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https://www.readbyqxmd.com/read/28830058/contrast-enhanced-ultrasonography-of-the-liver-using-sonovue
#1
Giovanna Ferraioli, Maria Franca Meloni
This review focuses on the use of contrast-enhanced ultrasonography (CEUS) with SonoVue Epub ahead of print (Bracco Imaging) for the diagnosis of focal liver lesions (FLLs), guidance during ablative treatment, and follow-up of liver tumors. Multicenter trials have shown that the performance of CEUS for the characterization of FLLs is similar to that of contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. CEUS with SonoVue has been effectively used for guiding the percutaneous treatment of malignant liver tumors that are invisible or poorly visualized in traditional gray-scale ultrasonography...
July 12, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28829843/magnetic-resonance-imaging-of-optic-nerve-traction-during-adduction-in-primary-open-angle-glaucoma-with-normal-intraocular-pressure
#2
Joseph L Demer, Robert A Clark, Soh Youn Suh, JoAnn A Giaconi, Kouros Nouri-Mahdavi, Simon K Law, Laura Bonelli, Anne L Coleman, Joseph Caprioli
Purpose: We used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG). Methods: Seventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and 31 controls underwent MRI in central gaze and 20° to 30° abduction and adduction. Optic nerve and sheath area centroids permitted computation of midorbital lengths versus minimum paths. Results: Average mean deviation (±SEM) was -8...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28829785/dendrimer-doxorubicin-conjugates-exhibit-improved-anticancer-activity-and-reduce-doxorubicin-induced-cardiotoxicity-in-a-murine-hepatocellular-carcinoma-model
#3
Sibu P Kuruvilla, Gopinath Tiruchinapally, A Colleen Crouch, Mohamed E H ElSayed, Joan M Greve
Hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer-related deaths every year globally. The most common form of treatment, hepatic arterial infusion (HAI), involves the direct injection of doxorubicin (DOX) into the hepatic artery. It is plagued with limited therapeutic efficacy and the occurrence of severe toxicities (e.g. cardiotoxicity). We aim to improve the therapeutic index of DOX delivered via HAI by loading the drug onto generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers targeted to hepatic cancer cells via N-acetylgalactosamine (NAcGal) ligands...
2017: PloS One
https://www.readbyqxmd.com/read/28829736/case-report-zika-virus-meningoencephalitis-and-myelitis-and-associated-magnetic-resonance-imaging-findings
#4
Faruq Pradhan, Joseph D Burns, Ahmed Agameya, Avignat Patel, Mohammad Alfaqih, Juan E Small, Winnie Ooi
Zika virus (ZIKV) has a wide clinical spectrum of associated neurologic disease including microcephaly and Guillain-Barre syndrome but, despite its known neurotropism, ZIKV meningoencephalitis and myelitis have been rare complications. We describe a case of ZIKV meningoencephalitis and probable myelitis and its associated magnetic resonance imaging findings that rapidly resolved during recovery in a previously healthy adult.
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28829620/correlation-of-3d-shift-and-3d-tilt-of-the-patella-in-patients-with-recurrent-dislocation-of-the-patella-and-healthy-volunteers-an-in-vivo-analysis-based-on-3-dimensional-computer-models
#5
Yuzo Yamada, Yukiyoshi Toritsuka, Norimasa Nakamura, Shuji Horibe, Kazuomi Sugamoto, Hideki Yoshikawa, Konsei Shino
BACKGROUND: The concepts of lateral deviation and lateral inclination of the patella, characterized as shift and tilt, have been applied in combination to evaluate patellar malalignment in patients with patellar dislocation. It is not reasonable, however, to describe the 3-dimensional (3D) positional relation between the patella and the femur according to measurements made on 2-dimensional (2D) images. PURPOSE: The current study sought to clarify the relation between lateral deviation and inclination of the patella in patients with recurrent dislocation of the patella (RDP) by redefining them via 3D computer models as 3D shift and 3D tilt...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28829584/two-dimensional-graphene-augments-nanosonosensitized-sonocatalytic-tumor-eradication
#6
Chen Dai, Shengjian Zhang, Zhuang Liu, Rong Wu, Yu Chen
Ultrasound (US) can activate sonosensitizers for sonodynamic therapy (SDT), but the low activation efficiency and therapeutic outcome significantly hinder its further clinical translation. Inspired by the principles of semiconductor physics and photocatalysis chemistry, we herein report on augmenting the sonocatalytic efficiency of semiconductor TiO2-based nanosonosensitizers for highly efficient SDT by the integration of two-dimensional (2D) ultrathin graphene with TiO2 nanosonosensitizers. The high electroconductivity of graphene facilitates the separation of the electrons (e-) and holes (h+) pairs from the energy band of TiO2 and avoids their recombination upon external US irradiation, thus it significantly augments the therapeutic efficiency of TiO2 nanosonosensitizers for SDT against tumor...
