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https://www.readbyqxmd.com/read/28643370/developing-a-natural-history-progression-model-for-duchenne-muscular-dystrophy-using-the-six-minute-walk-test
#1
Lora Hamuro, Phyllis Chan, Giridhar Tirucherai, Malaz AbuTarif
The six minute walk test (6MWT) is used as a clinical endpoint to evaluate drug efficacy in Duchenne Muscular Dystrophy (DMD) trials. A model was developed using digitized 6MWT data that estimated two slopes and two intercepts to characterize 6MWT improvement during development and 6MWT decline. Mean baseline 6MWT was 362 (± 87) meters. The model predicted an improvement at a rate of 20 meter/year (9.4-30, 95% confidence interval (CI)) up until 10 years old (6.78-13.1, 95% CI), and then decline at a rate of 85 meter/year (72-98, 95% CI)...
June 23, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28639841/effects-of-a-mindfulness-based-intervention-on-symptoms-and-signs-in-chronic-heart-failure-a-feasibility-study
#2
Jonna Norman, Michael Fu, Inger Ekman, Lena Björck, Kristin Falk
AIMS: Despite treatment recommended by guidelines, many patients with chronic heart failure remain symptomatic. Evidence is accumulating that mindfulness-based interventions (MBIs) have beneficial psychological and physiological effects. The aim of this study was to explore the feasibility of MBI on symptoms and signs in patients with chronic heart failure in outpatient clinical settings. METHODS: A prospective feasibility study. Fifty stable but symptomatic patients with chronic heart failure, despite optimized guideline-recommended treatment, were enrolled at baseline...
June 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28629466/intra-articular-injection-in-the-knee-of-adipose-derived-stromal-cells-stromal-vascular-fraction-and-platelet-rich-plasma-for-osteoarthritis
#3
Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim
BACKGROUND: Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. We evaluated the safety and preliminary efficacy of administering SVF and PRP intra-articularly into patients with osteoarthritis grade 1 and 2. METHODS: A total of ten patients underwent a local tumescent liposuction procedure to remove approximately 100 ml of fat tissue from the abdomen...
June 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28616089/severe-pulmonary-arterial-hypertension-associated-with-congenital-cardiac-shunts-evolution-under-specific-treatment
#4
R I Negoi, I Ghiorghiu, F Filipoiu, M Hostiuc, I Negoi, C Ginghina
Objective: The aim of this study was to compare the effects of Sildenafil, Bosentan and combined therapy in patients with congenital cardiac shunts associated pulmonary artery hypertension (CCS-PAH). Design: Prospective observational study (February 2011 - January 2014) with a historical control group (January 2009 - January 2011). Setting: "CC Iliescu" Institute for Emergency Cardiovascular Diseases of Bucharest, a tertiary university-affiliated center. Patients: All cases with CCS-PAH. Interventions: Specific vasodilatory therapy: Sildenafil, Bosentan or combined therapy...
April 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28606655/mortality-in-pulmonary-arterial-hypertension-due-to-congenital-heart-disease-serial-changes-improve-prognostication
#5
M T U Schuijt, I M Blok, A H Zwinderman, A C M J van Riel, M J Schuuring, R J de Winter, A L Duijnhouwer, A P J van Dijk, B J M Mulder, B J Bouma
BACKGROUND: Adult patients with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) suffer from high mortality. This underlines the importance of adequate risk stratification to guide treatment decisions. Several baseline parameters are associated with mortality, however, their prognostic value may weaken after years of follow-up. Therefore we investigated the prognostic value of serial changes in standard clinical parameters in PAH-CHD. METHODS: In this prospective observational cohort study we included consecutive PAH-CHD adults, between 2005 and 2016...
