Read by QxMD icon Read


Kenichi Asano, Kenta Kikuchi, Masato Tanaka
Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype, and ontogeny. They acquire tissue-specific phenotype in order to maintain normal tissue physiology. This review summarizes the current knowledge about the functions of CD169-positive macrophage subset residing in the lymphoid organs and intestinal tract. Strategically positioned at the interface between tissue and circulating fluid, CD169+ macrophages in the lymphoid organs capture blood- and lymph-borne particulate materials...
June 14, 2018: Journal of Biochemistry
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Takuto Hikichi, Hiromasa Ohira
AIM: To investigate the location to which a pancreatic stent should be inserted to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). METHODS: Over a ten-year period at our hospital, 296 patients underwent their first ERCP procedure and had a pancreatic stent inserted; this study included 147 patients who had ERCP performed primarily for biliary investigation and had a pancreatic stent inserted to prevent PEP. We divided these patients into two groups: 131 patients with a stent inserted into the pancreatic head (head group) and 16 patients with a stent inserted up to the pancreatic body or tail (body/tail group)...
June 14, 2018: World Journal of Gastroenterology: WJG
Shintaro Mandai, Takayasu Mori, Naohiro Nomura, Taisuke Furusho, Yohei Arai, Hiroaki Kikuchi, Emi Sasaki, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
With-no-lysine (K) (WNK) kinases, which are mutated in the inherited form of hypertension pseudohypoaldosteronism type II, are essential regulators of membrane ion transporters. Here, we report that WNK1 positively regulates skeletal muscle cell hypertrophy via mediating the function of the pro-longevity transcription factor forkhead box protein O4 (FOXO4) independent of the conventional WNK signaling pathway linking SPS/STE20-related proline-alanine-rich kinase (SPAK)/oxidative stress response kinase 1 (OSR1) to downstream effector ion transporters...
June 14, 2018: Scientific Reports
Tomo Aoyagi, Fumiaki Morishita, Yutaka Sugiyama, Daisuke Ichikawa, Daisuke Mayumi, Yoshitomo Kikuchi, Atsushi Ogata, Kenji Muraoka, Hiroshi Habe, Tomoyuki Hori
1,4-Dioxane is one of the most common and persistent artificial pollutants in petrochemical industrial wastewaters and chlorinated solvent groundwater plumes. Despite its possible biological treatment in natural environments, the identity and dynamics of the microorganisms involved are largely unknown. Here, we identified active and diverse 1,4-dioxane-degrading microorganisms from activated sludge by high-sensitivity stable isotope probing of rRNA. By rigorously analyzing 16S rRNA molecules in RNA density fractions of 13 C-labeled and unlabeled 1,4-dioxane treatments, we discovered 10 significantly 13 C-incorporating microbial species from the complex microbial community...
June 13, 2018: ISME Journal
Makoto Takeda, Takanori Sakaguchi, Takanori Hiraide, Yasushi Shibasaki, Yoshifumi Morita, Hirotoshi Kikuchi, Koji Ikegami, Mitsutoshi Setou, Hiroyuki Konno, Hiroya Takeuchi
The molecular features of hepatocellular carcinoma arising from non-alcoholic fatty liver disease (NAFLD-HCC) are not well known. In this study, we investigated the mechanism by which NAFLD-HCC survives in a fat-rich environment. We found that caveolin (CAV)-1 was overexpressed in clinical specimens from NAFLD-HCC patients. HepG2, HLE, and HuH-7 HCC cell lines showed decreased proliferation in the presence of the saturated fatty acids palmitic acid and stearic acid, although only HLE cells expressed high levels of CAV-1...
June 13, 2018: Cancer Science
Shiyan Feng, Shoichi Kondo, Takahiro Kaseyama, Taichi Nakazawa, Takamasa Kikuchi, Roman Selyanchyn, Shigenori Fujikawa, Liana Christiani, Kazunari Sasaki, Masamichi Nishihara
The data presented in this article are related to polymer-polymer type charge-transfer blend membranes for fuel cell application. The visible spectra of the charge-transfer (CT) blend membranes indicated formation of CT complex in the blend membranes, and behavior of CT complex formation by polymers was clarified by Job plot of the visible spectra. The effect of fluorine for membrane property and fuel cell performance of CT blend membranes were evaluated by 19 F NMR and overvoltage analysis, respectively.
