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Intracranial metastasis

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https://www.readbyqxmd.com/read/28203373/a-silent-skull-metastatic-follicular-thyroid-carcinoma-mimicking-as-a-benign-scalp-tumor-in-a-pregnant-woman
#1
Tsung-Chun Huang, Yu-Kai Cheng, Tsung-Wei Chen, Yung-Chang Hsu, En-Wei Liu, Hsin-Han Chen
: Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. We reported a scalp tumor in a physically healthy 37-year-old pregnant female with a follicular thyroid carcinoma (FTC) with lung, bone and cranial metastasis in initial presentation. Silent neurogenic and physical examinations make an early diagnosis very challenging...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28178168/rapid-intracranial-response-to-osimertinib-without-radiotherapy-in-nonsmall-cell-lung-cancer-patients-harboring-the-egfr-t790m-mutation-two-case-reports
#2
Taro Koba, Takashi Kijima, Takayuki Takimoto, Haruhiko Hirata, Yujiro Naito, Masanari Hamaguchi, Tomoyuki Otsuka, Muneyoshi Kuroyama, Izumi Nagatomo, Yoshito Takeda, Hiroshi Kida, Atsushi Kumanogoh
RATIONALE: Most of nonsmall cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) activating mutations eventually acquire resistance to the first EGFR-tyrosine kinase inhibitors (TKIs) therapy after varying periods of treatment. Of note, approximately one-third of those patients develop brain metastases, which deteriorate their quality of life and survival. The effect of systemic chemotherapy on brain metastases after acquisition of EGFR-TKI resistance is limited, and thus far, whole-brain radiation therapy, which may cause the harmful effect on neurocognitive functions, has been the only established therapeutic option for especially symptomatic brain metastases...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28176389/imaging-diagnosis-antemortem-detection-of-oligodendroglioma-cerebrospinal-fluid-drop-metastases-in-a-dog-by-serial-magnetic-resonance-imaging
#3
Mariana Vigeral, R Timothy Bentley, Nicholas J Rancilio, Margaret A Miller, Hock Gan Heng
An English Bulldog underwent radiation therapy of an intracranial, left lateral ventricle mass. Following resolution of the primary mass, an intraventricular fourth ventricle lesion developed. Subsequently, multiple lesions developed from the cervical central canal and leptomeninges. Serial magnetic resonance imaging documented the propagation of lesions along the cerebrospinal fluid (CSF) pathways, known as "CSF drop metastasis." Histopathology confirmed multifocal intraventricular and leptomeningeal oligodendroglioma...
February 7, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28175548/339%C3%A2-comparative-prognostic-value-of-the-cumulative-intracranial-tumor-volume-and-score-index-for-radiosurgery-in-brain-metastasis
#4
Brian R Hirshman, Bayard Wilson, Proudfoot A James, Takao Koiso, Osamu Nagano, Bob S Carter, Toru Serizawa, Masaaki Yamamoto, Clark C Chen
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28168075/metastatic-renal-cell-carcinoma-presenting-as-a-paranasal-sinus-mass-the-importance-of-differential-diagnosis
#5
Massimo Ralli, Giancarlo Altissimi, Rosaria Turchetta, Mario Rigante
Metastases in the paranasal sinuses are rare; renal cell carcinoma is the most common cancer that metastasizes to this region. We present the case of a patient with a 4-month history of a rapidly growing mass of the nasal pyramid following a nasal trauma, associated with spontaneous epistaxis and multiple episodes of hematuria. Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28156671/a-novel-risk-stratification-model-for-patients-with-brain-metastasis-incorporating-with-physiological-signals
#6
Tsung-Ying Ho, Eng-Yen Huang, Chong-Jong Wang
: 38 Background: Brain metastasis (BM) develops in 10%-40% of patients with malignancies. Survival expectancy is critical for choosing an optimal treatment for BM patients. Previous reports have proposed different risk stratification systems based on clinical and image-related factors. Heart rate variability (HRV), a physiological factor, has also been reported as a novel prognosticator for BM patients. In this study, we proposed a novel risk stratification model for BM patients by incorporating HRV signals...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28154933/serious-tumor-seeding-after-brainstem-biopsy-and-its-treatment-a-case-report-and-review-of-the-literature
#7
D Pinggera, I Kvitsaridtze, G Stockhammer, W Eisner, C Thomé, C F Freyschlag, P Moser, J Kerschbaumer
Stereotactic brain biopsies for histopathological diagnosis are a common technique in case of intracranial lesions, particularly in those not amenable for resection. Tumor seeding alongside the surgical trajectory after fine-needle aspiration is a known problem in several visceral tumors. Whereas in these cases a complete resection of the biopsy trajectory may later be performed, this strategy is not feasible in stereotactic brain biopsy. We report a case of tumor seeding along the entire biopsy tract after stereotactic biopsy of a brainstem metastasis...
