Shivraj M Yabaji, Vadim Zhernovkov, Prasanna Babu Araveti, Suruchi Lata, Oleksii S Rukhlenko, Salam Al Abdullatif, Yuriy Alekseev, Qicheng Ma, Gargi Dayama, Nelson C Lau, William R Bishai, Nicholas A Crossland, Joshua D Campbell, Boris N Kholodenko, Alexander A Gimelbrant, Lester Kobzik, Igor Kramnik
A quarter of human population is infected with Mycobacterium tuberculosis , but less than 10% of those infected develop clinical, mostly pulmonary, TB. To dissect mechanisms of susceptibility in immunocompetent individuals, we developed a genetically defined sst1 -susceptible mouse model that uniquely reproduces a defining feature of human TB: development of necrotic lung lesions after infection with virulent Mtb. In this study, we explored the connectivity of the sst1 -regulated pathways during prolonged macrophage activation with TNF...
March 10, 2024: bioRxiv