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https://www.readbyqxmd.com/read/28648524/molecular-modelling-of-biomolecules-by-paramagnetic-nmr-and-computational-hybrid-methods
#1
REVIEW
Kala Bharath Pilla, Kari Gaalswyk, Justin L MacCallum
The 3D atomic structures of biomolecules and their complexes are key to our understanding of biomolecular function, recognition, and mechanism. However, it is often difficult to obtain structures, particularly for systems that are complex, dynamic, disordered, or exist in environments like cell membranes. In such cases sparse data from a variety of paramagnetic NMR experiments offers one possible source of structural information. These restraints can be incorporated in computer modelling algorithms that can accurately translate the sparse experimental data into full 3D atomic structures...
June 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28647596/testing-the-physiological-plausibility-of-conflicting-psychological-models-of-response-inhibition-a-forward-inference-fmri-study
#2
Marion Criaud, Marieke Longcamp, Jean-Luc Anton, Bruno Nazarian, Muriel Roth, Guillaume Sescousse, Antonio P Strafella, Bénédicte Ballanger, Philippe Boulinguez
The neural mechanisms underlying response inhibition and related disorders are unclear and controversial for several reasons. First, it is a major challenge to assess the psychological bases of behaviour, and ultimately brain-behaviour relationships, of a function which is precisely intended to suppress overt measurable behaviours. Second, response inhibition is difficult to disentangle from other parallel processes involved in more general aspects of cognitive control. Consequently, different psychological and anatomo-functional models coexist, which often appear in conflict with each other even though they are not necessarily mutually exclusive...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28647385/hunger-and-disinhibition-but-not-cognitive-restraint-are-associated-with-central-norepinephrine-transporter-availability
#3
A Bresch, M Rullmann, J Luthardt, G A Becker, M Patt, Y-S Ding, A Hilbert, O Sabri, S Hesse
The relationship between food-intake related behaviours measured by the Three-Factor Eating Questionnaire (TFEQ) and in vivo norepinephrine transporter (NET) availability has not been explored yet. We investigated ten obese individuals (body mass index (BMI) 42.4 ± 3.7 kg/m(2)) and ten normal-weight healthy controls (HC, BMI 23.9 ± 2.5 kg/m(2)) with (S,S)-[(11)C]-O-methylreboxetine ([(11)C]MRB) positron emission tomography (PET). All participants completed the TFEQ, which measures cognitive restraint, disinhibition and hunger...
June 21, 2017: Appetite
https://www.readbyqxmd.com/read/28645751/psychometric-evaluation-of-the-german-version-of-the-intuitive-eating-scale-2-in-a-community-sample
#4
Ulrike Alexandra Ruzanska, Petra Warschburger
Intuitive eating is based on a strong physical connection with the body, aligned to internal cues of hunger and satiety, and a low preoccupation with food. The aim of this study was to provide a German version of the Intuitive Eating Scale-2 (IES-2) and to examine its psychometric properties with data collected from 532 participants aged 18-91 years. The IES-2 was translated into German following the World Health Organization guidelines (2016). Cronbach's alpha as a measure of internal consistency was .89 for the IES-2 total score, as well as ...
June 20, 2017: Appetite
https://www.readbyqxmd.com/read/28644445/effects-of-daily-restraint-with-and-without-injections-on-skeletal-properties-in-c57bl-6nhsd-mice
#5
Rachel A Larsen, Jessica L Peveler, Joshuah B Klutzke, Debra L Hickman, Mohammad W Aref, Joseph M Wallace, Drew M Brown, Matthew R Allen
No abstract text is available yet for this article.
June 23, 2017: Lab Animal
https://www.readbyqxmd.com/read/28642096/pine-needle-extract-prevents-hippocampal-memory-impairment-in-acute-restraint-stress-mouse-model
#6
Jin-Seok Lee, Hyeong-Geug Kim, Hye-Won Lee, Won-Yong Kim, Yo-Chan Ahn, Chang-Gue Son
ETHNOPHARMACOLOGICAL RELEVANCE: The Pinus densiflora leaf has been traditionally used to treat mental health disorders as a traditional Chinese medicine. Here we examined the ethnopharmacological relevance of pine needle on memory impairment caused by stress. AIM OF THE STUDY: To elucidate the possible modulatory actions of 30% ethanolic pine needle extract (PNE) on stress-induced hippocampal excitotoxicity, we adopted an acute restraint stress mouse model. MATERIALS AND METHODS: Mice were orally administered with PNE (25, 50, or 100mg/kg) or ascorbic acid (100mg/kg) for 9 days, and were then subjected to restraint stress (6h/day) for 3 days (from experimental day 7 to 9)...