June 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28605481/measurement-properties-of-short-lower-extremity-functional-exercise-tests-in-people-with-chronic-obstructive-pulmonary-disease-systematic-review
#6
Kylie N Johnston, Adrian J Potter, Anna Phillips
Background: An increasing variety of short functional exercise tests are reported in people with chronic obstructive pulmonary disease (COPD). Systematic review of the psychometric properties of these exercise tests is indicated. Purpose: The aim of this study was to determine the reliability, validity and responsiveness of short (less than 6 minutes duration) lower extremity functional exercise tests in people with COPD. Data Sources: Five databases were searched: MEDLINE, EmBASE, Scopus, AMED and CINAHL...
June 12, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28603368/comparison-between-stair-climbing-test-and-six-minute-walk-test-after-lung-resection-using-video-assisted-thoracoscopic-surgery-lobectomy
#7
Yohei Kubori, Ryosuke Matsuki, Akira Hotta, Tomoyuki Morisawa, Akira Tamaki
[Purpose] Currently, the six-minute walk distance (6MWD) is used to evaluate exercise capacity in people following lung resection for non-small cell lung cancer. However, it is unclear whether the 6MWD can detect changes in cardiorespiratory fitness induced by exercise training or lung resection. Conversely, the stair-climbing test is used frequently for the preoperative evaluation of lung resection candidates. It is considered a sensitive method for detecting changes associated with training, but is not used to evaluate exercise capacity after lung resection...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28597761/metabolic-and-functional-evaluation-of-the-heart-and-lungs-in-pulmonary-hypertension-by-gated-2-18f-fluoro-2-deoxy-d-glucose-positron-emission-tomography
#8
Didem Saygin, Kristin B Highland, Samar Farha, Margaret Park, Jacqueline Sharp, Emir Charles Roach, W H Wilson Tang, James D Thomas, Serpil C Erzurum, Donald R Neumann, Frank P DiFilippo
Pulmonary hypertension (PH) is associated with a metabolic shift towards glycolysis in both the right ventricle and lung. This results in increased glucose uptake to compensate for the lower energy yield of glycolysis, which creates a potential for 2-[18F] fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) to be a useful tool in the evaluation of participants with PH. We investigated the utility of PET for PH by comparing FDG-PET uptake in the right ventricle and lungs in 30 participants with PH and eight healthy controls and correlating these measurements with echocardiographic (ECHO) measurements and other traditional assessments commonly used in PH...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28597751/the-modified-borg-dyspnea-scale-does-not-predict-hospitalization-in-pulmonary-arterial-hypertension
#9
Debasree Banerjee, Jane Kamuren, Grayson L Baird, Amy Palmisciano, Ipsita Krishnan, Mary Whittenhall, James R Klinger, Corey E Ventetuolo
Background Breathlessness is the most common symptom reported by patients with pulmonary arterial hypertension (PAH). The Modified Borg Dyspnea Scale (MBS) is routinely obtained during the six-minute walk test in the assessment of PAH patients, but it is not known whether the MBS predicts clinical outcomes such as hospitalizations in PAH. Methods We performed a retrospective study of World Health Organization (WHO) Group 1 PAH patients followed at our center. The dates of the first three MBS and hospitalizations that occurred within three months of a documented MBS were collected...
April 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28595744/functional-electrical-stimulation-improves-quality-of-life-by-reducing-intermittent-claudication
#10
David G Embrey, Gad Alon, Brenna A Brandsma, Felix Vladimir, Angela Silva, Bethann M Pflugeisen, Paul J Amoroso
OBJECTIVE: To determine if Functional Electrical Stimulation (FES) would improve ischemic pain, walking distance, and quality of life of patients with intermittent claudication. DESIGN: Single blind, randomized block, two factorial design. PATIENTS: Patients diagnosed with Peripheral Artery Disease (PAD) and intermittent claudication (IC). Ankle Brachial Index ranged 0.4-0.9 on at least one leg. Patients were randomly assigned to experimental (FES+Walk, N=13) or control (WALK, N=14) groups...
