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https://www.readbyqxmd.com/read/29128908/cetuximab-tpf-radiotherapy-in-oesophageal-cancer
#1
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
BACKGROUND: Pre-operative chemoradiotherapy using a 5-fluorouracil (5-FU)/cisplatin backbone is widely used to improve surgical outcomes in locoregional oesophageal cancer patients, despite a non-negligible failure rate. OBJECTIVE: We evaluated intensification of this approach to improve patient outcomes by adding cetuximab to induction 5-FU/cisplatin/docetaxel (TPF) and to chemoradiotherapy in a phase II study. PATIENTS AND METHODS: Between November 2006 and April 2009, 50 patients with stage II-IVa squamous cell carcinoma (SCC) or adenocarcinoma of the oesophagus or gastro-oesophageal junction initiated three TPF/cetuximab cycles...
November 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29074184/hpv-distribution-in-cervical-cancer-in-portugal-a-retrospective-study-from-1928-to-2005
#2
Ana Félix, Laia Alemany, Sara Tous, Silvia de Sanjosé, F Xavier Bosch
OBJECTIVES: To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. METHODS: Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. RESULTS: Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0-61.6%) were positive for HPV DNA...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29049862/primary-mediastinal-large-b-cell-lymphoma-outcome-of-a-series-of-pediatric-patients-treated-with-high-dose-methotrexate-and-cytarabine-plus-anti-cd20
#3
Marta Pillon, E Carraro, L Mussolin, V Conter, A Tondo, M Aricò, R Mura, A Sala, L Vinti, S Buffardi, P Pierani, E S G d'Amore, G Basso
Between 2007 and 2013, 13 children diagnosed with primary mediastinal large B-cell lymphoma (PMLBL) were treated according to a modified version of AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) LNH-97 protocol based on high-dose methotrexate, anthracyclines, and addition of anti-CD20. Ten patients achieved a continuous complete remission with front-line therapy. The overall 5-year survival was 91.7%, and event-free survival was 83.9%, with only one patient dying of progressive disease. Despite the few cases, these results demonstrate that this therapy, which includes anti-CD20, given in a multicenter setting, is feasible with acceptable toxicity in children with PMLBL...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28977239/communicating-bad-news-an-integrative-review-of-the-nursing-literature
#4
Cassiana Mendes Bertoncello Fontes, Daniele Vieira de Menezes, Maria Helena Borgato, Marcos Roberto Luiz
Objectives: describe how the process of breaking bad news is established and identify how nurses approach the task of giving bad news. Method: integrative review of the literature for articles in Portuguese and English published between 1993-2014, in the databases: Bireme, PubMed, Scopus, Web of Science, CINAHL and Embase. Nine articles were included using the selection flow chart. A digital form was completed for each article according to the Consolidated Criteria for Reporting Qualitative Research checklist and the level of scientific evidence was determined...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28944755/the-intriguing-effect-of-delay-time-to-sentinel-lymph-node-biopsy-on-survival-a-propensity-score-matching-study-on-a-cohort-of-melanoma-patients
#5
Antonio Tejera-Vaquerizo, Miguel Angel Descalzo-Gallego, Victor Traves, Celia Requena, Isidro Bolumar, Angel Pla, Eduardo Nagore
BACKGROUND: Time between primary melanoma excision and sentinel lymph node biopsy (SLNB) has not been sufficiently studied as an independent predictor of survival in cutaneous melanoma. OBJECTIVES: We used propensity score matching to evaluate whether early SLNB (performed ≤40 days from excisional biopsy) is associated with higher mortality in patients with cutaneous melanoma. MATERIALS & METHODS: A retrospective cohort study at a tertiary melanoma referral centre...
September 23, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28895713/-hypochromic-microcytic-anemias-guideline-for-diagnosis-executive-summary
#6
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28884278/hpv-prevalence-in-vulvar-cancer-in-austria
#7
Sophie Pils, Lisa Gensthaler, Laia Alemany, Reinhard Horvat, Silvia de Sanjosé, Elmar A Joura
BACKGROUND: Even if vulvar cancer is not common, over one hundred women are affected in Austria per year. There is strong evidence that basaloid and warty variants are associated with types of human papillomavirus (HPV). METHODS: The aim of this study is to analyze the types of HPV in vulvar cancer in Austria. This cross-sectional period-prevalence international collaborative study on archival specimens was performed in cooperation with the Institut Catalan di Oncologia in Barcelona, Spain...
November 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28830607/partnership-of-the-sociedade-brasileira-de-oncologia-pedi%C3%A3-trica-and-international-society-of-pediatric-oncology-to-improve-nutritional-care-for-children-with-cancer-in-brazil
#8
Karina Viani, Vicente Odone Filho, Sima Ferman, Teresa Cristina Cardoso Fonseca, Vanessa da Cunha Oliveira, Priscila Dos Santos Maia Lemos, Ronald D Barr, Elena J Ladas
The authors present a proposal of a partnership between the Sociedade Brasileira de Oncologia Pediátrica (SOBOPE) and the International Society of Pediatric Oncology (SIOP) to promote the standardization and improvement of nutritional care of kids under cancer treatment in Brazil. The results of the first meeting in Brazil as well as plans for future meetings are described.
