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Ovarian , endometrial , cervical , vulvar , cancer ,

Dong Hoon Suh, Miseon Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed...
November 2016: Journal of Gynecologic Oncology
Joseph Menczer
PURPOSE: Platelets have multiple functions and they also play an important role in malignancies. Elevated platelet count and thrombocytosis at the time of diagnosis in patients with many solid tumors correlates with prognosis and is associated with poor survival. The aim of the following report is to review the literature concerning elevated platelet count and thrombocytosis in gynecologic malignancies. METHOD: A PubMed search of all English literature peer-reviewed publications was performed containing the terms elevated platelet count or thrombocytosis and vulvar cancer, cervical cancer, endometrial cancer, and ovarian cancer...
October 6, 2016: Archives of Gynecology and Obstetrics
Jorge Daniel Oldan, Parth S Patel
IMPORTANCE: Positron emission tomography/Computed tomography(PET/CT) is widely used for gynecologic cancers. OBJECTIVE: To determine when PET/CT should be used for gynecologic cancers. EVIDENCE ACQUISITION: PubMed was reviewed for articles on PET/CT of all gynecologic cancers. National Comprehensive Cancer Network, Society of Gynecologic Oncology, and American College of Radiology guidelines were reviewed. RESULTS: Whole-body PET/CT is useful for (1) initial staging of cervical and endometrial cancer, posttherapy assessment, radiation therapy planning, and posttreatment surveillance of cervical cancer, and (2) assessment of recurrence of cervical, endometrial, or ovarian cancer in the presence of symptoms...
September 2016: Obstetrical & Gynecological Survey
Tarra Evans, Ursula Matulonis
Next-generation sequencing (NGS) has risen to the forefront of tumor analysis and has enabled unprecedented advances in the molecular profiling of solid tumors. Through massively parallel sequencing, previously unrecognized genomic alterations have been unveiled in many malignancies, including gynecologic cancers, thus expanding the potential repertoire for the use of targeted therapies. NGS has expanded the understanding of the genomic foundation of gynecologic malignancies and has allowed identification of germline and somatic mutations associated with cancer development, enabled tumor reclassification, and helped determine mechanisms of treatment resistance...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Alla G Wernicke, Sae Kim, He Liu, Neil H Bander, Edyta C Pirog
The goal of the study was to examine expression of prostate-specific membrane antigen (PSMA) in neovasculature of gynecologic cancers, as PSMA-targeted therapy has showed a promise in treatment of advanced carcinomas. The study included cervical carcinoma (n=28), vulvar carcinoma (n=20), endometrial carcinoma (n=23), primary ovarian carcinoma (n=21), metastatic ovarian carcinoma (n=25), and normal cervix (n=12) as negative control. All cases were immunostained using anti-CD31 antibody to delineate capillary endothelial cells...
February 9, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Saptarshi Ghosh, Pamidimukkala Bramhananda Rao
INTRODUCTION: Osseous metastasis in gynaecological epithelial tumours is an extremely rare phenomenon occurring in less than 1% of these cancers. AIM: To analyse the clinical characteristics and prognosis in patients with gynaecological epithelial cancers with bone metastases. MATERIALS AND METHODS: This was a single institutional retrospective study done with the data available from January 2008 to January 2015. Out of 1686 patients with epithelial gynaecological malignancies there were a total 18 (1...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
Shannon N Westin, Charlotte C Sun, Celestine S Tung, Robin A Lacour, Larissa A Meyer, Diana L Urbauer, Michael M Frumovitz, Karen H Lu, Diane C Bodurka
PURPOSE: While overall survival from gynecologic malignancies has greatly improved over the last three decades, required treatments can lead to multiple health issues for survivors. Our objective was to identify health concerns that gynecologic cancer survivors face. METHODS: A systematic, stratified sample of women with gynecologic malignancies was surveyed for 18 health issues occurring before, during, or after treatment. The impact of clinical features and treatment modality on health issues was assessed through multivariate logistic regression models...
April 2016: Journal of Cancer Survivorship: Research and Practice
Marcelo A Queiroz, Rahel A Kubik-Huch, Nik Hauser, Bianka Freiwald-Chilla, Gustav von Schulthess, Johannes M Froehlich, Patrick Veit-Haibach
PURPOSE: To compare the diagnostic accuracy of PET/MRI and PET/CT for staging and re-staging advanced gynaecological cancer patients as well as identify the potential benefits of each method in such a population. MATERIAL AND METHODS: Twenty-six patients with suspicious or proven advanced gynaecological cancer (12 ovarian, seven cervical, one vulvar and four endometrial tumours, one uterine metastasis, and one primary peritoneal cancer) underwent whole-body imaging with a sequential trimodality PET/CT/MR system...
