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Intracranial metastasis

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https://www.readbyqxmd.com/read/29464141/survival-and-failure-outcomes-predicted-by-brain-metastasis-volumetric-kinetics-in-melanoma-patients-following-upfront-treatment-with-stereotactic-radiosurgery-alone
#1
Michael C LeCompte, Emory McTyre, Adrianna Henson, Michael Farris, Catherine Okoukoni, Christina K Cramer, Pierre Triozzi, Jimmy Ruiz, Kounosuke Watabe, Hui-Wen Lo, Michael T Munley, Adrian W Laxton, Stephen B Tatter, Xiaobo Zhou, Michael Chan
Introduction The roles of early whole brain radiotherapy (WBRT) and upfront stereotactic radiosurgery (SRS) alone in the treatment of melanoma patients with brain metastasis remain uncertain. We investigated the volumetric kinetics of brain metastasis development and associations with clinical outcomes for melanoma patients who received upfront SRS alone. Methods Volumetric brain metastasis velocity (vBMV) was defined as the volume of new intracranial disease at the time of distant brain failure (DBF) for the first DBF (DBF1) and second DBF (DBF2) averaged over the time since initial or most recent SRS...
December 11, 2017: Curēus
https://www.readbyqxmd.com/read/29454960/a-case-of-subarachnoid-hemorrhage-from-ruptured-oncotic-fusiform-aneurysms-from-choriocarcinoma-metastasis-treated-with-aneurysmectomy-and-vessel-reconstruction
#2
Yuichi Ito, Yoshio Araki, Takashi Izumi, Sho Okamoto, Masaaki Kimura, Toshihiko Wakabayashi
BACKGROUND: Oncotic aneurysm is a rare condition with a high mortality rate. Since no consensus has been reached regarding therapeutic strategy for ruptured oncotic aneurysm, treatment remains challenging. CASE DESCRIPTION: A 35-year-old woman developed sudden onset of severe headache. Computed tomography showed subarachnoid hemorrhage and cerebral angiography revealed two fusiform aneurysms in the distal portion of the left middle cerebral artery. Aneurysmectomy with vessel reconstruction using a superficial temporal artery graft was performed to maintain blood flow to the distal middle cerebral artery...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29436187/efficacy-of-pemetrexed-based-chemotherapy-in-comparison-to-non-pemetrexed-based-chemotherapy-in-advanced-alk-non-small-cell-lung-cancer
#3
Jaemin Jo, Se Hyun Kim, Yu Jung Kim, Juhyun Lee, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong Wan Kim, Dae Seog Heo, Jin Haeng Chung, Yoon Kyung Jeon, Jong Seok Lee
PURPOSE: Previous retrospective studies suggest that anaplastic lymphoma kinase (ALK) mutation-positive (ALK+) non-small cell lung cancer (NSCLC) patients are sensitive to pemetrexed. To determine its efficacy, we retrospectively evaluated clinical outcomes of pemetrexed-based chemotherapy in patients with ALK+ NSCLC. MATERIALS AND METHODS: We identified 126 patients with advanced, ALK+ NSCLC who received first-line cytotoxic chemotherapy. We compared response, progression-free survival (PFS), and overall survival (OS) rates according to chemotherapy regimens...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29434454/sequential-spinal-and-intracranial-dural-metastases-in-gastric-adenocarcinoma-a-case-report
#4
Hongsik Kim, Kyung Sik Yi, Won-Dong Kim, Seung-Myoung Son, Yaewon Yang, Jihyun Kwon, Hye Sook Han
Dural metastasis from primary gastric adenocarcinoma has been rarely reported, and its prognosis is very poor because it frequently leads to acute subdural hematoma. Here, we describe a case with sequential spinal and cranial dural metastases from gastric adenocarcinoma without subdural hematoma. A 43-year-old woman with gastric adenocarcinoma and well-controlled peritoneal carcinomatosis presented with back pain, right radiating leg pain, left facial palsy, and hearing loss. Magnetic resonance imaging of the spine and brain revealed dural masses at the lumbosacral junction with invasion to the L5 and S1 nerve roots and at the skull base with invasion to the internal auditory canal...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29411634/undifferentiated-thymic-carcinoma-with-intracranial-metastasis-in-a-two-year-old
#5
Nuthan Kumar, Narendra Chaudhary, Anne Jennifer Prabhu, Leena Robinson Vimala, Deepthi Boddu, Leni Grace Mathew
Thymic carcinoma with central nervous system involvement is very rare in children. A 27-month-old girl presented with a unilateral squint, vomiting, and behavioral changes. Imaging studies showed a silent anterior mediastinal mass and a large metastatic mass at the base of the skull. Biopsy of the anterior mediastinal mass confirmed an undifferentiated tumor consistent with thymic carcinoma. The child died within 3 months of the onset of symptoms, due to progression of the disease. These lethal tumors of unknown histogeneses and etiology are aggressive in nature, resistant to therapy, and have a rapidly fatal course...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29404894/corticotrophic-pituitary-carcinoma-with-cervical-metastases-case-series-and-literature-review
#6
REVIEW
Frederick Yoo, Edward C Kuan, Anthony P Heaney, Marvin Bergsneider, Marilene B Wang
PURPOSE: Pituitary tumors are the second most common intracranial tumors, however, pituitary carcinoma is a rare clinical entity which represents only 0.1-0.2% of all pituitary tumors. Diagnosis of pituitary carcinoma requires the presence of metastasis. Early identification of pituitary carcinoma is difficult, and only recently have guidelines been published for the treatment of aggressive pituitary tumors. We present two cases from our institution, with a review of other cases available in literature in order to better characterize this rare disease...
