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https://www.readbyqxmd.com/read/29685116/characterization-treatment-and-prognosis-of-retinoblastoma-with-central-nervous-system-metastasis
#1
Huimin Hu, Weiling Zhang, Yizhuo Wang, Dongsheng Huang, Jitong Shi, Bin Li, Yi Zhang, Yan Zhou
BACKGROUND: Retinoblastoma is the most common primary intraocular tumor and more and more attention has been paid to the developing countries. This study was aimed to evaluate the clinical features, treatment, and prognosis of retinoblastoma patients with central nervous system (CNS) metastasis in Beijing Tongren Hospital, one of the largest tertiary eye centers in China. METHODS: Clinical data of 31 consecutive retinoblastoma patients with CNS metastases, who were diagnosed at the Department of Pediatrics in Beijing Tongren Hospital between September 2005 and December 2015, were retrospective analyzed...
April 23, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29684573/bevacizumab-reduces-s100a9-mdsc-linked-to-intracranial-control-in-patients-with-egfr-mutant-lung-adenocarcinoma
#2
Po-Hao Feng, Kuan-Yuan Chen, Yu-Chen Huang, Ching-Shan Luo, Shen Ming Wu, Tzu-Tao Chen, Chun-Nin Lee, Chi-Tai Yeh, Hsiao-Chi Chuang, Chia-Li Han, Chiou-Feng Lin, Wei-Hwa Lee, Chih-Hsi Kuo, Kang-Yun Lee
BACKGROUND: In vitro models have demonstrated immune-modulating effects of bevacizumab. Combinations of EGFR tyrosine kinase inhibitor (TKI) with bevacizumab improve progression free survival (PFS) in patients with EGFR mutated lung adenocarcinoma. How bevacizumab confers this clinical effect and underlying mechanisms are not clear. PATIENT AND METHODS: Fifty-five patients with stage 4 EGFR mutated lung adenocarcinoma were enrolled. Myeloid derived suppressor cells (MDSCs), T helper cells (Th1/Th2) and cytotoxic T lymphocytes (CTLs) were analyzed by flow cytometry...
April 20, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29682040/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#3
Jun Jie Ng, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous reports in literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682026/prognostic-implications-of-histological-clear-cells-in-high-grade-intracranial-ependymal-tumors-a-retrospective-analysis-from-a-tertiary-care-hospital-in-pakistan
#4
Fauzan Alam Hashmi, Hamid Hussain Rai, Muhammad Faheem Khan, Muhammad Ehsan Bari
Background: Clear cell variant in ependymal tumors is rare. We aimed to compare the features and outcome of the World Health Organization (WHO) Grade 3 ependymal tumors with clear cells to the WHO Grade 3 classic anaplastic ependymoma (AE). Materials and Methods: A retrospective cohort study conducted at the Department of Neurosurgery, Aga Khan University, Pakistan, from 2003 to 2013. The medical records and radiology of patients with proven histopathology were reviewed...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678476/cabazitaxel-plus-lapatinib-as-therapy-for-her2-metastatic-breast-cancer-with-intracranial-metastases-results-of-a-dose-finding-study
#5
Denise A Yardley, Lowell L Hart, Patrick J Ward, Gail L Wright, Mythili Shastry, Lindsey Finney, Laura M DeBusk, John D Hainsworth
BACKGROUND: Lapatinib is an oral small molecule tyrosine kinase epidermal growth factor receptor-1/HER2 inhibitor that crosses the blood-brain barrier and is active against central nervous system (CNS) metastases. Cabazitaxel is a taxoid that is effective against taxane-resistant metastatic breast cancer (MBC) and has distinguished itself by its ability to cross the blood-brain barrier. The present phase II study (ClinicalTrials.gov identifier, NCT01934894) evaluated the combination of these agents to treat HER2+ MBC patients with CNS metastases...
