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https://www.readbyqxmd.com/read/28916003/genetic-diversity-and-antibiotic-susceptibility-of-staphylococcus-aureus-isolates-from-wild-boars
#1
D Seinige, A Von Altrock, C Kehrenberg
We here report the occurrence of S. aureus in wild boars and characterize isolates genotypically and phenotypically in order to get knowledge about the occurrence of clonal lineages and genotypes in free-living wild animals. Forty-one S. aureus isolates obtained from 111 wild boars hunted in Lower Saxony, Germany, were investigated and compared to human and livestock isolates. The S. aureus belonged to multilocus sequence types ST1, ST7, ST30, ST133, ST425, ST804, ST890 and to the new ST3237, ST3238, ST3255 and ST3369...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28915926/antimicrobial-resistance-patterns-of-staphylococcus-species-isolated-from-cats-presented-at-a-veterinary-academic-hospital-in-south-africa
#2
Daniel Nenene Qekwana, Dikeledi Sebola, James Wabwire Oguttu, Agricola Odoi
BACKGROUND: Antimicrobial resistance is becoming increasingly important in both human and veterinary medicine. This study investigated the proportion of antimicrobial resistant samples and resistance patterns of Staphylococcus isolates from cats presented at a veterinary teaching hospital in South Africa. Records of 216 samples from cats that were submitted to the bacteriology laboratory of the University of Pretoria academic veterinary hospital between 2007 and 2012 were evaluated. Isolates were subjected to antimicrobial susceptibility testing against a panel of 15 drugs using the disc diffusion method...
September 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28914846/-analysis-of-the-efficiency-of-antimicrobial-treatment-for-community-acquired-pneumonia-in-clinical-practice
#3
O V Zhukova, O V Ruina, S V Kononova, T M Konyshkina
AIM: To analyze actual drug consumption based on the defined daily dose (DDD analysis) and to analyze the utilization of drugs based on their proportion of the total defined daily doses (DU90% analysis) for the antimicrobial therapy of community-acquired pneumonia (CAP) in clinical practice at a hospital in Russia. MATERIAL AND METHODS: The investigation materials were the data of 117 case histories of male (51.3%) and female (48.7%) patients hospitalized with CAP at Nizhny Novgorod City Clinical Hospital Five in 2015...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28914188/a-retrospect-study-on-thiazole-derivatives-as-the-potential-antidiabetic-agents-in-drug-discovery-amp-developments
#4
Gopal L Khatik, Ashok Kumar Datusalia, Waquar Ahsan, Paranjeet Kaur, Manish Vyas, Amit Mittal, Surendra Kumar Nayak
BACKGROUND: Heterocycles containing thiazole, a moiety with sulfur and nitrogen is a core structure which found in a number of biologically active compounds. The thiazole ring is notable as a component of the certain natural products, such as vitamin B1 (thiamine) and penicillins. Thiazole is also known as wonder nucleus and has versatile in different biological fields. A number of new compounds contain heterocycle thiazole moieties, thus it is one of the important areas of research. METHODS: We searched the scientific database using relevant keywords...
September 15, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28913699/morphological-analysis-of-the-filamentous-fungus-penicillium-chrysogenum-using-flow-cytometry-the-fast-alternative-to-microscopic-image-analysis
#5
Daniela Ehgartner, Christoph Herwig, Jens Fricke
An important parameter in filamentous bioreactor cultivations is the morphology of the fungi, due to its interlink to productivity and its dependency on process conditions. Filamentous fungi show a large variety of morphological forms in submerged cultures. These range from dispersed hyphae, to interwoven mycelial aggregates, to denser hyphal aggregates, the so-called pellets. Depending on the objective function of the bioprocess, different characteristics of the morphology are favorable and need to be quantified accurately...
