keyword
https://read.qxmd.com/read/38476894/effect-of-tofacitinib-on-the-phenotype-and-activity-of-caco%C3%A2-2-cells-in-a-model-of-inflammatory-bowel-disease
#21
JOURNAL ARTICLE
Estera Skudrzyk, Łukasz Bułdak, Grzegorz Machnik, Bogusław Okopień
Reports have indicated that autoimmune bowel disorders affect an increasing number of people on every continent; therefore, it is important to better understand inflammatory bowel disease (IBD) and to explore new treatment options for patients suffering from it. Research has indicated the important role of enterocytes in IBD. Understanding the role of the intestinal epithelium in the pathogenesis of IBD may contribute to a better understanding of the inflammatory processes and aid in the identification of potential therapeutic treatments...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476341/successful-treatment-of-refractory-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome-and-paradoxical-psoriasis-with-secukinumab-a-case-report
#22
Danyang Fan, Fuqiu Li, Zhe Liu, Zhanhan Tang, Sha Lv
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease mainly manifested as skin and osteoarticular lesions. Herein, we describe a female patient with SAPHO syndrome exhibited paradoxical psoriasis and primary palmoplantar pustulosis (PPP) worsened during treatment with adalimumab. We then switched to secukinumab and obtained significant improvement in both skin lesions and osteoarticular pain. These findings suggest that secukinumab might be an appropriate option for patients with SAPHO syndrome who present with TNF-α-inhibitor-induced paradoxical psoriasis...
2024: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/38476167/mechanisms-of-mesothelial-cell-response-to-viral-infections-hdac1-3-inhibition-blocks-poly-i-c-induced-type-i-interferon-response-and-modulates-the-mesenchymal-inflammatory-phenotype
#23
JOURNAL ARTICLE
Flavia Trionfetti, Claudia Montaldo, Ivan Caiello, Giulio Bontempi, Michela Terri, Marta Tiberi, Vanessa Marchant, Alessandro Domenici, Paolo Menè, Marco Cordani, Clemens Zwergel, Giusi Prencipe, Marta Ruiz-Ortega, Sergio Valente, Antonello Mai, Marco Tripodi, Raffaele Strippoli
Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging evidence suggests a role for viral pathogens. Toll-like receptors (TLRs) specifically recognize conserved pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and fungi, thereby orchestrating the ensuing inflammatory/immune responses. Among TLRs, TLR3 recognizes viral dsRNA and triggers antiviral response cascades upon activation...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38475949/effects-of-sitagliptin-activation-of-the-stromal-cell-derived-factor-1-cxc-chemokine-receptor-4-signaling-pathway-on-the-proliferation-apoptosis-inflammation-and-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-induced-by-lipopolysaccharide
#24
JOURNAL ARTICLE
Xiaoxue Tang, Zheng Zhou, Qiqi Li, Dandan Jiang
OBJECTIVES: This study aimed to investigate the effects of sitagliptin on the proliferation, apoptosis, inflammation, and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) in lipopolysaccharide (LPS)-induced inflammatory microenvironment and its molecular mechanism. METHODS: hPDLSCs were cultured in vitro and treated with different concentrations of sitagliptin to detect cell viability and subsequently determine the experimental concentration of sitagliptin...
February 1, 2024: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://read.qxmd.com/read/38474754/metabolic-dysfunction-associated-steatotic-liver-disease-in-a-dish-human-precision-cut-liver-slices-as-a-platform-for-drug-screening-and-interventions
#25
JOURNAL ARTICLE
Mei Li, Frederik T Larsen, Marius C van den Heuvel, Konstanze Gier, Alan R Gorter, Dorenda Oosterhuis, Johan Bijzet, Vincent E de Meijer, Kim Ravnskjaer, Anika Nagelkerke, Peter Olinga
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare problem with limited therapeutic options. Progress in this field depends on the availability of reliable preclinical models. Human precision-cut liver slices (PCLSs) have been employed to replicate the initiation of MASLD, but a comprehensive investigation into MASLD progression is still missing. This study aimed to extend the current incubation time of human PCLSs to examine different stages in MASLD. Healthy human PCLSs were cultured for up to 96 h in a medium enriched with high sugar, high insulin, and high fatty acids to induce MASLD...
