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Intracranial metastasis

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https://www.readbyqxmd.com/read/29053047/perineural-spread-of-basosquamous-carcinoma-to-the-orbit-cavernous-sinus-and-infratemporal-fossa
#1
Alec L Amram, William J Hertzing, Stacy V Smith, Patricia Chévez-Barrios, Andrew G Lee
Basosquamous carcinoma is a rare, highly aggressive variant of basal cell carcinoma with elevated rates of recurrence, perineural invasion, and metastasis. We describe a patient who presented with unilateral complete ophthalmoplegia, ptosis, optic neuropathy, and trigeminal neuropathy due to perineural intracranial invasion of nasal basosquamous carcinoma via the sphenopalatine fossa to the cavernous sinus, orbit, and infratemporal fossa. To our knowledge, this is the first reported case of basosquamous carcinoma with perineural invasion involving the cavernous sinus in the English language ophthalmic literature...
October 20, 2017: Orbit
https://www.readbyqxmd.com/read/29046796/pulmonary-and-pleural-metastasis-of-intracranial-anaplastic-meningioma-in-a-3-year-old-boy-a-case-report
#2
Yuko Honda, Rie Shirayama, Hiromi Morita, Koichi Kusuhara
In adults, meningiomas occasionally display aggressive behavior and may occasionally metastasize. By contrast, pediatric meningiomas are rare, and there is limited information regarding their clinical characteristics, treatment and prognosis. We herein report the case of a 3-year-old boy with anaplastic meningioma with a history of local recurrence and late pulmonary metastasis. At diagnosis, a 70-mm mass lesion in was identified in the right frontal lobe, with intratumoral hemorrhage. The tumor was attached to the falx cerebri and was completely resected...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29040677/navigation-linked-heads-up-display-in-intracranial-surgery-early-experience
#3
Justin R Mascitelli, Leslie Schlachter, Alexander G Chartrain, Holly Oemke, Jeffrey Gilligan, Anthony B Costa, Raj K Shrivastava, Joshua B Bederson
BACKGROUND: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow. OBJECTIVE: To detail our initial experience with HUD. METHODS: We retrospectively reviewed patients who underwent HUD-assisted surgery from April 2016 through April 2017...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29032518/synchronous-solitary-calvarial-yolk-sac-tumor-metastasis-as-the-initial-presentation-of-mediastinal-germ-cell-tumor
#4
Kirti Gupta, Madhivanan Karthigeyan, Ayushman Satapathy, Pravin Salunke
INTRODUCTION: In children, malignant tumors presenting as a calvarial mass that too as initial manifestation are unusual. Also, brain metastases per se are rare in pediatric solid tumors with an incidence of just 1.5%. CASE DESCRIPTION: We present a child with calvarial metastasis which was the presenting symptom of an otherwise asymptomatic large malignant mediastinal germ cell tumor (GCT). The lesion was dural-based involving both calvaria as well as the underlying brain parenchyma...
