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wound healing arginine

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https://www.readbyqxmd.com/read/28292986/arginine-is-a-critical-substrate-for-the-pathogenesis-of-pseudomonas-aeruginosa-in-burn-wound-infections
#1
Jake Everett, Keith Turner, Qiuxian Cai, Vernita Gordon, Marvin Whiteley, Kendra Rumbaugh
Environmental conditions affect bacterial behavior and can greatly influence the course of an infection. However, the environmental cues that elicit bacterial responses in specific infection sites are relatively unknown. Pseudomonas aeruginosa is ubiquitous in nature and typically innocuous. However, it is also one of the most prevalent causes of fatal sepsis in burn wound patients. The aim of this study was to determine the impact of environmental factors, specifically the availability of arginine, on the pathogenesis of P...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28250059/netrin-1-restores-cell-injury-and-impaired-angiogenesis-in-vascular-endothelial-cells
#2
Ying Xing, Jingbo Lai, Xiangyang Liu, Nana Zhang, Jie Ming, Hengxin Liu, Xi Zhang
Diabetic foot ulceration (DFU) represents a common vascular complication of diabetes mellitus (DM) with high morbidity and disability resulting from amputation. Netrin-1 level was decreased in type 2 DM patients and has been identified as a protective regulator against diabetes-triggered myocardial infarction and nephropathy. Unfortunately, its role and molecular mechanism in DFU remain poorly elucidated. Here, netrin-1 levels were reduced in DM and DFU patients relative to healthy controls, with netrin-1 levels being lowest in DFU patients...
March 1, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28228068/stress-in-gastrointestinal-tract-and-stable-gastric-pentadecapeptide-bpc-157-finally-do-we-have-a-solution
#3
Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Josipa Vlainic, Zarko Rasic, Martina Lovric Bencic
Selye's syndrome produced by diverse nocuous agents and "response to damage as such" means Selye's stress triad in stress coping response to reestablish homeostasis. Logically, from the gastrointestinal tract viewpoint, such organoprotective/healing response implies the angiogenic growth factors that commonly signify the healing. Thereby, the gastric pentadecapeptide BPC 157-organoprotection (huge range of beneficial effects) signifies the Selye's stress concept/stress coping response implemented in and from gastrointestinal tract, and BPC 157 as an integrative mediator that integrates the adaptive bodily response to stress...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28166447/nutrition-support-for-persistent-inflammation-immunosuppression-and-catabolism-syndrome
#4
Frederick A Moore, Stuart Phillips, Craig McClain, Jayshil J Patel, Robert Martindale
Despite tremendous advances in critical care, multiple-organ failure continues to be a significant problem. However, in recent years, far fewer patients with multiple-organ failure die early, but many experience ongoing immune dysregulation and are developing persistent inflammation, immunosuppression, and catabolism syndrome (PICS). Most PICS patients are discharged to nonhome destinations, fail to rehabilitate, and succumb to indolent death. From a nutrition perspective, patients with PICS experience persistent inflammation-induced cachexia despite evidenced-based recommended intensive care unit nutrition support...
February 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27865272/proline-arginine-rich-pr-39-cathelicidin-structure-expression-and-functional-implication-in-intestinal-health
#5
REVIEW
Ravi Holani, Chaitanya Shah, Qahir Haji, G Douglas Inglis, Richard R E Uwiera, Eduardo R Cobo
Proline-Arginine-39 (PR-39) is a small cationic, proline and arginine rich, cathelicidin that plays an important role in the porcine innate immune system. Although PR-39 was first discovered in intestinal cell lysates of pigs, subsequent research has indicated that it is primarily expressed in bone marrow and other lymphoid tissues including the thymus and spleen, as well as in leukocytes. Mature PR-39 cathelicidin has anti-microbial activity against many gram-negative and some gram-positive bacteria. PR-39 is also a bridge between the innate and adaptive immune system with recognized immunomodulatory, wound healing, anti-apoptotic, and pro-angiogenic functions...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27743199/arginine-silicate-inositol-complex-accelerates-cutaneous-wound-healing
#6
Ali Said Durmus, Mehmet Tuzcu, Oguzhan Ozdemir, Cemal Orhan, Nurhan Sahin, Ibrahim Hanifi Ozercan, James Richard Komorowski, Shakir Ali, Kazim Sahin
Arginine silicate inositol (ASI) complex is a composition of arginine, silicon, and inositol that has been shown to have beneficial effects on vascular health. This study reports the effects of an ASI ointment on wound healing in rats. A full-thickness excision wound was created by using a disposable 5 mm diameter skin punch biopsy tool. In this placebo-controlled study, the treatment group's wound areas were covered by 4 or 10 % ASI ointments twice a day for 5, 10, or 15 days. The rats were sacrificed either 5, 10, or 15 days after the wounds were created, and biopsy samples were taken for biochemical and histopathological analysis...
