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Kidney disease

Robert Strassl, Martin Schiemann, Konstantin Doberer, Irene Görzer, Elisabeth Puchhammer-Stöckl, Farsad Eskandary, Željko Kikic, Guido A Gualdoni, Mathias G Vossen, Susanne Rasoul-Rockenschaub, Harald Herkner, Georg A Böhmig, Gregor Bond
Background: Drug-induced immunosuppression following kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious disease. Tailoring of drug dosing to prevent both rejection and infection is greatly desirable. The apathogenic and ubiquitous torque teno virus (TTV) reflects immunocompetence of the host and might be a potential candidate for immunologic monitoring. Methods: To assess TTV as an infection biomarker, virus load was prospectively quantified in peripheral blood of 169 consecutive renal allograft recipients at the Medical University Vienna...
July 11, 2018: Journal of Infectious Diseases
Mark R Hanudel, Michele F Eisenga, Maxime Rappaport, Kristine Chua, Bo Qiao, Grace Jung, Victoria Gabayan, Barbara Gales, Georgina Ramos, Maarten A de Jong, Jelmer J van Zanden, Martin H de Borst, Stephan J L Bakker, Elizabeta Nemeth, Isidro B Salusky, Carlo A J M Gaillard, Tomas Ganz
Background: Erythropoietin (EPO) has been reported as a novel determinant of fibroblast growth factor 23 (FGF23) production; however, it is unknown whether FGF23 is stimulated by chronic exposure to EPO or by EPO administration in nonpolycystic chronic kidney disease (CKD) models. Methods: We analyzed the effects of chronic EPO on FGF23 in murine models with chronically high EPO levels and normal kidney function. We studied the effects of exogenous EPO on FGF23 in wild-type mice, with and without CKD, injected with EPO...
July 10, 2018: Nephrology, Dialysis, Transplantation
Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Keven Ang, Wern Ee Tang, Chee Fang Sum, Subramaniam Tavintharan, Su Chi Lim
Background: The progression trajectory of renal filtration function has not been well characterized in patients with early-onset type 2 diabetes mellitus (T2DM) although albuminuria is often reported in this population. We aim to study the risk of progressive chronic kidney disease (CKD) in individuals with early-onset T2DM. Methods: In total, 1189 T2DM participants were followed for 3.9 (interquartile range 3.2-4.7) years. Progressive CKD was defined as estimated glomerular filtration rate (eGFR) decline of ≥5 mL/min/1...
July 10, 2018: Nephrology, Dialysis, Transplantation
Despina Karasavvidou, Pierre Boutouyrie, Rigas Kalaitzidis, Hakim Kettab, Kosmas Pappas, Dimitrios Stagikas, Nikolaos Antonakis, Dimitrios Tsalikakis, Moses Elisaf, Stephane Laurent
In the general population aortic stiffening, assessed by carotid femoral pulse wave velocity (cf-PWV), is associated with cognitive dysfunction (CO/DY). Data in chronic kidney disease (CKD) are limited. This study tests the hypothesis that large artery stiffness and microvascular damage in CKD patients are related to the damage of brain microcirculation reflected by impaired cognitive function. A cross-sectional study enrolled 151 patients (mean age 58.4 years; 64.5% males; 44 patients with CKD stage 1; 47 with stage 2; 25 with stage 3; and 35 with stage 4)...
July 14, 2018: Journal of Clinical Hypertension
Eiichiro Kanda, Naoki Kashihara, Kunihiro Matsushita, Tomoko Usui, Hirokazu Okada, Kunitoshi Iseki, Kenichi Mikami, Tetsuhiro Tanaka, Takashi Wada, Hirotaka Watada, Kohjiro Ueki, Masaomi Nangaku
No abstract text is available yet for this article.
July 13, 2018: Clinical and Experimental Nephrology
Lunshan Wang, Yuhuai Sun, Xinan Cai, Guifeng Fu
PURPOSE: In this study, we investigated the diagnostic value of human epididymis protein 4 (HE4) in acute and chronic renal dysfunction and analyzed the correlation between HE4 levels and the results of routine renal function tests. We aimed to provide evidence to establish HE4 as a novel biomarker of renal injury and its appropriate application as a marker of ovarian cancer. METHODS: We collected 259 serum samples from hospitalized patients with different causes of renal damage...
