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treatment of hepatocellular carcinoma

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https://www.readbyqxmd.com/read/29656300/the-sineoculis-homeobox-homolog-1-six1-gene-regulates-paclitaxel-resistance-by-affecting-reactive-oxygen-species-and-autophagy-in-human-hepatocellular-carcinoma-cell-line-hepg2
#1
Baowei Li, Shahe Zhao, Ruipeng Geng, Zhongchao Huo, Hui Zhang
BACKGROUND The objective of this study was to explore the role of SIX1 in paclitaxel (TAX) resistance of HepG2 cells via reactive oxygen species (ROS) and autophagy pathway. MATERIAL AND METHODS Hepatoma cell line HepG2 was treated with SIX1 knockdown or/and TAX. Cell growth was detected by MTT assay and colony formation assay. Cell apoptosis was evaluated with flow cytometry. ROS levels were detected using flow cytometry (stained with DCFH2-DA). Western blot was conducted to detect the expression of SIX1 and autophagy-related proteins...
April 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29655836/incidence-of-hepatocellular-carcinoma-in-patients-with-hcv-associated-cirrhosis-treated-with-direct-acting-antiviral-agents
#2
Vincenza Calvaruso, Giuseppe Cabibbo, Irene Cacciola, Salvatore Petta, Salvatore Madonia, Alessandro Bellia, Fabio Tinè, Marco Distefano, Anna Licata, Lydia Giannitrapani, Tullio Prestileo, Giovanni Mazzola, Maria Antonietta Di Rosolini, Licia Larocca, Gaetano Bertino, Antonio Digiacomo, Francesco Benanti, Luigi Guarneri, Alfonso Averna, Carmelo Iacobello, Antonio Magro, Ignazio Scalisi, Fabio Cartabellotta, Francesca Savalli, Marco Barbara, Antonio Davì, Maurizio Russello, Gaetano Scifo, Giovanni Squadrito, Calogero Cammà, Giovanni Raimondo, Antonio Craxì, Vito Di Marco
BACKGROUND & AIMS: Studies have produced conflicting results of the incidence of hepatocellular carcinoma (HCC) in patients with in hepatitis C virus (HCV)-associated cirrhosis treated with direct-acting antivirals (DAAs). Data from clinics are needed to accurately assess the occurrence rate of HCC in patients with cirrhosis in the real world. METHODS: We collected data from a large prospective study of 2249 consecutive patients (mean age, 65.4 years and 56...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655574/current-treatment-for-non-alcoholic-fatty-liver-disease
#3
C Moctezuma-Velázquez
Non-alcoholic fatty liver disease is the most prevalent hepatopathy, estimated at 30% in the general population. In the coming years, it will likely be the most common indication for liver transplantation and the most frequent cause of hepatocellular carcinoma. Current treatment for non-alcoholic fatty liver disease is based on dietary and exercise interventions that have been shown to be efficacious, even for reverting fibrosis. Unfortunately, compliance with general measures involving lifestyle modifications is very poor, making pharmacologic strategies a necessary option...
April 11, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29655570/interleukin-7-enhances-anti-tumor-activity-of-cd8-t-cells-in-patients-with-hepatocellular-carcinoma
#4
Dengke Teng, Lei Ding, Bo Cai, Qiang Luo, Hui Wang
Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals were enrolled. IL-7 expression and its receptor α chain CD127 level was measured. The regulatory activity of IL-7 to peripheral and liver-resident CD8+ T cells was investigated in co-culture systems which were directly or indirectly contacted with HCC cell line HepG2 in vitro...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29653312/improved-chemo-photothermal-therapy-of-hepatocellular-carcinoma-using-chitosan-coated-gold-nanoparticles
#5
Dina S Salem, Mahmoud A Sliem, Mohamed El-Sesy, Samia A Shouman, Yehia Badr
A green method was used for producing gold nanoparticles (Au NPs) using chitosan as a natural cationic, biodegradable and biocompatible polymer. In this method, chitosan acts as a reducing and stabilizing agent for the synthesis of Au NPs. Different concentrations of chitosan solutions (0.01%, 0.05%, 0.1%, 0.2%, 0.5% and 1%) were applied. In an attempt to mitigate the side effects of anti-cancer drug, 5-fluorouracil (5-FU), through reducing drug doses in photothermal therapy, the formed positively-charged chitosan-wrapped Au NPs were used as a drug delivery system for negatively charged 5-FU to hepatocellular carcinoma cells (HepG2)...