August 2015: European Radiology
Christhardt Köhler, Sarah Kyeyamwa, Simone Marnitz, Audrey Tsunoda, Filiberto Vercelino, Achim Schneider, Giovanni Favero
INTRODUCTION: Pelvic ± para-aortic lymphadenectomy (LAE) is an essential element of staging and treatment of different gynecologic malignancies. However, LAE can induce asymptomatic and symptomatic pelvic lymphoceles (LCs) in a considerable percentage of patients. Therapy of symptomatic LCs may cause additional morbidity. The best strategy to reduce the rate of LCs has not established yet. MATERIALS AND METHODS: Between January 2011 and May 2012, transperitoneal laparoscopic pelvic ± para-aortic LAE was performed at the Department of Gynecology at Charité University Hospital Berlin in 238 patients with cervical, endometrial, ovarian, or groin-positive vulvar cancer...
March 2015: Journal of Minimally Invasive Gynecology
Jean-Baptiste Guy, Jane-Chloé Trone, François Casteillo, Fabien Forest, Cécile Pacaut, Coralie Moncharmont, Sophie Espenel, Alexis Vallard, Julien Langrand Escure, Olivier Collard, Michel Peoc'h, Nicolas Magné
Carcinosarcoma, also known as mixed mesodermal tumor or malignant mixed Mullerian tumor (MMMT) is a pathological entity combining a sarcomatous and a carcinomatous component. Found in thoracic, digestive, genitourinary, liver or skin locations, the most common location is the female genital tract. In gynecological tumors, carcinosarcoma accounts for about 2-5% of endometrial cancers, and 1% of ovarian cancers. To date, there is no consensus on the therapeutic strategy. It relies mostly on maximum cytoreductive surgery...
July 2014: Bulletin du Cancer
Alireza Mehrtash, Antonio Damato, Guillaume Pernelle, Lauren Barber, Nabgha Farhat, Akila Viswanathan, Robert Cormack, Tina Kapur
Gynecologic malignancies, including cervical, endometrial, ovarian, vaginal and vulvar cancers, cause significant mortality in women worldwide. The standard care for many primary and recurrent gynecologic cancers consists of chemoradiation followed by brachytherapy. In high dose rate (HDR) brachytherapy, intracavitary applicators and/or interstitial needles are placed directly inside the cancerous tissue so as to provide catheters to deliver high doses of radiation. Although technology for the navigation of catheters and needles is well developed for procedures such as prostate biopsy, brain biopsy, and cardiac ablation, it is notably lacking for gynecologic HDR brachytherapy...
March 12, 2014: Proceedings—Society of Photo-Optical Instrumentation Engineers
Chyong-Huey Lai, Gigin Lin, Tzu-Chen Yen, Feng-Yuan Liu
OBJECTIVES: The purpose of this review is to summarize literature pertaining to clinical roles of positron emission tomography (PET) or integrated PET and computed tomography (PET/CT) scans, magnetic resonance imaging (MRI) and emerging techniques of these two molecular imaging tools for gynecologic malignancies. METHODS: PubMed and MEDLINE databases search for articles published before June 2014 was performed. Only English-language articles were considered. Search terms included "cervical cancer", "endometrial cancer", "uterine cancer", "uterine sarcoma", "ovarian cancer" and "vulvar cancer", in association with "FDG", "PET", "PET/CT", "MRI", "PET/MR", "diffusion", "spectroscopy" and "clinical trial"...
October 2014: Gynecologic Oncology
V M Merabishvili, E V Bakhidze, É I Laliantsi, A F Urmancheeva, I A Krasil'nikov
The article presents an analysis of the situation with cancer in the world, Russia and more detailed (database of the Population-based Cancer Registry) in St. Petersburg. It is presented medium-term morbidity of the population of St. Petersburg per cervical cancer, endometrial cancer and ovarian neoplasms. The use of geoinformation systems allowed presenting incidence (standardized indicators) by districts of the town.