February 2, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28101173/particularly-interesting-cys-his-rich-protein-is-highly-expressed-in-human-intracranial-aneurysms-and-resists-aneurysmal-rupture
#8
Yu-Tao Peng, Xiang-En Shi, Zhi-Qiang Li, Xin He, Yu-Ming Sun
Particularly interesting Cys-His-rich protein (PINCH) has several biological functions in cancer development, invasion and metastasis in malignant cells, and the expression of PINCH is upregulated in several cancer types, including breast cancer, gastric adenocarcinoma and rectal cancer. However, the contribution of PINCH to human cerebral aneurysms remains largely unknown. Therefore, the significance of PINCH expression in cerebral aneurysm growth and rupture was examined in the present study. The protein expression levels of alpha-smooth muscle actin, osteopontin (OPN), matrix metalloproteinase (MMP) 9 and PINCH were evaluated using immunohistochemistry and western blot analyses...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28076323/clinical-outcome-of-tyrosine-kinase-inhibitors-alone-or-combined-with-radiotherapy-for-brain-metastases-from-epidermal-growth-factor-receptor-egfr-mutant-non-small-cell-lung-cancer-nsclc
#9
Qianqian Zhu, Yanan Sun, Yingying Cui, Ke Ye, Chengliang Yang, Daoke Yang, Jie Ma, Xiao Liu, Jinming Yu, Hong Ge
This study compared treatment outcomes between TKI monotherapy and TKI administration combined with brain radiotherapy (TKI + RT) in 133 non-small cell lung cancer (NSCLC) patients with brain metastasis (BM). We also evaluated the association of different epidermal growth factor receptor (EGFR) mutation subtypes with treatment outcome. To screen for potential variables affecting cranial progression free survival (PFS) and overall survival (OS), we performed univariate and multivariate analysis based on Cox proportional-hazards models...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28068937/the-efficacy-and-roles-of-combining-temozolomide-with-whole-brain-radiotherapy-in-protection-neurocognitive-function-and-improvement-quality-of-life-of-non-small-cell-lung-cancer-patients-with-brain-metastases
#10
Xia Deng, Zhen Zheng, Baochai Lin, Huafang Su, Hanbin Chen, Shaoran Fei, Zhenghua Fei, Lihao Zhao, Xiance Jin, Cong-Ying Xie
BACKGROUND: Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). The efficacy and roles of combining temozolomide (TMZ) with whole brain radiotherapy (WBRT) in protection neurocognitive function (NCF) and improvement quality of life (QOL) were investigated and compared with WBRT alone in the treatment of NSCLC patients with BM. METHODS: A total of 238 NSCLC patients with BM were reviewed and categorized into WBRT plus TMZ (RCT) arm and WBRT alone (RT), respectively...
January 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28061499/primary-intracranial-malignant-melanoma-with-extracranial-metastasis
#11
Kengo Hirota, Chika Yoshimura, Osami Kubo, Hidetoshi Kasuya
We report a case of primary intracranial malignant melanoma (PIMM) with extracranial metastases. The patient was an 82-year-old woman diagnosed with PIMM under the left cerebellar tentorium. We performed a tumor resection followed by gamma knife surgery. An magnetic resonance imaging at 11 months after surgery showed a local intracranial recurrence. At 12 months, vertebral metastasis was suspected, and 2-[fluorine-18]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) showed multiple extracranial metastases...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28050451/choriocarcinoma-in-ongoing-pregnancy-presenting-with-intracranial-metastasis
#12
Sujata Siwatch, Vanita Suri, Pooja Sikka, Neelam Aggarwal, Seema Chopra
Choriocarcinoma presents usually as persistent trophoblastic disease, with prognosis worsening with duration from antecedent pregnancy. We present a unique case of a woman with choriocarcinoma who presented in the third trimester of pregnancy with eclampsia. She was managed with magnesium sulphate and underwent a caesarean section. However, she developed seizures in the post-partum period that were further investigated and attributed to intracranial metastatic lesions of Gestational Trophoblastic Neoplasia (GTN)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048626/su-f-t-212-a-comparison-of-treatment-strategies-for-intracranial-stereotactic-radiosurgery
#13
T Lamberton, J Slater, A Wroe
PURPOSE: Stereotactic radiosurgery is an effective and noninvasive treatment for intracranial lesions that uses highly focused radiation beams in a single treatment fraction. The purpose of this study is to investigate the dosimetric differences between the treatment brain metastasis with a proton beam vs. intensity modulated radiation therapy (IMRT). METHODS: Ten separate brain metastasis targets where chosen and treatment plans were created for each, using three different strategies: custom proton beam shaping devices, standardized proton beam shaping devices, and IMRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047601/su-f-t-629-effect-of-multi-leaf-collimator-mlc-width-on-plan-quality-of-single-isocenter-vmat-intracranial-stereotactic-radiosurgery-for-multiple-metastases
#14
J Kraus, E Thomas, X Wu, J Fiveash, R Popple
PURPOSE: Single-isocenter VMAT has been shown able to create high quality plans for complex intracranial multiple metastasis SRS cases. Linacs capable of the technique are typically outfitted with an MLC that consists of a combination of 5 mm and 10 mm leaves (standard) or 2.5 mm and 5 mm leaves (high-definition). In this study, we test the hypothesis that thinner collimator leaves are associated with improved plan quality. METHODS: Ten multiple metastasis cases were identified and planned for VMAT SRS using a 10 MV flattening filter free beam...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28031050/prognostic-factors-and-failure-patterns-in-non-metastatic-nasopharyngeal-carcinoma-after-intensity-modulated-radiotherapy
#15
Yan-Ping Mao, Ling-Long Tang, Lei Chen, Ying Sun, Zhen-Yu Qi, Guan-Qun Zhou, Li-Zhi Liu, Li Li, Ai-Hua Lin, Jun Ma
BACKGROUND: The prognostic values of staging parameters require continual re-assessment amid changes in diagnostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non-metastatic nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era. METHODS: We reviewed the data from 749 patients with newly diagnosed, biopsy-proven, non-metastatic NPC in our cancer center (South China, an NPC endemic area) between January 2003 and December 2007...
