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https://www.readbyqxmd.com/read/29908297/prevention-of-breast-cancer-treatment-induced-bone-loss-in-premenopausal-women-treated-with-zoledronic-acid-final-5-year-results-from-the-randomized-double-blind-placebo-controlled-probone-ii-trial
#1
Ioannis Kyvernitakis, Peter Herbert Kann, Friederike Thomasius, Olaf Hars, Peyman Hadji
PURPOSE: Premenopausal women receiving chemotherapy or endocrine treatment for early breast cancer are at increased risk for cancer treatment induced bone loss (CTIBL). The aim of the randomized, double-blind ProBONE II trial was to investigate whether a 2-year adjuvant treatment with 4 mg intravenous zoledronic acid (ZOL) every 3 months versus placebo would prevent CTIBL after a five-year period. METHODS: Thirty-one of the 34 participants in the ZOL arm and thirty-four of the 36 participants in the placebo arm were followed-up to the 5-year visit and completed the study as planned...
June 13, 2018: Bone
https://www.readbyqxmd.com/read/29907642/telomerase-reverse-transcriptase-coordinates-with-the-epithelial-to-mesenchymal-transition-through-a-feedback-loop-to-define-properties-of-breast-cancer-stem-cells
#2
Ahmed El-Badawy, Nehal I Ghoneim, Mohamed A Nasr, Hoda Elkhenany, Toka A Ahmed, Sara M Ahmed, Nagwa El-Badri
Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high telomerase enzymatic activity. In contrast, cancer stem cells (CSCs) have short telomeres despite high expression of hTERT, indicating that the role of hTERT in CSCs is not limited to telomere elongation and/or maintenance. The function of hTERT in CSCs remains poorly understood...
June 15, 2018: Biology Open
https://www.readbyqxmd.com/read/29906025/malignant-tumors-as-cause-of-disability-at-the-instituto-mexicano-del-seguro-social
#3
Edgar Jesús Zitle-García, Alma Lucila Sauceda-Valenzuela, Iván de Jesús Ascencio-Montiel, Jesús García-Paredes
Background: Cancer represents an important issue in health, with the economic impact that it takes. The aim of this paper is to analyze the epidemiological characteristics of a population with social security who was diagnosed with some type of cancer and required a disability pension. Methods: Observational study, retrolective cohort type, carried out at the Instituto Mexicano del Seguro Social (IMSS) with IMSS beneficiaries ruled with a state of disability due to malignancy during the period 2006 to 2012...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29905920/breast-cancer-risk-evaluation-by-utilizing-gail-model-and-association-between-breast-cancer-risk-perception-with-early-diagnosis-applications-among-midwives-and-nurses-working-in-primary-health-services
#4
Ebru Turhan, Gokben Yasli
OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905576/ce-breast-cancer-screening-a-review-of-current-guidelines
#5
Roberta Baron, Karen Drucker, Liza Lagdamen, Maureen Cannon, Carrie Mancini, Erica Fischer-Cartlidge
Recent updates have led to variations in national recommendations. ABSTRACT: Breast cancer accounts for more than a quarter million diagnoses each year in the United States. Routine screening is the primary method used to detect cancer in its earliest stages, before symptoms develop. Recent changes to national screening guidelines have resulted in a lack of consensus and confusion among health care providers and the public. This article reviews the guidelines of the American Cancer Society, the U...
June 13, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29905007/simultaneous-downregulation-of-mir-21-and-mir-155-through-oleuropein-for-breast-cancer-prevention-and-therapy
#6
Maryam Abtin, Mohammad R Alivand, Mahmoud S Khaniani, Milad Bastami, Mohammad Zaeifizadeh, Sima M Derakhshan
Breast cancer (BC) is the leading cause of cancer mortality in women worldwide. It recently was proven that miRNAs play a critical role in BC development. The use of natural agents for control of cancer by modulating miRNAs is promising. Oleuropein is a natural polyphenolic agent with anti-neoplastic properties and is well tolerated by humans. This study was undertaken to determine the therapeutic effects of oleuropein through modulation of master oncomiRs (miR-21 and miR-155) in BC cells. The present study provides the first link between miRNA and oleuropein as a mechanism in BC...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904116/neutrophil-tlr4-and-pkr-are-targets-of-breast-cancer-cell-glycosaminoglycans-and-effectors-of-glycosaminoglycan-induced-april-secretion
#7
Uilst Bat-Erdene, Eric Quan, Kelvin Chan, Brianna-Marie Lee, Wejdan Matook, Ki-Young Lee, Jesusa L Rosales
A proliferation-inducing ligand (APRIL), which induces survival and migration signals and tumor growth, is commonly observed in breast cancer tissues but is not often expressed in breast cancer cells themselves. Here, we examined whether breast cancer cells induce APRIL secretion from neutrophils, which are frequently recruited into the breast tumor microenvironment. We found that breast cancer cells do stimulate neutrophils to secrete APRIL through their glycosaminoglycans. Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion...
