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Qiang Du, Ruofei Yu, Han Wang, Dong Yan, Qi Yuan, Yixin Ma, Dennis Slamon, Dongmei Hou, Huiling Wang, Qi Wang
OBJECTIVES: Autoantibodies tumor-associated antigens (TAAs) could be a valuable tool for the diagnosis or early detection of cancer due to their relatively high specificity and stability. The purpose of this study is to detect the level of tumor-associated autoantibodies in lung cancer and assess the diagnostic potential of autoantibodies in screening strategy for early stage lung cancer. MATERIALS AND METHODS: Levels of tumor-associated autoantibodies (AAbs) were measured against a panel of seven tumor-associated antigens (p53, PGP9...
January 22, 2018: Clinical Respiratory Journal
Ju-Yeon Lee, Seon-Young Kim, Kyung-Yeol Bae, Jae-Min Kim, Il-Seon Shin, Jin-Sang Yoon, Sung-Wan Kim
INTRODUCTION: The number of Internet users is increasing dramatically due to high-speed Internet connections and the use of cellular Internet service among rural adolescents in Korea. This study examined the prevalence of problematic Internet use (PIU) and factors associated with PIU among rural adolescents in Korea. METHODS: In total, 1168 adolescents aged 13 to 18 years from a rural area in Korea participated in this cross-sectional school survey. Problematic Internet use was categorized with Young's Internet Addiction Test using a validated cutoff...
January 21, 2018: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
Svenn-Erik Mamelund
BACKGROUND: Whether morbidity from the 1918-19 influenza pandemic discriminated by socioeconomic status has remained a subject of debate for 100 years. In lack of data to study this issue recent literature have hypothesized that morbidity was "socially neutral". OBJECTIVES: To study the associations between Influenza like illness (ILI) and socioeconomic status (SES), gender and wave during the 1918-19 influenza pandemic. METHODS: Availability of incidence data on the 1918-19 pandemic is scarce, in particular for waves other than the "fall wave" October-December 1918...
January 21, 2018: Influenza and Other Respiratory Viruses
V E Bianchi, V Locatelli
Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. We have searched in Pubmed clinical trial with the password: testosterone and insulin resistance, and testosterone and MetS. We found 19 studies on the correlation between testosterone level with insulin resistance and 18 on the effect of testosterone therapy on MetS...
January 21, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Najat O Hamed, Laila-Al-Ayadhi, Mohamed A Osman, Elkhawad Abdalla O, Hanan Qasem, Majida Al-Marshoud, Nada M Merghani, Afaf El-Ansary
BACKGROUND: AIM: Autism is a heterogeneous neurological disorder that is characterized by impairments in communication and social interactions, repetitive behaviors and sensory abnormalities. The etiology of autism remains unclear. Animal, genetic and postmortem studies suggest that an imbalance exists in the neuronal excitation and inhibition (E/I) system in autism. The aim of this study was to determine whether alterations of the measured parameters in children with autism are significantly associated with the risk of a sensory dysfunction...
January 22, 2018: Psychiatry and Clinical Neurosciences
D J Green, M Lewis, G Mansell, M Artus, K S Dziedzic, E M Hay, N E Foster, D A van der Windt
BACKGROUND: Previous research has identified similar prognostic factors in patients with musculoskeletal (MSK) conditions regardless of pain presentation, generating opportunities for management based on prognosis rather than specific pain presentation. METHODS: Data from seven RCTs (2,483 participants) evaluating a range of primary care interventions for different MSK pain conditions were used to investigate the course of symptoms and explore similarities and differences in predictors of outcome...
January 22, 2018: European Journal of Pain: EJP
Deisy Dos Santos Freitas, Glaucia Braz Alcantara
INTRODUCTION: Mauritia flexuosa is a dioecious species native to the Amazon, and the gender identification can currently be determined through the differentiation between female and male flowers in the first flowering. OBJECTIVES: To identify variations in the metabolome profiles of pooled and individual samples of leaves from female and male plants of M. flexuosa in reproductive phase, and the plant in its vegetative phase, using two extraction systems. MATERIAL AND METHODS: Extractions of leaves were separately conducted using deuterated water and methanol...
January 21, 2018: Phytochemical Analysis: PCA
John Baer, Matthew M Wyatt, Kenneth R Kreisler
OBJECTIVE: Pulmonary artery catheters (PACs) have routinely been positioned by wedging into the pulmonary artery before pulling back 1-2 centimeters or advancing the PAC several centimeters after achieving a pulmonary artery waveform. A rare, major complication is pulmonary artery rupture. This study presents transesophageal echocardiography (TEE) for PAC placement by leaving the catheter tip at the one o'clock position, upper window short-axis view of the ascending aorta at the bifurcation of the pulmonary artery (TEE distance)...