July 13, 2018: International Urology and Nephrology
Franz J Legat
Phototherapy and photochemotherapy (PUVA) are important treatment modalities in inflammatory skin diseases such as psoriasis and atopic dermatitis as well as in cutaneous T‑cell lymphoma (e.g., mycosis fungoides/Sezary syndrome). Many of these skin diseases are accompanied by distracting pruritus. In addition, patients may suffer from intense pruritus in systemic diseases of the kidney and liver as well as of the endocrine and hematopoietic system. UV-light during phototherapy is capable of not only improving the inflammatory skin lesions but also of reducing the pruritus in skin and systemic diseases...
July 13, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Slobodanka Lj Beatović, Marija Radulović, Milica M Janković, Vera M Artiko, Boris Ajdinović, Dragana P Šobić-Šaranović
OBJECTIVE: The aim of this study was to assess the diagnostic ability of renal output efficiency (OE), normalized residual activity (NORA) and conventional interpretation of the diethylene triamine pentaacetic acid (99m Tc-DTPA) diuretic renogram (CIR) in diagnosing urine flow obstruction. SUBJECTS AND METHODS: Group A consisted of 73 obstructed kidneys and Group B of 80 kidneys with dilated upper urinary tract. Forty eight kidneys were examined as the control Group C...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Diana Jalal, Brandon Renner, Jennifer Laskowski, Erik Stites, James Cooper, Karissa Valente, Zhiying You, Loni Perrenoud, Moglie Le Quintrec, Ismaeel Muhamed, Uwe Christians, Jelena Klawitter, Margaret A Lindorfer, Ronald P Taylor, V Michael Holers, Joshua M Thurman
BACKGROUND: Endothelial microparticles are associated with chronic kidney disease (CKD) and complement activation. We hypothesized that the complement pathway is activated in patients with CKD via endothelial microparticles and that complement activation correlates with endothelial dysfunction in CKD. METHODS AND RESULTS: We analyzed complement data of 30 healthy subjects, 30 patients with stage III/IV CKD, and 30 renal transplant recipients with stage III/IV CKD, evaluating the potential correlation of complement fragments with brachial artery flow-mediated dilation, Chronic Kidney Disease Epidemiology Collaboration glomerular filtration rate, and urinary albumin/creatinine ratio...
July 13, 2018: Journal of the American Heart Association
Elaine Ku, Joachim H Ix, Kenneth Jamerson, Navdeep Tangri, Feng Lin, Jennifer Gassman, Miroslaw Smogorzewski, Mark J Sarnak
BACKGROUND: During intensive BP lowering, acute declines in renal function are common, thought to be hemodynamic, and potentially reversible. We previously showed that acute declines in renal function ≥20% during intensive BP lowering were associated with higher risk of ESRD. Here, we determined whether acute declines in renal function during intensive BP lowering were associated with mortality risk among 1660 participants of the African American Study of Kidney Disease and Hypertension and the Modification of Diet in Renal Disease Trial...
July 13, 2018: Journal of the American Society of Nephrology: JASN
David Massicotte-Azarniouch, Manish M Sood
No abstract text is available yet for this article.
July 13, 2018: BMJ evidence-based medicine
Johannes Vermehren, James S Park, Ira Jacobson, Stefan Zeuzem
Treatment of chronic hepatitis C virus (HCV) infection has been revolutionized with the development of direct-acting antiviral agents (DAAs). Eight to twelve weeks of all-oral, once-daily treatments is now the standard of care and viral eradication can be achieved in >95% across different patient populations. Despite these advances, several unresolved issues remain, including treatment of HCV genotype 3, chronic kidney disease, and in patients in whom DAA therapy has failed. Glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) are the most recently approved DAA regimens...
July 10, 2018: Journal of Hepatology
Lior Greenbaum, Yinon Gilboa, Annick Raas-Rothschild, Ortal Barel, Nitzan Kol, Haike Reznik Wolf, Ben Pode-Shakked, Yael Finezilber, Baruch Messing, Michal Berkenstadt
Diaphanospondylodysostosis (DSD) is a rare autosomal recessive skeletal disorder, characterized mainly by ossification defects in vertebrae, thorax malformations, renal cystic dysplasia and usually death in the perinatal period. DSD is caused by mutations in the BMPER (Bone Morphogenetic Protein-Binding Endothelial Cell Precursor-Derived Regulator) gene. We describe the prenatal findings of a non-consanguineous Jewish couple (shared Balkan origin), with three affected fetuses that presented with malformations in the spine and chest, reduced ossification of the skull and spine, horseshoe kidney and increased nuchal translucency...
