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https://www.readbyqxmd.com/read/28420444/case-report-acth-secreting-pituitary-carcinoma-metastatic-to-the-liver-in-a-patient-with-a-history-of-atypical-pituitary-adenoma-and-cushing-s-disease
#1
Amy S Joehlin-Price, Douglas A Hardesty, Christina A Arnold, Lawrence S Kirschner, Daniel M Prevedello, Norman L Lehman
BACKGROUND: Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in relation to the existing literature. CASE PRESENTATION: The patient is a 51-year-old woman with Cushing's disease and intact adrenal glands who was diagnosed with metastatic pituitary carcinoma to the liver, 29 months after initial resection of an ACTH-secreting primary atypical pituitary adenoma (APA)...
April 18, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28414668/autoimmune-diabetes-presented-with-diabetic-ketoacidosis-induced-by-immunotherapy-in-an-adult-with-melanoma
#2
A A Alzenaidi, J Dendy, L Rejjal
INTRODUCTION: Immunotherapy has been approved for treatment of melanoma. Autoimmune endocrinopathies have been reported in trials involving immunotherapy but autoimmune diabetes has not been definitively linked to them. Here we describe a case of autoimmune diabetes presenting with DKA after receiving combined immunotherapy with anti-CTLA4 and anti-PD1 monoclonal antibodies. CASE: A 47year old gentleman with metastatic melanoma presented to our institution with confusion, abdominal pain and decreased oral intake...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28409338/fluorine-18-labeling-of-the-her2-targeting-single-domain-antibody-2rs15d-using-a-residualizing-label-and-preclinical-evaluation
#3
Zhengyuan Zhou, Ganesan Vaidyanathan, Darryl McDougald, Choong Mo Kang, Irina Balyasnikova, Nick Devoogdt, Angeline N Ta, Brian R McNaughton, Michael R Zalutsky
PURPOSE: Our previous studies with F-18-labeled anti-HER2 single-domain antibodies (sdAbs) utilized 5F7, which binds to the same epitope on HER2 as trastuzumab, complicating its use for positron emission tomography (PET) imaging of patients undergoing trastuzumab therapy. On the other hand, sdAb 2Rs15d binds to a different epitope on HER2 and thus might be a preferable vector for imaging in these patients. The aim of this study was to evaluate the tumor targeting of F-18 -labeled 2Rs15d in HER2-expressing breast carcinoma cells and xenografts...
April 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28382190/paradoxical-role-of-high-mobility-group-box-1-in-glioma-a-suppressor-or-a-promoter
#4
REVIEW
Richard A Seidu, Min Wu, Zhaoliang Su, Huaxi Xu
Gliomas represent 60% of primary intracranial brain tumors and 80% of all malignant types, with highest morbidity and mortality worldwide. Although glioma has been extensively studied, the molecular mechanisms underlying its pathology remain poorly understood. Clarification of the molecular mechanisms involved in their development and/or treatment resistance is highly required. High mobility group box 1 protein (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation and migration, through receptor for advanced glycation end products and toll like receptors in a number of cancers including gliomas...
March 3, 2017: Oncology Reviews
https://www.readbyqxmd.com/read/28374234/targeted-therapies-for-melanoma-brain-metastases
#5
REVIEW
Anna S Berghoff, Matthias Preusser
Brain metastases are a major clinical challenge occurring in up to 60% of patients suffering from metastatic melanoma. They cause significant clinical symptoms and impair the overall survival prognosis. The introduction of targeted therapies including BRAF and MEK inhibitors as well as CTLA-4 and PD-1 axis targeting immune checkpoint inhibitors have dramatically improved the treatment and prognosis of patients with extracranial metastatic melanoma. Although, similar response rates for extra- and intracranial metastases have been reported, only few data from brain metastasis specific trails are available so far...
April 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28369930/hepatocellular-carcinoma-with-intracranial-metastasis-in-a-japanese-macaque-macaca-fuscata
#6
Takako Miyabe-Nishiwaki, Akihiro Hirata, Akihisa Kaneko, Akiyo Ishigami, Yoko Miyamoto, Atsushi Yamanaka, Keishi Owaki, Hiroki Sakai, Tokuma Yanai, Juri Suzuki
BACKGROUND: A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos. METHODS: The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia. RESULTS: The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain...
April 3, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28362929/metastatic-liposarcoma-of-the-skull-base-a-case-report-and-review-of-literature
#7
Nirmeen Zagzoog, Greta Ra, Alex Koziarz, John Provias, Doron Sommer, Saleh A Almenawer, Kesava Reddy
BACKGROUND AND IMPORTANCE: Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature. CLINICAL PRESENTATION: A 43-year-old female patient diagnosed with left scapular myxoid liposarcoma was treated with surgical resection...