June 2018: Data in Brief
Ann Rancourt, Sébastien S Dufresne, Guillaume St-Pierre, Julie-Christine Lévesque, Haruka Nakamura, Yodai Kikuchi, Masahiko S Satoh, Jérôme Frenette, Sachiko Sato
The muscle membrane, sarcolemma, must be firmly attached to the basal lamina. The failure of proper attachment results in muscle injury, which is the underlying cause of Duchenne muscular dystrophy (DMD), in which mutations in the dystrophin gene disrupts the firm adhesion. In patients with DMD, even moderate contraction causes damage, leading to progressive muscle degeneration. The damaged muscles are repaired through myogenesis. Consequently, myogenesis is highly active in patients with DMD, and the repeated activation of myogenesis leads to the exhaustion of the myogenic stem cells...
June 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Masae Sakuma, Ayaka Suzuki, Minako Kikuchi, Hidekazu Arai
The objective was to evaluate the effect of replacing milk with soymilk or calcium-fortified soymilk as a part of a meal on postprandial serum phosphorus levels. This study had a randomized crossover design. Ten healthy subjects were enrolled and consumed three test meals that contained either milk, soymilk, or calcium-fortified soymilk containing the same amount of calcium as milk. Blood samples were collected at 0, 30, 60, 120, 240 and 360 min and urine samples were collected from 0 to 360 min after consuming the test meal...
May 2018: Journal of Clinical Biochemistry and Nutrition
Kimiyo Kikuchi, Junko Yasuoka, Keiko Nanishi, Ashir Ahmed, Yasunobu Nohara, Mariko Nishikitani, Fumihiko Yokota, Tetsuya Mizutani, Naoki Nakashima
In South-East Asia, the maternal and child mortality rate has declined over the past decades; however, it varies among and within the countries in the region, including Cambodia. The continuum of care is an integrated series of care that women and children are required to avail continuously from pregnancy to the child/motherhood period. This study aimed to assess the completion rate of the continuum of care and examine the factors associated with the continuum of care in Ratanakiri, Cambodia. A cross-sectional study was conducted in Ratanakiri...
2018: PloS One
Tetsushi Kubota, Shinji Kuroda, Nobuhiko Kanaya, Toshiaki Morihiro, Katsuyuki Aoyama, Kakiuchi Yoshihiko, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Toshiyoshi Fujiwara
An issue of concern is that no current HER2-targeted therapeutic agent is effective against Trastuzumab (Tmab)-resistant gastric cancer. Gold nanoparticles (AuNPs) are promising drug carriers with unique characteristics of a large surface area available for attachment of materials such as antibodies. Here, we created HER2-targeted AuNPs (T-AuNPs) and examined their therapeutic efficacy and cytotoxic mechanisms using HER2-postive Tmab-resistant (MKN7) or Tmab-sensitive (NCI-N87) gastric cancer cell lines. In vitro, T-AuNPs showed stronger cytotoxic effects than controls against MKN7 and NCI-N87 cells although Tmab had no effect on MKN7 cells...
June 7, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Hirokazu Kumazaki, Masako Okamoto, Sho Kanzaki, Ken-Ichi Okada, Masaru Mimura, Yoshio Minabe, Mitsuru Kikuchi
Olfactory traits in individuals with autism spectrum disorder (ASD) are considered the strongest predictors of social impairment. Compared to other sensory abnormalities, olfactory abnormalities in individuals with ASD are poorly understood. In this chapter, we provide an overview of the current assessment in individuals with ASD. Several confounding factors have to be considered when conducting research on olfaction in individuals with ASD. Qualitative measures of olfaction contain only limited information about the olfactory stimuli...
2018: Methods in Molecular Biology
Maria Ioanna Stefanou, German Ott, Ulf Ziemann, Annerose Mengel
No abstract text is available yet for this article.
June 8, 2018: BMJ Case Reports
Masahiko Kemmochi, Shigeru Sasaki, Masako Takahashi, Tomitaka Nishimura, Chisa Aizawa, Jun Kikuchi
Introduction: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint...
June 2018: Journal of Orthopaedics
Koji Kikuchi, Akira Nakamura, Masaki Arata, Dongbo Shi, Mami Nakagawa, Tsubasa Tanaka, Tadashi Uemura, Toshihiko Fujimori, Akira Kikuchi, Akiyoshi Uezu, Yasuhisa Sakamoto, Hiroyuki Nakanishi
The Wnt signaling pathway can be grouped into two classes, the β-catenin-dependent and β-catenin-independent pathways. Wnt5a signaling through a β-catenin-independent pathway promotes microtubule (MT) remodeling during cell-substrate adhesion, cell migration, and planar cell polarity formation. Although Wnt5a signaling and MT remodeling are known to form an interdependent regulatory loop, the underlying mechanism remains unknown. Here we show that in HeLa cells, the paralogous MT-associated proteins Map7 and Map7D1 (Map7/7D1) form an interdependent regulatory loop with Disheveled, the critical signal transducer in Wnt signaling...
