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https://www.readbyqxmd.com/read/29457656/fatty-acid-binding-protein-deletion-prevents-stress-induced-preference-for-cocaine-and-dampens-stress-induced-corticosterone-levels
#1
John Hamilton, Matthew Marion, Antonio Figueiredo, Brendan H Clavin, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thanos
Genetic and pharmacological manipulation of endocannabinoid (eCB) signaling has previously been shown to have an important role on the rewarding properties of drugs of abuse, including cocaine. Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). The role of these transporters in modulating the brains reward system has yet to be investigated...
February 19, 2018: Synapse
https://www.readbyqxmd.com/read/29454275/long-term-follow-up-of-patients-undergoing-tibialis-posterior-transfer-is-acquired-pes-planus-a-complication
#2
Mira Pecheva, Adam Devany, Basil Nourallah, Steven Cutts, Chandra Pasapula
In this retrospective study, a series of 10 elective patients treated with transfer of the tibialis posterior (TP) tendon for pes cavus and drop foot are described. Since TP transfer completely subtracts the role of this tendon, this cohort of patients provides an opportunity to examine the consequences of tibialis posterior (TP) deficiency. After a mean follow up period of 44.7 months, only one patient showed evidence of strain in the spring ligament but none of the patients in this series developed clinical or radiological evidence of planovalgus deformity...
November 22, 2017: Foot
https://www.readbyqxmd.com/read/29453839/making-policies-about-emerging-technologies
#3
Gregory E Kaebnick, Michael K Gusmano
Can we make wise policy decisions about still-emerging technologies-decisions that are grounded in facts yet anticipate unknowns and promote the public's preferences and values? There is a widespread feeling that we should try. There also seems to be widespread agreement that the central element in wise decisions is the assessment of benefits and costs, understood as a process that consists, at least in part, in measuring, tallying, and comparing how different outcomes would affect the public interest. But how benefits and costs are best weighed when making decisions about whether to move forward with an emerging technology is not clear...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29446553/children-s-moral-experiences-of-crisis-management-in-a-child-mental-health-setting
#4
Marjorie Montreuil, Catherine Thibeault, Linda McHarg, Franco A Carnevale
The experiences of children related to conflict and crisis management in child mental health settings, especially those aged 12 and below, have been rarely studied. This study examined the moral experiences of children related to conflict and crisis management and the related use of restraint and seclusion in a child mental health setting. A 5-month focused ethnography using a participatory hermeneutic framework was conducted in a day hospital programme for children with severe disruptive disorders within a mental health institute...
February 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29444592/antidepressant-like-effects-of-vaccinium-bracteatum-in-chronic-restraint-stress-mice-functional-actions-and-mechanism-explorations
#5
Dool-Ri Oh, Yujin Kim, Eun-Jin Choi, Myung-A Jung, Kyo-Nyeo Oh, Ji-Ae Hong, Donghyuck Bae, Kwangsu Kim, Huwon Kang, Jaeyong Kim, Young Ran Kim, Seung Sik Cho, Chul-Young Choi
The fruit of Vaccinium bracteatum Thunb. (VBF) is commonly known as the oriental blueberry in Korea. The aim of this study was to evaluate the antidepressant-like effects of water VBF extract (VBFW) in a mouse model of chronic restraint stress (CRS) and to identify the underlying mechanisms of its action. The behavioral effects of VBFW were assessed in the forced swim test (FST) and open field test (OFT). The levels of serum corticosterone (CORT), brain monoamines, in addition to the extracellular signal-regulated kinases (ERKs)/protein kinase B (Akt) signaling pathway were evaluated...
February 14, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29441444/listening-to-the-patient-perspective-psychiatric-inpatients-attitudes-towards-physical-restraint
#6
Yaniv Spinzy, M Saed, S Aviv, G Cohen-Rappaport
When other options fail, physical restraint is used in inpatient psychiatric units as a means to control violent behavior of agitated inpatients and to prevent them from harm. The professional and social discourse regarding the use of restrictive measures and the absence of the inpatients' attitudes towards these measures is notable. Our research therefore tries to fill this gap by interviewing inpatients about these issues. To assess the subjective experience and attitudes of inpatients who have undergone physical restraint...
February 14, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29439906/dermoid-cysts-of-the-conus-medullaris-clinical-review-case-series-and-management-strategies
#7
Salah G Aoun, Mary Ashley Liu, Megan Still, Tarek Y El Ahmadieh, Mazin Al Tamimi, Wayne Gluf
BACKGROUND: The management of dermoid cysts can be tedious as they have a tendency to recur, and respond poorly to chemotherapy and radiation. Management is especially difficult for tumors involving highly eloquent areas such as the conus medullaris. OBJECTIVE: We aim to provide a summary of the pathology, clinical presentation, and operative management strategies of dermoid cysts involving the conus medullaris. METHODS: Two clinical cases of dermoid cysts of the conus are presented, as well as a commented surgical video...