June 15, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29903796/should-women-aged-70-74-be-invited-to-participate-in-screening-mammography-a-report-on-two-australian-community-juries
#8
Chris Degeling, Alexandra Barratt, Sanchia Aranda, Robin Bell, Jenny Doust, Nehmat Houssami, Jolyn Hersch, Ruben Sakowsky, Vikki Entwistle, Stacy M Carter
OBJECTIVE: To elicit informed views from Australian women aged 70-74 regarding the acceptability of ceasing to invite women their age to participate in government-funded mammography screening (BreastScreen). DESIGN: Two community juries held in 2017. SETTING: Greater Sydney, a metropolis of 4.5 million people in New South Wales, Australia. PARTICIPANTS: 34 women aged 70-74 with no personal history of breast cancer, recruited by random digit dialling and previously randomly recruited list-based samples...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29901185/salidroside-inhibits-migration-invasion-and-angiogenesis-of-mda%C3%A2-mb-231-tnbc-cells-by-regulating-egfr-jak2-stat3-signaling-via-mmp2
#9
Dong Young Kang, Nipin Sp, Doh Hoon Kim, Youn Hee Joung, Hyo Gun Lee, Young Min Park, Young Mok Yang
The major hallmarks of tumor progression are angiogenesis, migration and metastasis. Among the components of Rhodiola rosea, salidroside (p‑hydroxyphenethyl-β‑d-glucoside) is one of the most potent, and is present in all Rhodiola species. Recent data have revealed the anticancer effects of salidroside; however, the mechanism underlying its ability to inhibit tumor angiogenesis remains unknown. The present study aimed to analyze how salidroside affects major factors involved in breast cancer, and to elucidate its ability to inhibit angiogenesis and invasion...
June 5, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29901116/retrospective-analysis-of-estrogen-receptor-1-and-n%C3%A2-acetyltransferase-gene-expression-in-normal-breast-tissue-primary-breast-tumors-and-established-breast-cancer-cell-lines
#10
Samantha M Carlisle, David W Hein
The expression levels of estrogen receptor 1 (ESR1), arylamine N‑acetyltransferase 1 (NAT1), and arylamine N‑acetyltransferase 2 (NAT2) are implicated in breast cancer; however, their co-expression profiles in normal breast tissue, primary breast tumors and established breast cancer cell lines are undefined. NAT1 expression is widely reported to be associated with ESR1 expression and is frequently investigated in breast cancer etiology. Furthermore, the NAT2 phenotype has been reported to modify breast cancer risk in molecular epidemiological association studies...
June 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29899271/the-effects-of-combinatorial-genistein-and-sulforaphane-in-breast-tumor-inhibition-role-in-epigenetic-regulation
#11
Bidisha Paul, Yuanyuan Li, Trygve O Tollefsbol
Dietary compounds that possess the properties of altering epigenetic processes are gaining popularity as targets for cancer prevention studies. These compounds when administered at optimal concentrations and especially in combination can have enhanced effects in cancer prevention or therapy. It is important to study the interaction of two or more compounds in order to assess their role in enhancing prevention. Genistein (GEN), found in soy, has been extensively studied for its role as an epigenetic modifier especially as a DNA methyltransferase (DNMT) inhibitor and sulforaphane (SFN), found in cruciferous vegetables, is known as a histone deacetylase (HDAC) inhibitor...
June 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29899079/hormone-therapy-and-breast-cancer-emerging-steroid-receptor-mechanisms
#12
Meghan Samantha Perkins, Renate Louw-du Toit, Donita Africander
Although hormone therapy is widely used by millions of women to relieve symptoms of menopause, it has been associated with several side-effects such as coronary heart disease, stroke and increased invasive breast cancer risk. These side-effects have caused many women to seek alternatives to conventional hormone therapy, including the controversial custom-compounded bioidentical hormone therapy suggested to not increase breast cancer risk. Historically estrogens and the estrogen receptor were considered the principal factors promoting breast cancer development and progression, however, a role for other members of the steroid receptor family in breast cancer pathogenesis is now evident, with emerging studies revealing an interplay between some steroid receptors...
June 13, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29898744/osm-potentiates-preintravasation-events-increases-ctc-counts-and-promotes-breast-cancer-metastasis-to-the-lung
#13
Ken Tawara, Celeste Bolin, Jordan Koncinsky, Sujatha Kadaba, Hunter Covert, Caleb Sutherland, Laura Bond, Joseph Kronz, Joel R Garbow, Cheryl L Jorcyk
BACKGROUND: Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of an inflammatory cytokine, oncostatin M (OSM), in the preintravasation aspects of breast cancer metastasis. METHODS: OSM expression levels in human breast cancer tissue samples were assessed using tissue microarrays, and expression patterns based on clinical stage were assessed...
June 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29896978/associations-between-cancer-screening-behavior-and-complementary-medicine-use-results-of-a-national-cross-sectional-survey-of-9151-australian-women
#14
Jane Elizabeth Frawley, Erica McIntyre, David Sibbritt, Jon Wardle, Janet Schloss, Romy Lauche, Jon Adams
INTRODUCTION: Complementary medicine (CM) use has been found to influence the uptake of conventional cancer treatment. This study examines associations between CM use and cancer screening rates. METHODS: Women aged 62 to 67 years from the Australian Longitudinal Study on Women's Health were surveyed regarding their use of cancer screening initiatives. Associations between cancer screening behavior and visits to CM practitioners were analyzed. RESULTS: Of the 9151 women, 9049 (98...
