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Joana Cardoso, Marta Mesquita, António Dias Pereira, Mónica Bettencourt-Dias, Paula Chaves, José B Pereira-Leal
Barrett's esophagus is the major risk factor for esophageal adenocarcinoma. It has a low but non-neglectable risk, high surveillance costs and no reliable risk stratification markers. We sought to identify early biomarkers, predictive of Barrett's malignant progression, using a meta-analysis approach on gene expression data. This in silico strategy was followed by experimental validation in a cohort of patients with extended follow up from the Instituto Português de Oncologia de Lisboa de Francisco Gentil EPE (Portugal)...
2016: PloS One
Piero Farruggia, Giuseppe Puccio, Alessandra Sala, Alessandra Todesco, Monica Terenziani, Rosamaria Mura, Salvatore D'Amico, Tommaso Casini, Clara Mosa, Marta Pillon, Maria Paola Boaro, Gaetano Bottigliero, Roberta Burnelli, Caterina Consarino, Fausto Fedeli, Maurizio Mascarin, Katia Perruccio, Elisabetta Schiavello, Angela Trizzino, Umberto Ficola, Alberto Garaventa, Mario Rossello
The purpose of the study was to determine if abdomen/pelvis computed tomography (CT) can be safety omitted in the initial staging of a subgroup of children affected by Hodgkin Lymphoma (HL). Every participating center of A.I.E.O.P (Associazione Italiana di Ematologia ed Oncologia Pediatrica) sent local staging reports of 18F-fluorodeoxyglucose positron emission tomography (PET) and abdominal ultrasound (US) along with digital images of staging abdomen/pelvis CT to the investigation center where the CT scans were evaluated by an experienced pediatric radiologist...
September 2016: Cancer Medicine
Leandro Cardoso Barchi, Carlos Eduardos Jacob, Cláudio José Caldas Bresciani, Osmar Kenji Yagi, Donato Roberto Mucerino, Fábio Pinatel Lopasso, Marcelo Mester, Ulysses Ribeiro-Júnior, André Roncon Dias, Marcus Fernando Kodama Pertille Ramos, Ivan Cecconello, Bruno Zilberstein
INTRODUCTION: Minimally invasive surgery widely used to treat benign disorders of the digestive system, has become the focus of intense study in recent years in the field of surgical oncology. Since then, the experience with this kind of approach has grown, aiming to provide the same oncological outcomes and survival to conventional surgery. Regarding gastric cancer, surgery is still considered the only curative treatment, considering the extent of resection and lymphadenectomy performed...
April 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Marta Pillon, Lara Mussolin, Elisa Carraro, Valentino Conter, Maurizio Aricò, Luciana Vinti, Alberto Garaventa, Matilde Piglione, Salvatore Buffardi, Alessandra Sala, Nicola Santoro, Luca Lo Nigro, Rossella Mura, Annalisa Tondo, Fiorina Casale, Piero Farruggia, Paolo Pierani, Simone Cesaro, Emanuele S G d'Amore, Giuseppe Basso
Burkitt lymphoma (BL) and Diffuse Large B-Cell Lymphoma (DLBCL) account for most cases of non-Hodgkin lymphoma (NHL) in childhood. We report the clinical characteristics, outcome and prognostic factors in children with BL or DLBCL treated according to the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) LNH-97 protocol. Patients aged up to 18 years that were newly diagnosed with BL/DLBCL were included in the study. Therapy consisted of pre-phase followed by 2-6 high-dose chemotherapy courses tailored according to lactate dehydrogenase (LDH) value and disease stage...
July 8, 2016: British Journal of Haematology
M E Knott, J N Minatta, L Roulet, G Gueglio, L Pasik, S M Ranuncolo, M Nuñez, L Puricelli, M S De Lorenzo
BACKGROUND: The finding of new biomarkers is needed to have a better sub-classification of primary renal tumors (RCC) as well as more reliable predictors of outcome and therapy response. In this study, we evaluated the role of circulating FGF21, an endocrine factor, as a diagnostic and prognostic biomarker for ccRCC. MATERIALS AND METHODS: Serum samples from healthy controls (HC), clear cell and chromophobe RCC cancer patients were obtained from the serum biobank "Biobanco Público de Muestras Séricas Oncológicas" (BPMSO) of the "Instituto de Oncología "Ángel H...
