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carotid Intraplaque hemorrhage

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https://www.readbyqxmd.com/read/27908279/co-existing-intracranial-and-extracranial-carotid-artery-atherosclerotic-plaques-and-recurrent-stroke-risk-a-three-dimensional-multicontrast-cardiovascular-magnetic-resonance-study
#1
Yilan Xu, Chun Yuan, Zechen Zhou, Le He, Donghua Mi, Rui Li, Yuanyuan Cui, Yilong Wang, Yongjun Wang, Gaifen Liu, Zhuozhao Zheng, Xihai Zhao
BACKGROUND: As a systemic disease, atherosclerosis commonly affects intracranial and extracranial carotid arteries simultaneously which is defined as co-existing plaques. Previous studies demonstrated that co-existing atherosclerotic diseases are significantly associated with ischemic cerebrovascular events. The aim of this study was to investigate the characteristics of co-existing intracranial and extracranial carotid atherosclerotic plaques and their relationships with recurrent stroke by using 3D multi-contrast magnetic resonance (MR) vessel wall imaging...
December 2, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27806835/determinants-of-carotid-atherosclerotic-plaque-burden-in-a-stroke-free-population
#2
Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H Franco, Wiro J Niessen, Stefan Klein, Meike W Vernooij, Aad Van der Lugt, Jolanda J Wentzel
BACKGROUND AND AIMS: In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. METHODS: The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm(3)), wall volume (outer wall-inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified...
October 14, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27718372/carotid-plaque-fissure-an-underestimated-source-of-intraplaque-hemorrhage
#3
Mat J Daemen, Marina S Ferguson, Frank J Gijsen, Daniel S Hippe, M Eline Kooi, Kevin Demarco, Allard C van der Wal, Chun Yuan, Thomas S Hatsukami
BACKGROUND AND AIMS: Plaque fissuring, a phenomenon morphologically distinct from the classical rupture of a thinned fibrous cap, has not been well characterized in carotid atherosclerosis. The aim of this study was to establish the prevalence of plaque fissures in advanced carotid plaques with an otherwise intact luminal surface, and to determine whether they might be a source of intraplaque hemorrhage (IPH). METHODS: We evaluated 244 surgically intact, 'en bloc' embedded, serially sectioned carotid endarterectomy specimens and included only those plaques with a grossly intact luminal surface...
September 28, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27556726/comparison-study-between-multicontrast-atherosclerosis-characterization-match-and-conventional-multicontrast-mri-of-carotid-plaque-with-histology-validation
#4
Yuanyuan Dai, Peng Lv, Jiang Lin, Rongkui Luo, Hao Liu, Aihua Ji, Hui Liu, Caixia Fu
PURPOSE: To compare Multicontrast ATherosclerosis Characterization (MATCH) with conventional multicontrast magnetic resonance imaging (MRI) in the characterization and quantification of carotid plaque components. MATERIALS AND METHODS: Fifty-three consecutive patients underwent carotid plaque 3.0T MRI including conventional multicontrast sequences and MATCH, with 13 of them having carotid endarterectomy for histology validation. The detection of major plaque components including lipid-rich necrotic core (LRNC), loose matrix (LM), intraplaque hemorrhage (IPH), and calcification (CA) and measurement of lumen area, outer wall area, normalized wall index (NWI), and plaque components areas were compared between the two protocols...
August 24, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27544892/targeted-near-infrared-fluorescence-imaging-of%C3%A2-atherosclerosis-clinical-and-intracoronary-evaluation-of-indocyanine-green
#5
Johan W Verjans, Eric A Osborn, Giovanni J Ughi, Marcella A Calfon Press, Ehsan Hamidi, Antonios P Antoniadis, Michail I Papafaklis, Mark F Conrad, Peter Libby, Peter H Stone, Richard P Cambria, Guillermo J Tearney, Farouc A Jaffer
OBJECTIVES: This study sought to determine whether indocyanine green (ICG)-enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. BACKGROUND: New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration-approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability...