June 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28590432/faller-classification-in-older-adults-using-wearable-sensors-based-on-turn-and-straight-walking-accelerometer-based-features
#11
Dylan Drover, Jennifer Howcroft, Jonathan Kofman, Edward D Lemaire
Faller classification in elderly populations can facilitate preventative care before a fall occurs. A novel wearable-sensor based faller classification method for the elderly was developed using accelerometer-based features from straight walking and turns. Seventy-six older individuals (74.15 ± 7.0 years), categorized as prospective fallers and non-fallers, completed a six-minute walk test with accelerometers attached to their lower legs and pelvis. After segmenting straight and turn sections, cross validation tests were conducted on straight and turn walking features to assess classification performance...
June 7, 2017: Sensors
https://www.readbyqxmd.com/read/28588077/predictors-and-association-with-clinical-outcomes-of-the-changes-in-exercise-capacity-following-transcatheter-aortic-valve-replacement
#12
Omar Abdul-Jawad Altisent, Rishi Puri, Ander Regueiro, Chekrallah Chamandi, Tania Rodriguez-Gabella, Maria Del Trigo, Francisco Campelo-Parada, Thomas Couture, Josep R Marsal, Mélanie Côté, Jean-Michel Paradis, Robert DeLarochellière, Daniel Doyle, Siamak Mohammadi, Eric Dumont, Josep Rodés-Cabau
Background -There are presently no objective data specifically examining variations in exercise capacity post-TAVR. We describe the changes in exercise capacity between baseline and 6 months post-TAVR, and ascertain factors associated with a lack of improvement in exercise capacity post-TAVR. Methods -A total of 305 patients (mean age: 79±9 years; 44% men; STS score: 6.7%±4.2%) undergoing TAVR completed both baseline and follow-up exercise capacity assessments at 6 months post-TAVR. Exercise capacity was evaluated by the six-minute walk test (6MWT)...
June 6, 2017: Circulation
https://www.readbyqxmd.com/read/28580370/robotic-assist-as-needed-as-an-alternative-to-therapist-assisted-gait-rehabilitation
#13
Shraddha Srivastava, Pei Chun Kao, Darcy S Reisman, John P Scholz, Sunil K Agrawal, Jill S Higginson
OBJECTIVE: Body Weight Supported Treadmill Training (BWSTT) with therapists' assistance is often used for gait rehabilitation post-stroke. However, this training method is labor-intensive, requiring at least one or as many as three therapists at once for manual assistance. Previously, we demonstrated that providing movement guidance using a performance-based robot-aided gait training (RAGT) that applies a compliant, assist-as-needed force-field improves gait pattern and functional walking ability in people post-stroke...
October 2016: International Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28579149/assessment-of-dyspnea-and-dynamic-hyperinflation-in-male-patients-with-chronic-obstructive-pulmonary-disease-during-a-six-minute-walk-test-and-an-incremental-treadmill-cardiorespiratory-exercise-test
#14
M Alfonso, V Bustamante, P Cebollero, M Antón, S Herrero, J B Gáldiz
The six minute walk test (6MWT) is a standardized test that provides information on exercise capacity in patients with COPD. It is considered a submaximal test in opposition to incremental cardiopulmonary exercise tests (CPET) that provide valuable information on all the systems involved in exercise. OBJECTIVES: 1. To compare the perceptive, physiological responses and degree of dynamic hyperinflation during two exercise tests: the 6MWT and the incremental CPET on a treadmill. 2. To evaluate how dyspnea is related to dynamic hyperinflation (DH) and other functional parameters in both tests...
June 1, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28577650/physical-activity-level-and-performance-in-the-six-minute-walk-test-of-children-and-adolescents-with-sickle-cell-anemia
#15
Hugo Nivaldo Melo, Simone Joanna-Maria Stoots, Marijn Aimee Pool, Vitor Oliveira Carvalho, Lucas Oliveira Carvalho Almeida, Max Luan De Carvalho Aragão, Charles Agyemang, Rosana Cipolotti
BACKGROUND: To establish determinants of maximum walking distance in the 6-minute walk test of children and adolescents with sickle cell anemia, and to compare the performance in this test with physical activity level between patients and healthy controls. METHODS: A cross-sectional study was performed in which the participants answered the Physical Activity Questionnaire for Older Children and Adolescents, and completed the 6-minute walk test. MAIN RESULTS: Fifty-seven patients and 58 controls were studied...