October 14, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27737343/oral-or-topical-administration-of-l-arginine-changes-the-expression-of-tgf-and-inos-and-results-in-early-wounds-healing
#7
Márcio Sousa Jerônimo, Adria do Prado Barros, Vinícius Elord Zen MoritaI, Erika Oliveira Alves, Nathalia Lobão Barroso de Souza, Rosane Mansan de Almeida, Yanna Karla Medeiros Nóbrega, Florêncio Figueiredo Cavalcanti, Rivadávio Amorin, Maria de Fátima Borin, Anamélia Lorenzetti Bocca
PURPOSE: To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process. METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration...
September 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27647919/diabetic-wound-regeneration-using-peptide-modified-hydrogels-to-target-re-epithelialization
#8
Yun Xiao, Lewis A Reis, Nicole Feric, Erica J Knee, Junhao Gu, Shuwen Cao, Carol Laschinger, Camila Londono, Julia Antolovich, Alison P McGuigan, Milica Radisic
There is a clinical need for new, more effective treatments for chronic wounds in diabetic patients. Lack of epithelial cell migration is a hallmark of nonhealing wounds, and diabetes often involves endothelial dysfunction. Therefore, targeting re-epithelialization, which mainly involves keratinocytes, may improve therapeutic outcomes of current treatments. In this study, we present an integrin-binding prosurvival peptide derived from angiopoietin-1, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), as a therapeutic candidate for diabetic wound treatments by demonstrating its efficacy in promoting the attachment, survival, and collective migration of human primary keratinocytes and the activation of protein kinase B Akt and MAPKp42/44 The QHREDGS peptide, both as a soluble supplement and when immobilized in a substrate, protected keratinocytes against hydrogen peroxide stress in a dose-dependent manner...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27627764/effects-of-diclofenac-l-name-l-arginine-and-pentadecapeptide-bpc-157-on-gastrointestinal-liver-and-brain-lesions-failed-anastomosis-and-intestinal-adaptation-deterioration-in-24-hour-short-bowel-rats
#9
Nermin Lojo, Zarko Rasic, Anita Zenko Sever, Danijela Kolenc, Darko Vukusic, Domagoj Drmic, Ivan Zoricic, Marko Sever, Sven Seiwerth, Predrag Sikiric
Stable gastric pentadecapeptide BPC 157 was previously used to ameliorate wound healing following major surgery and counteract diclofenac toxicity. To resolve the increasing early risks following major massive small bowel resectioning surgery, diclofenac combined with nitric oxide (NO) system blockade was used, suggesting therapy with BPC 157 and the nitric oxide synthase (NOS substrate) L-arginine, is efficacious. Immediately after anastomosis creation, short-bowel rats were untreated or administered intraperitoneal diclofenac (12 mg/kg), BPC 157 (10 μg/kg or 10 ng/kg), L-NG-nitroarginine methyl ester (L-NAME, 5 mg/kg), L-arginine (100 mg/kg) alone or combined, and assessed 24 h later...
2016: PloS One
https://www.readbyqxmd.com/read/27392604/polymeric-nanocapsules-a-potential-new-therapy-for-corneal-wound-healing
#10
Sonia Reimondez-Troitiño, Ignacio Alcalde, Noemi Csaba, Almudena Íñigo-Portugués, María de la Fuente, Federico Bech, Ana C Riestra, Jesús Merayo-Lloves, María J Alonso
Corneal injuries are one of the most frequently observed ocular diseases, leading to permanent damage and impaired vision if they are not treated properly. In this sense, adequate wound healing after injury is critical for keeping the integrity and structure of the cornea. The goal of this work was to assess the potential of polymeric nanocapsules, either unloaded or loaded with cyclosporine A or vitamin A, alone or in combination with mitomycin C, for the treatment of corneal injuries induced by photorefractive keratectomy surgery...