June 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28639441/effect-of-periodized-high-intensity-interval-training-hiit-on-body-composition-and-attitudes-towards-hunger-in-active-men-and-women
#7
Todd A Astorino, Brendyn Heath, Jason Bandong, Gina M Ordille, Ramon Contreras, Matthew Montell, Matthew M Schubert
BACKGROUND: High intensity interval training (HIIT) increases maximal oxygen uptake similar to aerobic exercise. However, changes in body composition are equivocal in response to HIIT. AIM: We examined changes in body composition and dietary restraint in response to 20 sessions of HIIT varying in structure. METHODS: Thirty nine active men and women (age and VO2max = 22.5 ± 4.4 yr and 40.1 ± 5.6 mL/kg/min) were randomized to one of three periodized HIIT regimes performed on a cycle ergometer...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28637154/shoulder-pain-after-stroke-experiences-consequences-in-daily-life-and-effects-of-interventions-a-qualitative-study
#8
Ingrid Lindgren, Gunvor Gard, Christina Brogårdh
PURPOSE: To describe experiences of shoulder pain after stroke, how pain affects daily life and perceived effects of interventions. METHOD: A qualitative interview study including 13 community-dwelling persons (six women; median age 65 years) with persistent shoulder pain after stroke. RESULTS: Three categories emerged from the content analysis. In "Multiple pain characteristics" an insidious pain onset was reported. The pain existed both day and night and could be located around the shoulder girdle but also have radiation to the arm and hand...
March 3, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28636328/structural-dynamics-of-native-like-ions-in-the-gas-phase-results-from-tandem-ion-mobility-of-cytochrome-c
#9
Samuel J Allen, Rachel M Eaton, Matthew F Bush
Ion mobility (IM) is a gas-phase separation technique that is used to determine the collision cross sections of native-like ions of proteins and protein complexes, which are in turn used as restraints for modeling the structures of those analytes in solution. Here, we evaluate the stability of native-like ions using tandem IM experiments implemented using Structures for Lossless Ion Manipulations (SLIM). In this implementation of tandem IM, ions undergo a first dimension of IM up to a switch that is used to selectively transmit ions of a desired mobility...
June 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28635348/hope-coping-skills-and-the-prefrontal-cortex-in-alcohol-use-disorder-recovery
#10
Spencer D Bradshaw, Sterling T Shumway, Cynthia M Dsauza, Neli Morris, Nicholas D Hayes
BACKGROUND: Alcohol use disorders adversely affect individual and societal health. These disorders are a chronic brain disease, and protective factors against relapse should be studied. Prefrontal cortex (PFC) dysfunction is evident in alcohol use disorders, and research that explores recovery of the PFC in alcohol use disorders is needed, specifically in regard to how psychological and behavioral factors can augment medicalized treatments and protect against relapse. For example, hope or a belief that recovery is possible is an important cognitive construct-thought to precede behavioral action-that has been associated with relapse...
March 1, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28635150/a-pilot-study-of-post-seclusion-and-or-restraint-review-intervention-with-patients-and-staff-in-a-mental-health-setting
#11
Marie-Hélène Goulet, Caroline Larue, Ashley J Lemieux
PURPOSE: To develop and evaluate a "post-seclusion and/or restraint review" (PSRR) intervention implemented in an acute psychiatric care unit. DESIGN AND METHODS: Twelve staff members and three patients were enrolled in a participatory case study. To evaluate PSRR intervention, qualitative analysis was carried out. Seclusion and restraint use 6 months before and after the PSRR implementation was compared. FINDINGS: Nurses reported that they were able to explore the patient's feelings during the PSRR intervention with patients, which led to restoration of the therapeutic relationship...
June 20, 2017: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/28632394/changes-in-eating-behaviors-of-children-with-obesity-in-response-to-carbohydrate-modified-and-portion-controlled-diets
#12
Shelley Kirk, Jessica G Woo, Bonnie Brehm, Stephen R Daniels, Brian E Saelens
OBJECTIVE: This study's objective was to determine whether two distinct carbohydrate (CHO)-modified diets and a standard portion-controlled (PC) diet differentially impacted children's eating behaviors and whether eating behavior scores predicted lower BMI among children with obesity. METHODS: Children (n = 102) aged 7-12 years with obesity were randomly assigned to a 12-month intervention of a low-carbohydrate (LC), reduced glycemic load (RGL), or standard PC diet...
June 20, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28632288/all-arthroscopic-superior-shoulder-capsule-reconstruction-with-partial-rotator-cuff-repair
#13
E Grant Sutter, Jonathan A Godin, Grant E Garrigues
Massive irreparable rotator cuff tears are difficult to treat. Although several treatment options exist, none provides superior long-term results. There is no consensus on optimal surgical technique. Superior capsular reconstruction is an operative treatment option aimed at restoring native biomechanics of the glenohumeral joint by providing a restraint to superior subluxation. Partial rotator cuff repair for massive tears has also been shown to improve shoulder kinematics and can be performed in conjunction with superior capsule reconstruction...
