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https://www.readbyqxmd.com/read/28992682/nanocurcumin-mediated-down-regulation-of-telomerase-via-stimulating-tgf%C3%AE-1-signaling-pathway-in-hepatocellular-carcinoma-cells
#1
Molood Shariati, Samira Hajigholami, Ziba Veisi Malekshahi, Maliheh Entezari, Narges Bodaghabadi, Majid Sadeghizadeh
Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and Transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGFβ1 pathway in a hepatocellular carcinoma cell line (Huh7). Methods: MTT assay was used to determine the effect of nonocurcumin on viability of Huh7 cells...
October 10, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28921388/immunomodulatory-potential-of-nanocurcumin-based-formulation
#2
Mahendra Kumar Trivedi, Sambhu Charan Mondal, Mayank Gangwar, Snehasis Jana
Vitamins, minerals, and nanocurcumin play a substantial role in various nutraceutical/pharmaceutical formulations that are widely used in therapeutics, cosmetics, and dietary supplements. The current study aimed to investigate the comparative in vitro immunomodulatory effect of a novel nanocurcumin-based formulation with curcumin in LPS-induced cytokine expression, NK cells' activity, and phagocytosis. The proinflammatory cytokines (TNF-α, IL-1β, and MIP-1α) and NK cells' activity were measured in cell supernatants using ELISA assay; however, phagocytosis activity was performed using colorimetric analysis...
December 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28855623/nanocurcumin-is-superior-to-native-curcumin-in-preventing-degenerative-changes-in-experimental-cerebral-malaria
#3
Chaitanya Dende, Jairam Meena, Perumal Nagarajan, Viswanathan Arun Nagaraj, Amulya Kumar Panda, Govindarajan Padmanaban
Curcumin has many pharmacological activities despite its poor bioavailability and in vivo stability. Here, we show that a nanoformulated curcumin (PLGA-curcumin) has better therapeutic index than native curcumin in preventing the onset of neurological symptoms and delaying the death of mice in experimental cerebral malaria. Oral PLGA-curcumin was at least as effective as native curcumin at a 15-fold lower concentration in preventing the breakdown of blood-brain barrier and inhibition of brain mRNAs for inflammatory cytokines, chemokine receptor CXCR3 and its ligand CXCL10, with an increase in the anti-inflammatory cytokine IL-10...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28752270/combination-treatment-with-dendrosomal-nanocurcumin-and-doxorubicin-improves-anticancer-effects-on-breast-cancer-cells-through-modulating-cxcr4-nf-%C3%AE%C2%BAb-smo-regulatory-network
#4
Mohammad Amin Mahjoub, Babak Bakhshinejad, Majid Sadeghizadeh, Sadegh Babashah
Despite advantageous antitumor properties of doxorubicin, the considerable cytotoxicity of this chemotherapeutic agent has made it necessary to develop combination treatment strategies. The aim of the current study was to investigate the possible synergism between dendrosomal nanocurcumin (DNC) and doxorubicin in eliciting anticancer effects on MDA-MB-231 metastatic breast cancer cells. The expression levels of CXCL12/CXCR4 axis and Hedgehog pathway genes were evaluated in patient-derived breast carcinoma tissues by qRT-PCR...
August 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28698350/efficacy-of-nanocurcumin-supplementation-on-insulin-resistance-lipids-inflammatory-factors-and-nesfatin-among-obese-patients-with-non-alcoholic-fatty-liver-disease-nafld-a-trial-protocol
#5
Seyed Ali Jazayeri-Tehrani, Seyed Mahdi Rezayat, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Milad Daneshi-Maskooni, Mohammad-Javad Hosseinzadeh-Attar
OBJECTIVES: Different studies have been conducted on the role of curcumin in health since having multiple properties, including antioxidant and anti-inflammatory effects. Due to the lack of studies regarding curcumin effects on obese patients with non-alcoholic fatty liver disease (NAFLD), our protocol was designed to assess nanocurcumin impacts on blood sugar, lipids, inflammatory indices, insulin resistance and liver function, especially by nesfatin. SETTING: This trial will be conducted in the Oil Company central hospital of Tehran, Iran with a primary level of care...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28681128/role-of-vital-trace-elements-in-nanocurcumin-centered-formulation-a-novel-approach-to-resuscitate-the-immune-system
#6
Mahendra Kumar Trivedi, Mayank Gangwar, Sambhu Charan Mondal, Snehasis Jana
The present paper described the immunomodulatory potential of novel nanocurcumin-based formulation enriched with trace elements and vitamins on cyclophosphamide-induced immunosuppression in rat model. Major immune-related assays were monitored such as hemagglutination assay, delayed-type hypersensitivity (DTH) reaction, cellular immune response, IgG, IgE, IgM, cerebrospinal fluid biomarkers, hematological study, antioxidant profile, and lipid biomarkers. Chemical characterization of novel formulation showed retention time (R t ) 18...