July 8, 2016: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/27375697/effects-of-early-enteral-nutrition-on-the-gastrointestinal-motility-and-intestinal-mucosal-barrier-of-patients-with-burn-induced-invasive-fungal-infection
#11
Yu Zhang, Fang Gu, Fengxian Wang, Yuanda Zhang
OBJECTIVE: To evaluate the effects of early enteral nutrition on the gastrointestinal motility and intestinal mucosal barrier of patients with burn-induced invasive fungal infection. METHODS: A total of 120 patients with burn-induced invasive fungal infection were randomly divided into an early enteral nutrition (EN) group and a parenteral nutrition (PN) group (n=60). The patients were given nutritional support intervention for 14 days, and the expression levels of serum transferrin, albumin, total protein, endotoxin, D-lactic acid and inflammatory cytokines were detected on the 1st, 7th and 14th days respectively...
May 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27363017/human-cytomegalovirus-may-promote-tumour-progression-by-upregulating-arginase-2
#12
Helena Costa, Xinling Xu, Gitta Overbeek, Suhas Vasaikar, C Pawan K Patro, Ourania N Kostopoulou, Masany Jung, Gowhar Shafi, Sharan Ananthaseshan, Giorgos Tsipras, Belghis Davoudi, Abdul-Aleem Mohammad, Hoyin Lam, Klas Strååt, Vanessa Wilhelmi, Mingmei Shang, Jesper Tegner, Joo Chuan Tong, Kum Thong Wong, Cecilia Söderberg-Naucler, Koon-Chu Yaiw
BACKGROUND: Both arginase (ARG2) and human cytomegalovirus (HCMV) have been implicated in tumorigenesis. However, the role of ARG2 in the pathogenesis of glioblastoma (GBM) and the HCMV effects on ARG2 are unknown. We hypothesize that HCMV may contribute to tumorigenesis by increasing ARG2 expression. RESULTS: ARG2 promotes tumorigenesis by increasing cellular proliferation, migration, invasion and vasculogenic mimicry in GBM cells, at least in part due to overexpression of MMP2/9...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27348151/can-specific-nutrients-stimulate-bowel-wound-healing
#13
Sabine Ellinger
PURPOSE OF REVIEW: The purpose of review is to provide an overview on specific nutrients which play an important role in bowel wound healing, and to judge the efficacy of supplementation to derive recommendations for clinical practice. RECENT FINDINGS: Glutamine, arginine, butyrate, ω-3 fatty acids, nucleotides, and several micronutrients are involved in bowel wound healing. However, with regard to clinical trials, the efficacy of supplementation of specific nutrients on bowel wound healing in patients with inflammatory bowel diseases has not been clarified yet...
June 24, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27339751/calendula-officinalis-ameliorates-l-arginine-induced-acute-necrotizing-pancreatitis-in-rats
#14
Jagdeep Kaur, Shabir Sidhu, Kanwaljit Chopra, M U Khan
CONTEXT: Calendula officinalis L. (Asteraceae) has been traditionally used in treating inflammation of internal organs, gastrointestinal tract ulcers and wound healing. OBJECTIVE: The present study investigates the effect of ethanol extract (95%) of Calendula officinalis flowers in l-arginine induced acute necrotizing pancreatitis in rats. MATERIALS AND METHODS: Rats were divided into four groups: normal control, l-arginine control, Calendula officinalis extract (COE) treated and melatonin treated (positive control), which were further divided into subgroups (24 h, day 3 and 14) according to time points...
December 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27264087/a-material-conferring-hemocompatibility
#15
William Everett, David J Scurr, Anna Rammou, Arnold Darbyshire, George Hamilton, Achala de Mel
There is a need for biomimetic materials for use in blood-contacting devices. Blood contacting surfaces maintain their patency through physico-chemical properties of a functional endothelium. A poly(carbonate-urea) urethane (PCU) is used as a base material to examine the feasibility of L-Arginine methyl ester (L-AME) functionalized material for use in implants and coatings. The study hypothesizes that L-AME, incorporated into PCU, functions as a bioactive porogen, releasing upon contact with blood to interact with endothelial nitric oxide synthase (eNOS) present in blood...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27252277/when-is-it-appropriate-to-use-arginine-in-critical-illness
#16
REVIEW
Jayshil J Patel, Keith R Miller, Cameron Rosenthal, Martin D Rosenthal
In health, arginine is considered a nonessential amino acid but can become an essential amino acid (ie, conditionally essential amino acid) during periods of metabolic or traumatic stress as endogenous arginine supply is inadequate to meet physiologic demands. Arginine depletion in critical illness is associated with impairments in microcirculatory blood flow, impaired wound healing, and T-cell dysfunction. The purpose of this review is to (1) describe arginine metabolism and role in health and critical illness, (2) describe the relationship between arginine and asymmetric dimethylarginine, and (3) review studies of supplemental arginine in critically ill patients...