February 23, 2024: Nutrients
https://read.qxmd.com/read/38474247/changes-in-inflammatory-cytokines-in-responders-and-non-responders-to-tnf%C3%AE-inhibitor-and-il-17a-inhibitor-a-study-examining-psoriatic-arthritis-patients
#26
JOURNAL ARTICLE
Marie Skougaard, Magnus Friis Søndergaard, Sisse Bolm Ditlev, Lars Erik Kristensen
This study aimed to examine the changes in biomarker levels in responders and non-responders to tumor necrosis factor alpha inhibitor (TNFi) and interleukin-17A inhibitor (IL-17Ai) in psoriatic arthritis (PsA) patients over a 4-month period after treatment initiation. A total of 68 PsA patients initiating either TNFi, IL-17Ai, or methotrexate treatment were included. Blood plasma and clinical outcome measures were collected adjacent to treatment initiation and after four months. A commercially available multiplex immunoassay was included to evaluate 54 biomarkers...
March 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474152/downregulation-of-mitochondrial-fusion-protein-expression-affords-protection-from-canonical-necroptosis-in-h9c2-cardiomyoblasts
#27
JOURNAL ARTICLE
Yuki Toda, Sang-Bing Ong, Toshiyuki Yano, Atsushi Kuno, Hidemichi Kouzu, Tatsuya Sato, Wataru Ohwada, Yuki Tatekoshi, Toshifumi Ogawa, Masaki Shimizu, Masaya Tanno, Masato Furuhashi
Necroptosis, a form of necrosis, and alterations in mitochondrial dynamics, a coordinated process of mitochondrial fission and fusion, have been implicated in the pathogenesis of cardiovascular diseases. This study aimed to determine the role of mitochondrial morphology in canonical necroptosis induced by a combination of TNFα and zVAD (TNF/zVAD) in H9c2 cells, rat cardiomyoblasts. Time-course analyses of mitochondrial morphology showed that mitochondria were initially shortened after the addition of TNF/zVAD and then their length was restored, and the proportion of cells with elongated mitochondria at 12 h was larger in TNF/zVAD-treated cells than in non-treated cells (16...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474034/cellular-and-molecular-determinants-of-biologic-drugs-resistance-and-therapeutic-failure-in-inflammatory-bowel-disease
#28
REVIEW
Pierluigi Puca, Ivan Capobianco, Gaetano Coppola, Federica Di Vincenzo, Valentina Trapani, Valentina Petito, Lucrezia Laterza, Daniela Pugliese, Loris Riccardo Lopetuso, Franco Scaldaferri
The advent of biologic drugs has revolutionized the treatment of Inflammatory Bowel Disease, increasing rates of response and mucosal healing in comparison to conventional therapies by allowing the treatment of corticosteroid-refractory cases and reducing corticosteroid-related side effects. However, biologic therapies (anti-TNFα inhibitors, anti-α4β7 integrin and anti-IL12/23) are still burdened by rates of response that hover around 40% (in biologic-naïve patients) or lower (for biologic-experienced patients)...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474001/synergy-between-pedf-and-doxorubicin-in-breast-cancer-cells-effects-on-metastatic-and-metabolic-pathways
#29
JOURNAL ARTICLE
Raziyeh Abooshahab, Hani Al-Salami, Crispin R Dass
Pigment epithelium-derived factor (PEDF), a serine protease inhibitor (Serpin) family member, shows promise in inhibiting tumour growth. In our study, we explored the effects of PEDF on the efficacy of the frontline chemotherapy agent doxorubicin (Dox) in BC cells. We found that Dox+PEDF treatment significantly reduced glucose uptake in MDA-MB-231 cells compared to the control ( p = 0.0005), PEDF ( p = 0.0137), and Dox ( p = 0.0171) alone but paradoxically increased it in MCF-7 cells. Our findings further revealed that PEDF, Dox, and Dox+PEDF substantially hindered tumour cell migration from tumour spheroids, with Dox+PEDF showing the most significant impact ( p < 0...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472651/involvement-of-calpain-in-neurovascular-unit-damage-through-up-regulating-parp-nf-%C3%AE%C2%BAb-signaling-during-experimental-ischemic-stroke
#30
JOURNAL ARTICLE
Wenhao Yan, Chunyang Wang, Yumei Zhao, Yingying Jiang, Ming Sun
Calpain and PARP-NF-κB signaling are reported to participate in the ischemic brain injury. In this study, it was investigated whether calpain was contributed to the neurovascular unit (NVU) damage through up-regulating PARP-NF-κB signaling during experimental ischemic stroke. Male Sprague-Dawley rats were suffered from 90 min of middle cerebral artery occlusion, followed by reperfusion. The NVU damage was evaluated by the permeability of blood-brain barrier (BBB), the degradation of proteins in extracellular matrix and tight junctions, and ultrastructural changes...