February 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29433697/where-does-your-state-stand-on-shackling-of-pregnant-incarcerated-women
#8
Ginette G Ferszt, Michelle Palmer, Christine McGrane
Pregnant incarcerated women have been identified as a particularly high-risk group and among the most vulnerable women in the United States. The use of shackling or restraints poses health risks to pregnant women and their fetuses. Currently, only 22 states have legislation prohibiting or limiting the shackling of pregnant women. Here we provide an overview of the potential negative health outcomes that can result from shackling pregnant women, especially during labor and birth, and suggest strategies for nurses who wish to promote optimal health care for incarcerated women and to advocate for anti-shackling legislation in their states...
February 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/29431452/smoking-by-young-women-with-restrained-eating-following-a-food-prime-in-the-context-of-an-alternative-distractor
#9
Michelle A Kovacs, Amanda M Palmer, John B Correa, Thomas H Brandon
Female smokers with elevated dietary restraint (high restrainers) may smoke more than nonrestrained eaters after a disinhibiting food event. The current study aimed to determine whether high restrainers smoke merely to distract themselves from unplanned eating or whether the weight-control aspects of smoking play a role. Primary aims were to test the effect of restraint status and a food prime on smoking and eating behavior in the presence of an alternative distractor (a computer tablet) and to examine the role of expectancies...
February 12, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29431294/rapid-tranquilization-an-audit-of-irish-mental-health-nursing-practice
#10
Michael Nash, Caitriona McDonagh, Aisling Culhane, Imelda Noone, Agnes Higgins
Rapid tranquillization is a pharmacological intervention sometimes employed in mental health care for the management of acute behavioural disturbance. It is a form of restrictive practice, which, along with seclusion and restraint, is a conventional and controversial intervention in the therapeutic management of risk in mental health settings. This study surveyed mental health nurses practice in rapid tranquillization. A self-report questionnaire was utilized which addressed aspects such as definitions of rapid tranquillization, presence of rapid tranquillization policy, types of incidents where it is used and postintervention monitoring...
February 12, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29430399/associated-reconstruction-of-anterior-cruciate-and-anterolateral-ligaments-with-single-asymmetric-hamstring-tendons-graft
#11
Alejandro Espejo-Baena, Alejandro Espejo-Reina, Abel Gómez-Cáceres, Maria Josefa Espejo-Reina, Jaime Dalla Rosa-Nogales
The anterior cruciate ligament (ACL) rupture is a common disease that accounts for 250,000 cases/year in the United States. The anterolateral ligament (ALL) has been suggested to be an important restraint for rotational instability, and its reconstruction provides a reinforcement to the ACL reconstruction in this aspect, especially in high-demand athletes and in knees with high-grade pivot shift. Different techniques for associated ACL and ALL reconstruction have been described, but the ideal technique remains unclear...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29429513/protective-roles-of-rutin-against-restraint-stress-on-spermatogenesis-in-testes-of-adult-mice
#12
Asif Mehfooz, Quanwei Wei, Kaizhi Zheng, Mohamed Babo Fadlalla, Gracijela Maltasic, Fangxiong Shi
In order to investigate the effects of Rutin against restraint stress, 50 adult male mice were divided into five groups: control, restraint stress (RS), and RS with 2 doses of Rutin treatments. Mice were restrained in a conical tube for 4 h daily and Rutin was injected intraperitoneally for 15 consecutive days. Restraint stress significantly decreases body weights, testis and epididymis weights, thymus weights, visceral fats, serum concentrations of testosterone, sperm counts, sperm motility and sperm viability, while it increases serum epinephrine levels, adrenal gland weights and abnormal sperms...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29428865/attentional-bias-is-more-predictive-of-eating-behavior-after-self-control-exertion
#13
Garrett A Pollert, Jennifer C Veilleux
There is experimental evidence to suggest that attentional bias to food stimuli may predict food intake. The process model of ego-depletion (Inzlicht & Schmeichel, 2012) proposes that after self-control exertion, attention shifts toward rewarding objects such as palatable food, which in turn should prompt greater food consumption as an indicator of lower self-control. In the current study, 84 female restrained and unrestrained eaters engaged in a self-control or neutral task, followed by a measure of attentional bias and an eating task...
February 7, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29425158/free-vibration-analysis-of-moderately-thick-orthotropic-functionally-graded-plates-with-general-boundary-restraints
#14
Yu Fu, Jianjun Yao, Zhenshuai Wan, Gang Zhao
In this paper, a modified Fourier series method is presented for the free vibration of moderately thick orthotropic functionally graded plates with general boundary restraints based on the first-order shear deformation theory. Regardless of boundary restraints, displacements and rotations of each plate are described as an improved form of double Fourier cosine series and several closed-form auxiliary functions to eliminate all the boundary discontinuities and jumps. Exact solutions are obtained by the energy functions of the plates based on Rayleigh-Ritz method...