December 28, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28025960/metastatic-spread-of-systemic-neoplasms-to-central-nervous-system-tumors-review-of-the-literature-and-case-presentation-of-esophageal-carcinoma-metastatic-to-meningioma
#16
Bertram Richter, Lakshmi Harinath, Cunfeng Pu, Kristen Stabingas
Metastatic spread of a systemic neoplasm to a central nervous system malignancy is a rare but well-documented phenomenon. Over 100 case reports of tumor-to-tumor spread involving the central nervous system have been described since the first report in 1930. Overwhelmingly, intracranial meningioma represents the most common recipient tumor, while breast and lung are the first and second most common donor malignancies, respectively. The propensity for meningiomas to harbor metastatic lesions has been attributed to cell-to-cell adhesion molecules, favorable metabolic environment as well as hormonal and mechanical factors...
December 27, 2016: Clinical Neuropathology
https://www.readbyqxmd.com/read/28024719/prognostic-impact-of-adjuvant-chemotherapy-in-high-risk-nasopharyngeal-carcinoma-patients
#17
Yi-Chun Liu, Wen-Yi Wang, Chih-Wen Twu, Rong-San Jiang, Kai-Li Liang, Ching-Te Wu, Po-Ju Lin, Jing-Wen Huang, He-Yuan Hsieh, Jin-Ching Lin
OBJECTIVES: To investigate the prognostic impact of adjuvant chemotherapy (AdjCT) in patients with high-risk nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: A total 403 NPC patients with at least one of the following criteria (1) neck node>6cm; (2) supraclavicular node metastasis; (3) skull base destruction/intracranial invasion plus multiple nodes metastasis; or (4) multiple neck nodes metastasis with one of nodal size>4cm were retrospectively reviewed...
January 2017: Oral Oncology
https://www.readbyqxmd.com/read/28005654/calvarial-mass-confused-with-trichilemmal-cyst-hepatocellular-cancer-metastasis
#18
Gökhan Polat, Recep Sade
The hepatocellular cancer calvarial metastasis is a rare condition that commonly presents cranial swelling. Therefore, calvarial swelling may confuse with frequent lesions of the scalp. The authors' patient was operated as trichilemmal cyst. But, intracranial extension was seen in operation. Calvarial metastasis of hepatocellular cancer was observed by examination of the patient.
December 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27992010/spontaneous-intracranial-epidural-hematoma-during-rivaroxaban-treatment
#19
Leonardo Gilmone Ruschel, Felipe Marques Monteiro do Rego, Jerônimo Buzetti Milano, Gustavo Simiano Jung, Luis Fernando Silva, Ricardo Ramina
According to our research, this is the first case described in the literature of spontaneous intracranial epidural hematoma secondary to the use of Xareltor. Spontaneous intracranial epidural hematomas are rarely described in the literature. They are associated with infectious diseases of the skull, coagulation disorders, vascular malformations of the dura mater and metastasis to the skull. Long-term post-marketing monitoring and independent reports will probably detect the full spectrum of hemorrhagic complications of the use of rivaroxaban...
November 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27991438/limitations-of-analytical-dose-calculations-for-small-field-proton-radiosurgery
#20
Changran Geng, Juliane Daartz, Kimberley Lam-Tin-Cheung, Marc Bussiere, Helen A Shih, Harald Paganetti, Jan Schuemann
The purpose of the work was to evaluate the dosimetric uncertainties of an analytical dose calculation engine and the impact on treatment plans using small fields in intracranial proton stereotactic radiosurgery (PSRS) for a gantry based double scattering system. 50 patients were evaluated including 10 patients for each of 5 diagnostic indications of: arteriovenous malformation (AVM), acoustic neuroma (AN), meningioma (MGM), metastasis (METS), and pituitary adenoma (PIT). Treatment plans followed standard prescription and optimization procedures for PSRS...
January 7, 2017: Physics in Medicine and Biology
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