March 8, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29675794/association-between-programmed-cell-death-ligand-1-expression-and-extracranial-metastasis-in-intracranial-solitary-fibrous-tumor-hemangiopericytoma
#6
Dai Kamamoto, Kentaro Ohara, Yohei Kitamura, Kazunari Yoshida, Yutaka Kawakami, Hikaru Sasaki
BACKGROUND: Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) often shows extracranial metastasis, and treatment options are very limited. Immune-checkpoint molecules have not been studied well in SFT/HPCs, and their role in intracranial SFT/HPCs remains unclear. METHODS: We investigated the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and tumor-infiltrating lymphocytes (TIL) in 16 patients of intracranial SFT/HPC by immunohistochemistry to determine if correlation with prognosis exists...
April 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29668616/lung-metastases-from-intracranial-bleeding-meningioma-a-case-report
#7
Su Hu, Yaqi Zhang, Yue Sun, Yang Yu, Jia Wang, Hui Dai, Feng Sun, Chunhong Hu
RATIONALE: Meningioma is slow-growing benign neoplasm that derived from the meningothelial cells of the arachnoid mater, and it is the most common type of primary brain tumor. Although cases of extracranial metastatic meningioma have been reported previously, few cases have reported the concurrent occurrence of primary meningioma with intratumoral bleeding and lung metastases. Here we report a case of meningioma with concurrent intratumoral bleeding and lung metastases. PATIENT CONCERNS: The patient was admitted to our hospital with sudden left limb paralysis combined with complaints of headache and dizziness...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29650833/-a-case-of-local-recurrence-of-descending-colon-cancer-with-ileus-obstruction-and-lung-liver-and-brain-metastasis
#8
Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai, Takeo Azuhata, Yuko Takamoto
We report a 50-year-old man with local recurrence of descending colon cancer with ileus obstruction and brain metastasis, 2 years 6 months after initial resection due to perforation of descending colon cancer(Hartmann procedure, D2 lymph node resection, Stage II, tub2). He complained of left upper abdominal pain and abdominal fullness. He also complained of paresis of the right upper extremity and of experiencing convulsions 1 month before admission. He was diagnosed with local recurrence of descending colon cancer, based on findings of contrast radiography and the presence of colonic fiber...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29644484/intracranial-control-and-survival-outcome-of-tyrosine-kinase-inhibitor-tki-alone-versus-tki-plus-radiotherapy-for-brain-metastasis-of-epidermal-growth-factor-receptor-mutant-non-small-cell-lung-cancer
#9
SooYoon Sung, Sea-Won Lee, Yoo-Kang Kwak, Jin Hyung Kang, Sook Hee Hong, Yeon-Sil Kim
INTRODUCTION: The efficacy of tyrosine kinase inhibitors (TKIs) with and without radiotherapy (RT) has not been determined in patients with brain metastases from epidermal growth factor receptor-mutant TKI naïve non-small cell lung cancer (NSCLC). METHODS: Between 2008 and 2016, 586 patients were diagnosed with NSCLC and treated with TKIs at a hospital in Seoul, South Korea; 81 of these patients met the eligibility criteria for our study. Outcomes analyzed included intracranial progression (ICP), neurological death, and overall survival (OS)...
April 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29598947/locoregional-extension-and-patterns-of-failure-for-nasopharyngeal-carcinoma-with-intracranial-extension
#10
Caineng Cao, Feng Jiang, Qifeng Jin, Ting Jin, Shuang Huang, Qiaoying Hu, Yuanyuan Chen, Yongfeng Piao, Yonghong Hua, Xinglai Feng, Xiaozhong Chen
OBJECTIVE: To evaluate the locoregional extension and patterns of failure for nasopharyngeal carcinoma (NPC) with intracranial extension to improve clinical target volume (CTV) delineation. PATIENTS AND METHODS: A total of 205 NPC patients with intracranial extension by magnetic resonance imaging (MRI) were retrospectively reviewed. RESULTS: According to the cumulative incidence rates of tumor invasion, we initially classified anatomic sites surrounding the nasopharynx into three risk grades: high risk (≥35%), medium risk (≥10-35%), and low risk (<10%)...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594220/role-of-radiotherapy-in-extracranial-metastatic-malignant-melanoma-in-the-modern-era
#11
Ryan S Youland, Miran L Blanchard, Roxanna Dronca, Lisa Kottschade, Svetomir N Markovic, Kenneth R Olivier, Sean S Park
Background: To assess the role of radiotherapy in metastatic malignant melanoma (MM) patients in modern era. Materials and methods: This is a retrospective study of MM patients treated with radiotherapy at Mayo Clinic from 1999 to 2014. Patients with pre- and post-treatment imaging studies (CT, MRI, and/or PET/CT) were assessed for metastasis failure (MF), regional/distant failure, and overall survival (OS). Results: In 75 MM patients, 56 and 68 lesions were treated with conventional/hypofractionated radiotherapy (CHRT) and stereotactic body radiotherapy (SBRT), respectively...
