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https://www.readbyqxmd.com/read/28183788/prognostic-factors-in-ectopic-cushing-s-syndrome-due-to-neuroendocrine-tumors-a-multicenter-study
#1
Maria Vittoria Davi', Elisa Cosaro, Serena Piacentini, Giuseppe Reimondo, Nora Albiger, Giorgio Arnaldi, Antongiulio Faggiano, Giovanna Mantovani, Nicola Fazio, Alessandro Piovesan, Emanuela Arvat, Franco Grimaldi, Letizia Canu, Massimo Mannelli, Alberto Giacinto Ambrogio, Francesca Pecori Giraldi, Chiara Martini, Andrea Lania, Manuela Albertelli, Diego Ferone, Maria Chiara Zatelli, Davide Campana, Annamaria Colao, Carla Scaroni, Massimo Terzolo, Laura De Marinis, Sara Cingarlini, Rocco Micciolo, Giuseppe Francia
OBJECTIVE: Evidence is limited regarding outcome of patients with ectopic Cushing's syndrome (ECS) due to neuroendocrine tumors (NETs). DESIGN: We assessed the prognostic factors affecting the survival of patients with NETs and ECS. METHODS: Retrospective analysis of clinicopathological features, severity of hormonal syndrome, treatments from a large cohort of patients with NETs and ECS collected from 17 Italian centers. RESULTS: Our series included 110 patients, 58...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28183214/appearance-of-a-thymic-mass-after-treatment-of-cushing-s-syndrome
#2
Alessandro P Delitala, Laura Olita, Carla Piras, Rossella Cosseddu, Giorgio Bagella, Giuseppe Fanciulli
A 23-year-old woman was referred to our center with hirsutism, acne, weight gain, weakness, and irregular menses. Laboratory tests revealed increased levels of cortisol and sex hormones, and reduced adrenocorticotropic hormone levels. The patient underwent a right adrenalectomy. Pathology of the resected right adrenal gland showed an adrenal carcinoma. Computed tomography 8 months after the surgery revealed a thymic mass that was not detected preoperatively. The frequency of rebound thymic hyperplasia after normalization of hypercortisolism is not known, but possibly as high as 40%...
February 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28180906/clinical-outcomes-following-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism
#3
M J Hannon, W C Sze, R Carpenter, L Parvanta, M Matson, A Sahdev, M R Druce, D M Berney, M Waterhouse, S A Akker, W M Drake
No abstract text is available yet for this article.
November 15, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28145058/patient-reported-postoperative-pain-body-image-and-cosmetic-satisfaction-after-transumbilical-laparoendoscopic-single-site-adrenalectomy
#4
Takeo Nomura, Kohei Takei, Satoki Abe, Yuko Fukuda, Naoyuki Yamanaka, Shinya Sejiyama, Mutsushi Yamasaki, Tadamasa Shibuya, Tadasuke Ando, Ken-Ichi Mori, Yasuhiro Sumino, Fuminori Sato, Hiromitsu Mimata
INTRODUCTION: Laparoendoscopic single-site surgery is a recently innovated urologic surgical procedure. Transumbilical laparoendoscopic single-site adrenalectomy (LESS-A) is technically safe and feasible in patients with benign adrenal tumors. To improve patient counseling and informed consent, we evaluated patient-reported postoperative pain, body image, and cosmetic satisfaction after transumbilical LESS-A. METHODS: We reviewed 24 patients who underwent transumbilical LESS-A and assessed their operative and esthetic outcomes and incisional pain...
February 1, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28138953/clinical-benefits-of-unilateral-adrenalectomy-in-patients-with-subclinical-hypercortisolism-due-to-adrenal-incidentaloma-results-from-a-single-center
#5
Luigi Petramala, Giuseppe Cavallaro, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Antonio Concistrè, Umberto Costi, Maurizio Bufi, Piernatale Lucia, Giuseppe De Vincentis, Gino Iannucci, Giorgio De Toma, Claudio Letizia
INTRODUCTION: This study was designed to evaluate the results of unilateral laparoscopic adrenalectomy in patients with subclinical hypercortisolism (SH) due to adrenal incidentaloma (AI) concerning the main cardiometabolic disorders. METHODS: We have studied between January 2000 to December 2015, 645 patients with AI (283 males and 362 females; mean age 61.9 ± 10 years) and we found 70 patients with SH (27 males and 43 females; mean age 61.9 ± 8.4 years)...