April 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28362239/associations-between-clinical-outcome-and-navigated-transcranial-magnetic-stimulation-characteristics-in-patients-with-motor-eloquent-brain-lesions-a-combined-navigated-transcranial-magnetic-stimulation-diffusion-tensor-imaging-fiber-tracking-approach
#8
Nico Sollmann, Noémie Wildschuetz, Anna Kelm, Neal Conway, Tobias Moser, Lucia Bulubas, Jan S Kirschke, Bernhard Meyer, Sandro M Krieg
OBJECTIVE Navigated transcranial magnetic stimulation (nTMS) and diffusion tensor imaging fiber tracking (DTI FT) based on nTMS data are increasingly used for preoperative planning and resection guidance in patients suffering from motor-eloquent brain tumors. The present study explores whether nTMS-based DTI FT can also be used for individual preoperative risk assessment regarding surgery-related motor impairment. METHODS Data derived from preoperative nTMS motor mapping and subsequent nTMS-based tractography in 86 patients were analyzed...
March 31, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28353599/glioblastoma-multiforme-in-conus-medullaris-with-intracranial-metastasis-after-postoperative-adjuvant-therapy
#9
Chengrui Yan, Xiangyi Kong, Hua Yin, Yu Wang, Huayu He, Hui Zhang, Jun Gao, Yongning Li, Wenbin Ma
Spinal glioblastoma multiforme is not common among spinal cord tumors. According to our literature review, only 27 cases originating from the conus medullaris were reported. We herein reported a case of a 10-year-old child diagnosed with glioblastoma multiforme. The patient received adjuvant radiotherapy and standard temozolomide chemotherapy after total excision. Intracranial lesions were found 1 month after postoperative adjuvant therapy. We described the clinical characteristics and postoperative therapy of the patient, and reviewed all of the published cases of conus medullaris glioblastoma...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28327994/quality-of-life-following-stereotactic-radiosurgery-for-single-and-multiple-brain-metastases
#10
Jacob A Miller, Rupesh Kotecha, Gene H Barnett, John H Suh, Lilyana Angelov, Erin S Murphy, Michael A Vogelbaum, Alireza Mohammadi, Samuel T Chao
BACKGROUND: Given the neurological morbidity and poor prognosis associated with brain metastases, it is critical to deliver appropriate therapy while remaining mindful of patient quality of life (QOL). For many patients, stereotactic radiosurgery (SRS) effectively controls intracranial disease, but QOL outcomes have not been characterized. OBJECTIVE: To determine the effect of number of brain metastases upon QOL preservation following SRS. METHODS: The EuroQol 5 Dimensions questionnaire (EQ-5D) and Patient Health Questionnaire 9 instruments were prospectively collected from a cohort of patients undergoing SRS for brain metastasis between 2008 and 2015...
February 23, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327948/three-or-more-courses-of-stereotactic-radiosurgery-for-patients-with-multiply-recurrent-brain-metastases
#11
Rupesh Kotecha, Nicholas Damico, Jacob A Miller, John H Suh, Erin S Murphy, Chandana A Reddy, Gene H Barnett, Michael A Vogelbaum, Lilyana Angelov, Alireza M Mohammadi, Samuel T Chao
BACKGROUND: Although patients with brain metastasis are treated with primary stereotactic radiosurgery (SRS), the use of salvage therapies and their consequence remains understudied. OBJECTIVE: To study the intracranial recurrence patterns and salvage therapies for patients who underwent multiple SRS courses. METHODS: A retrospective review was performed of 59 patients with brain metastases who underwent ≥3 SRS courses for new lesions. Cox regression analyzed factors predictive for overall survival...
February 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28324921/epidemiology-of-intracranial-metastases-in-korea-a-national-cohort-investigation
#12
Tackeun Kim, Changhoon Song, Jung Ho Han, In-Ah Kim, Yu Jung Kim, Se Hyun Kim, Jee Hyun Kim, Chae-Yong Kim
Purpose: To investigate the epidemiologic features of intracranial metastases (ICMET) in Korea, we performed a cohort study using the National Health Insurance Service-National Sample Cohort database, which comprised healthcare usage information of approximately 1 million Korean individuals over 12 years. Materials and Methods: We enrolled 998,602 subjects, after excluding 18,218 subjects diagnosed with any cancer during the washout period (2002-2004). The observation period was 9 years (2005-2013; 8,725,438 person-years)...