October 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29588244/intracranial-epidural-metastases-of-adrenal-pheochromocytoma-a-rare-entity
#12
Lillian B Boettcher, Hussam Abou-Al-Shaar, Vijay M Ravindra, Jeffrey Horn, Cheryl Ann Palmer, Sarah T Menacho
Pheochromocytomas are uncommon neuroendocrine tumors of the adrenal medulla. Malignant behavior is seen in approximately 10% of these lesions, evidenced by distant metastasis to sites without chromaffin tissue. The authors report a rare case of intracranial epidural metastases of an adrenal pheochromocytoma in a 24-year-old man. The patient originally presented at the age of 10 years with adrenal pheochromocytoma and subsequently developed extensive metastatic bone and lung disease. He was monitored in the intervening years until recent imaging demonstrated an enlarging right parietal mass...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29571176/intraoperative-ultrasound-appearance-of-a-pancreatic-cerebral-metastasis-a-case-report
#13
Carmine Antonio Donofrio, Lina Raffaella Barzaghi, Jody Filippo Capitanio, Andrea Cavalli, Pietro Panni, Silvia Snider, Pietro Mortini
BACKGROUND:  Brain metastases (BMs) derived from pancreatic adenocarcinoma (PAC) have an extremely low incidence (0.1-0.4%) and are usually associated with a very poor prognosis. The treatment strategy is palliative and includes conventional radiotherapy, stereotactic radiosurgery, chemotherapy, and surgical resection. CASE DESCRIPTION:  A 39-year-old man with a history of PAC developed a systemic tumor relapse with intracranial progression. Magnetic resonance imaging (MRI) documented a right rolandic, cortical, and cystic lesion with leptomeningeal intrasulcular extension...
March 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29561699/efficacy-generated-by-afatinib-in-a-lung-adenocarcinoma-patient-harboring-her2-s310y-mutation
#14
Jian Wang, Yuxin Wen, Guanggui Ding, Peikun Ding, Lu Zhang, Jing Liu, Tengfei Zhang, Lin Yang
Afatinib exhibits therapeutic efficacy for lung adenocarcinoma patients harboring HER2 exon 20 insertions. HER2 S310Y single site substitution was discovered in recent years and afatinib efficacy for adenocarcinoma patients harboring S310Y mutation has not been reported. We presented a case of a 41-year-old male patient with lung adenocarcinoma harboring the HER2 S310Y mutation obtained clinical response to the treatment of afatinib, an oral HER family blocker. After the treatment of afatinib, the patient achieved partial response (PR) in chest lesions and almost complete response (CR) in intracranial lesions...
March 21, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29557535/the-breast-graded-prognostic-assessment-is-associated-with-the-survival-outcomes-in-breast-cancer-patients-receiving-whole-brain-re-irradiation
#15
Shih-Fan Lai, Yu-Hsuan Chen, Tony Hsiang-Kuang Liang, Che-Yu Hsu, Huang-Chun Lien, Yen-Sen Lu, Chiun-Sheng Huang, Sung-Hsin Kuo
INTRODUCTION: Whole brain (WB) re-irradiation for breast cancer patients with progressive brain metastasis after first-course WB radiotherapy (WBRT) is controversial. In this study, we sought to investigate the association between the molecular sub-classifications and breast-specific Graded Prognostic Assessment (GPA, which includes the Karnofsky performance status, molecular subtypes, and age as its indices) and the outcomes of breast cancer patients who received WB re-irradiation. METHODS: Twenty-three breast cancer patients who received WB re-irradiation for relapsed and progressive intracranial lesions after first-course WBRT between 2004 and 2016 were retrospectively reviewed...