March 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28133213/-a-case-of-recurrent-breast-cancer-with-adrenal-metastasis-resected-using-laparoscopic-surgery
#6
Hirotomo Murakami, Yoko Ohtani, Tatsuya Kinoshita, Kiyo Tanaka, Hiroyuki Yasojima, Makiko Mizutani, Shoji Nakamori, Mitsugu Sekimoto, Kiyoshi Mori, Masayuki Mano, Norikazu Masuda
We report a case of recurrent breast cancer with involvement of the right adrenal grand, which was resected using laparoscopic surgery. The patient was a 41-year-old woman who underwent duct-lobular segmentectomy for ductal carcinoma in situ. Histopathology showed microinvasion, and tested positive for ER and PR, but negative for HER2, so we applied radiation to the remaining breast and administered tamoxifen. After 9 months, local recurrence was detected and quadrantectomy with axillary lymph node dissection was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133126/-resection-of-hepatocellular-carcinoma-with-synchronous-bilateral-adrenal-metastases
#7
Naoto Fujimoto, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Kunihiko Shu, Shiro Adachi, Keizo Dono
A 59-year-old man was admitted to our hospital with liver dysfunction. Examinations revealed a huge liver tumor in the right hepatic lobe and a mass in each adrenal gland. The preoperative diagnosis was hepatocellular carcinoma(HCC)with synchronous bilateral adrenal metastases. The patient underwent right hepatic lobectomy, cholecystectomy, and bilateral adrenalectomy. Histopathological examination of the specimens confirmed the diagnosis of HCC with synchronous bilateral adrenal metastases. After surgery, he received steroid replacement therapy and had a favorable clinical course without complications...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133120/-a-case-of-solitary-adrenal-metastasis-from-rectal-cancer-treated-by-adrenalectomy-after-preoperative-chemotherapy
#8
Kazuhito Tsuchida, Hayato Watanabe, Yohei Kameda, Mamoru Uchiyama, Masahiro Asari, Hitoshi Matsuura, Kazuki Yamanaka, Tomohiko Osaragi, Kazuyuki Tani, Ryuji Shiraishi, Osamu Matsubara, Yasushi Rino, Munetaka Masuda
Adrenal metastasis from colorectal cancer occurs in the presence of multiple synchronous metastases at other sites. We report a case of heterochronous solitary adrenal metastasis from rectal cancer. A 55-year-old man underwent anterior resection with D3 lymph node dissection for rectal cancer. The pathological stage of the tumor was III b, and adjuvant chemotherapy with mFOLFOX6 was administered for 6 months. Eighteen months after surgery, abdominal computed tomography(CT) revealed right solitary adrenal metastasis...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28127186/management-of-adrenal-masses
#9
REVIEW
Hattangadi Sanjay Bhat, Balagopal Nair Tiyadath
An adrenal mass can be either symptomatic or asymptomatic in the form of adrenal incidentalomas (AIs) in up to 8 % in autopsy and 4 % in imaging series. Once a diagnosis of adrenal mass is made, we need to differentiate whether it is functioning or nonfunctioning, benign, or malignant. In this article, we provide a literature review of the diagnostic workup including biochemical evaluation and imaging characteristics of the different pathologies. We also discuss the surgical strategies with laparoscopy as the mainstay with partial adrenalectomy in select cases and adrenalectomy in large masses...
March 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28118677/predicting-malignancy-in-adrenal-incidentaloma-and-evaluation-of-a-novel-risk-stratification-algorithm
#10
Elizabeth Foo, Robin Turner, Kuan-Chi Wang, Adam Aniss, Anthony J Gill, Stanley Sidhu, Roderick Clifton-Bligh, Mark Sywak
BACKGROUND: Incidentally discovered adrenal lesions known as adrenal incidentalomas (AI) are being encountered with increasing frequency due to the widespread use of abdominal computed tomography (CT). The aim of this study was to identify the clinical predictors of malignancy in AI and to evaluate the accuracy of a recently proposed risk stratification algorithm. METHODS: A retrospective analysis of 96 patients presenting with AI between 2004 and 2014 was undertaken; 66 patients underwent adrenalectomy, and 30 were managed non-operatively...