June 7, 2018: EMBO Reports
Hiroyuki Oshikane, Masahiko Watabe, Kazue Kikuchi-Utsumi, Toshio Nakaki
The PRA1-superfamily member PRAF3 plays pivotal roles in membrane traffic as a GDI displacement factor via physical interaction with a variety of Rab proteins, as well as in the modulation of antioxidant glutathione through its interaction with EAAC1 (SLC1A1). Overproduction of PRAF3 is known to be toxic to the host cells, although the factors capable of cancelling the toxicity remained unknown. We here show that Rab1a can rescue the cytotoxicity caused by PRAF3 possibly by "positively" regulating ER-Golgi trafficking, cancelling the "negative" modulation by PRAF3...
July 2018: Biochemistry and Biophysics Reports
Yasutaka Kuribayashi, Toshiro Iizuka, Kosuke Nomura, Tsukasa Furuhata, Satoshi Yamashita, Akira Matsui, Daisuke Kikuchi, Toshifumi Mitani, Mitsuru Kaise, Shu Hoteya
BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is sometimes extensive, and in our experience, patients not infrequently present with dysphagia after ESD even in the absence of esophageal stricture. The aim of this study was to evaluate esophageal motility using high-resolution manometry (HRM) in patients with and without dysphagia after extensive circumferential ESD. METHODS: HRM was performed in a total of 52 patients who had undergone ESD for superficial esophageal cancer and a mucosal defect after ESD exceeded more than two-thirds of the esophageal circumference...
June 5, 2018: Digestion
Kosuke Nomura, Mitsuru Kaise, Daisuke Kikuchi, Toshiro Iizuka, Yumiko Fukuma, Yasutaka Kuribayashi, Masami Tanaka, Takahito Toba, Tsukasa Furuhata, Satoshi Yamashita, Akira Matsui, Toshifumi Mitani, Shu Hoteya
Background and study aims:  Many studies have shown the utility of rigid three-dimensional (3 D) endoscopes in surgery, but few have reported the utility of flexible 3 D endoscopes. This ex vivo study was intended to investigate whether a newly developed 3 D endoscope (GIF-Y0083; Olympus) improves diagnostic accuracy for superficial gastric tumor. Methods:  Twelve observers comprising experts, trainees, and novices (4 each) evaluated 2 D and 3 D images of 20 specimens resected by gastric ESD...
June 2018: Endoscopy International Open
Attia Bari, Fatima Zeeshan, Ghazala Hanif, Uzma Jabeen, Iqbal Bano, Ahsan Waheed Rathore
Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a self-remitting, immune-mediated rare disorder having unique histopathological characteristics which is commonly seen in young Asian females, but can occur in all ethnicities. There is a strong association between KFD and Systemic Lupus Erythematosus (SLE). We present a case of a young Pakistani boy who presented with cervical lymphadenopathy, fever, blackish discoloration of finger tips, and Raynaud's phenomenon. His lymph node biopsy was suggestive of KFD...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Takeshi Yamada, Miwa Matsuda, Mayuko Seki, Megumi Hirose, Takashi Kikuchi
Sterepinic acids A⁻C ( 1 ⁻ 3 ), new carboxylic acids with two primary alcohols, have been isolated from a fungal strain of Stereum sp. OUPS-124D-1 attached to the marine alga Undaria pinnatifida . Dihydro-1,5-secovibralactone ( 4 ), a new vibralactone derivative, was isolated from the same fungal metabolites together with known vibralactone A ( 5 ), and 1,5-secovibralactone ( 6 ). The planar structures of these compounds have been elucidated by spectroscopic analyses using IR, HRFABMS, and NMR spectra. To determine the absolute configuration of the compounds, we used the phenylglycine methyl ester (PGME) method...
June 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Naresh Kumar, Yuichiro Hori, Kazuya Kikuchi
The epigenetic modification of DNA involves the conversion of cytosine to 5-methylcytosine, also known as DNA methylation. DNA methylation is important in modulating gene expression and thus, regulating genome and cellular functions. Recent studies have shown that aberrations in DNA methylation are associated with various epigenetic disorders or diseases including cancer. This stimulates great interest in the development of methods that can detect and visualize DNA methylation. For instance, fluorescent proteins (FPs) in conjugation with methyl-CpG-binding domain (MBD) have been employed for live-cell imaging of DNA methylation...
June 4, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"