July 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28776310/infrastructure-and-equipment-for-radiation-oncology-in-the-spanish-national-health-system-analysis-of-external-beam-radiotherapy-2015-2020
#9
A Rodríguez, M Algara, D Monge, J López-Torrecilla, F Caballero, R Morera, R Escó, H Pérez-Montero, C Ferrer, P C Lara
PURPOSE: Planning for radiation oncology requires reliable estimates of both demand for radiotherapy and availability of technological resources. This study compares radiotherapy resources in the 17 regions of the decentralised Spanish National Health System (SNHS). MATERIALS AND METHODS: The Sociedad Española de Oncología Radioterápica (SEOR) performed a cross-sectional survey of all Spanish radiation oncology services (ROS) in 2015. We collected data on SNHS radiotherapy units, recording the year of installation, specific features of linear accelerators (LINACs) and other treatment units, and radiotherapeutic techniques implemented by region...
August 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28737884/-deficiencia-de-hierro-y-anemia-ferrop%C3%A3-nica-gu%C3%A3-a-para-su-prevenci%C3%A3-n-diagn%C3%A3-stico-y-tratamiento-resumen-ejecutivo
#10
(no author information available yet)
No abstract text is available yet for this article.
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28704322/malignant-bowel-obstruction-in-relapsed-ovarian-cancer-with-peritoneal-carcinomatosis-an-occlusive-state
#11
Pedro Martinez Castro, Lara Vargas, Antonio Mancheño, Salvador Martín Utrilla, Francisco Pascual, Ignacio Romero, Cristina Zorrero, José Manuel Bosch, Andrés Poveda, Lucas Minig
OBJECTIVE: The aim of this study was to describe the clinical and oncological outcomes of women with malignant bowel obstruction (MBO) for relapsed ovarian cancer and peritoneal carcinomatosis. METHODS: A retrospective cohort study was performed in all consecutive patients admitted at Instituto Valenciano de Oncología, Valencia, Spain, between July 2013 and July 2016 with MBO for relapsed ovarian cancer and peritoneal carcinomatosis. All patients underwent the same protocol of conservative management...
September 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28669411/a-map-of-clinical-dermatology-research-centers-in-spain-results-of-the-maind-study
#12
A Molina-Leyva, M A Descalzo, I García-Doval
BACKGROUND AND OBJECTIVE: Bibliometric indicators and analyses of clinical research articles can help to quantify the scientific production of hospitals and institutions and identify their main areas of research. The aim of this study was to draw up a bibliometric map of clinical research in dermatology by Spanish hospitals and institutions through an analysis of quantitative, qualitative, and topic-based variables. MATERIAL AND METHOD: Bibliometric study of clinical research articles that met the inclusion criteria and had a definitive publication date between 2005 and 2014 in PubMed or Embase in which the corresponding author's affiliation was a Spanish dermatology department or institution...
November 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28665464/transitioning-from-anatomic-landmarks-to-ultrasound-guided-central-venous-catheterizations-guidelines-applied-to-clinical-practice
#13
Rodrigo Oom, Rui Casaca, Rita Barroca, Sara Carvalhal, Catarina Santos, Nuno Abecasis
INTRODUCTION: Centrally inserted central catheter (CICC) insertion is a commonly performed procedure that may give rise to different complications. Despite the suggestion of guidelines to use ultrasound guidance (USG) for vascular access, not all centers use it systematically. The aim of this study is to illustrate the experience with ultrasound in CICC placement at a high-volume oncological center, in a country where the landmark technique is standard. METHODS: Retrospective analysis of a prospective database was performed on CICC placement under USG in the Central Venous Catheter Unit of Instituto Português de Oncologia de Lisboa Francisco Gentil, from 2012 to 2015...
July 14, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28655531/results-of-the-third-aieop-cooperative-protocol-on-wilms-tumor-tw2003-and-related-considerations
#14
Filippo Spreafico, Davide Biasoni, Salvatore Lo Vullo, Lorenza Gandola, Paolo D'Angelo, Monica Terenziani, Maurizio Bianchi, Massimo Provenzi, Paolo Indolfi, Andrea Pession, Marilina Nantron, Andrea Di Cataldo, Carlo Morosi, Daniela Perotti, Serena Catania, Franca Fossati Bellani, Paola Collini
PURPOSE: TW2003, the third Italian prospective study on Wilms tumor, aimed to improve survival in patients with stage III-IV tumors, de-escalate therapy for stage I-II nonanaplastic tumors, refine the risk stratification of therapy, and develop a national infrastructure for biobanking and central pathology review. MATERIALS AND METHODS: TW2003 recruited children 18 years old or younger with primary intrarenal tumors. Local physicians chose nephrectomy with or without preoperative chemotherapy as the initial treatment based on the risk of unsafe and/or incomplete immediate surgery...