January 24, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28112963/case-of-drug-induced-acute-pancreatitis-produced-by-horsetail-infusions
#11
María Del Carmen García Gavilán, Antonio Miguel Moreno García, José Miguel Rosales Zabal, José María Navarro Jarabo, Andrés Sánchez Cantos
INTRODUCTION: The most frequent causes of acute pancreatitis are biliary stones, alcohol consumption, smoking and tumors. Some of them do not have any established cause, and they are catalogued as idiopathic pancreatitis. CASE REPORT: We report the case of a 56-year-old woman with a history of bilateral adrenalectomy on hormone replacement therapy with corticosteroids, who has recurrent episodes of mild acute pancreatitis with an etiologic study (laboratory and imaging tests) without significant findings...
January 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28111697/assessment-of-the-aldosteronona-resolution-score-as-a-predictive-resolution-score-of-hypertension-after-adrenalectomy-for-aldosteronoma-in-french-patients
#12
Ludwig Pasquier, Medhi Kirouani, Florian Fanget, Claire Nomine, Cécile Caillard, Vincent Arnault, Jean-Baptiste Finel, Niki Christou, Muriel Mathonnet, Christophe Trésallet, Antoine Hamy, Loïc de Calan, Laurent Brunaud, Fabrice Menegaux, Jean Christophe Lifante, Jean Benoit Hardouin, Delphine Drui, Éric Mirallié, Claire Blanchard
PURPOSE: Aldosteronoma Resolution Score (ARS) is a predictive score for cure of hypertension after adrenalectomy for hyperaldosteronism and has been validated in American patients. The aim of the study was to validate this score in a French population. METHOD: Data concerning patients operated from 2002 to 2015 in 7 French University Hospitals were retrospectively collected. Diagnosis of Aldosterone-producing adenoma (APA) was confirmed with clinical and biochemical hyperaldosteronism and adrenal nodule on CT scan...
January 22, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28111382/aldosterone-excess-may-inhibit-insulin-secretion-a-comparative-study-on-glucose-metabolism-pre-and-post-adrenalectomy-in-patients-with-primary-aldosteronism
#13
Yuya Tsurutani, Chiho Sugisawa, Akiko Ishida, Kosuke Inoue, Jun Saito, Masao Omura, Shoichiro Nagasaka, Tetsuo Nishikawa
Conflicting data have been published on the effects of aldosterone excess on glucose metabolism. Specifically, there are limited data on whether adrenalectomy in patients with aldosterone-producing adenomas (APA) can improve glucose metabolism. In this study we evaluated changes in glucose metabolism, before and after surgery for APA. The subjects were 61 patients treated with unilateral adrenalectomy, localized by adrenal venous sampling. A 75g-oral glucose tolerance test (OGTT) was performed before and 1 year after adrenalectomy...
January 20, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28108355/an-unusual-case-of-a-pheochromocytoma-mimicking-both-acute-coronary-syndrome-and-central-nervous-system-infection-case-report-and-literature-review
#14
Andreas Mitsis, Christina Hadjilouka, Maria Skarpari, Michael Myrianthefs
Pheochromocytoma has been called 'the great mimic', capable of presenting itself as many other medical conditions. We present a 58-year-old woman admitted with recurrent episodes of nausea and vomiting and high blood pressure. Elevated cardiac biomarkers and diffuse ST-T abnormalities on electrocardiography suggested myocardial injury. However the biochemical and electrocardiography abnormalities normalized in a few hours. The next day the combination of fever, mental disorientation and confusion associated with elevated levels of C-reactive protein and leukocytosis suggested infection of central neural system...