October 14, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29026572/nasopharyngeal-carcinoma-presenting-as-an-inconspicuous-primary-lesion-with-extensive-cavernous-sinus-involvement-and-temporal-lobe-extension-a-case-report-and-review-of-literature
#5
Courtney Pollard, Shane M Mesko, Lawrence E Ginsberg, Merrill S Kies, Shaan M Raza, Shirley Y Su, Sam Tung, Jack Phan
Detection of nodal metastasis in the neck or adjacent structures is common in nasopharyngeal carcinoma (NPC) when there is frank primary disease. Intracranial extension without obvious nasopharyngeal disease is not common. Here, we discuss a patient with NPC that presented with extensive intracranial disease with subtle findings in the nasopharynx.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29019889/high-dose-of-nimustine-as-an-add-on-treatment-for-small-cell-lung-cancer-with-intracranial-metastasis-a-case-report-and-literature-review
#6
Wei Luo, Ya-Lun Li, Ya Juan Chen, Qing Xiang, Hong Chen
RATIONALE: Small cell lung cancer (SCLC) characterized by high degree of malignancy and rapid tumor progression. Intracranial metastases often appear at the time of the initial diagnosis or treatment. Besides of radiotherapy, chemotherapy is supposed to have limited effect. PATIENT CONCERNS: A 66-year-old male had blurred vision and unsteady step with moderate headache, nausea, vomit. DIAGNOSES: The patient was diagnosed with SCLC with intracranial metastases...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28988669/-meningeal-metastasis-of-uterine-leiomyosarcoma-case-report-and-literature-review
#7
Pablo Sosa, Gabriela Cuadra, Raul Hidalgo
Brain metastases are the most commonly seen intracranial lesions in adults. What is more, meningiomas are the most common primary intracranial tumours after gliomas and their imaging characteristics are well known in both CT and MRI scans. However, there are lesions that can mimic meningiomas in imaging studies, including metastases of extracranial tumours, confronting us with a diagnostic and therapeutic challenge. We present the case of a patient with meningeal metastasis of a uterine leiomyosarcoma that was not known at the time of the surgical intervention...
October 4, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28984696/heterotopic-cutaneous-meningioma-an-unusual-presentation-occurring-in-a-patient-with-a-remote-history-of-intracranial-meningioma
#8
Chibuike Enwereuzo, Luis Moral, Jean M Henneberry
Meningioma is a neoplasm of the meninges, which usually occurs in intracranial sites. Extracranial meningioma has been frequently reported in the sinonasal tract and skull bone, often as extension of intracranial meningiomas. Isolated heterotopic meningioma without contiguous intracranial lesion is extremely rare. A 56-year-old woman presented in December 2015 with 2 firm subcutaneous scalp masses; one in the left lateral (temporal) and the other in the left superior (parietal) region. The clinical impression was that of lipoma...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28973506/cumulative-intracranial-tumor-volume-augments-the-prognostic-value-of-diagnosis-specific-graded-prognostic-assessment-model-for-survival-in-patients-with-melanoma-cerebral-metastases
#9
Brian R Hirshman, Bayard R Wilson, Mir Amaan Ali, Alexander J Schupper, James A Proudfoot, Steven J Goetsch, Bob S Carter, Georges Sinclair, Jiri Bartek, Veronica Chiang, Gerald Fogarty, Angela Hong, Clark C Chen
BACKGROUND: The diagnosis-specific graded prognostic assessment scale (ds-GPA) for patients with melanoma brain metastasis (BM) utilizes only 2 key prognostic variables: Karnofsky performance status and the number of intracranial metastases. We wished to determine whether inclusion of cumulative intracranial tumor volume (CITV) into the ds-GPA model for melanoma augmented its prognostic value. OBJECTIVE: To determine whether or not CITV augments the ds-GPA prognostic scale for melanoma...
August 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28973498/failure-to-rescue-and-mortality-following-resection-of-intracranial-neoplasms
#10
Hani Malone, Michael Cloney, Jingyan Yang, Dawn L Hershman, Jason D Wright, Alfred I Neugut, Jeffrey N Bruce
BACKGROUND: There is growing recognition that perioperative complication rates are similar between hospitals, but mortality rates are lower at high-volume centers. This may be due to differences in the ability to rescue patients from major complications. OBJECTIVE: To examine the relationship between hospital caseload and failure to rescue from complications following resection of intracranial neoplasms. METHODS: We identified adults in the Nationwide Inpatient Sample diagnosed with glioma, meningioma, brain metastasis, or acoustic neuroma, who underwent surgical resection between 1998 and 2010...