June 2016: Journal of Molecular Biomarkers & Diagnosis
María José Molina Garrido
Cada vez es mayor el número de ancianos con diagnóstico de cáncer que acuden a las consultas de Oncología Médica. El proceso del envejecimiento y la gran variabilidad existente en la población geriátrica implican que, para hacer un abordaje adecuado del paciente, se deba considerar la edad fisiológica del anciano, y no su edad biológica. Para ello, es preciso hacer una evaluación somera, específica e individualizada a cada uno de los ancianos con diagnóstico de cáncer que acudan a nuestra consulta...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Andrea Sartore-Bianchi, Livio Trusolino, Cosimo Martino, Katia Bencardino, Sara Lonardi, Francesca Bergamo, Vittorina Zagonel, Francesco Leone, Ilaria Depetris, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello, Patrizia Racca, Andrea Bertotti, Giulia Siravegna, Valter Torri, Alessio Amatu, Silvia Ghezzi, Giovanna Marrapese, Laura Palmeri, Emanuele Valtorta, Andrea Cassingena, Calogero Lauricella, Angelo Vanzulli, Daniele Regge, Silvio Veronese, Paolo M Comoglio, Alberto Bardelli, Silvia Marsoni, Salvatore Siena
BACKGROUND: We previously found that dual HER2 blockade with trastuzumab and lapatinib led to inhibition of tumour growth in patient-derived xenografts of HER2-amplified metastatic colorectal cancer. In this study, we aimed to assess the antitumour activity of trastuzumab and lapatinib in patients with HER2-positive colorectal cancer. METHODS: HERACLES was a proof-of-concept, multicentre, open-label, phase 2 trial done at four Italian academic cancer centres. We enrolled adult patients with KRAS exon 2 (codons 12 and 13) wild-type and HER2-positive metastatic colorectal cancer refractory to standard of care (including cetuximab or panitumumab), an Eastern Cooperative Oncology Group performance status of 0 or 1, and at least one measurable lesion...
June 2016: Lancet Oncology
Viviana Bacciedoni, Myriam Attie, Hugo Donato
The incidence of thrombosis is higher among newborn infants than in any other stage of pediatric development. This fact is the consequence of labile characteristics of the neonatal hemostatic system, in addition to exposure to multiple risk factors and the wide use of vascular catheters. Venous thromboses, which mainly affect the limbs, the right atrium and renal veins, are more frequently seen than arterial thromboses. A stroke may be caused by the occlusion of the arterial flow entering the brain or by occlusion of its venous drainage system...
April 2016: Archivos Argentinos de Pediatría
Alejandro Forner, María Reig, María Varela, Marta Burrel, Jaime Feliu, Javier Briceño, Javier Sastre, Luis Martí-Bonmati, Josep María Llovet, José Ignacio Bilbao, Bruno Sangro, Fernando Pardo, Carmen Ayuso, Concepció Bru, Josep Tabernero, Jordi Bruix
Hepatocellular carcinoma is the most common primary malignancy of the liver and one of the most frequent causes of death in patients with liver cirrhosis. Simultaneously with the recognition of the clinical relevance of this neoplasm, in recent years there have been important developments in the diagnosis, staging and treatment of HCC. Consequently, the Asociación Española para el Estudio del Hígado has driven the need to update clinical practice guidelines, continuing to invite all the societies involved in the diagnosis and treatment of this disease to participate in the drafting and approval of the document (Sociedad Española de Trasplante Hepático, Sociedad Española de Radiología Médica, Sociedad Española de Radiología Vascular e Intervencionista y Sociedad Española de Oncología Médica)...
June 3, 2016: Medicina Clínica
Andrea Ferrari, Roberto Rondelli, Andrea Pession, Maurizio Mascarin, Carlotta Buzzoni, Maria Luisa Mosso, Milena Maule, Elena Barisone, Marina Bertolotti, Carlo Alfredo Clerici, Momcilo Jankovic, Franca Fagioli, Andrea Biondi
This analysis compared the numbers of patients treated at Italian pediatric oncology group (Associazione Italiana Ematologia Oncologia Pediatrica [AIEOP]) centers with the numbers of cases predicted according to the population-based registry. It considered 32,431 patients registered in the AIEOP database (1989-2012). The ratio of observed (O) to expected (E) cases was 0.79 for children (0-14 years old) and 0.15 for adolescents (15-19 years old). The proportion of adolescents increased significantly over the years, however, from 0...