January 17, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28107213/computed-tomography-in-the-management-of-adrenal-tumors-does-size-still-matter
#15
Saïd C Azoury, Neeraja Nagarajan, Allen Young, Aarti Mathur, Jason D Prescott, Elliot K Fishman, Martha A Zeiger
OBJECTIVE: We sought to evaluate computed tomography (CT) imaging as a predictor of adrenal tumor pathology. METHODS: A retrospective review was conducted of patients who underwent unilateral adrenalectomy for an adrenal mass between January 2005 and July 2015. Tumors were classified as benign, indeterminate, or malignant based on preoperative CT findings. RESULTS: Of 697 patients who underwent unilateral adrenalectomy, 216 met the inclusion criteria...
January 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28102204/the-prevalence-of-ctnnb1-mutations-in-primary-aldosteronism-and-consequences-for-clinical-outcomes
#16
Vin-Cent Wu, Shuo-Meng Wang, Shih-Chieh Jeff Chueh, Shao-Yu Yang, Kuo-How Huang, Yen-Hung Lin, Jian-Jhong Wang, Rory Connolly, Ya-Hui Hu, Celso E Gomez-Sanchez, Kang-Yung Peng, Kwan-Dun Wu
Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence and clinical outcomes after adrenalectomy in APA patients harboring CTNNB1 mutations. The molecular expression of CYP11B2 and gonadal receptors in adenomas were also explored. Adenomas from 219 APA patients (95 men; 44.2%; aged 50.5 ± 11.9 years) showed a high rate of somatic mutations (n = 128, 58.4%). The majority of them harbored KCNJ5 mutations (n = 116, 52...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101185/hypokalemic-myopathy-in-primary-aldosteronism-a-case-report
#17
Chuifen Wu, Jun Xin, Minghua Xin, Hai Zou, Lie Jing, Caoyong Zhu, Wenhui Lei
Primary aldosteronism (PA) is a rare disorder. The majority of patients with PA present with typical features and are easily diagnosed. This disorder is usually diagnosed with hypokalemia, hypertension or an adrenal mass. However, patients with atypical symptoms may present a challenge for diagnosis and treatment. In the present study, a case of PA is described that presented with hypokalemic myopathy simulating polymyositis. The patient was a 44-year-old woman who presented with weakness and difficulty walking...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100576/perioperative-management-of-a-large-late-presenting-phaeochromocytoma
#18
Duncan Macrosson, Andrew Love
A 77-year-old man presenting to the emergency department with an acute coronary syndrome was later found to have a phaeochromocytoma. The lateness of this presentation was likely due to the protective α blocking effects of long-term terazosin therapy for his prostatism. α blockers such as terazosin are a well-recognised medical therapy in the perioperative optimisation of phaeochromocytoma because they treat the adrenergic effects of catecholamine release from the tumour such as hypertension. This patient was diagnosed with an ST elevation myocardial infarction (STEMI)...
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28097642/adrenal-cyst-with-both-m%C3%A3-llerian-and-mesothelial-differentiation-a-clinicopathological-and-immunohistochemical-study-with-implications-for-histogenesis
#19
Łukasz Koperski, Benedykt Szczepankiewicz, Paweł Pihowicz, Łukasz Fus, Ewa Wolińska, Barbara Górnicka
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis of which is still not fully understood. In this report we present a case of an adrenal cyst diagnosed incidentally on imaging in a 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement of the lesion, a right-sided laparoscopic adrenalectomy was performed. The cyst was lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, and focally by flat-to-cuboidal, mesothelium-like lining...
January 18, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28091891/adrenal-teratoma-a-case-series-and-review-of-the-literature
#20
Eric J Kuo, Anthony E Sisk, Zhiming Yang, Jiaoti Huang, Michael W Yeh, Masha J Livhits
Adrenal teratomas are rare neoplasms and there is limited data on their surgical outcomes and long-term prognosis. We aimed to review our institutional experience and compare this to the existing literature on adrenal teratomas in adults and children. An institutional pathology database was searched for cases of adrenal teratoma (June 1956-July 2016). Clinical and imaging data were abstracted from the medical records and pathology slides were obtained for review. In addition, a PubMed search for "adrenal teratoma" from June 1952 to July 2016 was performed to identify reports of primary adrenal teratoma in patients of all ages...
January 14, 2017: Endocrine Pathology
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