April 4, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29653269/microrna-26a-is-a-key-regulon-that-inhibits-progression-and-metastasis-of-c-myc-ezh2-double-high-advanced-hepatocellular-carcinoma
#6
Xiang Zhang, Xiao Zhang, Ting Wang, Lei Wang, Zhijun Tan, Wei Wei, Bo Yan, Jing Zhao, Kaichun Wu, Angang Yang, Rui Zhang, Lintao Jia
Overexpressed c-Myc and EZH2 usually mean high malignancy in cancers. Most of mortality from cancer is attributable to metastasis. MicroRNAs(miRNAs), like transcription factors, can regulate hundreds of genes. Here, we identify microRNA-26a (miR-26a) suppresses EZH2 and c-Myc by targeting EZH2 and CDK8 in Wnt pathway. MiR-26a is a well-known tumor-suppressive miRNA in multiple cancers, but how it is downregulated in hepatocellular carcinoma (HCC) is still unclear. Here, we disclose miR-26a is epigenetic silenced by a c-Myc-mediated PRC2-depandent way in HCC...
April 10, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29652561/treatment-of-metastatic-hepatocellular-carcinoma-in-pediatric-patients-two-case-reports
#7
Helen Pearson, A S Knisely, Maesha Deheragoda, Stergios Zacharoulis, Fernando Carceller
No abstract text is available yet for this article.
April 13, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29651140/novel-indole-fused-benzo-oxazepines-ifbos-inhibit-invasion-of-hepatocellular-carcinoma-by-targeting-il-6-mediated-jak2-stat3-oncogenic-signals
#8
Ashok K Singh, Archana S Bhadauria, Umesh Kumar, Vinit Raj, Amit Rai, Pranesh Kumar, Amit K Keshari, Dinesh Kumar, Biswanath Maity, Sneha Nath, Anand Prakash, Sudipta Saha
Inspired by the well-documented tumor protecting ability of paullones, recently, we synthesized novel paullone-like scaffolds, indole-fused benzo-oxazepines (IFBOs), and screened them against hepatocellular carcinoma (HCC) specific Hep-G2 cells. Three of the synthesized compounds significantly attenuated the progression of HCC in vitro. By computational studies, we further discovered that IFBOs exhibited a stable binding complex with the IL-6 receptor. In this context, we investigated in vivo study using the nitrosodiethyl amine (NDEA)-induced HCC model, which strengthened our previous findings by showing the blockade of the IL-6 mediated JAK2/STAT3 oncogenic signaling pathway...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650438/hepatitis-e-virus-infection-mimicking-acute-graft-rejection-in-a-liver-transplant-recipient
#9
M Allaire, C Bazille, J Selves, E Salamé, M Altieri
INTRODUCTION: In liver transplant (LT) patients, hepatitis E virus (HEV) can lead to acute liver failure, chronic hepatitis and graft cirrhosis. Few data on graft rejection associated with HEV are available and are subject to discussion. CASE REPORT: Here we report the case of a 58-year-old male patient who underwent LT in July 2015 for cirrhosis due to NASH and chronic alcohol intake complicated by hepatocellular carcinoma. LT was performed with a deceased donor isogroup and a mismatch CMV (donor+ and recipient-)...
April 10, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29649779/activation-of-hepatic-stellate-cells-during-liver-carcinogenesis-requires-fibrinogen-integrin-%C3%AE-v%C3%AE-5-in-zebrafish
#10
Chuan Yan, Qiqi Yang, Zhiyuan Gong
Hepatocellular carcinoma (HCC) is one of the most common cancers and it usually develops from a background of liver fibrosis or inflammation. The crosstalk between tumor cells and stromal cells plays an important and stimulating role during tumor progression. Previously we found in a krasV12 -induced zebrafish HCC model that oncogenic hepatocytes activate hepatic stellate cells (HSCs) by up-regulation of serotonin and activate neutrophils and macrophages by up-regulation of cortisol. In the present study, we found a novel signaling transduction mechanism between oncogenic hepatocytes and HSCs...
