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https://www.readbyqxmd.com/read/28319851/-31-p-dephased-13-c-detected-redor-for-nmr-crystallography-at-natural-isotopic-abundance
#1
Alexander I Greenwood, Mary C Clay, Chad M Rienstra
Typically, the process of NMR-based structure determination relies on accurately measuring a large number of internuclear distances to serve as restraints for simulated annealing calculations. In solids, the rotational-echo double-resonance (REDOR) experiment is a widely used approach to determine heteronuclear dipolar couplings corresponding to distances usually in the range of 1.5-8Å. A challenge in the interpretation of REDOR data is the degeneracy of symmetric subunits in an oligomer or equivalent molecules in a crystal lattice, which produce REDOR trajectories that depend explicitly on two or more distances instead of one...
February 28, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28319591/psychopathological-assessment-of-risk-of-restraint-in-acute-psychiatric-patients
#2
Federico Dazzi, Lorenzo Tarsitani, Michele Di Nunzio, Valeria Trincia, Gabriella Scifoni, Giuseppe Ducci
The study aims to identify independent predictors of physical restraint in acute psychiatric patients and to determine the predictive power of a risk assessment model centered on psychopathological dimensions. We included 1552 patients admitted to a psychiatric intensive care unit over a 5-year period. Patients were rated on the Brief Psychiatric Rating Scale (BPRS-E) at admission. Principal axis factoring (PAF) with varimax rotation was performed on BPRS-E items to identify psychopathological factors. Multiple logistic regression analysis was performed...
March 18, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28319140/role-of-muscle-il-6-in-gender-specific-metabolism-in-mice
#3
Amalia Molinero, Antonio Fernandez-Perez, Aina Mogas, Mercedes Giralt, Gemma Comes, Olaya Fernandez-Gayol, Mario Vallejo, Juan Hidalgo
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/refeeding). We also evaluated the responses to leptin and the activity of the insulin signalling pathway in skeletal muscle and liver by phosphorylation of Akt at Ser 473...
2017: PloS One
https://www.readbyqxmd.com/read/28317386/hepatoprotective-effect-of-blocking-n-methyl-d-aspartate-receptors-in-male-albino-rats-exposed-to-acute-and-repeated-restraint-stress
#4
Shaimaa Nasr Amin, Ahmed Amro El-Aidi, Maha Zickri, Laila Ahmed Rashed, Sherif Sabry Hassan
Stress affects multiple organs in the body in addition to the brain including the liver. We aimed to assess the effects of blocking N-methyl-D-aspartate (NMDA) glutamate receptors by memantine on the liver in acute and repeated restraint stress. Forty two male albino rats divided into seven groups; control, Acute restraint stress (ARS), ARS+memantine, repeated restraint stress, repeated restraint +memantine and positive control groups. We measured serum iron, zinc, alanine transferase and Aspartame transferase, hepatic malondialdehyde, tumor necrosis factor-alpha (TNF-α), glutathione peroxidase, Superoxide dismutase, metallothionein content, zinc transporter ZRT/IRT-like Protein 14 mRNA expression, hepcidin expression...
March 18, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28316272/prenatal-noise-and-restraint-stress-interact-to-alter-exploratory-behavior-and-balance-in-juvenile-rats-and-mixed-stress-reverses-these-effects
#5
Soumeya Badache, Slim Bouslama, Oualid Brahmia, Abdel Madjid Baïri, Abdel Krim Tahraoui, Ali Ladjamaa
We aimed to investigate in adolescent rats the individual and combined effects of prenatal noise and restraint stress on balance control, exploration, locomotion and anxiety behavior. Three groups of pregnant rats were exposed to daily repeated stress from day 11 to day 19 of pregnancy: 3 min noise (Noise Stress, NS); 10 min restraint (Restraint Stress, RS); or 3 min noise followed by 10 min restraint (Mixed Stress, MS). On postnatal days (PND) 44, 45 and 46, four groups of male rats (Control, NS, RS:, MS; 16 rats each), were tested as follows: 1) Beam walking (BW), 2) Open Field (OF), and 3) Elevated plus maze (EPM)...
