder leads to tooth loss, and has been linked to various systemic diseases, including various types of cancer. The aim of this study is to provide a systematic review and a meta-analysis of the relationship between PD, edentulism, and pancreatic cancer (PC). Patients and methods: From an initial review of 327 references we selected eight studies concerning periodontitis or edentulism with sufficient quantitative information to allow us to examine the risk of PC...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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