August 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28829303/a-subspace-approach-to-spectral-quantification-for-mr-spectroscopic-imaging
#7
Yudu Li, Fan Lam, Bryan Clifford, Zhi-Pei Liang
OBJECTIVE: To provide a new approach for incorporating both spatial and spectral priors into the solution of the spectral quantification problem for magnetic resonance spectroscopic imaging (MRSI). METHODS: A novel signal model is proposed, which represents the spectral distributions of each molecule as a subspace and the entire spectrum as a union-of-subspaces. Based on this model, the spectral quantification can be solved in two steps: a) subspace estimation based on the empirical distributions of the spectral parameters estimated using spectral priors, and b) parameter estimation for the union-of-subspaces model incorporating spatial priors...
August 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28829217/atlas-registration-for-edema-corrected-mri-lesion-volume-in-mouse-stroke-models
#8
Stefan Koch, Susanne Mueller, Marco Foddis, Thomas Bienert, Dominik von Elverfeldt, Felix Knab, Tracy D Farr, René Bernard, Monika Dopatka, André Rex, Ulrich Dirnagl, Christoph Harms, Philipp Boehm-Sturm
Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the lesion and hemispheres. Furthermore, a novel MATLAB toolbox to register mouse brain MR images to the Allen brain atlas is presented. Its capability to calculate edema-corrected lesion size was compared to the manual approach. Automated image registration performed equally well in in a mouse middle cerebral artery occlusion model (Pearson r = 0...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28829051/dopamine-transporter-and-reward-anticipation-in-a-dimensional-perspective-a-multimodal-brain-imaging-study
#9
Manon Dubol, Christian Trichard, Claire Leroy, Anca-Larisa Sandu, Mehdi Rahim, Bernard Granger, Eleni T Tzavara, Laurent Karila, Jean-Luc Martinot, Eric Artiges
Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the Nucleus Accumbens, within the mesolimbic pathway. While dopamine function and reward system neural activity are impaired in most psychiatric disorders, it is unknown if alterations in the dopamine system underlie variations in reward processing across a continuum encompassing health and these disorders. We explored the relationship between dopamine function and neural activity during reward anticipation in twenty-seven participants including healthy volunteers and psychiatric patients with schizophrenia, depression or cocaine addiction, using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) multimodal imaging with a voxel-based statistical approach...