August 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28958889/prophylactic-cranial-irradiation-for-resectable-small-cell-lung-cancer
#11
REVIEW
Aditya Halthore, Anuj Goenka, Rajiv Sharma, Jonathan P S Knisely
After definitive chemoradiation for small-cell lung cancer (SCLC), prophylactic cranial irradiation (PCI) has been established as standard of care in patients whose tumors respond to treatment. In the modern era, however, a subset of patients might receive upfront resection for SCLC, yet the role of PCI in these patients has not been elucidated. In this review, we examine the literature to better define the role of PCI in this subset of patients. For patients with ≥ T2 disease, incomplete resection, or those not receiving adjuvant chemotherapy, PCI is expected to offer a clinical benefit...
August 26, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28945873/long-term-survivorship-following-stereotactic-radiosurgery-alone-for-brain-metastases-risk-of-intracranial-failure-and-implications-for-surveillance-and-counseling
#12
Emile Gogineni, John A Vargo, Scott M Glaser, John C Flickinger, Steven A Burton, Johnathan A Engh, Nduka M Amankulor, Sushil Beriwal, Anette E Quinn, Cihat Ozhasoglu, Dwight E Heron
BACKGROUND: Historically, survival for even highly select cohorts of brain metastasis patients selected for SRS alone is <2 yr; thus, limited literature on risks of recurrence exists beyond 2 yr. OBJECTIVE: To investigate the possibility that for subsets of patients the risk of intracranial failure beyond 2 yr is less than the commonly quoted 50% to 60%, wherein less frequent screening may be appropriate. METHODS: As a part of our institutional radiosurgery database, we identified 132 patients treated initially with stereotactic radiosurgery (SRS) alone (± pre-SRS surgical resection) with at least 2 yr of survival and follow-up from SRS...
August 28, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28923299/masson-s-tumor-revealed-by-an-intracerebral-hematoma-case-report-and-a-review-of-the-literature
#13
C Salaud, D Loussouarn, K Buffenoir, T Riem
We report the case of a 56-year-old woman who underwent total resection of a Masson's tumor or intravascular papillary endothelial hyperplasia (IPEH), which was discovered due to a left temporal intracerebral hematoma revealed by aphasia. IPEH is more often localized on cutaneous and subcutaneous locations, intracranial IPEH are rare and only approximately twenty cases have been published to date. These tumors are a benign vascular lesion composed of papillary intravascular proliferation of epithelial cellular associated thrombosis with fibrin deposits responsible for vascular lumen obliteration...
September 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28913704/impact-of-etiology-age-and-gender-on-onset-and-severity-of-hyponatremia-in-patients-with-hypopituitarism-retrospective-analysis-in-a-specialised-endocrine-unit
#14
Dragana Miljic, Mirjana Doknic, Marko Stojanovic, Marina Nikolic-Djurovic, Milan Petakov, Vera Popovic, Sandra Pekic
BACKGROUND: Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency. This is important, since the need to screen for steroid deficiency, in patients with hyponatremia is often neglected. PATIENTS AND METHODS: In a retrospective study, twenty-five patients (13f/12m, age 58.9 ± 18.6 years) with hyponatremia (119.7 ± 10.5 mmol/L) were identified among 260 in-patients treated for hypopituitarism in our specialized endocrine unit, over the last decade...
September 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28901413/microrna%C3%A2-188-acts-as-a-tumour-suppressor-in-glioma-by-directly-targeting-the-igf2bp2-gene
#15
Li Ding, Ling Wang, Feng Guo
Glioma is the most common and aggressive human brain tumour and accounts for ~35‑61% of intracranial tumours. Despite considerable advances in treatments for glioma, the prognosis for patients with this disease remains unsatisfactory. MicroRNAs (miRNAs of miRs) are small regulatory RNA molecules that have been identified as being involved in the initiation and progression of human cancers, and represent novel therapeutic targets for anticancer treatments. The dysregulation of miR‑188 has been reported in various kinds of human cancer...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28883755/effect-of-glucose-level-on-chemical-hypoxia-and-hydrogen-peroxide-induced-chemokine-expression-in-human-glioblastoma-cell-lines
#16
Yieun Jung, So-Hee Ahn, Sang Hui Park, Youn-Hee Choi
Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape, local invasion, and metastasis of GBM. Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Treatment with cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) significantly increased the expression levels of IL-6, IL-8, and IP-10 in a dose-dependent manner in CRT-MG and U251-MG astroglioma cells, but not in microglia cells...