March 12, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38471516/g-protein-coupled-receptor-84-gene-expression-is-regulated-by-the-er-stress-response-in-the-liver
#31
JOURNAL ARTICLE
Soshi Kanemoto
G protein-coupled receptor 84 (Gpr84) is reportedly activated by medium-chain fatty acids and is involved in the pathology of liver fibrosis. Inflammatory stimulants such as lipopolysaccharide and tumor necrosis factor-α upregulate Gpr84 expression. However, the detailed molecular mechanism by which Gpr84 is induced remains unknown. Inflammatory stimulation also evokes endoplasmic reticulum (ER) stress, but there has been no direct evidence to link Gpr84 expression and the ER stress response. Administration of tunicamycin (Tm) provokes ER stress and acute steatosis in the liver tissue of mice...
March 12, 2024: Journal of Biochemistry
https://read.qxmd.com/read/38469019/erythromelalgia-secondary-to-anti-tumor-necrosis-factor-tnf-alpha-therapy-a-report-of-two-cases
#32
Fatima Zahra El Rhaoussi, Zineb Boukhal, Fouad Haddad, Mohamed Tahiri, Wafaa Hliwa, Ahmed Bellabah, Badre Wafaa
Erythromelalgia is a rare syndrome with a generally unknown etiology. Whether primary or secondary, this condition is characterized by paroxysmal episodes of erythema, pain, and heat in the extremities. We report two cases of erythromelalgia occurring after the initiation of treatment with infliximab. The first case involves a 38-year-old patient who had been followed since August 2022 for ileocolonic Crohn's disease classified as A2L3B3 according to the Montreal classification, which was resistant to treatment and required infliximab therapy...
February 2024: Curēus
https://read.qxmd.com/read/38468819/a-teenage-girl-with-altered-mental-status-and-paraparesis
#33
Ryo Miyakawa, Janice Louie, Chris Keh, Lisa Chen, Babak Javid, Joel D Ernst, Neela Goswami, Felicia C Chow
A teenage girl presented with fever and altered mental status. MRI showed diffuse leptomeningeal enhancement of the brain and spine. She was diagnosed by a positive cerebrospinal fluid (CSF) culture with tuberculous (TB) meningitis and was started on anti-TB medications and corticosteroids. Her mental status improved, but she was noted to have proximal weakness of the lower extremities. In the course of tapering corticosteroids at week 11 of anti-TB therapy, she became acutely confused and febrile. MRI demonstrated interval development of tuberculomas in the brain and a mass lesion in the thoracic spine causing cord compression...
May 2024: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/38468451/cooperative-induction-of-cxcl-chemokines-by-inflammatory-cytokines-and-oxidized-phospholipids
#34
JOURNAL ARTICLE
Alma Hodzic, Bernd Gesslbauer, Valery Bochkov, Olga V Oskolkova
Inflammation is initiated and driven by a mixture of mediators, which modify effects of each other. This study analysed in vitro pro-inflammatory activity of inflammatory cytokines (TNFα and IL-1β) in a combination with a lipid DAMP molecule, oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC). The study was performed on endothelial and monocytic cell lines. The cells were treated with different concentrations of TNFα or IL-1β, OxPAPC and their combinations, either in the presence or absence of drugs regulating inflammation...