April 9, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29649630/standard-cd44-modulates-yap1-through-a-positive-feedback-loop-in-hepatocellular-carcinoma
#11
Zhenhai Fan, Hongwei Xia, Huanji Xu, Ji Ma, Sheng Zhou, Wanting Hou, Qiulin Tang, Qiyong Gong, Yongzhan Nie, Feng Bi
High expression levels of CD44 and YAP have been identified as poor prognostic factors in hepatocellular carcinoma (HCC). However, the mechanistic relationship between CD44 and YAP during HCC tumorigenesis remains largely unknown. To investigate the mutual regulation between standard CD44 (CD44S) and YAP1 in HCC cell lines and tissue samples, CD44S and YAP1 expression in 40 pairs of tumor samples and matched distal normal tissues from HCC patients was examined by immunohistochemical staining. High expression of either CD44S or YAP1 was associated with a younger age and worse pathology grade...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29649145/combined-effect-of-anticancer-agents-and-cytochrome-c-decorated-hybrid-nanoparticles-for-liver-cancer-therapy
#12
Wejdan Al-Shakarchi, Ali Alsuraifi, Mohammed Abed, Marwan Abdullah, Alan Richardson, Anthony Curtis, Clare Hoskins
Hepatocellular carcinoma is an aggressive form of liver cancer that displays minimal symptoms until its late stages. Unfortunately, patient prognosis still remains poor with only 10% of patients surviving more than five years after diagnosis. Current chemotherapies alone are not offering efficient treatment, hence alternative therapeutic approaches are urgently required. In this work, we highlight the potential of combination of treatment of hepatocellular carcinoma with existing chemotherapies in combination with pro-apoptotic factor cytochrome C...
April 12, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29645345/comparison-of-clinical-outcome-of-hepatic-arterial-infusion-chemotherapy-and-sorafenib-for-advanced-hepatocellular-carcinoma-according-to-macrovascular-invasion-and-transcatheter-arterial-chemoembolization-refractory-status
#13
Kenichiro Kodama, Tomokazu Kawaoka, Hiroshi Aikata, Shinsuke Uchikawa, Yuki Inagaki, Masahiro Hatooka, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Keiichi Masaki, Yoji Honda, Nami Mori, Shintaro Takaki, Keiji Tsuji, Hirotaka Kohno, Hiroshi Kohno, Takashi Moriya, Michihiro Nonaka, Hideyuki Hyogo, Yasuyuki Aisaka, Kazuaki Chayama
AIM: Sorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC) with distant metastasis, unresectable HCC, and HCC refractory to transcatheter arterial chemoembolization (TACE) or with macroscopic vascular invasion (MVI). Also, hepatic arterial infusion chemotherapy (HAIC) has been used for advanced HCC in Southeast and East Asian countries. However, clearer information is needed for choosing appropriately between these therapies. METHODS: The subjects were 391 HAIC and 431 sorafenibs administered at our hospital and related hospitals...
April 12, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29645076/the-role-of-external-beam-radiotherapy-in-the-treatment-of-hepatocellular-cancer
#14
REVIEW
Fumiko Chino, Sarah Jo Stephens, Steve S Choi, Daniele Marin, Charles Y Kim, Michael A Morse, Devon J Godfrey, Brian G Czito, Christopher G Willett, Manisha Palta
Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated, oral antiviral therapies for hepatitis C. Curative options for patients with HCC are often limited by underlying liver dysfunction/cirrhosis and medical comorbidities. Less than one-third of patients are candidates for surgery, which is the current gold standard for cure...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29644547/sacmda-mirna-disease-association-prediction-with-short-acyclic-connections-in-heterogeneous-graph
#15
Biyao Shao, Bingtao Liu, Chenggang Yan
MiRNA-disease association is important to disease diagnosis and treatment. Prediction of miRNA-disease associations is receiving increasing attention. Using the huge number of known databases to predict potential associations between miRNAs and diseases is an important topic in the field of biology and medicine. In this paper, we propose a novel computational method of with Short Acyclic Connections in Heterogeneous Graph (SACMDA). SACMDA obtains AUCs of 0.8770 and 0.8368 during global and local leave-one-out cross validation, respectively...