January 22, 2018: Echocardiography
Yaxuan Ren, Min-Pei Lin, Yin-Han Liu, Xu Zhang, Jo Yung-Wei Wu, Wei-Hsuan Hu, Sian Xu, Jianing You
OBJECTIVE: Nock's (2009) integrated theoretical model suggests that both intrapersonal and interpersonal factors contribute to the development of nonsuicidal self-injury (NSSI). Based on this model, the present study examined the roles of family functioning and coping strategy in predicting NSSI, as well as the mediating effect of coping strategy in the relationship between family functioning and NSSI. Gender differences on the associations of these variables were also examined. METHOD: A sample of 1,989 secondary school students (52...
January 22, 2018: Journal of Clinical Psychology
Jef L Leroy, Marie Ruel, Celeste Sununtnasuk, Akhter Ahmed
Evidence on the nutritional status and diets of adolescents in low- and middle-income countries is scant. We characterized the nutritional status (body mass index Z-scores (BMIZs)) and nutrient intakes of adolescent boys and girls in rural areas in Bangladesh using the 2011-2012 BIHS data, used regression models to identify the socioeconomic determinants of these outcomes, and household fixed effects models to assess whether the gap between boys and girls changed with women's education and empowerment and household wealth...
January 22, 2018: Annals of the New York Academy of Sciences
Elijah Bisung, Susan J Elliott
This study uses a cross-sectional survey (n = 557) with a retrospective design to examine relationships between improvement in access to safe water supply (i.e. extension of municipal piped water) and a range of social outcomes including water insecurity, household time savings and allocation, and household water expenditure in Usoma, Kenya. Data were collected in July 2016, about 3 years after the intervention, using a modified version of the Household Water Insecurity Access Scale (HWIAS). Having assessed the validity and reliability of the modified HWIAS, we examine how differences in levels of access to safe water influence reported levels of water insecurity as well as amount of money and time savings, post the water intervention...
January 3, 2018: Social Science & Medicine
Melinda Pénzes, Kristie L Foley, Valentin Nădășan, Edit Paulik, Zoltán Ábrám, Róbert Urbán
PURPOSE: With an increasingly diverse tobacco product market, it is imperative to understand the trajectories of product experimentation in order to design effective prevention programs. This study aims to explore the bidirectional associations of conventional cigarette, e-cigarette and waterpipe experimentation in a large adolescent sample. METHODS: Longitudinal assessment of conventional cigarette, e-cigarette and waterpipe use initiation was conducted in a school-based cohort of 1369 9th graders (mean age=14...
January 11, 2018: Addictive Behaviors
Hong-Yu Li, Chong-Ran Sun, Min He, Li-Chun Yin, Hang-Gen Du, Jian-Min Zhang
BACKGROUND: Tumor location is a major prognostic factor in glioblastoma and may associate with clinical properties. The present study established and analyzed the correlation between tumor location and clinical properties of glioblastomas in frontal and temporal lobes. METHODS: This retrospective study determined the location of glioblastoma, frontal lobe(FL) or temporal lobe (TL), based on preoperative MR images. The glioblastomas in FL at clinical, radiological, and molecular levels were explored to define their clinical properties, including gender, age, sides, relationship to the ventricle, imaging subtypes, volumetrics, IDH mutation, promoter methylation of MGMT, PFS and OS as compared to glioblastomas in TL...
January 17, 2018: World Neurosurgery
Xueyou Liu, Jianguo Xu, Ke Mao, Mengmeng Wang, Peng Ren, M D Ding Lei, Yuan Fang, Wenjing Chen, Boyong Mao, Dong Zhou, Jinmei Li, Zhen Hong, Bo Yan, Dongmei An, Ling Liu, Jiani Chen, Rong Luo, Hui Zhou, Tao Yu, Heng Zhang
OBJECTIVE: To evaluate the potential risk factors associated with seizure recurrence in different periods after epilepsy surgery. METHODS: 303 refractory epilepsy patients after epilepsy surgery were included. Kaplan-Meier method with log-rank test and univariate and multivariate Cox proportional hazards model were performed to calculate the comparison of survival curves between groups and identify the risk factors associated with seizure recurrence in different periods after surgery, respectively...