February 5, 2018: Pituitary
https://www.readbyqxmd.com/read/29390401/high-dose-of-nimustine-as-an-add-on-treatment-for-small-cell-lung-cancer-with-intracranial-metastasis-a-case-report-and-literature-review-retraction
#7
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390382/brain-metastasis-in-a-patient-with-melanoma-receiving-pembrolizumab-therapy-a-case-report-and-review-of-the-literature
#8
Jin-Cheng Song, Xiao-Lei Ding, Xiu-Hua Sun, Mohammed Safi, Juan Tian
RATIONALE: Melanoma with brain metastasis is associated with a poor prognosis and high mortality rate. As patients with this condition have been excluded from most clinical trials, data on the use of anti-programmed death 1 therapy for these patients are limited. PATIENT CONCERNS: The patient was a 62-year-old man with a 10-year history of melanotic nevus in his right forearm. He was admitted to another hospital in August 2015 due to the growth of the melanotic nevus over 1 year and complaint of a mass in the right mid-axillary area...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381634/the-sellar-tumor-metastasis-or-chordoma
#9
Lin Zhou, Daming Cui, Lijin Feng, Liang Gao
Chordomas are uncommon, locally invasive chordate tumors, which are mostly observed in the axial skeleton. Numerous papers have described similar patients around different anatomic locations; however, rare document previously reported that intracranial chordoma was associated with clear cell renal cell carcinoma (ccRCC). The authors report a 51-year-old male patient with a history of right radical nephrectomy for ccRCC presented to us with progressive blurred vision. Ophthalmic examination showed vision loss and visual field defects...
January 19, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29369179/targeted-next-generation-sequencing-of-malignant-peripheral-nerve-sheath-tumor-of-the-pterygopalatine-fossa-with-intracranial-metastatic-recurrence
#10
Xinjie Bao, Xiangyi Kong, Chengxian Yang, Huanwen Wu, Wenbin Ma, Renzhi Wang
Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. Intracranial MPNSTs unrelated to cranial nerves are highly malignant tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. The pathogenesis of MPNST remains unclear. There are no conclusive explanations for the mechanisms underlying the initiation, progression, and metastasis of MPNST. In this paper, we describe a case of MPNST in the pterygopalatine fossa with intracranial metastatic recurrence and review related literatures...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29368289/liposomal-irinotecan-accumulates-in-metastatic-lesions-crosses-the-blood-tumor-barrier-btb-and-prolongs-survival-in-an-experimental-model-of-brain-metastases-of-triple-negative-breast-cancer
#11
Afroz S Mohammad, Jessica I Griffith, Chris E Adkins, Neal Shah, Emily Sechrest, Emma L Dolan, Tori B Terrell-Hall, Bart S Hendriks, Helen Lee, Paul R Lockman
PURPOSE: The blood-tumor barrier (BTB) limits irinotecan distribution in tumors of the central nervous system. However, given that the BTB has increased passive permeability we hypothesize that liposomal irinotecan would improve local exposure of irinotecan and its active metabolite SN-38 in brain metastases relative to conventional irinotecan due to enhanced-permeation and retention (EPR) effect. METHODS: Female nude mice were intracardially or intracranially implanted with human brain seeking breast cancer cells (brain metastases of breast cancer model)...
January 9, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29354331/pazopanib-mediated-long-term-disease-stabilization-after-local-recurrence-and-distant-metastasis-of-primary-intracranial-leiomyosarcoma-a-case-report-on-the-efficacy-of-pazopanib-as-a-salvage-therapy
#12
Yasuhiro Kawabata, Tomokazu Aoki, Tetsurou Yamamoto, Hisateru Yasui, Satoru Sawai, Shunichi Fukuda, Satoru Kawarazaki, Tetsuya Tsukahara
Primary intracranial leiomyosarcoma (LMS) is an extremely rare tumor of the central nervous system. Only sporadic case reports have been published, and therefore data regarding long-term prognosis remain scarce. A 76-year-old woman presented with a right parietal mass, which had grown rapidly in the month prior to admission. Neuroimaging showed a resemblance to intraosseous meningioma. Gross total resection of the tumor was achieved, and histological diagnosis confirmed LMS. Because positron emission tomography (PET) with fluorodeoxyglucose (FDG) just after the resection showed no abnormal uptake, we diagnosed the tumor as primary intracranial LMS...