June 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28629613/out-of-the-institution-into-the-classroom-legal-challenges-to-the-use-of-restraint-and-seclusion-in-school-settings-in-the-united-states
#14
Lycette Nelson
The issue of restraint and seclusion of children with mental and developmental disabilities in schools has gained greater attention in the United States in recent years as more children with disabilities are attending mainstream schools. This article looks at how cases brought on behalf of children who have been subjected to such treatment fit or fail to fit within a well-developed jurisprudence that provides constitutional protections for the rights of people with mental disabilities to be free from discrimination and from cruel and unusual punishment...
June 16, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28626944/food-insecurity-and-eating-disorder-pathology
#15
Carolyn Black Becker, Keesha Middlemass, Brigitte Taylor, Clara Johnson, Francesca Gomez
OBJECTIVE: The primary aim of this study was to investigate eating disorder (ED) pathology in those living with food insecurity. A secondary aim was to investigate whether any-reason dietary restraint, weight self-stigma, and worry increased as level of food insecurity increased. METHOD: Participants (N = 503) seeking food from food pantries completed questionnaires assessing level of food insecurity, demographics, ED pathology, dietary restraint, weight self-stigma, and worry...
June 18, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28626906/behavioural-implications-of-traditional-treatment-and-closed-loop-automated-insulin-delivery-systems-in-type-1-diabetes-applying-a-cognitive-restraint-theory-framework
#16
REVIEW
A R Kahkoska, E J Mayer-Davis, K K Hood, D M Maahs, K S Burger
As the prevalence of obesity in Type 1 diabetes rises, the effects of emerging therapy options should be considered in the context of both weight and glycaemic control outcomes. Artificial pancreas device systems will 'close the loop' between blood glucose monitoring and automated insulin delivery and may transform day-to-day dietary management for people with Type 1 diabetes in multiple ways. In the present review, we draw directly from cognitive restraint theory to consider unintended impacts that closed-loop systems may have on ingestive behaviour and food intake...
June 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28625590/intranasal-cotinine-improves-memory-and-reduces-depressive-like-behavior-and-gfap-cells-loss-induced-by-restraint-stress-in-mice
#17
Nelson Perez-Urrutia, Cristhian Mendoza, Nathalie Alvarez-Ricartes, Patricia Oliveros-Matus, Florencia Echeverria, J Alex Grizzell, George E Barreto, Alexandre Iarkov, Valentina Echeverria
Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-like behavior and synaptic loss when co-administered during restraint stress, a model of PTSD and stress-induced depression, in mice. Here, we investigated the effects of post-treatment with intranasal cotinine on depressive- and anxiety-like behaviors, visual recognition memory as well as the number and morphology of GFAP+ immunoreactive cells, in the hippocampus and frontal cortex of mice subjected to prolonged restraint stress...
June 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28625000/mechanical-restraint-in-an-emergency-department-a-consecutive-series-of-593-cases
#18
Nicolas Beysard, Bertrand Yersin, Pierre-Nicolas Carron
The objective is to describe the characteristics of mechanically restrained patients in the emergency department (ED) of a university hospital and to evaluate the quality of restraint documentation that was filled out according to the dedicated protocol with respect to the law on restraint. All adult patients (≥16 years) who were admitted to the ED from January 2009 to December 2010 and were mechanically restrained were included. We assessed medical and demographic characteristics, the completeness of the dedicated protocol, and the concomitant use of chemical sedation...
June 17, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28624376/orthorexia-nervosa-and-eating-disorder-symptoms-in-registered-dietitian-nutritionists-in-the-united-states
#19
Kaylee Tremelling, Lona Sandon, Gloria L Vega, Carrie J McAdams
BACKGROUND: Registered dietitian nutritionists are trained to identify optimal food choices for clients based on medical state and lifestyle. Orthorexia nervosa (ON) is a proposed disorder related to obsessions about eating healthfully. Eating disorders (EDs) are serious mental illnesses with symptoms related to eating, body image, and self-esteem. Both ON and EDs are more common among RDNs than the general population. OBJECTIVE: This study examined the prevalence of ON and EDs in RDNs in the United States and, among this sample, assessed whether the presence of ON symptoms related to symptoms of EDs, including weight, shape, eating, and restraint...
June 14, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28624346/theta-burst-magnetic-stimulation-over-the-pre-supplementary-motor-area-improves-motor-inhibition
#20
Ignacio Obeso, Leonora Wilkinson, James T Teo, Penelope Talelli, John C Rothwell, Marjan Jahanshahi
BACKGROUND: Stopping an ongoing motor response or resolving conflict induced by conflicting stimuli are associated with activation of a right-lateralized network of inferior frontal gyrus (IFG), pre-supplementary motor area (pre-SMA) and subthalamic nucleus (STN). However, the roles of the right IFG and pre-SMA in stopping a movement and in conflict resolution remain unclear. We used continuous theta burst stimulation (cTBS) to examine the involvement of the right IFG and pre-SMA in inhibition and conflict resolution using the conditional stop signal task...
May 22, 2017: Brain Stimulation
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