March 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29551003/surveillance-for-metastatic-hemangiopericytoma-solitary-fibrous-tumors-systematic-literature-review-on-incidence-predictors-and-diagnosis-of-extra-cranial-disease
#16
REVIEW
Tarini Ratneswaren, Florence Rosie Avila Hogg, Mathew Joseph Gallagher, Keyoumars Ashkan
BACKGROUND: Intracranial hemangiopericytomas (HPC) and solitary fibrous tumors (SFTs) (HPC-SFT) are rare vascular tumors that resemble meningioma on imaging and predominantly affect young adults. HPC-SFT have a high rate of local recurrence with well-known propensity for extracranial metastases. This provides clinical dilemmas frequently encountered in oncology: (i) How should these patients be monitored long term? (ii) Which primary tumors are more likely to metastasize? OBJECTIVES: This systematic review aims to identify the incidence, common locations and time to presentation of extra-cranial metastases of HPC-SFT...
March 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29510758/garcin-syndrome-caused-by-sphenoid-bone-metastasis-of-lung-cancer-a-case-study
#17
Satoshi Fukai, Naoyuki Okabe, Hayato Mine, Hironori Takagi, Hiroyuki Suzuki
BACKGROUND: Garcin syndrome, which consists of unilateral palsies of almost all cranial nerves without either sensory or motor long-tract disturbances or intracranial hypertension, can be caused by malignant tumors at the skull base. The case of a patient with lung cancer that metastasized to the sphenoid bone and resulted in Garcin syndrome is presented. CASE PRESENTATION: A 76-year-old woman was diagnosed as having non-small cell lung cancer with pericardial and diaphragmatic infiltration, cT4N1M0, stage 3A...
March 6, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29507845/stereotactic-radiosurgery-for-multiple-brain-metastases-two-cases-of-preserved-quality-of-life
#18
Anthony Pham, Becky Lee, Eric L Chang
Brain metastases are the most common intracranial tumors in the adult population and have been historically treated with whole brain radiation therapy (WBRT). However, as medical advances improve life expectancy, stereotactic radiosurgery (SRS) has replaced WBRT as the standard of care for limited (one to three) brain metastases due to the relative sparing of neurocognitive function (NCF) and therefore quality of life (QoL). The use of SRS has been less documented in the case of multiple (four or more) brain metastases, with literature limited to non-randomized studies showing comparable survival and local control...
December 28, 2017: Curēus
https://www.readbyqxmd.com/read/29507614/molecular-magnetic-resonance-imaging-of-endothelial-activation-in-the-central-nervous-system
#19
REVIEW
Maxime Gauberti, Antoine P Fournier, Fabian Docagne, Denis Vivien, Sara Martinez de Lizarrondo
Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, it constitutes a target of choice for molecular magnetic resonance imaging (MRI). In this review, we highlight the most recent advances in molecular MRI of brain endothelial activation and focus on the development of micro-sized particles of iron oxide (MPIO) targeting adhesion molecules including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), P-Selectin and E-Selectin...
2018: Theranostics
https://www.readbyqxmd.com/read/29502310/clinical-utility-of-simultaneous-whole-body-18-f-fdg-pet-mri-as-a-single-step-imaging-modality-in-the-staging-of-primary-nasopharyngeal-carcinoma
#20
Sheng-Chieh Chan, Chih-Hua Yeh, Tzu-Chen Yen, Shu-Hang Ng, Joseph Tung-Chieh Chang, Chien-Yu Lin, Tsang Yen-Ming, Kang-Hsing Fan, Bing-Shen Huang, Cheng-Lung Hsu, Kai-Ping Chang, Hung-Ming Wang, Chun-Ta Liao
PURPOSE: Both head and neck magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) play a crucial role in the staging of primary nasopharyngeal carcinoma (NPC). In this study, we sought to prospectively investigate the clinical utility of simultaneous whole-body 18F-FDG PET/MRI for primary staging of NPC patients. METHODS: We examined 113 patients with histologically confirmed NPC who underwent pretreatment, simultaneous whole-body PET/MRI and PET/CT for primary tumor staging...
March 3, 2018: European Journal of Nuclear Medicine and Molecular Imaging
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