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https://www.readbyqxmd.com/read/28936960/-role-of-phosphorylated-moesin-in-the-injury-of-pulmonary-microvascular-endothelial-cells-of-rats-and-its-mechanism
#1
Gang Wang, Gengyun Sun
OBJECTIVE: To investigate the role of phosphorylated Moesin (p-Moesin) in the injury of pulmonary microvascular endothelial cells (PMVECs) of rats induced by tumor necrosis factor-α (TNF-α), and to approach the impact of Rac1 signal pathway on Moesin phosphorylation. METHODS: PMVECs of rats were cultured in vitro and passed on to the third generation, and the TNF-α time-effect experiment, dose-effect experiment and Rac1 signaling pathway intervention experiment were performed respectively...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28935544/metformin-improves-obesity-associated-inflammation-by-altering-macrophages-polarization
#2
Yuanyuan Jing, Fan Wu, Dai Li, Lei Yang, Qi Li, Rong Li
Obesity is reported to be a chronic low-grade inflammatory state. Adipose tissue macrophages play a key role in obesity-related inflammation. Metformin, the most widely used anti-diabetic drug, has recently been reported to have an effect on inflammation, but the mechanism is poorly understood. This study aims to investigate how metformin works on chronic low-grade inflammation in obesity and whether the mechanism underlying it is associated with macrophage polarization. Metformin was administered for 7 weeks to high fat-fed C57/6J male mice in vivo...
September 18, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28935002/spontaneous-development-of-cutaneous-squamous-cell-carcinoma-in-mice-with-cell-specific-deletion-of-inhibitor-of-%C3%AE%C2%BAb-kinase-2
#3
Kelly S Kirkley, Kelly D Walton, Colleen Duncan, Ronald B Tjalkens
The deletion of NFκB in epithelial tissues by using skin-specific promoters can cause both tumor formation and severe inflammatory dermatitis, indicating that this signaling pathway is important for the maintenance of immune homeostasis in epithelial tissues. In the present study, we crossed mice transgenic for loxP-Ikbk2 and human Gfap-cre to selectively delete IKK2 in CNS astrocytes. Unexpectedly, a subset of mice developed severe and progressive skin lesions marked by hyperplasia, hyperkeratosis, dysplasia, inflammation, and neoplasia with a subset of lesions diagnosed as squamous cell carcinoma (SCC)...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28934756/tumor-necrosis-factor-receptor-mediates-fibroblast-growth-factor-inducible-14-signaling
#4
Xuening Wang, Shengxiang Xiao, Yumin Xia
Tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) engages its sole receptor, fibroblast growth factor-inducible 14 (Fn14), which participates in various inflammatory and immunologic processes. TWEAK/Fn14 interaction induces different cell fates depending on the local microenvironment, which correlates with certain expression profiles of TNF receptors (TNFR). The predominant expression of TNFR1 or TNFR2 facilitates cell death or proliferation, respectively, on TWEAK/Fn14 activation. TNFR-associated factors (TRAF) interact with Fn14, cellular inhibitor of apoptosis protein (cIAP)-1, and TNFR, consequently transducing signals from TWEAK to downstream cytokines and cell cycle mediators...
September 21, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28933987/rna-seq-analysis-provide-new-insights-into-mapk-signaling-of-apolipoproteinciii-induced-inflammation-in-porcine-vascular-endothelial-cells
#5
Yuan Yue, Hao Jiang, Shouqing Yan, Yao Fu, Chang Liu, Xulei Sun, Menglong Chai, Yan Gao, Bao Yuan, Chengzhen Chen, Lisheng Dai, Jiabao Zhang, Yu Ding
Apolipoprotein CIII (ApoCIII) has been shown to be associated with the inflammatory response, but the mechanism of its inflammatory effects remains unclear. Because vascular endothelial cells (VECs) play a key role in the development of inflammation, the present study was performed to investigate inflammatory mechanisms induced by ApoCIII in VECs. In this study, we screened differentially expressed genes (DEGs) using RNA-sequencing. The results identified 390 up-regulated genes and 257 down-regulated genes...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28933726/mollugin-has-an-anti-cancer-therapeutic-effect-by-inhibiting-tnf-%C3%AE-induced-nf-%C3%AE%C2%BAb-activation
#6
Zhe Wang, Ming Yue Li, Chunliu Mi, Ke Si Wang, Juan Ma, Xuejun Jin
The NF-κB signaling pathway plays a pivotal role in regulating the immune response and inflammation. However, it has been shown that NF-κB also has a major role in oncogenesis. Therefore, NF-κB inhibitors have been considered as potential drugs against cancer. Herein, we searched for NF-κB inhibitors from natural sources and identified mollugin from the roots of Rubia cordifolia L. as an inhibitor of NF-κB activation. We found that mollugin significantly inhibited the expression of an NF-κB reporter gene induced by tumor necrosis factor (TNF)-α in a dose-dependent manner...