April 11, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29643998/deletion-of-sphingosine-kinase-1-inhibits-liver-tumorigenesis-in-diethylnitrosamine-treated-mice
#16
Jinbiao Chen, Yanfei Qi, Yang Zhao, Dominik Kaczorowski, Timothy A Couttas, Paul R Coleman, Anthony S Don, Patrick Bertolino, Jennifer R Gamble, Mathew A Vadas, Pu Xia, Geoffrey W McCaughan
Primary liver cancer is the 3rd leading cause of cancer deaths worldwide with very few effective treatments. Sphingosine kinase 1 (SphK1), a key regulator of sphingolipid metabolites, is over-expressed in human hepatocellular carcinoma (HCC) and our previous studies have shown that SphK1 is important in liver injury. We aimed to explore the role of SphK1 specifically in liver tumorigenesis using the SphK1 knockout ( SphK1 -/- ) mouse. SphK1 deletion significantly reduced the number and the size of DEN-induced liver cancers in mice...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29642606/metabolism-driven-high-throughput-cancer-identification-with-glut5-specific-molecular-probes
#17
Srinivas Kannan, Vagarshak V Begoyan, Joseph R Fedie, Shuai Xia, Łukasz J Weseliński, Marina Tanasova, Smitha Rao
Point-of-care applications rely on biomedical sensors to enable rapid detection with high sensitivity and selectivity. Despite advances in sensor development, there are challenges in cancer diagnostics. Detection of biomarkers, cell receptors, circulating tumor cells, gene identification, and fluorescent tagging are time-consuming due to the sample preparation and response time involved. Here, we present a novel approach to target the enhanced metabolism in breast cancers for rapid detection using fluorescent imaging...
April 10, 2018: Biosensors
https://www.readbyqxmd.com/read/29642405/transcriptome-analysis-of-acute-phase-liver-graft-injury-in-liver-transplantation
#18
Nikki P Lee, Haiyang Wu, Kevin T P Ng, Ruibang Luo, Tak-Wah Lam, Chung-Mau Lo, Kwan Man
BACKGROUND: Liver transplantation remains the treatment of choice for a selected group of hepatocellular carcinoma (HCC) patients. However, the long-term benefit is greatly hampered by post-transplant HCC recurrence. Our previous studies have identified liver graft injury as an acute phase event leading to post-transplant tumor recurrence. METHODS: To re-examine this acute phase event at the molecular level and in an unbiased way, RNA sequencing (RNA-Seq) was performed on liver graft biopsies obtained from the transplant recipients two hours after portal vein reperfusion with an aim to capture frequently altered pathways that account for post-transplant tumor recurrence...
April 6, 2018: Biomedicines
https://www.readbyqxmd.com/read/29629806/comparative-effectiveness-of-transarterial-embolization-and-sorafenib-for-hepatocellular-carcinoma-a-population-based-study
#19
Sharon W Kwan, William P Harris, Laura S Gold, Paul L Hebert
OBJECTIVE: The purpose of this study was to compare the clinical effectiveness of embolization with that of sorafenib in the management of hepatocellular carcinoma as practiced in real-world settings. MATERIALS AND METHODS: This population-based observational study was conducted with the Surveillance, Epidemiology, and End Results-Medicare linked database. Patients 65 years old and older with a diagnosis of primary liver cancer between 2007 and 2011 who underwent embolization or sorafenib treatment were identified...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29629357/living-donor-liver-transplantation-prior-to-multiple-myeloma-treatment-in-a-patient-with-hepatitis-b-associated-hepatocellular-carcinoma-and-liver-cirrhosis-a-case-report
#20
Chan Woo Cho, Nuri Lee, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh
Clinical outcomes of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) in patients with multiple myeloma (MM) have not been established in terms of HCC recurrence and MM deterioration after LDLT. A 51-year-old man with chronic hepatitis B was diagnosed with HCC and MM. Since the patient also had decompensated liver cirrhosis (LC), he underwent LDLT prior to autologous peripheral blood stem cell transplantation (PBSCT) to prevent fulminant hepatitis due to HBV reactivation. The patient received Epstein-Barr virus prophylaxis and a triple immunosuppressive regimen of tacrolimus, everolimus, and steroid after LDLT...
April 2018: Annals of Surgical Treatment and Research
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