June 2016: Pediatric Blood & Cancer
Pablo Espinosa, Ruth M Pfeiffer, Zaida García-Casado, Celia Requena, Maria Teresa Landi, Rajiv Kumar, Eduardo Nagore
BACKGROUND: Melanoma survivors are at an increased risk of developing other malignancies, including keratinocyte skin cancer (KSC). While it is known that many risk factors for melanoma also impact risk of KSC in the general population, no previous study has investigated risk factors for KSC development in melanoma patients. OBJECTIVE: We assessed associations of personal and clinical characteristics, including skin phenotype and variations in the melanocortin 1 receptor (MC1R) gene, with KSC risk in melanoma patients...
January 2016: European Journal of Cancer
Elena Mazza, Alba Brandes, Silvia Zanon, Marika Eoli, Giuseppe Lombardi, Marina Faedi, Enrico Franceschi, Michele Reni
PURPOSE: Hydroxyurea (HU) is among the most widely used salvage therapies in progressive meningiomas. Platelet-derived growth factor receptors are expressed in virtually all meningiomas. Imatinib sensitizes transformed cells to the cytotoxic effects of chemotherapeutic agents that interfere with DNA metabolism. The combination of HU with imatinib yielded intriguing results in recurrent malignant glioma. The current trial addressed the activity of this association against meningioma. METHODS: Patients with recurrent or progressive WHO grade I-III meningioma, without therapeutic indication for surgery, radiotherapy, or stereotactic radiosurgery, aged 18-75 years, ECOG performance status 0-2, and not on enzyme-inducing anti-epileptic drugs were randomized to receive HU 500 mg BID ± imatinib 400 mg QD until progression, unacceptable toxicity, or patient's refusal...
January 2016: Cancer Chemotherapy and Pharmacology
Piero Farruggia, Giuseppe Puccio, Alessandra Sala, Alessandra Todesco, Salvatore Buffardi, Alberto Garaventa, Gaetano Bottigliero, Maurizio Bianchi, Marco Zecca, Franco Locatelli, Andrea Pession, Marta Pillon, Claudio Favre, Salvatore D'Amico, Massimo Provenzi, Angela Trizzino, Giulio Andrea Zanazzo, Antonella Sau, Nicola Santoro, Giulio Murgia, Tommaso Casini, Maurizio Mascarin, Roberta Burnelli
BACKGROUND: Many biological and inflammatory markers have been proposed as having a prognostic value at diagnosis of Hodgkin lymphoma (HL), but very few have been validated in paediatric patients. We explored the significance of these markers in a large population of 769 affected children. PATIENTS AND METHODS: By using the database of patients enrolled in A.I.E.O.P. (Associazione Italiana di Emato-Oncologia Pediatrica) trial LH2004 for paediatric HL, we identified 769 consecutive patients treated with curative intent from 1st June 2004 to 1st April 2014 with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), or hybrid COPP/ABV (cyclophosphamide, vincristine, prednisone, procarbazine, doxorubicin, bleomycin and vinblastine) regimens...
January 2016: European Journal of Cancer
I Martínez-Nicolás, D Ángel-García, P J Saturno, F López-Soriano
OBJECTIVE: Although several clinical practice guidelines have been developed in the last decades, cancer pain management is still deficient. The purpose of this work was to carry out a comprehensive and systematic literature review of current clinical practice guidelines on cancer pain management, and critically appraise their methodology and content in order to evaluate their quality and validity to cope with this public health issue. MATERIALS AND METHODS: A systematic review was performed in the main databases, using English, French and Spanish as languages, from 2008 to 2013...
January 2016: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
Desiree Caselli, Simone Cesaro, Franca Fagioli, Francesca Carraro, Ottavio Ziino, Giulio Zanazzo, Cristina Meazza, Antonella Colombini, Elio Castagnola
Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediatric hematology-oncology cooperative study group (Associazione Italiana Ematologia Oncologia Pediatrica, AIEOP). During a 2-year observation period, we observed a threefold increase in the colonization rate, and a fourfold increase of bloodstream infection episodes, caused by CPE, with a 90-day mortality of 14%...