September 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28871997/single-fraction-stereotactic-radiosurgery-srs-alone-versus-surgical-resection-and-srs-for-large-brain-metastases-a-multi-institutional-analysis
#17
MULTICENTER STUDY
Roshan S Prabhu, Robert H Press, Kirtesh R Patel, Danielle M Boselli, James T Symanowski, Scott P Lankford, Robert J McCammon, Benjamin J Moeller, John H Heinzerling, Carolina E Fasola, Anthony L Asher, Ashley L Sumrall, Zachary S Buchwald, Walter J Curran, Hui-Kuo G Shu, Ian Crocker, Stuart H Burri
PURPOSE: Stereotactic radiosurgery (SRS) dose is limited by brain metastasis (BM) size. The study goal was to retrospectively determine whether there is a benefit for intracranial outcomes and overall survival (OS) for gross total resection with single-fraction SRS versus SRS alone for patients with large BMs. METHODS AND MATERIALS: A large BM was defined as ≥4 cm(3) (2 cm in diameter) prior to the study. We reviewed the records of consecutive patients treated with single-fraction SRS alone or surgery with preoperative or postoperative SRS between 2005 and 2013 from 2 institutions...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28868193/cervical-cancer-metastasis-to-the-brain-a-case-report-and-review-of-literature
#18
REVIEW
Kaleigh Fetcko, Dibson D Gondim, Jose M Bonnin, Mahua Dey
BACKGROUND: Intracranial metastasis from cervical cancer is a rare occurrence. METHODS: In this study we describe a case of cervical cancer metastasis to the brain and perform an extensive review of literature from 1956 to 2016, to characterize clearly the clinical presentation, treatment options, molecular markers, targeted therapies, and survival of patients with this condition. RESULTS: An elderly woman with history of cervical cancer in remission, presented 2 years later with a right temporo-parietal tumor, which was treated with surgery and subsequent stereotactic radiosurgery (SRS) to the resection cavity...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28859365/incidence-of-brain-metastasis-from-esophageal-cancer
#19
G Welch, H J Ross, N P Patel, D E Jaroszewski, D E Fleischer, W G Rule, H R Paripati, F C Ramirez, J B Ashman
We investigated whether the incidence of brain metastasis (BM) from primary esophageal and esophagogastric cancer is increasing. A single-institution retrospective review identified 583 patients treated from January 1997 to January 2016 for stages I through IV cancer of the esophagus and esophagogastric junction (follow-up, ≥3 months). Collected data included demographic information, date and staging at primary diagnosis, histologic subtype, treatment regimen for primary lesion, date of BM diagnosis, presence or absence of central nervous system symptoms, presence or absence of extracranial disease, treatment regimen for intracranial lesions, and date of death...
September 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28841111/spinal-drop-metastasis-from-a-benign-fourth-ventricular-choroid-plexus-papilloma-in-a-pediatric-patient-case-report
#20
Ramin A Morshed, Darryl Lau, Peter P Sun, Lauren R Ostling
Choroid plexus papillomas (CPPs) are typically benign tumors that can occur in any age group but are more commonly found in pediatric patients. Although these tumors are benign, there are several reports in adult patients of distant metastases present either at the time of diagnosis or occurring months to years after initial resection. Here, the authors report the case of a 14-year-old boy who presented with symptoms of elevated intracranial pressure due to obstructive hydrocephalus that was caused by a large fourth ventricular mass...
August 25, 2017: Journal of Neurosurgery. Pediatrics
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