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https://www.readbyqxmd.com/read/28938502/-alarming-pregabalin-abuse-in-munich-prevalence-patterns-of-use-and-complications
#1
Nicolas Zellner, Florian Eyer, Tobias Zellner
Background Pregabalin is used e. g. for the treatment of neuropathic pain and anxiety disorder. Recently, its potential for abuse and addiction has become apparent. Methods From 2008 - 2015, we searched our database for the term "Pregabalin", including all patients treated in our department and all calls to the Poison Information Centre (PIC) Munich.From October 2013 to September 2014, all patients were included in a cohort study who either were admitted with a drug intoxication or who presented themselves for a course of detoxification (except ethanol)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938229/prevalence-and-correlates-of-comorbid-depression-in-a-nonclinical-online-sample-with-dsm-5-internet-gaming-disorder
#2
Hee Ryung Wang, Hyun Cho, Dai-Jin Kim
BACKGROUND: We investigated the prevalence and correlates of comorbid depression among patients with internet gaming disorder using the Internet Gaming Disorder scale (IGD-9) and the Patient Health Questionnaire-9 (PHQ-9) among nonclinical online survey respondents. METHODS: Korean adolescents and adults from 14 to 39 years of age were selected. We compared internet gaming use patterns and sociodemographic and clinical variables between patients with internet gaming disorder who had depression and those without depression...
August 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28937573/committee-opinion-no-721-smoking-cessation-during-pregnancy
#3
(no author information available yet)
Smoking is the one of the most important modifiable causes of poor pregnancy outcomes in the United States, and is associated with maternal, fetal, and infant morbidity and mortality. The physical and psychologic addiction to cigarettes is powerful; however, the compassionate intervention of the obstetrician-gynecologist can be the critical element in prenatal smoking cessation. An office-based protocol that systematically identifies pregnant women who smoke and offers treatment or referral has been proved to increase quit rates...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937568/committee-opinion-no-721-summary-smoking-cessation-during-pregnancy
#4
(no author information available yet)
Smoking is the one of the most important modifiable causes of poor pregnancy outcomes in the United States, and is associated with maternal, fetal, and infant morbidity and mortality. The physical and psychologic addiction to cigarettes is powerful; however, the compassionate intervention of the obstetrician-gynecologist can be the critical element in prenatal smoking cessation. An office-based protocol that systematically identifies pregnant women who smoke and offers treatment or referral has been proved to increase quit rates...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28936380/knowledge-and-attitude-of-teenagers-towards-electronic-cigarettes-in-karachi-pakistan
#5
Asim Shaikh, Hamza T Ansari, Zeerak Ahmad, Mahnoor Y Shaikh, Ilma Khalid, Maha Jahangir, Amna Majeed, Nimra Shakeel, Arsalan Ahmed, Roha Saeed Memon, Eleze Tariq, Rafia Irfan, Dania Madni
Introduction Studies have shown that electronic cigarettes have gained immense popularity and their use has increased dramatically all over the world. However, little is known about the knowledge and attitudes towards e-cigarettes in third world countries such as Pakistan. The aim of this study was to determine the perceptions of teenagers in Karachi regarding e-cigarettes and whether the differences in said perceptions were affected by gender and level of education. Methods We conducted a cross-sectional study in January 2017 using convenience sampling and interviewed 441 young individuals, aged 13 to 19 years, to determine their knowledge, attitudes, and practices regarding e-cigarettes...
July 13, 2017: Curēus
https://www.readbyqxmd.com/read/28935766/serotonin-2b-receptors-in-mesoaccumbens-dopamine-pathway-regulate-cocaine-responses
#6
Stéphane Doly, Emily Quentin, Raphaël Eddine, Stefania Tolu, Sebastian P Fernandez, Jesus Bertran-Gonzalez, Emmanuel Valjent, Arnauld Belmer, Xavier Viñals, Jacques Callebert, Philippe Faure, Frank J Meye, Denis Hervé, Patricia Robledo, Manuel Mameli, Jean-Marie Launay, Rafael Maldonado, Luc Maroteaux
Addiction is a maladaptive pattern of behavior following repeated use of reinforcing drugs in predisposed individuals, and leading to lifelong changes. A common substrate of these changes lies in alterations of neurons releasing dopamine in the ventral and dorsal territories of the striatum. The serotonin 5-HT2B receptor has been involved in various behaviors including impulsivity, response to antidepressants and to psychostimulants pointing toward putative interactions with the dopamine system. Despite these findings, it remains unknown whether 5-HT2B receptors directly modulate dopaminergic activity and the possible mechanisms involved...
