Kazuyoshi Tsutsui, George E Bentley, Takayoshi Ubuka, Etsuko Saigoh, Hong Yin, Tomohiro Osugi, Kazuhiko Inoue, Vishwajit S Chowdhury, Kazuyoshi Ukena, Nick Ciccone, Peter J Sharp, John C Wingfield
The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin secretion. Gonadal sex steroids and inhibin inhibit gonadotropin secretion via feedback from the gonads, but a neuropeptide inhibitor of gonadotropin secretion was, until recently, unknown in vertebrates. In 2000, we identified a novel hypothalamic dodecapeptide that inhibits gonadotropin release in cultured quail pituitaries and termed it gonadotropin-inhibitory hormone (GnIH)...
August 2007: General and Comparative Endocrinology