February 9, 2018: Materials
https://www.readbyqxmd.com/read/29424421/physical-restraint-perceptions-of-nurse-managers-registered-nurses-and-healthcare-assistants
#15
P Leahy-Warren, V Varghese, M R Day, M Curtin
AIM: To examine the perceptions of nurse managers, registered nurses and healthcare assistants of physical restraint use on older people in a long-term care setting in the Republic of Ireland. BACKGROUND: The use of physical restraint, although controversial, persists in long-term care settings, despite recommendations for restraint-free environments. Perception and attitude of staff can influence use of physical restraint. METHODS: A descriptive cross-sectional design was used...
February 9, 2018: International Nursing Review
https://www.readbyqxmd.com/read/29421591/voluntary-exercise-increases-resilience-to-social-defeat-stress-in-syrian-hamsters
#16
Rody C Kingston, Michael Smith, Tiara Lacey, Malcolm Edwards, Janae N Best, Chris M Markham
Exposure to social stressors can cause profound changes in an individual's well-being and can be an underlying factor in the etiology of a variety of psychopathologies, such as post-traumatic stress disorder (PTSD). In Syrian hamsters, a single social defeat experience results in behavioral changes collectively known as conditioned defeat (CD), and includes an abolishment of territorial aggression and the emergence of high levels of defensive behaviors. In contrast, voluntary exercise has been shown to promote stress resilience and can also have anxiolytic-like effects...
February 5, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29421246/repeated-restraint-stress-reduces-the-acquisition-and-relapse-of-methamphetamine-conditioned-place-preference-but-not-behavioral-sensitization
#17
Jee-Yeon Seo, Yong-Hyun Ko, Shi-Xun Ma, Bo-Ram Lee, Seok-Yong Lee, Choon-Gon Jang
The studies for the effects of stress on drug addiction were mostly obtained using sequential exposure to stress and drugs. However, few studies have been conducted on the effects of simultaneous exposure to stress and methamphetamine (METH) on METH-induced reward effects and behavioral sensitization. Thus, we examined the effects of simultaneous exposure to restraint stress and METH on METH-induced addictive behaviors using conditioned place preference (CPP) in mice. During the conditioning period, the mice were exposed to 2 h restraint stress before administration of METH or saline for 4 days...
February 5, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29419816/structural-prediction-of-protein-models-using-distance-restraints-derived-from-cross-linking-mass-spectrometry-data
#18
Zsuzsanna Orbán-Németh, Rebecca Beveridge, David M Hollenstein, Evelyn Rampler, Thomas Stranzl, Otto Hudecz, Johannes Doblmann, Peter Schlögelhofer, Karl Mechtler
This protocol describes a workflow for creating structural models of proteins or protein complexes using distance restraints derived from cross-linking mass spectrometry experiments. The distance restraints are used (i) to adjust preliminary models that are calculated on the basis of a homologous template and primary sequence, and (ii) to select the model that is in best agreement with the experimental data. In the case of protein complexes, the cross-linking data are further used to dock the subunits to one another to generate models of the interacting proteins...
March 2018: Nature Protocols
https://www.readbyqxmd.com/read/29419332/alcohol-as-a-factor-in-911-calls-in-denver
#19
Daniel Joseph, Jody A Vogel, C Sam Smith, Whitney Barrett, Gary Bryskiewicz, Aaron Eberhardt, David Edwards, Lara Rappaport, Christopher B Colwell, Kevin E McVaney
BACKGROUND: Excessive alcohol consumption is associated with a substantial number of emergency department visits annually and is responsible for a significant number of lives lost each year in the United States. However, a minimal amount is known about the impact of alcohol on the EMS system. OBJECTIVES: The primary objective was to determine the proportion of 9-1-1 calls in Denver, Colorado in which (1) alcohol was a contributing factor or (2) the individual receiving EMS services had recently ingested alcohol...
February 8, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29413810/transdiagnostic-vs-disorder-focused-perspective-in-children-and-adolescents-with-eating-disorders-findings-from-a-large-multisite-exploratory-study
#20
O Curzio, S Maestro, G Rossi, S Calderoni, L Giombini, S Scardigli, L Dalla Ragione, F Muratori
BACKGROUND: The transdiagnostic model of eating disorders (ED) proposes common cognitive mechanisms in patients with ED psychopathology. Little is known about their role in the maintenance of ED in children and adolescents. This study aimed to determine whether the relationships between key factors (low self-esteem, weight and shape control, clinical perfectionism, interpersonal problems, distress and mood instability) and core maintaining mechanisms (binge-eating and restraint) would support a transdiagnostic theory in young patients...
February 5, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
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