August 22, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28828916/magnetoencephalographic-identification-of-epileptic-focus-in-children-with-generalized-electroencephalographic-eeg-features-but-focal-imaging-abnormalities
#10
Garima Shukla, Jin Kazutaka, Ajay Gupta, John Mosher, Stephen Jones, Andreas Alexopoulos, Richard C Burgess
PURPOSE: Children with generalized seizures are often excluded as epilepsy surgery candidates. This prospective study was conducted to evaluate the utility of magnetoencephalography (MEG) to refine the location of the "irritative zone" in children with single lesions on magnetic resonance imaging (MRI) but with generalized ictal electroencephalographic (EEG) findings. METHODS: Patients admitted with refractory epilepsy with imaging studies showing focal or hemispheric abnormalities but scalp video EEG showing generalized or multiregional epileptiform abnormalities were included...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28828723/the-value-of-advanced-mri-techniques-in-the-assessment-of-cervical-cancer-a-review
#11
REVIEW
Evelyn Dappa, Tania Elger, Annette Hasenburg, Christoph Düber, Marco J Battista, Andreas M Hötker
OBJECTIVES: To assess the value of new magnetic resonance imaging (MRI) techniques in cervical cancer. METHODS: We searched PubMed and MEDLINE and reviewed articles published from 1990 to 2016 to identify studies that used MRI techniques, such as diffusion weighted imaging (DWI), intravoxel incoherent motion (IVIM) and dynamic contrast enhancement (DCE) MRI, to assess parametric invasion, to detect lymph node metastases, tumour subtype and grading, and to detect and predict tumour recurrence...
August 21, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28828623/efficacy-of-double-inversion-recovery-magnetic-resonance-imaging-for-the-evaluation-of-the-synovium-in-the-femoro-patellar-joint-without-contrast-enhancement
#12
Ye Na Son, Wook Jin, Geon-Ho Jahng, Jang Gyu Cha, Yong Sung Park, Seong Jong Yun, So Young Park, Ji Seon Park, Kyung Nam Ryu
OBJECTIVE: To investigate the efficacy of double inversion recovery (DIR) sequence for evaluating the synovium of the femoro-patellar joint without contrast enhancement (CE). METHODS: Two radiologists independently evaluated the axial DIR and CE T1-weighted fat-saturated (CET1FS) images of 33 knees for agreement; the visualisation and distribution of the synovium were evaluated using a four-point visual scaling system at each of the five levels of the femoro-patellar joint and the location of the thickest synovium...
August 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28828531/quantitative-mri-of-fatty-liver-disease-in-a-large-pediatric-cohort-correlation-between-liver-fat-fraction-stiffness-volume-and-patient-specific-factors
#13
Madalsa Joshi, Jonathan R Dillman, Kamalpreet Singh, Suraj D Serai, Alexander J Towbin, Stavra Xanthakos, Bin Zhang, Weizhe Su, Andrew T Trout
PURPOSE: Magnetic resonance imaging (MRI) techniques are increasingly used to quantify and monitor liver tissue characteristics including fat fraction, stiffness, and liver volume. The purpose of this study was to assess the inter-relationships between multiple quantitative liver metrics and patient-specific factors in a large pediatric cohort with known or suspected fatty liver disease. MATERIALS AND METHODS: In this IRB-approved, HIPAA-compliant study, we retrospectively reviewed patient data and quantitative liver MRI results in children with known/suspected fatty liver disease...
August 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28828513/-postmortem-imaging-procedures-experiences-and-perspectives
#14
REVIEW
S von Stillfried, P Isfort, R Knüchel-Clarke
Autopsies are of key importance for the understanding of the anatomy, pathophysiology and pathomorphology. In forensic medicine, the virtual autopsy is a standard instrument in autopsy practice. The advantage of postmortem imaging is the generation of a three-dimensional pre-autopsy snapshot of the body from head to toe with excellent visualization of skeletal pathologies and air inclusions. When angiography is performed, pathologies of the cardiovascular system can additionally be evaluated. The shortcomings of postmortem imaging are the low soft tissue contrast with CT imaging, the lack of haptic, olfactory and color impressions...