March 19, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28315642/comparison-of-atipamezole-with-yohimbine-for-antagonism-of-xylazine-in-mice-anesthetized-with-ketamine-and-xylazine
#6
Christopher F Janssen, Pauline Maiello, M Jerry Wright, Kara B Kracinovsky, Joseph T Newsome
The α2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect-and its undesirable side effects of bradycardia, hypotension, and poor tissue perfusion-can be reversed by administration of α2 antagonists, such as atipamezole or yohimbine. Although atipamezole and yohimbine dosing guidelines are available for mice, no controlled comparison has been performed to guide the lab animal community in the selection of one over the other...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28314479/new-insights-into-the-effects-and-mechanism-of-a-classic-traditional-chinese-medicinal-formula-on-influenza-prevention
#7
Huan Chen, Chong Jie, Lu-Ping Tang, He Meng, Xiao-Bo Li, Yan-Bing Li, Le-Xing Chen, Chang Yan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
BACKGROUND: KangBingDu (KBD) is a classic traditional Chinese medicinal formula widely used to treat influenza. However, little information is available from controlled studies regarding the anti-influenza pharmacological activities of KBD and its underlying mechanisms, at least partly due to the lack of appropriate study models. PURPOSE: We hypothesized that KBD might provide a protection against influenza infection by reducing the host's susceptibility to viruses...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28314239/likelihood-ratio-and-posterior-odds-in-forensic-genetics-two-sides-of-the-same-coin
#8
Amke Caliebe, Susan Walsh, Fan Liu, Manfred Kayser, Michael Krawczak
It has become widely accepted in forensics that, owing to a lack of sensible priors, the evidential value of matching DNA profiles in trace donor identification or kinship analysis is most sensibly communicated in the form of a likelihood ratio (LR). This restraint does not abate the fact that the posterior odds (PO) would be the preferred basis for returning a verdict. A completely different situation holds for Forensic DNA Phenotyping (FDP), which is aimed at predicting externally visible characteristics (EVCs) of a trace donor from DNA left behind at the crime scene...
March 6, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28304184/chronic-stress-induced-disruption-of-the-peri-infarct-neurovascular-unit-following-experimentally-induced-photothrombotic-stroke
#9
Zidan Zhao, Lin Kooi Ong, Sarah Johnson, Michael Nilsson, Frederick R Walker
How stress influences brain repair is an issue of considerable importance, as patients recovering from stroke are known to experience high and often unremitting levels of stress post-event. In the current study, we investigated how chronic stress modified the key cellular components of the neurovascular unit. Using an experimental model of focal cortical ischemia in male C57BL/6 mice, we examined how exposure to a persistently aversive environment, induced by the application of chronic restraint stress, altered the cortical remodeling post-stroke...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28303736/the-protective-effect-of-the-vacha-rhizome-extract-on-chronic-stress-induced-immunodeficiency-in-rat
#10
H N Sarjan, S Divyashree, H N Yajurvedi
CONTEXT: Chronic stress is an inevitable factor in the modern day society which affects cell mediated as well as humoral immunity. There is a need to prevent stress effects with traditionally used herbs. OBJECTIVE: The present study was undertaken to investigate the immunoprotective effect of Vacha (Acorus calamus L. Acoraceae) rhizome under stressful condition. MATERIALS AND METHODS: Soxlet extraction of Vacha rhizome was performed with increasing polarity of solvents, i...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28301060/prevalence-of-eating-disorders-and-picking-nibbling-in-elderly-women
#11
Eva M Conceição, Fabiana V S Gomes, Ana R Vaz, Ana Pinto-Bastos, Paulo P P Machado
OBJECTIVE: The aim of this study was to examine the point prevalence of eating disorders and picking/nibbling in elderly women. METHODS: This was a two-stage epidemiological study that assessed 342 women aged 65-94 years old. In Stage 1, the following screening measures were used to identify possible cases: the Mini-Mental State Examination, to screen and exclude patients with cognitive impairment; Weight Concerns Scale; SCOFF (Sick, Control, One, Fat, Food) Questionnaire; Eating Disorder Examination Questionnaire-dietary restraint subscale; and three questions to screen for picking/nibbling and night eating syndrome...
March 16, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28300139/fine-tuning-the-extent-and-dynamics-of-binding-cleft-opening-as-a-potential-general-regulatory-mechanism-in-parvulin-type-peptidyl-prolyl-isomerases
#12
András Czajlik, Bertalan Kovács, Perttu Permi, Zoltán Gáspári
Parvulins or rotamases form a distinct group within peptidyl prolyl cis-trans isomerases. Their exact mode of action as well as the role of conserved residues in the family are still not unambiguously resolved. Using backbone S(2) order parameters and NOEs as restraints, we have generated dynamic structural ensembles of three distinct parvulins, SaPrsA, TbPin1 and CsPinA. The resulting ensembles are in good agreement with the experimental data but reveal important differences between the three enzymes. The largest difference can be attributed to the extent of the opening of the substrate binding cleft, along which motional mode the three molecules occupy distinct regions...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299387/anterolateral-knee-biomechanics
#13
Andrew A Amis
This article reviews the evidence for the roles of the anterolateral soft-tissue structures in rotatory stability of the knee, including their structural properties, isometry, and contributions to resisting tibial internal rotation. These data then lead to a biomechanical demonstration that the ilio-tibial band is the most important structure for the restraint of anterolateral rotatory instability. Level of evidence V.
March 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28296431/does-unbelted-safety-requirement-affect-protection-for-belted-occupants
#14
Jingwen Hu, Kathleen D Klinich, Miriam A Manary, Carol A C Flannagan, Prabha Narayanaswamy, Matthew P Reed, Margaret Andreen, Mark Neal, Chin-Hsu Lin
OBJECTIVE: Federal regulations in the United States require vehicles to meet occupant performance requirements with unbelted test dummies. Removing the test requirements with unbelted occupants might encourage the deployment of seatbelt interlocks and allow restraint optimization to focus on belted occupants. The objective of this study is to compare the performance of restraint systems optimized for belted only occupants with those optimized for both belted and unbelted occupants using computer simulations and field crash data analyses...