August 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27241829/expression-and-purification-of-rhil-10-rgd-from-escherichia-coli-as-a-potential-wound-healing-agent
#17
Fangfang Yang, Yi Wan, Jiaqi Liu, Xuekang Yang, Hongtao Wang, Ke Tao, Juntao Han, Jihong Shi, Dahai Hu
Various protocols for recombinant Interleukin-10 (IL-10) purification in wound healing have been reported previously. However, the therapeutic effect was not obvious. Thus, it is of great importance to find new and effective approaches for therapy. In this study, we propose that IL-10 and Arginine-Glycine-Aspartic (RGD) peptide would be a valuable therapeutic for wound healing. To explore a high-efficiency and cost-effective approach for the production of IL-10 and RGD peptide with bioactivity, a synthetic gene was cloned into a recombinant pTWIN1 vector...
August 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27180260/intracellular-sources-of-ornithine-for-polyamine-synthesis-in-endothelial-cells
#18
Hui Li, Cynthia J Meininger, Fuller W Bazer, Guoyao Wu
Polyamines are essential for proliferation of endothelial cells (EC) and angiogenesis. This study was conducted to identify the metabolic source(s) of ornithine for polyamine synthesis in EC, using N(ω)-hydroxy-nor-L-arginine (Nor-NOHA, an inhibitor of arginase) and gabaculine (an inhibitor of ornithine aminotransferase; OAT). Nor-NOHA inhibited arginase with an IC50 value of 10 µM for intact EC. Nor-NOHA (0.5 mM) alone inhibited arginase activity in EC by 98 %, increased total cellular concentrations of arginine by 14 %, and decreased total cellular concentrations of ornithine, putrescine and spermidine by 17, 65 and 74 %, respectively...
October 2016: Amino Acids
https://www.readbyqxmd.com/read/26782276/is-preoperative-protein-rich-nutrition-effective-on-postoperative-outcome-in-non-small-cell-lung-cancer-surgery-a-prospective-randomized-study
#19
RANDOMIZED CONTROLLED TRIAL
Seyda Ors Kaya, Tevfik Ilker Akcam, Kenan Can Ceylan, Ozgur Samancılar, Ozgur Ozturk, Ozan Usluer
OBJECTIVE: Protein-rich nutrition is necessary for wound healing after surgery. In this study, the benefit of preoperative nutritional support was investigated for non-small cell lung cancer patients who underwent anatomic resection. METHODS: A prospective study was planned with the approval of our institutional review board. Fifty-eight patients who underwent anatomic resection in our department between January 2014 and December 2014 were randomized. Thirty-one patients were applied a preoperative nutrition program with immune modulating formulae (enriched with arginine, omega-3 fatty acids and nucleotides) for ten days...
January 19, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/26509249/growth-factors-for-treating-diabetic-foot-ulcers
#20
REVIEW
Arturo J Martí-Carvajal, Christian Gluud, Susana Nicola, Daniel Simancas-Racines, Ludovic Reveiz, Patricio Oliva, Jorge Cedeño-Taborda
BACKGROUND: Foot ulcers are a major complication of diabetes mellitus, often leading to amputation. Growth factors derived from blood platelets, endothelium, or macrophages could potentially be an important treatment for these wounds but they may also confer risks. OBJECTIVES: To assess the benefits and harms of growth factors for foot ulcers in patients with type 1 or type 2 diabetes mellitus. SEARCH METHODS: In March 2015 we searched the Cochrane Wounds Group Specialised Register, The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), Ovid MEDLINE, Ovid MEDLINE (In-Process & Other Non-Indexed Citations, Ovid EMBASE and EBSCO CINAHL...
2015: Cochrane Database of Systematic Reviews
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