August 21, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28828369/lung-imaging-how-to-get-better-look-inside-the-lung
#15
REVIEW
Lorenzo Ball, Veronica Vercesi, Federico Costantino, Karthikka Chandrapatham, Paolo Pelosi
In the last years, imaging has played a key role in the diagnosis and monitoring and critical illness, including acute respiratory distress syndrome (ARDS). Chest X-ray (CXR) and computed tomography (CT) are the conventional techniques most performed in the critically ill patients, the latter being the gold standard to assess lung aeration in ARDS patients. In addition, two bedside techniques are now gaining popularity alongside the conventional ones: lung ultrasound (LUS) and electrical impedance tomography (EIT)...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28828346/hirayama-s-disease-a-rare-clinical-variant-of-amyotrophic-lateral-sclerosis
#16
Swati C Aundhakar, Sanket K Mahajan, Daanish A Chhapra
Hirayama's disease is a rare clinical variant of amyotrophic lateral sclerosis where distal muscles are involved more compared to proximal muscles and vice-versa occurs only in 10% cases and so it is differentiated from O'Sullivan McLeod syndrome which involves only small muscles of single limb. Here, we present a case of Hirayama's disease where disease achieved a plateau after 3 years with no further progression. His electrophysiological studies, and clinical picture, and magnetic resonance imaging findings were consistent with a diagnosis of Hirayama's disease...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28828228/the-impact-of-hemodynamic-variability-and-signal-mixing-on-the-identifiability-of-effective-connectivity-structures-in-bold-fmri
#17
Natalia Z Bielczyk, Alberto Llera, Jan K Buitelaar, Jeffrey C Glennon, Christian F Beckmann
PURPOSE: Multiple computational studies have demonstrated that essentially all current analytical approaches to determine effective connectivity perform poorly when applied to synthetic functional Magnetic Resonance Imaging (fMRI) datasets. In this study, we take a theoretical approach to investigate the potential factors facilitating and hindering effective connectivity research in fMRI. MATERIALS AND METHODS: In this work, we perform a simulation study with use of Dynamic Causal Modeling generative model in order to gain new insights on the influence of factors such as the slow hemodynamic response, mixed signals in the network and short time series, on the effective connectivity estimation in fMRI studies...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828218/recruitment-of-orbitofrontal-cortex-during-unpredictable-threat-among-adults-at-risk-for-affective-disorders
#18
Namik Kirlic, Robin L Aupperle, Masaya Misaki, Rayus Kuplicki, Ruben P Alvarez
BACKGROUND: Mood and anxiety disorders are characterized by altered prefrontal-amygdala function and increased behavioral inhibition (BI) in response to potential threat. Whether these alterations constitute a vulnerability or a symptom of illness remains unclear. The medial orbitofrontal cortex (mOFC) is thought to play a central role in estimating probability and cost of threat, in turn informing selection of subsequent behaviors. To better understand the behavioral and neural processes that may be associated with risk for psychopathology, we used a virtual reality paradigm to examine behavioral and neural responses of psychiatrically healthy adults with familial history of affective disorders during anticipation of unpredictable threat...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828207/cerebral-gray-matter-volume-reduction-in-subcortical-vascular-mild-cognitive-impairment-patients-and-subcortical-vascular-dementia-patients-and-its-relation-with-cognitive-deficits
#19
Maoyu Li, Yao Meng, Minzhong Wang, Shuang Yang, Hui Wu, Bin Zhao, Guangbin Wang
INTRODUCTION: Subcortical vascular mild cognitive impairment (svMCI) is the predementia stage of subcortical vascular dementia (SVaD). The aim of this research is to explore and compare cerebral gray matter (GM) volume reduction in svMCI patients and SVaD patients, and to investigate the relationship between cerebral GM volume reduction and cognitive deficits. METHODS: Thirty one svMCI patients, 29 SVaD patients, and 31 healthy controls were recruited in our research...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828142/acute-anterior-myocardial-infarction-seen-on-conventional-iodine-contrast-ct
#20
Christian Hagdrup, Peter Sommer Ulriksen, Per Lav Madsen
Diagnosis of acute myocardial infarction (AMI) is based on clinical symptoms of chest pain and dyspnea in combination with electrocardiographic changes and a raise in myocardial-specific biomarkers. Imaging is by echocardiography and magnetic resonance. The preferred technique for identification of previous myocardial infarction (MI) is magnetic resonance imaging with late gadolinium technique, but in the acute patient echocardiography is applied. In selected cases, important information can be obtained from other imaging modalities...
September 2017: Radiology case reports
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