2014: Voprosy Onkologii
Beverly Long, Ramez N Eskander, Krishnansu S Tewari
Recent retrospective studies have reported the use of stereotactic radiosurgery (SRS) in the treatment of gynecologic cancers. SRS uses real-time imaging and high dose radiation beams attached to precise robotic arms to target malignant lesions while sparing normal tissue. The purpose of this review is to examine the indications for SRS in gynecologic oncology, review the current literature regarding the use of SRS in gynecologic cancers, and identify future directions for research in this area. Literature on stereotactic radiosurgery was reviewed using the PubMed search engine...
June 28, 2014: World Journal of Radiology
Sophie Pils, Elmar A Joura, Max-Paul Winter, Anup Shrestha, Agnes Jaeger-Lansky, Johannes Ott
BACKGROUND: The vaccinations against human papilloma virus (HPV) are highly effective in preventing persistent infection. The level of knowledge about HPV and the consequences of an infection with this virus are low in the general population and in patients who suffer from HPV-associated diseases. We aimed to compare the level of knowledge about HPV and about the women's individual malignant disease between women with and without HPV-associated gynecologic cancer as well as the knowledge about individual malignant diseases...
2014: BMC Cancer
F Giammarile, S Vidal-Sicart, R A Valdés Olmos
Beside the classical applications of sentinel lymph node mapping, some new procedures are emerging and showing feasibility and clinical utility. In this chapter, we will report on sentinel lymph node mapping in 1) malignancies of the female reproductive system (cervical cancer, endometrial cancer, vulvar cancer and ovarian cancer); 2) malignancies of the male reproductive system (prostate cancer, penile cancer and testicular cancer); 3) malignancies in kidney and bladder. This paper presents the uncommon applications of sentinel lymph node mapping in urogenital neoplasms...
June 2014: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Yanqiong Liu, Aiping Qin, Taijie Li, Xue Qin, Shan Li
Objective. Epidemiologic and clinical findings are inconsistent concerning the risk for gynecologic cancers associated with statin use. We conducted a detailed meta-analysis of all relevant original studies to evaluate the effects of statin on the risk of gynecologic cancers. Methods. We searched PubMed, Embase, and Cochrane library databases up to February 2014 looking for eligible studies. Summary relative risk (RR) estimates and 95% confidence intervals (CIs) were used to calculate the risk using random-effects models...
June 2014: Gynecologic Oncology
Vivian M Spaans, Marjolijn D Trietsch, Stijn Crobach, Ellen Stelloo, Dennis Kremer, Elisabeth M Osse, Natalja T ter Haar, Ronald van Eijk, Susanne Muller, Tom van Wezel, J Baptist Trimbos, Tjalling Bosse, Vincent T H B M Smit, Gert Jan Fleuren
Somatic mutations play a major role in tumour initiation and progression. The mutation status of a tumour may predict prognosis and guide targeted therapies. The majority of techniques to study oncogenic mutations require high quality and quantity DNA or are analytically challenging. Mass-spectrometry based mutation analysis however is a relatively simple and high-throughput method suitable for formalin-fixed, paraffin-embedded (FFPE) tumour material. Targeted gene panels using this technique have been developed for several types of cancer...
2014: PloS One
Francesco Giammarile, M Fani Bozkurt, David Cibula, Jaume Pahisa, Wim J Oyen, Pilar Paredes, Renato Valdes Olmos, Sergi Vidal Sicart
The accurate harvesting of a sentinel node in gynaecological cancer (i.e. vaginal, vulvar, cervical, endometrial or ovarian cancer) includes a sequence of procedures with components from different medical specialities (nuclear medicine, radiology, surgical oncology and pathology). These guidelines are divided into sectione entitled: Purpose, Background information and definitions, Clinical indications and contraindications for SLN detection, Procedures (in the nuclear medicine department, in the surgical suite, and for radiation dosimetry), and Issues requiring further clarification...
July 2014: European Journal of Nuclear Medicine and Molecular Imaging
Christine Ang, Andrew Bryant, Desmond P J Barton, Christophe Pomel, Raj Naik
BACKGROUND: Cancer is a leading cause of death worldwide. Gynaecological cancers (i.e. cancers affecting the ovaries, uterus, cervix, vulva and vagina) are among the most common cancers in women. Unfortunately, given the nature of the disease, cancer can recur or progress in some patients. Although the management of early-stage cancers is relatively straightforward, with lower associated morbidity and mortality, the surgical management of advanced and recurrent cancers (including persistent or progressive cancers) is significantly more complicated, often requiring very extensive procedures...
2014: Cochrane Database of Systematic Reviews
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