September 21, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28935267/methylphenidate-doses-in-attention-deficit-hyperactivity-disorder-and-comorbid-substance-use-disorders
#7
Charlotte Skoglund, Lena Brandt, Brian D'Onofrio, Henrik Larsson, Johan Franck
Patients with Attention Deficit/Hyperactivity Disorder (ADHD) and comorbid Substance Use Disorders (SUD) are increasingly being treated with central stimulant medication despite limited evidence for its effectiveness. Lack of longitudinal follow-up studies of dosing and adverse effects has resulted in conflicting treatment guidelines. This study aims to explore whether individuals with ADHD and comorbid SUD are treated with higher stimulant doses than individuals with ADHD only, and whether doses increase over time as a sign of tolerance, a core symptom of addiction...
September 18, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28935057/no-349-substance-use-in-pregnancy
#8
Alice Ordean, Suzanne Wong, Lisa Graves
OBJECTIVES: To improve awareness and knowledge of problematic substance use in pregnancy and to provide evidence-based recommendations for the management of this challenging clinical issue for all health care providers. OPTIONS: This guideline reviews the use of screening tools, general approach to care, and recommendations for the clinical management of problematic substance use in pregnancy. OUTCOMES: Evidence-based recommendations for screening and management of problematic substance use during pregnancy and lactation...
October 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28934555/cardiovascular-effects-of-methadone-and-concomitant-use-of-diazepam-during-methadone-maintenance-treatment-induction-low-concentration-risk
#9
Vesna Mijatović, Isidora Samojlik, Stojan Petković, Saša Vukmirović, Arsen Uvelin, Aleksandra Dickov
Background The aim is to evaluate the role of diazepam concentrations in development of low-concentration-methadone-associated QTc prolongation in patients with opioid use disorder during methadone maintenance treatment (MMT) induction. Research design and methods Individuals with addiction disorder on MMT were studied before the beginning of MMT and after one and six months of MMT. Serum concentrations of methadone, diazepam, electrolytes and ECG were analyzed. Results Thirty patients were enrolled. The mean methadone concentration at time points was 177±119 ng/ml and 343±182 ng/ml, while the mean diazepam concentration was 561±437 ng/ml and 1045±933 ng/ml...
September 21, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28933931/legacies-of-1917-in-contemporary-russian-public-health-addiction-hiv-and-abortion
#10
Michele Rivkin-Fish
I examine the legacies of Soviet public health policy and the socialist health care system and trace how the Soviet past figures in contemporary Russian policymaking and debates about drug use, HIV, and abortion. Drug policies and mainstream views of HIV reflect continuities with key aspects of Soviet-era policies, although political leaders do not acknowledge these continuities in justifying their policies. In abortion policy, by contrast, which is highly debated in the public realm, advocates represent themselves as differing from Soviet-era policies to justify their positions...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933310/socialization-alleviates-burden-of-oxidative-stress-in-hippocampus-and-prefrontal-cortex-in-morphine-addiction-period-in-male-rats
#11
Hamidreza Famitafreshi, Morteza Karimian
INTRODUCTION: Addiction is a compulsive drug-seeking and drug-taking behavior. Reduction of high-risk behaviors can reduce the burden of addiction in society and can improve the overall prognosis of drug addiction. The aim of this study is to show that reduction of oxidative stress with socialization will reduce occurrence of high-risk behavior during addiction period. METHODS AND MATERIALS: Fifty-four male Sprague-Dawley rats were randomly divided into four groups: socialized, isolated, addicted socialized and addicted isolated...
September 19, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28932964/treatment-strategies-for-the-opioid-dependent-patient
#12
REVIEW
Shweta Teckchandani, Meredith Barad
PURPOSE OF REVIEW: This review is intended to help the headache physician think through and plan for management issues concerning the use of opioids. We ask the headache physician to consider if there are instances where prescribing or continuing prescriptions of opiates is plausible, and if so, how can the physician proceed as safely as possible. Our goal is to start a conversation regarding the inevitable encounter with a patient on opiates or requesting opiates. RECENT FINDINGS: The use of opiates in our society has reached a crisis in staggering death and addiction rates...
September 20, 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28932934/using-the-multiple-choice-procedure-to-measure-the-relative-reinforcing-efficacy-of-gambling-initial-validity-evidence-among-college-students
#13
Leon H Butler, Jessica G Irons, Drew T Bassett, Christopher J Correia
The multiple choice procedure (MCP) is used to assess the relative reinforcing value of concurrently available stimuli. The MCP was originally developed to assess the reinforcing value of drugs; the current within-subjects study employed the MCP to assess the reinforcing value of gambling behavior. Participants (N = 323) completed six versions of the MCP that presented hypothetical choices between money to be used while gambling ($10 or $25) versus escalating amounts of guaranteed money available immediately or after delays of either 1 week or 1 month...