July 5, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28672774/combinatorial-therapy-of-exercise-preconditioning-and-nanocurcumin-formulation-supplementation-improves-cardiac-adaptation-under-hypobaric-hypoxia
#7
Sarita Nehra, Varun Bhardwaj, Anju Bansal, Deepika Saraswat
BACKGROUND: Chronic hypobaric hypoxia (cHH) mediated cardiac insufficiencies are associated with pathological damage. Sustained redox stress and work load are major causative agents of cardiac insufficiencies under cHH. Despite the advancements made in pharmacological (anti-oxidants, vasodilators) and non-pharmacological therapeutics (acclimatization strategies and schedules), only partial success has been achieved in improving cardiac acclimatization to cHH. This necessitates the need for potent combinatorial therapies to improve cardiac acclimatization at high altitudes...
September 26, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28501696/the-role-of-nitric-oxide-in-anticonvulsant-effect-of-nanocurcumine-on-pentylenetetrazole-induced-seizure-in-mice
#8
Alireza Aminirad, Seyyedeh Elaheh Mousavi, Nahid Fakhraei, Seyyedeh Mahbubeh Mousavi, Seyed Mahdi Rezayat
A plant alkaloid obtained from Curcuma longa, curcumin possesses anti-oxidant and anti-inflammatory effects. Nanoformulations have been developed for preclinical studies which demonstrate enhanced therapeutic efficacy. Effect of acute intraperitoneal (i.p.) administration of curcumin C3 complex nanoparticles [1,5, 10, 20, 40, 80mg/kg, (i.p.)] 75min prior to PTZ, on clonic seizure thresholds induced by intravenous infusion of pentylenetetrazole (PTZ) 0.5% was investigated in comparison with curcumin (40 and 80mg/kg, i...
May 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28397291/selection-and-optimization-of-nano-formulation-of-p-glycoprotein-inhibitor-for-reversal-of-doxorubicin-resistance-in-colo205-cells
#9
Tapan K Dash, Venkata Sai Badireenath Konkimalla
OBJECTIVE: The prime objective of current work was to develop a strategy for preparation of combinational nano-formulation for reversal of drug resistance. METHODS: As a model system, doxorubicin (DOX)-resistant COLO205 cells were developed and validated. From co-treatment studies with DOX, curcumin was selected as it reversed DOX-resistance at lowest concentration. In an attempt to increase its solubility, curcumin was encapsulated into hydroxypropyl-β-cyclodextrin (HP-β-CD)...