September 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28912880/spectroscopic-analysis-and-docking-simulation-on-the-recognition-and-binding-of-tem-1-%C3%AE-lactamase-with-%C3%AE-lactam-antibiotics
#6
Jianting Yang, Qian Li, Liujiao Bian
The interaction between TEM-1 β-lactamase and antibiotics is very important in the hydrolysis of antibiotics. In the present study, the recognition and binding of TEM-1 β-lactamase with three β-lactam antibiotics, including penicillin G, cefalexin and cefoxitin, was investigated by fluorescence and ultraviolet-visible absorption spectra in combination with molecular docking in the temperature range of 278-288 K and under simulated physiological conditions. The results demonstrated that the fluorescence emissions of TEM-1 β-lactamase were extinguished by static quenching and the energy of TEM-1 β-lactamase was transferred in a non-radioactive manner...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911638/assessment-of-antibacterial-drug-residues-in-milk-for-consumption-in-kosovo
#7
Adem Rama, Lorena Lucatello, Cristiana Benetti, Guglielmo Galina, Drita Bajraktari
The objective of this study was to assess the occurrence of drug residues in the raw milk collected from individual farms and milk collection points during 2009-2010 in six different major regions of Kosovo (Prishtinë, Gjilan, Mitrovicë, Pejë, Gjakovë, Prizren). In the present study, a total of 1734 raw milk samples were collected, and qualitatively screened with two different tests, the Delvotest SP assay and an enzyme-linked receptor-binding assay (SNAP). Overall, 106 (6.11%) out of 1734 samples examined with Delvotest SP contained possible drug residues (5...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28906539/a-programme-to-increase-appropriate-usage-of-benzathine-penicillin-for-management-of-streptococcal-pharyngitis-and-rheumatic-heart-disease-in-zambia
#8
Aidan Long, Joyce Chipili Lungu, Elizabeth Machila, Sherri Schwaninger, Jonathan Spector, Brigitta Tadmor, Mark Fishman, Bongani M Mayosi, John Musuku
Rheumatic heart disease is highly prevalent and associated with substantial morbidity and mortality in many resource-poor areas of the world, including sub-Saharan Africa. Primary and secondary prophylaxis with penicillin has been shown to significantly improve outcomes and is recognised to be the standard of care, with intra-muscular benzathine penicillin G recommended as the preferred agent by many technical experts. However, ensuring compliance with therapy has proven to be challenging. As part of a public-private partnership initiative in Zambia, we conducted an educational and access-to-medicine programme aimed at increasing appropriate use of benzathine penicillin for the prevention and management of rheumatic heart disease, according to national guidelines...
July 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28904182/finegoldia-magna-isolated-from-orthopedic-joint-implant-associated-infections
#9
Bo Söderquist, Sanna Björklund, Bengt Hellmark, Anders Jensen, Holger Brüggemann
Background: The anaerobic Gram-positive coccus Finegoldia magna is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by F. magnaMethods: We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as F. magna from patients with orthopedic infections. The isolates found were determined to species level by MALDI-TOF MS. The antibiotic susceptibility pattern was determined by Etest...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28902135/point-prevalence-surveys-of-antimicrobial-use-among-hospitalized-children-in-six-hospitals-in-india-in-2016
#10
Sumanth Gandra, Sanjeev K Singh, Dasaratha R Jinka, Ravishankar Kanithi, Ashok K Chikkappa, Anita Sharma, Dhanya Dharmapalan, Anil Kumar Vasudevan, Onkaraiah Tunga, Akhila Akula, Garima Garg, Yingfen Hsia, Srinivas Murki, Gerardo Alvarez-Uria, Mike Sharland, Ramanan Laxminarayan
The prevalence of antimicrobial resistance in India is among the highest in the world. Antimicrobial use in inpatient settings is an important driver of resistance, but is poorly characterized, particularly in hospitalized children. In this study, conducted as part of the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children (GARPEC) project, we examined the prevalence of and indications of antimicrobial use, as well as antimicrobial agents used among hospitalized children by conducting four point prevalence surveys in six hospitals between February 2016 and February 2017...
September 13, 2017: Antibiotics
https://www.readbyqxmd.com/read/28900682/treatment-of-staphylococcus-aureus-infections
#11
Michael Z David, Robert S Daum
Staphylococcus aureus, although generally identified as a commensal, is also a common cause of human bacterial infections, including of the skin and other soft tissues, bones, bloodstream, and respiratory tract. The history of S. aureus treatment is marked by the development of resistance to each new class of antistaphylococcal antimicrobial drugs, including the penicillins, sulfonamides, tetracyclines, glycopeptides, and others, complicating therapy. S. aureus isolates identified in the 1960s were sometimes resistant to methicillin, a ß-lactam antimicrobial active initially against a majority S...
September 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#12
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28898319/-tetanus-a-current-disease-in-pediatric-population-case-report
#13
María Del Pilar Cejudo-García de Alba, Jaime Guadalupe Valle-Leal, Jesús Gabriel Sánchez Beltrán, Amado de Jesús Francisco Vázquez-Amparano
INTRODUCTION: Tetanus is an acute disease caused by a toxin produced by Clostridium tetanii. The disease can affect people of any age, and the fatality rate is high. Thanks to immunization the number of cases of the disease has decreased, although they are still present in isolation in countries with social and economic backwardness. OBJECTIVE: To describe a case of a pediatric patient with generalized tetanus to reinforce the relevance of prophylaxis and early detection...