September 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27541684/change-in-carotid-intraplaque-hemorrhage-in-community-dwelling-subjects-a-follow-up-study-using-serial-mr-imaging
#6
Quirijn J A van den Bouwhuijsen, Mariana Selwaness, Hui Tang, Wiro J Niessen, Albert Hofman, Oscar H Franco, Aad van der Lugt, Meike W Vernooij
Purpose To investigate intraplaque hemorrhage (IPH) development and change over time. Materials and Methods Institutional review board approval and written informed consent from all participants were obtained. From a population-based study on subclinical atherosclerosis, 40 participants with IPH at baseline magnetic resonance (MR) imaging (53 carotids with IPH) were randomly selected and were matched with 27 control subjects (53 carotids without IPH) to undergo a second MR examination (mean interval, 17 months ± 4 [standard deviation]) to assess IPH change...
August 19, 2016: Radiology
https://www.readbyqxmd.com/read/27540477/recent-advances-in-pathogenesis-assessment-and-treatment-of-atherosclerosis
#7
REVIEW
J David Spence
In recent years, there have been a number of advances in the pathogenesis and treatment of atherosclerosis and in assessing prognosis in carotid atherosclerosis. Risk stratification to improve vascular prevention by identifying patients most likely to benefit from intensive therapy is much improved by measuring carotid plaque burden. In patients with asymptomatic carotid stenosis, a number of modalities can be used to identify the 10-15% who could benefit from endarterectomy or stenting. Transcranial Doppler embolus detection, echolucency and ulceration on 3D ultrasound, intraplaque hemorrhage on magnetic resonance imaging (MRI), and reduced cerebrovascular reserve are useful already; new approaches including plaque texture on ultrasound and imaging of plaque inflammation and early calcification on positron emission tomography/computed tomography (PET/CT) are in development...
2016: F1000Research
https://www.readbyqxmd.com/read/27540090/the-association-between-carotid-intraplaque-hemorrhage-and-outcomes-of-carotid-stenting-a-systematic-review-and-meta-analysis
#8
Waleed Brinjikji, Vance T Lehman, John Huston, M Hassan Murad, Giuseppe Lanzino, Harry J Cloft, David F Kallmes
BACKGROUND AND PURPOSE: The purpose of this systematic review and meta-analysis was to determine whether carotid stenting patients with intraplaque hemorrhage (IPH) identified on preoperative MRI were more likely to suffer perioperative ischemic complications compared with patients without IPH. METHODS: We conducted a comprehensive literature search of studies published between January 1, 2005 and December 31, 2015 reporting perioperative outcomes of carotid stenting among patients with and without IPH on hemorrhage sensitive carotid MRI sequences...
August 18, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27510300/quantitative-fat-and-r2-mapping-in-vivo-to-measure-lipid-rich-necrotic-core-and-intraplaque-hemorrhage-in-carotid-atherosclerosis
#9
Sandeep Koppal, Marcel Warntjes, Jeremy Swann, Petter Dyverfeldt, Johan Kihlberg, Rodrigo Moreno, Derek Magee, Nicholas Roberts, Helene Zachrisson, Claes Forssell, Toste Länne, Darren Treanor, Ebo D de Muinck
PURPOSE: The aim of this work was to quantify the extent of lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in atherosclerotic plaques. METHODS: Patients scheduled for carotid endarterectomy underwent four-point Dixon and T1-weighted magnetic resonance imaging (MRI) at 3 Tesla. Fat and R2* maps were generated from the Dixon sequence at the acquired spatial resolution of 0.60 × 0.60 × 0.70 mm voxel size. MRI and three-dimensional (3D) histology volumes of plaques were registered...
August 11, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27430263/semi-automatic-carotid-intraplaque-hemorrhage-detection-and-quantification-on-magnetization-prepared-rapid-acquisition-gradient-echo-mp-rage-with-optimized-threshold-selection
#10
Jin Liu, Niranjan Balu, Daniel S Hippe, Marina S Ferguson, Vanesa Martinez-Malo, J Kevin DeMarco, David C Zhu, Hideki Ota, Jie Sun, Dongxiang Xu, William S Kerwin, Thomas S Hatsukami, Chun Yuan
BACKGROUND: Intraplaque hemorrhage (IPH) is associated with atherosclerosis progression and subsequent cardiovascular events. We sought to develop a semi-automatic method with an optimized threshold for carotid IPH detection and quantification on MP-RAGE images using matched histology as the gold standard. METHODS: Fourteen patients scheduled for carotid endarterectomy underwent 3D MP-RAGE cardiovascular magnetic resonance (CMR) preoperatively. Presence and area of IPH were recorded using histology...