March 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28303203/a-case-of-acute-subdural-hematoma-due-to-bleeding-from-metastatic-chondrosarcoma-of-the-skull
#13
Kenzo Kosugi, Satoshi Takahashi, Hikaru Sasaki, Ryota Tamura, Kentaro Ohara, Kazunari Yoshida
BACKGROUND: Intra or peritumoral hemorrhage of brain and skull tumors sometimes presents as stroke. Skull metastasis of chondrosarcoma is relatively rare, and furthermore, a case of intratumoural hemorrhage of skull metastasis of chondrosarcoma has not been reported. CASE DESCRIPTION: A 73-year-old man underwent right lower leg amputation in the past because of chondrosarcoma and was operated for a skull metastasis. He presented with a sudden headache, and head computed tomography revealed a right acute subdural hematoma (SDH) adjacent to the recurrent skull metastatic tumor...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28303067/intraspinal-meningioma-with-malignant-transformation-and-distant-metastasis
#14
Kenyu Ito, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Yoji Shido, Yoshida Go, Hideyuki Arima, Shunsuke Kanbara, Takanori Hirose, Yukihiro Matsuyama, Yoshihiro Nishida, Naoki Ishiguro
Meningioma is typically considered to be a benign tumor. Malignant transformation and metastasis of meningiomas are rare. Moreover, most meningiomas are intracranial, and there are few reports on intraspinal meningiomas. This report aimed to describe the clinical features and pathological findings of a case of malignant transformation and distant metastasis of intraspinal meningioma, with a review of the literature. A 44-year-old man with a bilateral lower limb paresis was diagnosed with an intradural extramedullary tumor of the thoracic spine...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28291424/giant-melanotic-neuroectodermal-tumor-of-infancy-melanotic-progonoma-of-the-head-and-neck-report-of-a-malignant-case
#15
Giancarlo Nicosia, Pietro Spennato, Ferdinando Aliberti, Daniele Cascone, Lucia Quaglietta, Maria Elena Errico, Mario Muto, Franco Ionna, Giuseppe Cinalli
Melanotic neuroectodermal tumor of infancy is a rare congenital pigmented neoplasm of neural crest origin, locally aggressive, growing rapidly and developing during the 1st year of life. It most commonly arises from the maxilla, cranial vault, and mandible. Occasionally, it exhibits malignant behavior with local lymph nodes involvement. Cases misdiagnosed and left untreated for a long time can present challenges due to the tumor mass and infiltration. In these cases, adjuvant chemotherapy can be extremely helpful before radical excision...
February 24, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28283001/cranial-subarachnoid-and-subdural-haemorrhage-caused-by-spinal-melanoma-metastasis
#16
Farouk Olubajo, Stavros Stavropoulos, M Masood Hussain, Chris Rowland-Hill, Shailendra Achawal
A 73-year-old female with a history of metastatic melanoma presented with extensive intracranial subarachnoid haemorrhage. Cranial imaging failed to reveal any vascular anomaly or tumour. MRI of the neuroaxis revealed a melanoma metastasis at T10 with associated subarachnoid haemorrhage. We review the literature on this rare presentation of subarachnoid haemorrhage.
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28275428/control-of-brain-metastases-with-alectinib-in-anaplastic-lymphoma-kinase-rearranged-lung-cancer
#17
Wang Chun Kwok, Terence Chi Chun Tam, Macy Mei Sze Lui, David Chi Leung Lam, James Chung Man Ho
Brain metastasis from non-small cell lung cancer remains a challenge to physicians. It occurs in 30% of patients with advanced stage adenocarcinoma of lung and is often regarded as the ominous sign of disease progression and death. Alectinib is likely to be a promising agent, even after the failure of crizotinib and ceritinib, for patients with anaplastic lymphoma kinase (ALK) -driven non-small cell lung cancer with brain metastasis, resulting in a durable response for both intracranial and extra-cranial diseases...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28255529/calcified-middle-cranial-fossa-mass
#18
James Botros, Kimmo Hatanpaa, Brandon Isaacson, Samuel L Barnett
A 21-year-old male presented for evaluation of transient loss of consciousness and was found to have a hyperdense mass in the left middle fossa. He underwent craniotomy for tumor resection. Intra- and extradural invasion was noted. Gross total resection was achieved. Pathology demonstrated a densely cellular neoplasm with predominately spindle cell morphology in a collagen-containing stroma, areas of vascular proliferation, focal mineralization, and regions of cartilage formation. High mitotic index and regions of necrosis were seen...
January 2017: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/28254368/the-impact-of-tumor-biology-on-survival-and-response-to-radiation-therapy-among-patients-with-non-small-cell-lung-cancer-brain-metastases
#19
Jacob A Miller, Rupesh Kotecha, Manmeet S Ahluwalia, Alireza M Mohammadi, John H Suh, Gene H Barnett, Erin S Murphy, Michael A Vogelbaum, Lilyana Angelov, Samuel T Chao
PURPOSE: To investigate the natural history and response to radiation therapy among ALK-rearranged, EGFR-mutated, wild-type adenocarcinoma, and squamous cell non-small cell lung cancer (NSCLC) brain metastases. METHODS AND MATERIALS: Patients with NSCLC brain metastasis diagnosed from 1989 through 2014 at a single tertiary-care institution were included. The primary outcome was overall survival, whereas secondary outcomes included local failure, distant intracranial failure, and radiation necrosis...
January 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28247036/ferritin-heavy-chain-as-a-molecular-imaging-reporter-gene-in-glioma-xenografts
#20
Sen Cheng, Ruifang Mi, Yu Xu, Guishan Jin, Junwen Zhang, Yiqiang Zhou, Zhengguang Chen, Fusheng Liu
PURPOSE: The development of glioma therapy in clinical practice (e.g., gene therapy) calls for efficiently visualizing and tracking glioma cells in vivo. Human ferritin heavy chain is a novel gene reporter in magnetic resonance imaging. This study proposes hFTH as a reporter gene for MR molecular imaging in glioma xenografts. METHODS: Rat C6 glioma cells were infected by packaged lentivirus carrying hFTH and EGFP genes and obtained by fluorescence-activated cell sorting...
February 28, 2017: Journal of Cancer Research and Clinical Oncology
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