January 17, 2018: World Neurosurgery
Koji Tamai, Joshua Romanu, Phillip Grisdela, Permsak Paholpak, Pengfei Zheng, Hiroaki Nakamura, Zorica Buser, Jeffrey C Wang
BACKGROUND CONTEXT: Cervical sagittal vertical axis (cSVA) of ≥40mm is recognized as the key factor of poor health-related quality of life, poor surgical outcomes, and correction loss after surgery for cervical deformity. However, little is known about the radiological characteristics of patients with cSVA≥40mm. PURPOSE: The purpose of this study was to identify the radiological characteristics of patients with cervical imbalance. DESIGN: Retrospective analysis of weight-bearing cervical magnetic resonance (MR) images PATIENT SAMPLE: Consecutive 1,500 MR images of symptomatic patients in weight-bearing position OUTCOME MEASURES: cSVA, cervical alignment, cervical balance parameters (T1 slope, Co-C2 angle, C2-C7 angle, C7-T1 angle, neck tilt and thoracic inlet angle), disc degeneration (Pfirmann and Suzuki classification), endplate degeneration (Modic change), Spondylolisthesis (antero- and retrolisthesis), antero-posterior (AP) diameter of dural sac, cross-sectional area (CSA) and fat infiltration ratio of the transversospinalis muscles at C4 and C7 levels METHODS: Patients were divided into two groups: cervical sagittal vertical axis (cSVA) ≥40mm and <40mm...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
Eirini Flouri, Martina K Narayanan, Ane Nærde
BACKGROUND: Parents of young children generally report more depressive symptoms than parents of adult children or people without children, mainly because the presence of young children increases exposure to significant stressors (such as stressful life events). However, most studies on the depressogenic role of stressful life events in parents of young children have focussed on mothers. METHODS: Using data from 1138 families with young children in Norway, we investigated gender differences in the effect of stressful life events after a child's birth on the development of parental depressive symptoms in 3 follow-ups at child's ages 3-6 years...
January 3, 2018: Journal of Affective Disorders
Jan Scott, Tracey A Davenport, Richard Parker, Daniel F Hermens, Penelope A Lind, Sarah E Medland, Margaret J Wright, Nicholas G Martin, Nathan A Gillespie, Ian B Hickie
BACKGROUND: Sex differences in rates of depression emerge during adolescence. However, it is unclear whether symptom patterns and trajectories differ significantly according to gender in youth. Barriers to research include the fact that most self-report tools are weighted towards psychological rather than somatic symptoms. METHODS: Data were collected on symptoms of depression in about 1800 individuals at ages 12, 14 and 16 years. Odds ratios and 95% confidence intervals were used to examine the trajectory of psychological and somatic phenotypes and self-reported depression caseness over time...
December 7, 2017: Journal of Affective Disorders
Marco Daverio, Franz E Babl, Ruth Barker, Dario Gregori, Liviana Da Dalt, Silvia Bressan
OBJECTIVES: Helmets use has proved effective in reducing head trauma (HT) severity in children riding non-motorised recreational vehicles. Scant data are available on their role in reducing concussive symptoms in children with HT while riding non-motorised recreational vehicles such as bicycles, push scooters and skateboards (BSS). We aimed to investigate whether helmet use is associated with a reduction in acute concussive symptoms in children with BSS-related-HT. METHODS: Prospective study of children <18 years who presented with a BSS related-HT between April 2011 and January 2014 at a tertiary Paediatric Emergency Department (ED)...
January 22, 2018: Brain Injury: [BI]
Juan José Egea-Guerrero, Ana Rodríguez-Rodríguez, Manuel Quintana-Díaz, María Dolores Freire-Aragón, Diego Raya-Collados, Conary Hernández-García, Álvaro Ortiz-Manzano, Ángel Vilches-Arenas, Ana Díez-Naz, Juan Miguel Guerrero, Francisco Murillo-Cabezas
INTRODUCTION: The aim of this study was to validate the S100B protein as a diagnostic tool for ruling out the presence of intracranial lesion (IL) after mild traumatic brain injury (mTBI). Subjects with a Glasgow Coma Scale (GCS) score of 15 and at least one neurological symptom post-trauma were selected from a large Spanish cohort. METHODS: A number of 260 patients with mTBI were enrolled. Blood samples were extracted within 6 h and CT scan performed within 24 h post-injury...
January 22, 2018: Brain Injury: [BI]
K Hasáková, J Bezakova, M Vician, R Reis, M Zeman, I Herichova
miRNAs are small regulatory RNA molecules involved in posttranscriptional gene silencing. Their biosynthesis results in the formation of duplex consisting of a leading and a passenger strand of mature miRNA. The leading strand exhibits the main activity but recent findings indicate a certain role of the passenger strand as well. Deregulated levels of miRNA were found in many types of cancers including colorectal cancer. miR-21 and miR-16 were indicated as possible markers of colorectal cancer, however, small attention to gender differences in their expression was paid so far...
December 30, 2017: Physiological Research
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