2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27383756/motion-insensitive-carotid-intraplaque-hemorrhage-imaging-using-3d-inversion-recovery-preparation-stack-of-stars-ir-prep-sos-technique
#11
Seong-Eun Kim, John A Roberts, Laura B Eisenmenger, Booth W Aldred, Osama Jamil, Bradley D Bolster, Xiaoming Bi, Dennis L Parker, Gerald S Treiman, J Scott McNally
PURPOSE: Carotid artery imaging is important in the clinical management of patients at risk for stroke. Carotid intraplaque hemorrhage (IPH) presents an important diagnostic challenge. 3D magnetization prepared rapid acquisition gradient echo (MPRAGE) has been shown to accurately image carotid IPH; however, this sequence can be limited due to motion- and flow-related artifact. The purpose of this work was to develop and evaluate an improved 3D carotid MPRAGE sequence for IPH detection...
July 7, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27367236/carotid-artery-stenosis-with-a-high-intensity-signal-plaque-on-time-of-flight-magnetic-resonance-angiography-and-association-with-evidence-of-intraplaque-hypoxia
#12
Atsushi Ogata, Masatou Kawashima, Tomihiro Wakamiya, Masashi Nishihara, Jun Masuoka, Yukiko Nakahara, Ryo Ebashi, Kohei Inoue, Yukinori Takase, Hiroyuki Irie, Tatsuya Abe
OBJECTIVE Hypoxia induces angiogenesis and plays a major role in the progression of carotid plaques. During carotid intervention, plaques with high-intensity signals on time-of-flight (TOF) magnetic resonance angiography (MRA) often cause ischemic stroke and embolic complications. However, the role of intraplaque hypoxia before carotid endarterectomy (CEA) and carotid artery stenting is not presently understood. In this study the authors aimed to investigate the relationship between intraplaque hypoxia and MRA findings...
July 1, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27352423/intraplaque-hemorrhage-a-potential-consequence-of-periodontal-bacteria-gathering-in-human-carotid-atherothrombosis
#13
Adrian Brun, Hélène Rangé, Bastien Prouvost, Olivier Meilhac, Mikael Mazighi, Pierre Amarenco, Guy Lesèche, Philippe Bouchard, Jean-Baptiste Michel
Periodontal diseases are multifactorial inflammatory diseases, caused by a bacterial biofilm involving both innate and adaptative immunity, characterized by the destruction of tooth-supporting tissues. In the context of periodontitis, the spread of weak pathogenic bacteria into the bloodstream has been described. These bacteria will preferentially localize to existing clot within the circulation. Atherothrombosis of the carotid arteries is a local pathology and a common cause of cerebral infarction. Intraplaque hemorrhages render the lesion more prone to clinical complications such as stroke...
2016: Bulletin du Groupèment International Pour la Recherche Scientifique en Stomatologie & Odontologie
https://www.readbyqxmd.com/read/27333748/-plaque-imaging-of-cervical-carotid-arteries
#14
REVIEW
Makoto Sasaki
Magnetic resonance plaque imaging is widely used to characterize atherosclerotic plaques of the cervical carotid artery to prevent future stroke events and surgical complications. Intraplaque contrast considerably varies among the T1-weighted MRI techniques, which should be optimized. Non-gated 2-dimensional spin-echo or 3-dimensional fast spin-echo techniques with appropriate scanning parameters can readily characterize vulnerable intraplaque components including lipid, necrosis, and hemorrhage.
April 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27313129/vitamin-d-and-vulnerable-carotid-plaque
#15
J S McNally, T M Burton, B W Aldred, S-E Kim, M S McLaughlin, L B Eisenmenger, G J Stoddard, J J Majersik, D V Miller, G S Treiman, D L Parker
BACKGROUND AND PURPOSE: MR imaging-detected carotid intraplaque hemorrhage indicates vulnerable plaque with high stroke risk. Angiotensin II stimulates intraplaque hemorrhage in animal models, and the angiotensin system is highly regulated by vitamin D. Our purpose was to determine whether low vitamin D levels predict carotid intraplaque hemorrhage in humans. MATERIALS AND METHODS: In this cross-sectional study, 65 patients with carotid disease underwent carotid MR imaging and blood draw...