March 11, 2024: Immunology
https://read.qxmd.com/read/38467420/interrogating-endothelial-barrier-regulation-by-temporally-resolved-kinase-network-generation
#35
JOURNAL ARTICLE
Ling Wei, Selasi Dankwa, Kamalakannan Vijayan, Joseph D Smith, Alexis Kaushansky
Kinases are key players in endothelial barrier regulation, yet their temporal function and regulatory phosphosignaling networks are incompletely understood. We developed a novel methodology, Temporally REsolved KInase Network Generation (TREKING), which combines a 28-kinase inhibitor screen with machine learning and network reconstruction to build time-resolved, functional phosphosignaling networks. We demonstrated the utility of TREKING for identifying pathways mediating barrier integrity after activation by thrombin with or without TNF preconditioning in brain endothelial cells...
May 2024: Life Science Alliance
https://read.qxmd.com/read/38467155/recent-advances-in-molecular-pathways-and-therapeutic-implications-for-peptic-ulcer-management-a-comprehensive-review
#36
JOURNAL ARTICLE
Deepak Chandra Joshi, Nirmal Joshi, Ajeet Kumar, Shubhrat Maheshwari
Peptic ulcers, recognized for their erosive impact on the gastrointestinal mucosa, present a considerable challenge in gastroenterology. Epidemiological insights underscore the global prevalence of peptic ulcers, affecting 5-10+% of individuals, with a yearly incidence of 0.3 to 1.9 cases per thousand. Recent decades have witnessed a decline in complications, attributed to improved diagnostics and therapeutic advancements. The review deepens into H. pylori -associated and NSAID-induced ulcers, emphasizing their distinct prevalence in developing and industrialized nations, respectively...
March 11, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38466213/mirikizumab-omvoh-for-ulcerative-colitis
#37
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38466121/isorhamnetin-ameliorates-cisplatin-induced-acute-kidney-injury-in-mice-by-activating-slpi-mediated-anti-inflammatory-effect-in-macrophage
#38
JOURNAL ARTICLE
Jia Jian, Li Yu-Qing, Han Rang-Yue, Zhong Xia, Xie Ke-Huan, Yan Ying, Wang Li, Tan Rui-Zhi
Objective: Isorhamnetin (IH) has been reported to have significant anti-inflammatory effects in various diseases, but its role and mechanism in AKI remain unclear. This study aimed to explore the potential role and mechanism of isorhamnetin in inhibiting macrophage related inflammation and improving AKI injury. Methods: We established an AKI mouse model by intraperitoneal injection of cisplatin in vivo , and constructed an inflammatory cell model by stimulating RAW264.7 cells with LPS. Creatinine and urea nitrogen were measured to evaluate the changes of renal function in AKI mice...
March 11, 2024: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/38464510/pain-in-axial-spondyloarthritis-role-of-the-jak-stat-pathway
#39
REVIEW
Carlo Selmi, Maria Sole Chimenti, Lucia Novelli, Bhumik K Parikh, Francesca Morello, Kurt de Vlam, Francesco Ciccia
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that is characterized by new bone formation in the axial musculoskeletal system, with X-ray discriminating between radiographic and non-radiographic forms. Current therapeutic options include non-steroidal anti-inflammatory drugs in addition to biological disease-modifying anti-rheumatic drugs that specifically target tumor necrosis factor-alpha (TNFα) or interleukin (IL)-17. Pain is the most critical symptom for axSpA patients, significantly contributing to the burden of disease and impacting daily life...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38464096/diet-induced-metabolic-and-immune-impairments-are-sex-specifically-modulated-by-soluble-tnf-signaling-in-the-5xfad-mouse-model-of-alzheimer-s-disease
#40
Maria Elizabeth De Sousa Rodrigues, MacKenzie L Bolen, Lisa Blackmer-Raynolds, Noah Schwartz, Jianjun Chang, Malú Gámez Tansey, Timothy Robert Sampson
UNLABELLED: Emerging evidence indicates that high-fat, high carbohydrate diet (HFHC) impacts central pathological features of Alzheimer's disease (AD) across both human incidences and animal models. However, the mechanisms underlying this association are poorly understood. Here, we identify compartment-specific metabolic and inflammatory dysregulations that are induced by HFHC diet in the 5xFAD mouse model of AD pathology. We observe that both male and female 5xFAD mice display exacerbated adiposity, cholesterolemia, and dysregulated insulin signaling...
February 28, 2024: bioRxiv
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