July 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28931201/tnf-%C3%AE-inhibitor-as-a-cause-of-refractory-suppurative-laryngitis-and-rhinosinusitis
#7
Sevtap Akbulut, Lyndsay L Madden, Berrylin J Ferguson, Clark A Rosen
No abstract text is available yet for this article.
September 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28929503/induction-of-heme-oxygenase-1-increases-infection-of-dog-macrophages-by-l-infantum
#8
Breno Fernando Martins de Almeida, Kathlenn Liezbeth Oliveira Silva, Gabriela Lovizutto Venturin, Vanessa Marim Chiku, Aline Aparecida Correa Leal, Anelise Maria Bosco, Paulo Cesar Ciarlini, Valéria Marçal Felix de Lima
AIMS: We aimed to induce and inhibit HO-1, ascertaining its effect on infection rate, parasite load and the levels of superoxide, reactive oxygen species (ROS), nitric oxide (NO), TNF-alpha and IL-10 in cultured macrophages from healthy dogs infected by Leishmania infantum. METHODS AND RESULTS: Macrophages obtained from 15 healthy dogs were cultured alone or infected with L. infantum, with or without association of HO-1 inducer and inhibitor. The infection rate and the parasite load were determined by the number of infected macrophages and number of promastigotes per macrophage, respectively...
September 20, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28929123/in-vitro-immunomodulatory-activity-of-a-transition-state-analog-inhibitor-of-human-purine-nucleoside-phosphorylase-in-cutaneous-leishmaniasis
#9
Natália Barbosa Carvalho, Fernanda Ventin de Oliveira Prates, Rafael de Castro da Silva, Mayra Elizabeth Ferreira Dourado, Camila Farias Amorim, Paulo Roberto Lima Machado, Fernanda Grendene Pacheco, Temis Weber Furlanetto Corte, Pablo Machado, Diógenes Santiago Santos, Edgar Marcelino de Carvalho
Cutaneous leishmaniasis (CL) is the most common clinical form of American tegumentary leishmaniasis caused by Leishmania (Viannia) braziliensis. CL is associated with a strong Th1 immune response. This exacerbated inflammatory response is correlated with severity of disease and delays the healing time of the ulcer. The fourth-generation immucillin derivative (DI4G), a potent inhibitor of purine nucleoside phosphorylase, has been proposed as a promising agent in the treatment of diseases associated with T cell activation...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28928604/kaempferide-protects-against-myocardial-ischemia-reperfusion-injury-through-activation-of-the-pi3k-akt-gsk-3%C3%AE-pathway
#10
Dong Wang, Xinjie Zhang, Defang Li, Wenjin Hao, Fanqing Meng, Bo Wang, Jichun Han, Qiusheng Zheng
The aim of this study is to investigate both the efficacy and mechanism of action of kaempferide (Kae) as a therapy for the treatment of cardiovascular disease. A rat model of myocardial ischemia/reperfusion (I/R) injury was established by ligation of the left anterior descending coronary artery for 30 min followed by a 2 h perfusion. In our study, we show that Kae remarkably improved cardiac function, alleviated myocardial injury via a decrease in myocardial enzyme levels, and attenuated myocardial infarct size in a dose-dependent manner...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28927688/effects-of-dietary-hawthorn-extract-on-growth-performance-immune-responses-growth-and-immune-related-genes-expression-of-juvenile-golden-pompano-trachinotus-ovatus-and-its-susceptibility-to-vibrio-harveyi-infection
#11
Xiaohong Tan, Zhenzhu Sun, Zhong Huang, Chuanpeng Zhou, Heizhao Lin, Lianjie Tan, Pengwei Xun, Qian Huang
The present study was conducted to investigate the effects of dietary hawthorn extract (HTE) supplementation on growth performance, immune responses, hepatic antioxidant abilities, growth- and immune-related and heat shock protein genes expression and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with HTE at 0 (Diet 1), 0.50 (Diet 2), 1.00 (Diet 3), 2.00 (Diet 4), 4.00 (Diet 5) and 10.00 (Diet 6) g kg(-1) were fed to golden pompano for 8 weeks. The highest final body weight, weight gain rate, specific growth rate, feed efficiency ratio and protein efficiency rate were observed in fish fed Diet 2 (P < 0...