April 11, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28125510/dendrosomal-nanocurcumin-prevents-morphine-self-administration-behavior-in-rats-despite-ca1-damage
#10
Jalaleden Noroozi, Majid Hassanpour-Ezatti, Hojjat A Alaei
Dendrosomal nanocurcumin (DNC) is fabricated from esterification of oleic acid and polyethylene glycol residues with curcumin. DNC has shown antioxidant, neuroprotective, and neurogenesis-enhancing effects. In addition, it can attenuate morphine tolerance. Morphine self-administration is associated with neurodegenerative changes of CA1 neurons in the adult hippocampus. The present study evaluated the effect of DNC pretreatment on morphine self-administration and hippocampal damage. Rats were pretreated with DNC (5 and 10 mg/kg, intraperitoneally) 30 min before a morphine self-administration paradigm performed in 2-h/sessions for 12 days under a FR-1 schedule...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28096969/dendrosomal-nanocurcumin-and-p53-overexpression-synergistically-trigger-apoptosis-in-glioblastoma-cells
#11
Reihaneh Keshavarz, Babak Bakhshinejad, Sadegh Babashah, Narges Baghi, Majid Sadeghizadeh
OBJECTIVES: Glioblastoma is the most lethal tumor of the central nervous system. Here, we aimed to evaluate the effects of exogenous delivery of p53 and a nanoformulation of curcumin called dendrosomal curcumin (DNC), alone and in combination, on glioblastoma tumor cells. MATERIALS AND METHODS: MTT assay was exploited to measure the viability of U87-MG cells against DNC treatment. Cells were separately subjected to DNC treatment and transfected with p53-containing vector and then were co-exposed to DNC and p53 overexpression[A GA1][B2]...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28031196/nanotized-curcumin-and-miltefosine-a-potential-combination-for-treatment-of-experimental-visceral-leishmaniasis
#12
Brajendra Tiwari, Richa Pahuja, Pradeep Kumar, Srikanta Kumar Rath, Kailash Chand Gupta, Neena Goyal
Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance, which develops over a period of time. Combination therapies (CT) are now in use to treat many diseases, such as cancer and malaria, since it is more effective and affordable than monotherapy. CT are believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania In the present study, we investigated the effect of a combination of a traditional Indian medicine (ayurveda), a natural product curcumin and miltefosine, the only oral drug for visceral leishmaniasis (VL) using a Leishmania donovani-hamster model...
March 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27924631/cardioprotective-effects-of-curcumin-loaded-magnetic-hydrogel-nanocomposite-nanocurcumin-against-doxorubicin-induced-cardiac-toxicity-in-rat-cardiomyocyte-cell-lines
#13
Mehrdad Namdari, Ali Eatemadi
Curcumin, is a yellow substance extracted from Curcuma longa rhizomes, it is a crystalline compound that has been traditionally applied in culinary practices and medicines in India. The aim of our study is to demonstrate the efficacy of curcumin-loaded magnetic hydrogel nanocomposite in the treatment of heart hypertrophy. 10 rats weighing 150-200 g each were induced with heart failure using 2.5 mg/kg doxorubicin for 2 weeks. The test groups were treated with curcumin-loaded magnetic hydrogel nanocomposite while the control was treated with curcumin alone...
June 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27747859/curcumin-as-potential-therapeutic-natural-product-a-nanobiotechnological-perspective
#14
REVIEW
Soumitra Shome, Anupam Das Talukdar, Manabendra Dutta Choudhury, Mrinal Kanti Bhattacharya, Hrishikesh Upadhyaya
OBJECTIVES: Nanotechnology-based drug delivery systems can resolve the poor bioavailability issue allied with curcumin. The therapeutic potential of curcumin can be enhanced by making nanocomposite preparation of curcumin with metal oxide nanoparticles, poly lactic-co-glycolic acid (PLGA) nanoparticles and solid lipid nanoparticles that increases its bioavailability in the tissue. KEY FINDINGS: Curcumin has manifold therapeutic effects which include antidiabetic, antihypertensive, anticancer, anti-inflammatory and antimicrobial properties...
December 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27626325/chronic-hypobaric-hypoxia-induces-right-ventricular-hypertrophy-and-apoptosis-in-rats-therapeutic-potential-of-nanocurcumin-in-improving-adaptation
#15
Sarita Nehra, Varun Bhardwaj, Santosh Kar, Deepika Saraswat
Nehra, Sarita, Varun Bhardwaj, Santosh Kar, and Deepika Saraswat. Chronic hypobaric hypoxia induces right ventricular hypertrophy and apoptosis in rats: therapeutic potential of nanocurcumin in improving adaptation. High Alt Med Biol. 17:342-352, 2016.-a sustained work load on the right heart on ascent to high altitudes promotes right ventricular hypertrophy (RVH), which eventually undergoes decompensation and promotes pathological damage. However, the exact set of events leading to damage remains unidentified...