July 10, 2018: European Journal of Medical Genetics
Haijing Wu, Wei Liao, Qianwen Li, Hai Long, Heng Yin, Ming Zhao, Vera Chan, Chak-Sing Lau, Qianjin Lu
The tissue-resident memory T (TRM ) cells constitute a newly identified subset of memory T cells which are non-circulating and they persist for long-term in epithelial barrier tissues, including skin, lung, gastrointestinal tract and reproductive tract, and in non-barrier tissues, including brain, kidney, pancreas and joint. These cells provide rapid on-site immune protection against previous exposed pathogens in peripheral tissues. There cells are transcriptionally, functionally and phenotypically distinguished from circulating effector memory T cells...
July 10, 2018: Autoimmunity Reviews
Jayaweera Arachchige Asela Sampath Jayaweera, Anpalaham Joseph
OBJECTIVES: Military personnel, because of the unique nature of their duties, are reluctant to face stressors. Living in hot and humid conditions they frequently suffer dehydration. Army soldiers living in dry zone of Sri Lanka, were screened for chronic kidney disease (CKD), common non-communicable diseases and methicillin resistant Staphylococcus aureus (MRSA) colonization. Albumin creatinine ratio > 30 mg/g urine taken as cut-off for detection of CKD. RESULTS: Screened 417 soldiers, all were men and body mass index were 21...
July 13, 2018: BMC Research Notes
Vanessa Gerolde Cardoso, Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Mariana Charleaux de Ponte, Niels Olsen Saraiva Camara, Maria Oliveira-Souza
BACKGROUND: Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether the chronic effects of Ang II via AT1 receptor (AT1R) would result in endoplasmic reticulum (ER) stress/PKC-delta/p38 MAPK stimulation, and consequently podocyte apoptosis. METHODS: Wistar rats were treated with Ang II (200 ng·kg-1 ·min-1 , 42 days) and or losartan (10 mg·kg-1 ·day-1 , 14 days)...
July 13, 2018: BMC Nephrology
Tamara Milagres, Fernando E García-Arroyo, Miguel A Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson, Carlos Roncal-Jimenez
BACKGROUND: Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have recently reported a model of CKD induced by heat stress. Here we test the hypothesis that rehydration with fructose may induce worse kidney injury than rehydration with equal amounts of water, and we also test if this fructose-induced injury is associated with activation of inflammasomes in the kidney...
July 13, 2018: BMC Nephrology
Jingru Lu, Xiangzhong Zhao, Alessandro Paiardini, Yanhua Lang, Irene Bottillo, Leping Shao
BACKGROUND: Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115 G-L-W117 ) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif...
July 13, 2018: BMC Nephrology
Michele Losurdo, Giulia Dowgier, Maria Stella Lucente, Mario Cinone, Michele Camero, Maria Loredana Colaianni, Giuseppe Passantino, Gianluca Ventriglia, Domenico Buonavoglia, Nicola Decaro
The long-term shedding of Canine alphaherpesvirus 1 (CaHV-1) by neonatal pups with natural infection is reported. The pups belonged to a litter of 11 pointers of a breeding kennel in southern Italy, 9 of which developed a fatal form of systemic infection, as resulted by the detection of CaHV-1 in internal organs (kidney, liver, lung and brain) of one of this dogs and in the vaginal swab of their mother. The two remaining animals displayed a milder form of disease, with one pup showing ocular involvement, and underwent a progressive recovery...
July 6, 2018: Research in Veterinary Science
Francisco Kerdel, Frank Don
Psoriasis is a chronic, immune-mediated, inflammatory disease that if left untreated can result in prolonged subclinical inflammation that affects a variety of organs, including the heart, liver, kidney, and intestines, as well as joints and muscles. Relatedly, psoriasis significantly increases patients' risks for developing certain comorbidities. Disease progression in psoriasis is unpredictable, and some patients have mild disease that is stable for many years, while in others, mild disease quickly progresses to moderate-to-severe psoriasis...
July 1, 2018: Journal of Drugs in Dermatology: JDD
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