September 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28923396/smac-mimetics-and-type-ii-interferon-synergistically-induce-necroptosis-in-various-cancer-cell-lines
#12
Michael John Cekay, Stefanie Roesler, Tanja Frank, Anne-Kathrin Knuth, Ines Eckhardt, Simone Fulda
Since cancer cells often evade apoptosis, induction of necroptosis as another mode of programmed cell death is considered as a promising therapeutic alternative. Here, we identify a novel synergistic interaction of Smac mimetics that antagonize x-linked Inhibitor of Apoptosis (XIAP), cellular Inhibitor of Apoptosis (cIAP) 1 and 2 with interferon (IFN)γ to induce necroptosis in apoptosis-resistant cancer cells in which caspase activation is blocked. The synergistic is confirmed by calculation of combination indices (CIs) and found in both solid and hematological cancer cell lines as well as for different Smac mimetics (i...
September 18, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28923390/tnf-%C3%AE-and-il-6-inhibitors-conjugates-of-n-substituted-indole-and-aminophenylmorpholin-3-one-as-anti-inflammatory-agents
#13
Palwinder Singh, Sukhmeet Kaur, Anuradha Sharma, Gurcharan Kaur, Rajbir Bhatti
The conjugates obtained by the combination of indole and aminophenyl morpholinone were screened for TNF-α and IL-6 inhibition in microglial cells. Compound 4 was found to be the most potent anti-inflammatory agent as it reduced LPS induced level of inflammatory cytokines TNF-α and IL-6 by 71% and 53%, respectively. A significant decrease in NO and MMPs release from BV2 cells in culture pretreated with this compound as well as inhibition of nuclear translocation of NF-κB and AP-1 was observed. 75% inhibition of acetic acid induced algesia in swiss albino mice was noticed in the presence of compound 4...
September 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28923269/dpp-4-inhibition-protects-human-umbilical-vein-endothelial-cells-from-hypoxia-induced-vascular-barrier-impairment
#14
Naoko Hashimoto, Kento Ikuma, Yui Konno, Masanori Hirose, Hiroyuki Tadokoro, Hiroshi Hasegawa, Yoshio Kobayashi, Hiroyuki Takano
Dipeptidyl peptidase-4 (DPP-4) inhibitors are relatively new class of anti-diabetic drugs. Some protective effects of DPP-4 on cardiovascular disease have been described independently from glucose-lowering effect. However, the detailed mechanisms by which DPP-4 inhibitors exert on endothelial cells remain elusive. The purpose of this research was to determine the effects of DPP-4 inhibitor on endothelial barrier function. Human umbilical vein endothelial cells (HUVECs) were cultured and exposed to hypoxia in the presence or absence of Diprotin A, a DPP-4 inhibitor...
August 26, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28923114/homocysteine-exaggerates-microglia-activation-and-neuroinflammation-through-microglia-localized-stat3-overactivation-following-ischemic-stroke
#15
Shuang Chen, Zhiping Dong, Man Cheng, Yaqian Zhao, Mengying Wang, Na Sai, Xuan Wang, Huan Liu, Guowei Huang, Xumei Zhang
BACKGROUND: Elevated plasma homocysteine (Hcy) levels have been indicated as a strong and modifiable risk factor of ischemic stroke; the previous studies have shown that exposure to Hcy activates cultured microglia. However, whether neurotoxicity of Hcy involves microglia activation following brain ischemia and the underlying mechanisms remains incompletely understood. METHODS: The cerebral damage was evaluated by staining with 2,3,5-triphenyltetrazolium chloride, hematoxylin-eosin, and Fluoro Jade B...