February 2016: Infectious Diseases
Virginia Sanchini, Giuseppina Bonizzi, Davide Disalvatore, Massimo Monturano, Salvatore Pece, Giuseppe Viale, Pier Paolo Di Fiore, Giovanni Boniolo
Traditional Informed Consent is becoming increasingly inadequate, especially in the context of research biobanks. How much information is needed by patients for their consent to be truly informed? How does the quality of the information they receive match up to the quality of the information they ought to receive? How can information be conveyed fairly about future, non-predictable lines of research? To circumvent these difficulties, some scholars have proposed that current consent guidelines should be reassessed, with trust being used as a guiding principle instead of information...
May 2016: Bioethics
Abraham Hernández Blanquisett, Carmen Herrero Vicent, Joaquín Gavilá Gregori, Ángel Guerrero Zotano, Vicente Guillem Porta, Amparo Ruiz Simón
BACKGROUND: Breast cancer is one of the most common cancers diagnosed during pregnancy. Pregnancy-associated breast cancer (PABC) is defined as breast cancer diagnosed during pregnancy or within 12 months of delivery. Nowadays PABC can be safely diagnosed, staged, and treated during pregnancy with good outcomes for both the mother and the fetus. Recent studies suggest that prognosis of women diagnosed during postpartum seems to be worse. In order to gain a better understanding of the PABC, we reviewed our centre's experience...
2015: Ecancermedicalscience
Piero Farruggia, Andrea Di Cataldo, Rita M Pinto, Elena Palmisani, Alessandra Macaluso, Laura Lo Valvo, Maria E Cantarini, Assunta Tornesello, Paola Corti, Francesca Fioredda, Stefania Varotto, Baldo Martire, Isabella Moroni, Giuseppe Puccio, Giovanna Russo, Carlo Dufour, Marta Pillon
Pearson syndrome (PS) is a very rare and often fatal multisystemic mitochondrial disorder involving the liver, kidney, pancreas, and hematopoietic and central nervous system. It is characterized principally by a transfusion-dependent anemia that usually improves over time, a tendency to develop severe infections, and a high mortality rate. We describe a group of 11 PS patients diagnosed in Italy in the period 1993-2014. The analysis of this reasonably sized cohort of patients contributes to the clinical profile of the disease and highlights a rough incidence of 1 case/million newborns...
2016: JIMD Reports
Paola Quarello, Franca Fagioli, Giuseppe Basso, Maria C Putti, Massimo Berger, Matteo Luciani, Carmelo Rizzari, Giuseppe Menna, Riccardo Masetti, Franco Locatelli
Paediatric patients with acute myeloid leukaemia (AML) who fail induction due to primary resistance to chemotherapy account for a significant proportion of cases and have a particularly dismal prognosis. We report the clinical and biological data, and final outcome of 48 paediatric patients with primary-resistant AML enrolled in the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 clinical trial. These patients had a significantly higher white blood cell count at diagnosis compared to other AML patients...
November 2015: British Journal of Haematology
Maurizio Aricò, Lara Mussolin, Elisa Carraro, Salvatore Buffardi, Nicola Santoro, Paolo D'Angelo, Alessandra Lombardi, Paolo Pierani, Eugenia Giraldi, Rossella Mura, Alessandra Sala, Alberto Garaventa, Annalisa Tondo, Matilde Piglione, Luca Lo Nigro, Simone Cesaro, Katia Perruccio, Angelo Rosolen, Giuseppe Basso, Marta Pillon
BACKGROUND: Inherited conditions affecting genetic aberration, viral oncogenesis, reduced immune surveillance, and long-lasting antigen stimulation may build the way to lymphomagenesis in humans. METHODS: We extracted from the database of 4 consecutive trials for pediatric non-Hodgkin lymphoma (NHL) all cases with an associated genetic disease. RESULTS: Among 1,430 patients, 34 (2.4%) had an associated inherited condition and a mature B-lineage (n = 28), anaplastic large cell lymphoma (n = 4), or T-lineage (n = 2) NHL...
October 2015: Pediatric Blood & Cancer
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