December 2016: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/27610163/analysis-of-the-antiproliferative-effects-of-curcumin-and-nanocurcumin-in-mda-mb231-as-a-breast-cancer-cell-line
#16
Mohammad Hossein Khosropanah, Amin Dinarvand, Afsaneh Nezhadhosseini, Alireza Haghighi, Sima Hashemi, Fereidon Nirouzad, Sepideh Khatamsaz, Maliheh Entezari, Mehrdad Hashemi, Hossein Dehghani
Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27534650/nanocurcumin-accords-protection-against-acute-hypobaric-hypoxia-induced-lung-injury-in-rats
#17
Sarita Nehra, Varun Bhardwaj, Anju Bansal, Deepika Saraswat
Decline in oxygen availability experienced under hypobaric hypoxia (HH) mediates imbalance in lung fluid clearance and is a causative agent of acute lung injury. Here, we investigate the pathological events behind acute HH mediated lung injury and assess the therapeutic efficacy of nanocurcumin in its amelioration. We assess the protective efficacy of nanotized curcumin (nanocurcumin) in ameliorating HH induced lung injury and compare to curcumin. Rats exposed to acute HH (6, 12, 24, 48 and 72 h) were subjected to histopathology, blood-gas analysis and clinical biochemistry, cytokine response and redox damage...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27504245/fabrication-and-vibration-characterization-of-curcumin-extracted-from-turmeric-curcuma-longa-rhizomes-of-the-northern-vietnam
#18
Hoang Van Nong, Le Xuan Hung, Pham Nam Thang, Vu Duc Chinh, Le Van Vu, Phan Tien Dung, Tran Van Trung, Pham Thu Nga
In this report, we present the research results on using the conventional method and microwave technology to extract curcuminoid from turmeric roots originated in different regions of Northern Vietnam. This method is simple, yet economical, non-toxic and still able to achieve high extraction performance to get curcuminoid from turmeric roots. The detailed results on the Raman vibration spectra combined with X-ray powder diffraction and high-performance liquid chromatography/mass spectrometry allowed the evaluation of each batch of curcumin crystalline powder sample received, under the conditions of applied fabrication technology...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27406082/a-comparative-study-of-dietary-curcumin-nanocurcumin-and-other-classical-amyloid-binding-dyes-for-labeling-and-imaging-of-amyloid-plaques-in-brain-tissue-of-5%C3%A3-familial-alzheimer-s-disease-mice
#19
COMPARATIVE STUDY
Panchanan Maiti, Tia C Hall, Leela Paladugu, Nivya Kolli, Cameron Learman, Julien Rossignol, Gary L Dunbar
Deposition of amyloid beta protein (Aβ) is a key component in the pathogenesis of Alzheimer's disease (AD). As an anti-amyloid natural polyphenol, curcumin (Cur) has been used as a therapy for AD. Its fluorescent activity, preferential binding to Aβ, as well as structural similarities with other traditional amyloid-binding dyes, make it a promising candidate for labeling and imaging of Aβ plaques in vivo. The present study was designed to test whether dietary Cur and nanocurcumin (NC) provide more sensitivity for labeling and imaging of Aβ plaques in brain tissues from the 5×-familial AD (5×FAD) mice than the classical Aβ-binding dyes, such as Congo red and Thioflavin-S...
November 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27283711/water-soluble-nanocurcumin-extracted-from-turmeric-challenging-the-microflora-from-human-oral-cavity
#20
Judy Gopal, Manikandan Muthu, Se-Chul Chun
Water soluble nanocurcumin prepared from commercial turmeric powders was compared against ethanol extracted curcumin particles. The oral microflora from five different human volunteers was collected and the efficacy of solvent extracted curcumin versus water extracted nanocurcumin was demonstrated. Nanocurcumin activity against oral microflora confirms its antimicrobial potency. Confocal laser scanning microscopic results revealed the enhanced entry of nanocurcumin particles into microbial cells. The nanosized nature of nanocurcumin appears to have led to increased cellular interaction and thereby efficient destruction of microbial cells in the mouth...
November 15, 2016: Food Chemistry
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