November 2017: Journal of Urology
https://www.readbyqxmd.com/read/28612488/front-line-window-therapy-with-cisplatin-in-patients-with-primary-disseminated-ewing-sarcoma-a-study-by-the-associazione-italiana-di-ematologia-ed-oncologia-pediatrica-and-italian-sarcoma-group
#15
Roberto Luksch, Giovanni Grignani, Paolo D'Angelo, Arcangelo Prete, Nadia Puma, Marta Podda, Michela Casanova, Andrea Ferrari, Carlo Morosi, Franca Fagioli, Massimo Aglietta, Stefano Ferrari, Piero Picci, Maura Massimino
The aim was to assess the activity of cisplatin (CDDP) in Ewing sarcoma (ES). The study consisted of front-line window therapy with CDDP 120 mg/sqm every 3 weeks for two courses in children and young adults with primary disseminated ES. Response was assessed using the Response Evaluation Criteria in Solid Tumours criteria, and Simon's two-stage design was applied. Twelve consecutive patients were enrolled in stage 1. Only one objective response was observed. Since the target response rate was not achieved, accrual was stopped and CDDP as a single agent in ES was judged unworthy of further assessment...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28598537/factors-possibly-affecting-prognosis-in-children-with-wilms-tumor-diagnosed-before-24-months-of-age-a-report-from-the-associazione-italiana-ematologia-oncologia-pediatrica-aieop-wilms-tumor-working-group
#16
Paolo D'Angelo, Andrea Di Cataldo, Monica Terenziani, Gianni Bisogno, Paola Collini, Martina Di Martino, Fraia Melchionda, Clara Mosa, Marilina Nantron, Daniela Perotti, Giuseppe Puccio, Annalisa Serra, Serena Catania, Filippo Spreafico
BACKGROUND: Children with Wilms' tumor (WT) aged under 24 months (infants) have a better prognosis than older patients. Our aim was to study the epidemiology of this age group, with focus on the modality of diagnosis, tumor size, and association with malformations/syndromes, seeking to understand if any of these factors might be related to prognosis. PATIENTS AND METHODS: Infants diagnosed with WT between 2003 and February 2010 were evaluated. A query form was used to collect data on the modality of WT diagnosis (symptomatic or incidental), tumor volume, maximum diameter, site, and stage...
December 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28538811/patient-survival-and-risk-of-death-after-prostate-cancer-treatment-in-the-brazilian-unified-health-system
#17
Sonia Faria Mendes Braga, Mirian Carvalho de Souza, Raphael Romie de Oliveira, Eli Iola Gurgel Andrade, Francisco de Assis Acurcio, Mariangela Leal Cherchiglia
OBJECTIVE: Analyze the probability of specific survival and factors associated with the risk of death of patients with prostate cancer who received outpatient cancer treatment in the Brazilian Unified Health System, Brazil. METHODS: Retrospective cohort study using the National Database of Oncology, developed through the deterministic-probabilistic pairing of health information systems: outpatient (SIA), hospital (SIH) and mortality (SIM). The probability of overall and specific survival was estimated by the time elapsed between the date of the first ambulatory treatment, from 2002 to 2003, until the patient's death or the end of the study...
May 15, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28513766/intervening-factors-for-the-initiation-of-treatment-of-patients-with-stomach-and-colorectal-cancer
#18
Thaína Dalla Valle, Ruth Natalia Teresa Turrini, Vanessa de Brito Poveda
Objective: to identify the time between symptoms, the request for care and the beginning of treatment in patients with stomach and colorectal cancer as well as the factors that interfere in these processes. Method: correlational descriptive study, including 101 patients diagnosed with stomach or colorectal cancer, treated in a hospital specialized in oncology. Results: the 101 patients investigated there was predominance of males, mean age of 61...
May 15, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28492585/-biosimilari-in-oncologia-tutti-sono-d-accordo-ma-nessuno-li-usa
#19
Bishal Gyawali
Riassunto. Ridurre il costo dei biologici è un'importante opportunità per affrontare il problema della tossicità finanziaria in oncologia, una delle questioni più rilevanti per i sistemi sanitari. Fare ricorso ai biosimilari, le alternative meno costose ai biologici, è una strategia importante per raggiungere lo scopo. Ma l'entusiasmo provato nel riuscire a sviluppare questi prodotti resta privo di significato se non si traduce in una maggiore prescrizione da parte dei medici, preoccupati dalla possibile insorgenza di reazioni avverse o di minore efficacia...
April 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28449306/malignant-ovarian-germ-cell-tumors-in-pediatric-patients-the-aieop-associazione-italiana-ematologia-oncologia-pediatrica-study
#20
M Terenziani, G Bisogno, R Boldrini, G Cecchetto, M Conte, L Boschetti, M D De Pasquale, D Biasoni, A Inserra, F Siracusa, M E Basso, F De Leonardis, D Di Pinto, F Barretta, F Spreafico, P D'Angelo
OBJECTIVE: Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment-related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT. METHODS: Patients were treated according to their stage: surgery and surveillance for stage I; a modified bleomycin-etoposide-cisplatin (BEP) regimen for stages II (three cycles), III, and IV (three cycles) with surgery on residual disease...
November 2017: Pediatric Blood & Cancer
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