June 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29896316/premenopausal-breast-cancer-potential-clinical-utility-of-a-multi-omics-based-machine-learning-approach-for-patient-stratification
#15
Holger Fröhlich, Sabyasachi Patjoshi, Kristina Yeghiazaryan, Christina Kehrer, Walther Kuhn, Olga Golubnitschaja
Background: The breast cancer (BC) epidemic is a multifactorial disease attributed to the early twenty-first century: about two million of new cases and half a million deaths are registered annually worldwide. New trends are emerging now: on the one hand, with respect to the geographical BC prevalence and, on the other hand, with respect to the age distribution. Recent statistics demonstrate that young populations are getting more and more affected by BC in both Eastern and Western countries...
June 2018: EPMA Journal
https://www.readbyqxmd.com/read/29895705/inhibition-of-her2-enriches-for-jagged1-dependent-breast-cancer-stem-cells-role-for-membrane-jagged1
#16
Deep Shah, Debra Wyatt, Andrew Baker, Patricia Simms, Daniel S Peiffer, Michelle L Fernandez, Emad A Rakha, Andrew R Green, Aleksandra Filipovic, Lucio Miele, Clodia Osipo
PURPOSE: Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as Cancer Stem Cells (CSCs). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. Notch promotes breast CSCs survival and self-renewal, and overexpression of Notch1 and the Notch ligand Jagged1 predict poor outcome. Resistance to anti-HER2 therapy in HER2+ breast cancer requires Notch1, and that combination of trastuzumab and a Gamma Secretase Inhibitor (GSI) prevents tumor relapse in xenograft models...
June 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29892519/bone-targeted-agent-treatment-patterns-and-the-impact-of-bone-metastases-on-patients-with-advanced-breast-cancer-in-real-world-practice-in-six-european-countries
#17
Roger von Moos, Jean-Jacques Body, Alex Rider, Jonathan de Courcy, Debajyoti Bhowmik, Francesca Gatta, Guy Hechmati, Yi Qian
Background: Bone metastases (BMs) are common in patients with breast cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), like zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Materials and methods: We evaluated the management of BMs and pain in six European countries (Belgium, France, Germany, Italy, Spain, and UK) using the Adelphi Breast Cancer Disease Specific Programme, which included a physician survey and patient-reported outcomes (PROs) to assess the impact of BMs on pain and QoL...
June 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29890702/cellular-and-molecular-mediators-of-bone-metastatic-lesions
#18
REVIEW
Giulia Battafarano, Michela Rossi, Francesco Marampon, Andrea Del Fattore
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling activity, and displaying some features of bone cells. This interplay between tumor and bone cells alters the physiological bone remodeling, leading to the generation of a vicious cycle that promotes bone metastasis growth. To prevent the skeletal-related events (SRE) associated with bone metastasis, approaches to inhibit osteoclast bone resorption are reported...
June 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29890631/the-roles-of-p53-in-mitochondrial-dynamics-and-cancer-metabolism-the-pendulum-between-survival-and-death-in-breast-cancer
#19
REVIEW
David E Moulder, Diana Hatoum, Enoch Tay, Yiguang Lin, Eileen M McGowan
Cancer research has been heavily geared towards genomic events in the development and progression of cancer. In contrast, metabolic regulation, such as aberrant metabolism in cancer, is poorly understood. Alteration in cellular metabolism was once regarded simply as a consequence of cancer rather than as playing a primary role in cancer promotion and maintenance. Resurgence of cancer metabolism research has identified critical metabolic reprogramming events within biosynthetic and bioenergetic pathways needed to fulfill the requirements of cancer cell growth and maintenance...
June 8, 2018: Cancers
https://www.readbyqxmd.com/read/29890364/oxygen-boosted-immunogenic-photodynamic-therapy-with-gold-nanocages-manganese-dioxide-to-inhibit-tumor-growth-and-metastases
#20
Ruijing Liang, Lanlan Liu, Huamei He, Zhikuan Chen, Zhiqun Han, Zhenyu Luo, Zhihao Wu, Mingbing Zheng, Yifan Ma, Lintao Cai
Metastatic triple-negative breast cancer (mTNBC) is an aggressive disease among women worldwide, characterized by high mortality and poor prognosis despite systemic therapy with radiation and chemotherapies. Photodynamic therapy (PDT) is an important strategy to eliminate the primary tumor, however its therapeutic efficacy against metastases and recurrence is still limited. Here, we employed a template method to develop the core-shell gold nanocage@manganese dioxide (AuNC@MnO2 , AM) nanoparticles as tumor microenvironment responsive oxygen producers and near-infrared (NIR)-triggered reactive oxygen species (ROS) generators for oxygen-boosted immunogenic PDT against mTNBC...
May 31, 2018: Biomaterials
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