Amrutha Swaminathan, Hélène Delage, Snehajyoti Chatterjee, Laurence Belgarbi-Dutron, Raphaelle Cassel, Nicole Martinez, Brigitte Cosquer, Sujata Kumari, Fabien Mongelard, Béatrice Lannes, Jean-Christophe Cassel, Anne-Laurence Boutillier, Philippe Bouvet, Tapas K Kundu
Although the elaborate combination of histone and non-histone protein complexes defines chromatin organization and hence regulates numerous nuclear processes, the role of chromatin organizing proteins remains unexplored at the organismal level. The highly abundant, multifunctional, chromatin-associated protein and transcriptional coactivator positive coactivator 4 (PC4/Sub1) is absolutely critical for life, because its absence leads to embryonic lethality. Here, we report results obtained with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically in the brain...
September 23, 2016: Journal of Biological Chemistry