April 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28573757/circuit-class-therapy-for-improving-mobility-after-stroke
#16
REVIEW
Coralie English, Susan L Hillier, Elizabeth A Lynch
BACKGROUND: Circuit class therapy (CCT) offers a supervised group forum for people after stroke to practise tasks, enabling increased practice time without increasing staffing. This is an update of the original review published in 2010. OBJECTIVES: To examine the effectiveness and safety of CCT on mobility in adults with stroke. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register (last searched January 2017), CENTRAL (the Cochrane Library, Issue 12, 2016), MEDLINE (1950 to January 2017), Embase (1980 to January 2017), CINAHL (1982 to January 2017), and 14 other electronic databases (to January 2017)...
June 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28571696/functional-electrical-stimulation-improves-muscle-strength-and-endurance-in-patients-after-cardiac-surgery-a-randomized-controlled-trial
#17
Jociane Schardong, Gabriela Castro Kuinchtner, Graciele Sbruzzi, Rodrigo Della Méa Plentz, Antônio Marcos Vargas da Silva
BACKGROUND: Functional electrical stimulation (FES) has shown benefits in patients with chronic heart failure. Therefore, it is possible that FES can benefit patients similarly after cardiac surgery. OBJECTIVE: This randomized placebo-controlled trial aimed to evaluate the effects of FES on lower limb functional capacity, strength, endurance, and muscle mass after discharge from cardiac surgery. METHODS: Twenty patients were allocated (1:1) to the group receiving FES to the quadriceps (FESG) or FES placebo (FESPG)...
May 19, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28571188/six-minute-walk-test-a-tool-for-predicting-mortality-in-chronic-pulmonary-diseases
#18
Mp Swathi Karanth, Nilkanth Tukaram Awad
INTRODUCTION: Six Minute Walk Test (6MWT) is a simple test used to measure exercise capacity in Chronic Pulmonary Diseases (CPDs). Decreased exercise capacity significantly affects the quality of life. The 6MWT is a known tool to measure exercise capacity and quality of life in CPD. However, the role of change in follow up Six Minute Walk Distance (6MWD) in assessing mortality and its correlation with known prognostic factors haven't been tested to the best of our knowledge. AIM: To study the correlation of change in 6MWD with change in spirometry and to study the role of 6MWD in predicting mortality in CPD...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28569553/effects-of-combined-exercise-training-and-electromyostimulation-treatments-in-chronic-heart-failure-a-prospective-multicentre-study
#19
Marie C Iliou, Bénédicte Vergès-Patois, Bruno Pavy, Anais Charles-Nelson, Catherine Monpère, Rudy Richard, Jean C Verdier
Background Exercise training as part of a comprehensive cardiac rehabilitation is recommended for patients with cardiac heart failure. It is a valuable method for the improvement of exercise tolerance. Some studies reported a similar improvement with quadricipital electrical myostimulation, but the effect of combined exercise training and electrical myostimulation in cardiac heart failure has not been yet evaluated in a large prospective multicentre study. Purpose The aim of this study was to determine whether the addition of low frequency electrical myostimulation to exercise training may improve exercise capacity and/or muscular strength in cardiac heart failure patients...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28569455/nordic-walking-and-specific-strength-training-for-neck-and-shoulder-pain-in-office-workers-a-pilot-study
#20
Atle H Saeterbakken, Solveig Nordengen, Vidar Andersen, Marius S Fimland
BACKGROUND: More than half of all adults have experienced neck pain during the last six months. Studies have demonstrated reduced pain in the neck-and shoulder region after specific strength training of the affected muscles, but specific endurance training of neck and shoulder muscles has not been properly examined. AIM: To examine the impact of Nordic walking (NW) compared to specific strength training (ST) and a non-training control group (Con) on self-reported neck-and shoulder pain among office workers...
June 1, 2017: European Journal of Physical and Rehabilitation Medicine
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