March 15, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28295121/outcomes-at-a-minimum-of-2-years-after-medial-collateral-ligament-reconstruction-using-partial-thickness-quadriceps-tendon-bone-autograft
#15
Iftach Hetsroni, Gideon Mann
This study reports outcomes at a minimum of 2 years after a technique using quadriceps tendon-bone autograft for medial collateral ligament reconstruction. This technique effectively restored medial stability in medial collateral ligament-deficient knees. It is particularly valuable when nonirradiated allograft is unavailable or harvesting medial knee restraints (semitendinosus) for medial collateral ligament reconstruction is to be avoided. [Orthopedics. 201x; xx(x):xx-xx.].
March 14, 2017: Orthopedics
https://www.readbyqxmd.com/read/28294985/effects-of-a-diet-based-weight-reducing-program-with-probiotic-supplementation-on-satiety-efficiency-eating-behaviour-traits-and-psychosocial-behaviours-in-obese-individuals
#16
Marina Sanchez, Christian Darimont, Shirin Panahi, Vicky Drapeau, André Marette, Valerie H Taylor, Jean Doré, Angelo Tremblay
This study evaluated the impact of probiotic supplementation (Lactobacillus rhamnosus CGMCC1.3724 (LPR)) on appetite sensations and eating behaviors in the context of a weight-reducing program. Obese men (n = 45) and women (n = 60) participated in a double-blind, randomized, placebo-controlled trial that included a 12-week weight loss period (Phase 1) based on moderate energy restriction, followed by 12 weeks of weight maintenance (Phase 2). During the two phases of the program, each subject consumed two capsules per day of either a placebo or a LPR formulation (10 mg of LPR equivalent to 1...
March 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28293718/transfection-of-primary-brain-capillary-endothelial-cells-for-protein-synthesis-and-secretion-of-recombinant-erythropoietin-a-strategy-to-enable-protein-delivery-to-the-brain
#17
Annette Burkhart, Thomas Lars Andresen, Achim Aigner, Louiza Bohn Thomsen, Torben Moos
Treatment of chronic disorders affecting the central nervous system (CNS) is complicated by the inability of drugs to cross the blood-brain barrier (BBB). Non-viral gene therapy applied to brain capillary endothelial cells (BCECs) denotes a novel approach to overcome the restraints in this passage, as turning BCECs into recombinant protein factories by transfection could result in protein secretion further into the brain. The present study aims to investigate the possibility of transfecting primary rat brain endothelial cells (RBECs) for recombinant protein synthesis and secretion of the neuroprotective protein erythropoietin (EPO)...
March 14, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28293639/proteomic-analysis-of-liver-proteins-in-a-rat-model-of-chronic-restraint-stress-induced-depression
#18
Cong Li, Zhengguang Guo, Ronghua Zhao, Wei Sun, Ming Xie
Depression is a global mental disorder disease and greatly threatened human health and stress is considered to be one of the important factors that lead to depression. In this study, we used newly developed iTRAQ labeling and high performance liquid chromatography (HPLC) and mass spectrum united analysis technology obtained the 2176 accurate proteins. Successively, we used the GO analysis and IPA software to analyze the 98 differentially expressed proteins of liver in depression rats due to chronic restraint stress, showing a map of proteomics analysis of liver proteins from the aspects of related functions, disease and function analysis, canonical pathway analysis, and associated network...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28292831/reduction-of-ether-type-glycerophospholipids-plasmalogens-by-nf-%C3%AE%C2%BAb-signal-leading-to-microglial-activation
#19
Md Shamim Hossain, Yuichi Abe, Fatma Ali, Mohammed Youssef, Masanori Honsho, Yukio Fujiki, Toshihiko Katafuchi
Neuroinflammation characterized by activation of glial cells is observed in various neurodegenerative diseases including Alzheimer's disease (AD). Although the reduction of ether-type glycerophospholipids, plasmalogens (Pls), in the brain is reported in AD patients, the mechanism of the reduction and its impact on neuroinflammation remained elusive. In the present study, we found for the first time that various inflammatory stimuli reduced the Pls levels in the murine glial cells via NF-κB activation which then down-regulated a Pls synthesizing enzyme, glycerone phosphate O-acyltransferase (Gnpat) through the increased c-Myc recruitment onto the Gnpat promoter...
March 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28291758/using-more-than-801%C3%A2-296-small-molecule-crystal-structures-to-aid-in-protein-structure-refinement-and-analysis
#20
Jason C Cole, Ilenia Giangreco, Colin R Groom
The Cambridge Structural Database (CSD) is the worldwide resource for the dissemination of all published three-dimensional structures of small-molecule organic and metal-organic compounds. This paper briefly describes how this collection of crystal structures can be used en masse in the context of macromolecular crystallography. Examples highlight how the CSD and associated software aid protein-ligand complex validation, and show how the CSD could be further used in the generation of geometrical restraints for protein structure refinement...
March 1, 2017: Acta Crystallographica. Section D, Structural Biology
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