Ana Casajús, Pablo Zubiaur, Enrique Alday, Paula Soria-Chacartegui, Miriam Saiz-Rodriguez, Lara Gutierrez, Catalina Aragonés, Diana Campodónico, Antía Gómez-Fernández, Marcos Navares-Gómez, Gonzalo Villapalos-García, Gina Mejía-Abril, Dolores Ochoa, Francisco Abad-Santos
Tramadol is an important minor opioid prescribed for pain management. In this work, we analyzed the well-known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5 and CYP3A4) on tramadol efficacy and safety. 108 patients with pain after surgery admitted to a post anesthesia care unit (PACU) and prescribed tramadol were recruited. They were genotyped, and tramadol M1/M2 metabolite concentrations were determined by a newly validated HPLC-MS/MS method...
December 22, 2023: Clinical and Translational Science