September 18, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28923082/characterization-of-a-secreted-cystatin-of-the-parasitic-nematode-haemonchus-contortus-and-its-immune-modulatory-effect-on-goat-monocytes
#16
Yujian Wang, Lingyan Wu, Xinchao Liu, Shuai Wang, Muhammad Ehsan, RuoFeng Yan, XiaoKai Song, LiXin Xu, XiangRui Li
BACKGROUND: Haemonchosis is a disease of the small ruminant caused by a nematode parasite Haemonchus contortus, and it is most important and alarming challenges to the small ruminant's production. The infection of the H. contortus could cause high economic losses worldwide. H. contortus is a blood feeding parasite which penetrates into the abomasal mucosa to feed the blood of the host and causing the anemia and decreased total plasma protein. Modulation and suppression of the immune response of the host by nematode parasites have been reported extensively, and the cysteine protease inhibitor (cystatin) is identified as one of the major immunomodulators...
September 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28922437/molecular-biomarkers-as-predictors-for-biliary-complications-following-liver-transplantation-a-prospective-study
#17
Bogdan Dorobantu, Irinel Popescu, Simona Dima, Anca Nastase, Speranta Iacob
BACKGROUND: The biliary complications (BC) have been always considered the "Achilles' heel" of liver transplantation (LT), being one of the leading causes of postoperative morbidity. AIM: To analyse predictors of BC, by monitoring in the peripheral blood the biomarkers involved in the inflammation and hepatic fibrosis, such as the matrix metalloproteinases (MMP 2, 9) and their tissue inhibitors (TIMP1), the interleukins (IL 2, 8), alfa-TNF, the endothelins and their receptors...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28921811/a-role-for-the-non-receptor-tyrosine-kinase-ack1-in-tnf-alpha-mediated-apoptosis-and-proliferation-in-human-intestinal-epithelial-caco-2-cells
#18
Xinmei Zhao, Chaolan Lv, Shenbo Chen, Fachao Zhi
The roles of tumor necrosis factor alpha (TNF-alpha) and its mediators in cellular processes related to intestinal diseases remain elusive. In this study, we aimed to determine the biological role of activated Cdc42-associated kinase 1 (ACK1) in TNF-alpha-mediated apoptosis and proliferation in Caco-2 cells. ACK1 expression was knocked down using ACK1-specific siRNAs, and ACK1 activity was disrupted using a small molecule ACK1 inhibitor. The Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (TUNEL) and the BrdU incorporation assays were used to measure apoptosis and cell proliferation, respectively...
September 16, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28919340/design-and-synthesis-of-pregnenolone-2-cyanoacryloyl-conjugates-with-dual-nf-%C3%AE%C2%BAb-inhibitory-and-anti-proliferative-activities
#19
Jia-Li Song, Juan Zhang, Chang-Liang Liu, Chao Liu, Kong-Kai Zhu, Fei-Fei Yang, Xi-Gong Liu, João Paulo Figueiró Longo, Luis Alexandre Muehlmann, Ricardo Bentes Azevedo, Yu-Ying Zhang, Yue-Wei Guo, Cheng-Shi Jiang, Hua Zhang
Twenty-five novel pregnenolone/2-cyanoacryloyl conjugates (6-30) were designed and prepared, with the aim of developing novel anticancer drugs with dual NF-κB inhibitory and anti-proliferative activities. Compounds 22 and 27-30 showed inhibition against TNF-α-induced NF-κB activation in luciferase assay, which was confirmed by Western blotting. Among them, compound 30 showed potent NF-κB inhibitory activity (IC50=2.5μM) and anti-proliferative against MCF-7, A549, H157, and HL-60 cell lines (IC50=6.5-36...
September 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28917996/poor-efficacy-of-tnf-inhibitors-in-non-radiographic-axial-spondyloarthritis-in-the-absence-of-objective-signs-a-bicentric-retrospective-study
#20
Céline Vidal, Cédric Lukas, Bernard Combe, Francis Berenbaum, Yves Marie Pers, Christian Jorgensen, Jérémie Sellam, Jacques Morel
OBJECTIVE: To compare BASDAI 50 response rate to TNFi in axial spondyloarthritis (axSpA) depending on the presence or not of objective signs of axSpA and to look for predictive factors of TNFi efficacy. METHODS: Patients diagnosed with axSpA according to ASAS criteria "clinical arm" and treated between January 2001 and September 2015 with TNFi were included. First group included patients with at least one objective sign such as arthritis, dactylitis, enthesitis, uveitis, inflammatory bowel disease, elevated C-reactive protein or radiological sacroiliitis, and second group included non-radiographic axSpA (nr-axSpA) patients without any objective sign corresponding to patients with inflammatory back pain and either a good response to NSAID or a SpA family history...
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
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