2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28898293/the-vibrio-cholerae-var-regulon-encodes-a-metallo-%C3%AE-lactamase-and-an-antibiotic-efflux-pump-which-are-regulated-by-varr-a-lysr-type-transcription-factor
#14
Hong-Ting Victor Lin, Teresa Massam-Wu, Chen-Ping Lin, Yen-Jen Anna Wang, Yu-Chi Shen, Wen-Jung Lu, Pang-Hung Hsu, Yu-Hou Chen, Maria Ines Borges-Walmsley, Adrian Robert Walmsley
The genome sequence of V. cholerae O1 Biovar Eltor strain N16961 has revealed a putative antibiotic resistance (var) regulon that is predicted to encode a transcriptional activator (VarR), which is divergently transcribed relative to the putative resistance genes for both a metallo-β-lactamase (VarG) and an antibiotic efflux-pump (VarABCDEF). We sought to test whether these genes could confer antibiotic resistance and are organised as a regulon under the control of VarR. VarG was overexpressed and purified and shown to have β-lactamase activity against penicillins, cephalosporins and carbapenems, having the highest activity against meropenem...
2017: PloS One
https://www.readbyqxmd.com/read/28895381/penicillin-g-susceptibility-among-staphylococcus-aureus-is-not-so-infrequent-a-retrospective-study
#15
Josquin Moraly, Redouane Dahoumane, Vincent Dubée, Gabriel Préda, Jean-Luc Baudel, Jérémie Joffre, Naïke Bigé, Hafid Ait-Oufella, Eric Maury
No abstract text is available yet for this article.
September 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28894828/the-role-of-antibiotics-in-pediatric-chronic-rhinosinusitis
#16
REVIEW
Itzhak Brook
OBJECTIVES: Presenting the role of antibiotics in pediatric chronic rhinosinusitis based on its pathophysiology and microbiology. DATA SOURCE: Review of the literature searching PubMed for microbiology and treatment of pediatric chronic rhinosinusitis. RESULTS: Chronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses that persists for 12 weeks or longer, despite medical management. The microbiology of rhinosinusitis evolves through several stages...
June 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28893972/cross-sectional-study-of-antimicrobials-used-for-surgical-prophylaxis-by-bovine-veterinary-practitioners-in-australia
#17
Laura Y Hardefeldt, Glen F Browning, Karin A Thursky, James R Gilkerson, Helen Billman-Jacobe, Mark A Stevenson, Kirsten E Bailey
Antimicrobials are widely used in veterinary practices, but there has been no investigation of antimicrobial classes used or the appropriateness of their use in bovine practice. This study investigated antimicrobial use for surgical prophylaxis in bovine practice in Australia. A cross-sectional study of veterinarian antimicrobial usage patterns was conducted using an online questionnaire. Information solicited included respondent's details, the frequency with which antimicrobials were used for specific surgical conditions (including the dose, timing and duration of therapy) and details of practice antimicrobial use policies and sources of information about antimicrobials...
September 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28893518/curative-approaches-for-sickle-cell-disease-a-review-of-allogeneic-and-autologous-strategies
#18
Daniel E Bauer, Christian Brendel, Courtney D Fitzhugh
Despite sickle cell disease (SCD) first being reported >100years ago and molecularly characterized >50years ago, patients continue to experience severe morbidity and early mortality. Although there have been substantial clinical advances with immunizations, penicillin prophylaxis, hydroxyurea treatment, and transfusion therapy, the only cure that can be offered is hematopoietic stem cell transplantation (HSCT). In this work, we summarize the various allogeneic curative approaches reported to date and discuss open and upcoming clinical research protocols...
September 1, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28893360/borderline-oxacillin-resistant-staphylococcus-aureus-borsa-a-more-common-problem-than-expected
#19
Maria M Hryniewicz, Katarzyna Garbacz
Borderline oxacillin-resistant Staphylococcus aureus (BORSA) represents a quite poorly understood and inadequately defined phenotype of methicillin resistance. BORSA strains show low, borderline resistance to penicillinase-resistant penicillins (PRPs), with oxacillin MICs typically equal to 1-8 µg ml-1, and in contrast to methicillin-resistant S. aureus (MRSA), do not have an altered penicillin-binding protein, PBP2a, encoded by the mecA or mecC gene. Their resistance is typically associated with hyperproduction of beta-lactamases or, in some cases, point mutations in PBP genes...
September 12, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28893195/antimicrobial-resistance-in-bacterial-pathogens-among-hospitalized-children-with-community-acquired-lower-respiratory-tract-infections-in-dongguan-china-2011-2016
#20
Xiaoguang He, Mingyu Xie, Siping Li, Junqin Ye, Qi Peng, Qiang Ma, Xiaomei Lu, Baimao Zhong
BACKGROUND: Bacterial pathogens are a major cause of childhood community acquired lower respiratory tract infections (CA-LRTIs), and few data described the impact of antimicrobial resistance on children with CA-LRTIs. This study aims to investigate the antimicrobial resistance in common bacterial agents among hospitalized children with CA-LRTIs between 2011 and 2016 in Dongguan, China. METHODS: Sputum samples were collected from hospitalized children (0-5 years old) with CA-LRTIs in Dongguan Children's Hospital...
September 11, 2017: BMC Infectious Diseases
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