September 20, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28931068/erk1-2-signalling-protects-against-apoptosis-following-endoplasmic-reticulum-stress-but-cannot-provide-long-term-protection-against-bax-bak-independent-cell-death
#14
Nicola J Darling, Kathryn Balmanno, Simon J Cook
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through the cell intrinsic, mitochondrial pathway. Indeed, cells that lack the key executioner proteins BAX and BAK are protected from ER stress-induced apoptosis. Here we show that chronic ER stress causes the progressive inhibition of the extracellular signal-regulated kinase (ERK1/2) signalling pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28930612/genetic-addiction-risk-score-gars-%C3%A2-a-predictor-of-vulnerability-to-opioid-dependence
#15
Kenneth Blum, Amanda L C Chen, Panayotis K Thanos, Marcelo Febo, Zsolt Demetrovics, Kristina Dushaj, Abraham Kovoor, David Baron, David E Smith, Alphonso Kenison Roy Iii, Lyle Fried, Thomas J H Chen, Edwin Chapman, Edward Modestino, Bruce Steinberg, Rajendra D Badgaiyan
The interaction of neurotransmitters and genes that control the release of dopamine is the Brain Reward Cascade (BRC). Variations within the BRC, whether genetic or epigenetic, may predispose individuals to addictive behaviors and altered pain tolerance. This discussion authored by a group of concerned scientists and clinicians examines the Genetic Addiction Risk Score (GARS), the first test to accurately predict vulnerability to pain, addiction, and other compulsive behaviors, defined as Reward Deficiency Syndrome (RDS)...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930574/food-addiction-a-common-neurobiological-mechanism-with-drug-abuse
#16
Elsa Lindgren, Kyle Gray, Gregg Miller, Ryan Tyler, Corinde E Wiers, Nora D Volkow, Gene-Jack Wang
Drugs and food both exert a rewarding effect through the firing of dopamine neurons in the ventral tegmental area, resulting in the release of dopamine into the nucleus accumbens and effects on the mesolimbic pathway. Here, we review the neuroimaging literature to consider the validity of food addiction and the common neurobiological mechanisms that overlap in food and drug addiction. This review paper focuses on findings from Positron Emission Tomography (PET), functional Magnetic Resonance Imaging (fMRI) and structural imaging studies, as well as evidence from neuroimaging studies of bariatric surgery and pharmacological interventions on obese individuals...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930061/promoting-adoption-of-medication-for-opioid-and-alcohol-use-disorders-through-system-change
#17
James H Ford, Amanda J Abraham, Nicoleta Lupulescu-Mann, Raina Croff, Kim A Hoffman, Kelly Alanis-Hirsch, Mady Chalk, Laura Schmidt, Dennis McCarty
OBJECTIVE: The Medication Research Partnership (MRP), a collaboration between a national commercial health plan and nine addiction treatment centers, implemented organizational and system changes to promote use of federally approved medications for treatment of alcohol and opioid use disorders. METHOD: A difference-in-differences analysis examined change over time in the percentage of patients receiving a prescription medication for alcohol or opioid use disorders treated in MRP (n = 9) and comparison (n = 15) sites...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28930052/portrayal-of-alcohol-brands-popular-among-underage-youth-on-youtube-a-content-analysis
#18
Brian A Primack, Jason B Colditz, Eva B Rosen, Leila M Giles, Kristina M Jackson, Kevin L Kraemer
OBJECTIVE: We characterized leading YouTube videos featuring alcohol brand references and examined video characteristics associated with each brand and video category. METHOD: We systematically captured the 137 most relevant and popular videos on YouTube portraying alcohol brands that are popular among underage youth. We used an iterative process to codebook development. We coded variables within domains of video type, character sociodemographics, production quality, and negative and positive associations with alcohol use...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#19
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28929914/the-conundrum-of-opioid-tapering-in-long-term-opioid-therapy-for-chronic-pain-a-commentary
#20
Ajay Manhapra, Albert A Arias, Jane C Ballantyne
BACKGROUND: In response to the opioid epidemic and new guidelines, many patients on high-dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a unique clinical challenge is emerging: while many on LTOT have poor pain control, functional decline, psychiatric instability, aberrancies and misuse, these issues may often worsen with opioid tapering. Currently, a clear explanation and practical guidance on how to manage this perplexing clinical scenario is lacking...
September 20, 2017: Substance Abuse
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