June 16, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27209103/plaque-neovascularization-is-increased-in%C3%A2-human-carotid-atherosclerosis-related%C3%A2-to-prior-neck-radiotherapy-a-contrast-enhanced-ultrasound-study
#16
Benoy N Shah, Dorothy M Gujral, Navtej S Chahal, Kevin J Harrington, Christopher M Nutting, Roxy Senior
OBJECTIVES: The aim of this study was to determine the effect of radiotherapy (RT) on intraplaque neovascularization (IPN) in human carotid arteries. BACKGROUND: Exposure of the carotid arteries to RT during treatment for head and neck cancer is associated with increased risk for stroke. However, the effect of RT on IPN, a precursor to intraplaque hemorrhage and thus associated with plaque vulnerability, is unknown. METHODS: In this cross-sectional study, patients who had undergone unilateral RT for head and neck cancer ≥2 years previously underwent B-mode and contrast-enhanced ultrasound of both RT-side and non-RT-side carotid arteries...
June 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27165952/carotid-atherosclerotic-plaque-characteristics-on-magnetic-resonance-imaging-relate-with-history-of-stroke-and-coronary-heart-disease
#17
Mariana Selwaness, Daniel Bos, Quirijn van den Bouwhuijsen, Marileen L P Portegies, M Arfan Ikram, Albert Hofman, Oscar H Franco, Aad van der Lugt, Jolanda J Wentzel, Meike W Vernooij
BACKGROUND AND PURPOSE: Because atherosclerosis is a systemic disease, presence and composition on 1 location may relate to ischemic events in distant locations. We examined whether carotid atherosclerotic wall thickness, stenosis, and plaque composition are related to history of ischemic stroke and coronary heart disease (CHD). METHODS: From the population-based Rotterdam Study, 1731 asymptomatic participants (mean age, 72.4±9.1 years; 55% males) underwent magnetic resonance imaging of both carotid arteries...
June 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27139458/bilateral-symmetry-of-human-carotid-artery-atherosclerosis-a-multi-contrast-weighted-mr-study
#18
Feiyu Li, Xiaoying Wang
The systemic nature of atherosclerotic disease may entail an association in disease severity between left and right carotid arteries. However, the etiology of plaque features in high-risk lesions is presumably attributed to local risk factors. We explored the symmetry of plaque morphology and composition across a broad range of atherosclerotic disease severities. All participants underwent carotid MR imaging on a 3.0 T scanner with a bilateral four-element phased-array surface coil. Vessel boundary and plaque components [calcification, lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH)] of bilateral carotid arteries were outlined...
August 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27115144/dynamic-contrast-enhanced-mri-to-study-atherosclerotic-plaque-microvasculature
#19
REVIEW
Raf H M van Hoof, Sylvia Heeneman, Joachim E Wildberger, M Eline Kooi
Rupture of a vulnerable atherosclerotic plaque of the carotid artery is an important underlying cause of clinical ischemic events, such as stroke. Abundant microvasculature has been identified as an important aspect contributing to plaque vulnerability. Plaque microvasculature can be studied non-invasively with dynamic contrast-enhanced (DCE-)MRI in animals and patients. In recent years, several DCE-MRI studies have been published evaluating the association between microvasculature and other key features of plaque vulnerability (e...
June 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27102316/prediction-of-carotid-intraplaque-hemorrhage-using-adventitial-calcification-and-plaque-thickness-on-cta
#20
L B Eisenmenger, B W Aldred, S-E Kim, G J Stoddard, A de Havenon, G S Treiman, D L Parker, J S McNally
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage. MATERIALS AND METHODS: This was a retrospective cohort study of 96 patients who underwent carotid MRA and CTA within 1 month, from 2009 to 2016...
August 2016: AJNR. American Journal of Neuroradiology
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