January 2018: NMC Case Report Journal
https://www.readbyqxmd.com/read/29327171/efficacy-of-adjuvant-radiotherapy-in-the-intracranial-hemangiopericytoma
#13
Seung Hyuck Jeon, Sung-Hye Park, Jin Wook Kim, Chul-Kee Park, Sun Ha Paek, Il Han Kim
We retrospectively evaluated an efficacy of adjuvant radiotherapy (RT) in the intracranial hemangiopericytoma (HPC) and analyzed prognostic factors influencing treatment outcomes. Among 49 patients diagnosed as localized intracranial HPC between 1995 and 2016, 31 patients received adjuvant RT after surgery; 26 with fractionated RT and 5 with stereotactic radiosurgery using Gamma Knife. After gross total resection (GTR) (n = 32) and subtotal resection (STR) (n = 17), histopathological grade was confirmed to be grade II (n = 9) or grade III (n = 40)...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#14
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29286561/intracranial-metastasis-in-fibrolamellar-hepatocellular-carcinoma
#15
William J Hammond, Gadi Lalazar, James A Saltsman, Benjamin A Farber, Enrico Danzer, Tshering C Sherpa, Charles D Banda, Jeffrey R Andolina, Sasan Karimi, Cameron W Brennan, Michael S Torbenson, Michael P La Quaglia, Sanford M Simon
Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1-PRKACA, each necessitating neurosurgical intervention...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29274446/a-progressively-enlarging-cerebellar-hematoma-concurrent-with-t-dm1-treatment-case-report
#16
Marcelo D Vilela, William T Longstreth, Hugo As Pedrosa, Gabriel Ob Gil, Juliano M Duarte, Marco Antonio D Filho
BACKGROUND: Trastuzumab emtansine, an antibody-drug conjugate commonly abbreviated as T-DM1, is accepted as an effective therapy for trastuzumab-resistant metastatic HER2-positive breast cancer. T-DM1 significantly increases progression-free and overall survival when compared to lapatinib plus capecitabine in patients with HER2-positive breast cancer previously treated with trastuzumab and a taxane. Among the common side effects related to T-DM1, thrombocytopenia and mucosal hemorrhage are seen, although they are infrequently judged to be clinically significant...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29248834/cerebellar-metastasis-of-gastrointestinal-stromal-tumor-a-case-report-and-review-of-the-literature
#17
Mohamed Badri, Mohamed Chabaane, Ghassen Gader, Kamel Bahri, Ihsen Zammel
INTRODUCTION: Intracranial metastases of gastro intestinal tumors are very rare. To the best of our knowledge only few cases were reported on the literature. CASE DESCRIPTION: We describe the case of 66-year-old male that presented with headache and vomiting. Physical examination found a kinetic cerebellar syndrome. Brain CT scan and MRI showed a right cerebellar tumor. Sub-occipital craniotomy was performed and the tumor was completely resected. Surgical outcomes were marked by the occurrence of an abdominal pain two days after brain surgery...
December 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29237923/systemic-therapy-after-radiotherapy-significantly-reduces-the-risk-of-mortality-of-patients-with-1-3-brain-metastases-a-retrospective-study-of-250-patients
#18
Bo Li, Zhao-Xia Dai, Yi-Dong Chen, Yan-Wei Liu, Shuai Liu, Xue-Nan Gu, Xiao-Guang Qiu
BACKGROUND: For patients with a brain metastasis (BM), systemic therapy is usually administered after the completion of radiotherapy, especially in cases of multiple BMs. However, the role of systemic therapy in patients with a limited number of BMs is not clear. Therefore, we conducted a retrospective study to explore this question. METHODS: Consecutive patients with a pathologically confirmed malignancy and 1-3 intracranial lesions that had been documented within the last decade were selected from the databases of three hospitals in China...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29221687/leptomeningeal-carcinomatosis-in-colorectal-cancer-the-mayo-clinic-experience
#19
Gretchen Taylor, Nina Karlin, Thorvardur R Halfdanarson, Kyle Coppola, Axel Grothey
BACKGROUND: Leptomeningeal metastasis (LM) is an uncommon form of metastatic disease in many cancers. There remains a paucity of literature with regard to the course and management of LM in colorectal cancers (CRCs). The aim of this study was to estimate the incidence of LM in patients with CRC seen at our institution over a 15-year period, and to describe the clinical course and outcome of these cases. METHODS: LM in CRC primary cases between 2000 and 2014 were identified in the Mayo Clinic databases...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29204019/histologically-confirmed-intracranial-tumors-managed-at-enugu-nigeria
#20
Chika Anele Ndubuisi, Samuel C Ohaegbulam, Linda U Iroegbu, Mike Ezeali Ekuma, Wilfred C Mezue, Uwadiegwu Alphonsus Erechukwu
Background: There is controversy about the global distribution of intracranial tumors (ICTs). The previous reports from Africa suggested low frequency and different pattern of distribution of brain tumors from what obtains in other continents. The limitations at that time, including paucity of diagnostic facilities and personnel, have improved. Objective: The objective of this study is to analyze the current trend and distribution of histology confirmed brain tumors managed in Enugu, in a decade...
October 2017: Journal of Neurosciences in Rural Practice
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