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https://www.readbyqxmd.com/read/27932687/diabetes-distress-among-persons-with-type-1-diabetes-associations-with-disordered-eating-depression-and-other-psychological-health-concerns
#1
Margaret A Powers, Sara A Richter, Diann M Ackard, Cheryl Craft
PURPOSE: The purpose of this study is to evaluate associations between diabetes distress and a range of psychological health behaviors and concerns among persons with type 1 diabetes for the benefit of enhancing early identification and intervention of at-risk individuals. METHODS: Persons with type 1 diabetes (n = 268; 57.1% female, 91.0% white, 76.8% <18 years of age, average A1C 8.4%) completed the 2-item Diabetes Distress Screening Scale (DDS2) and a battery of psychometrically sound instruments measuring satisfaction with life, self-esteem, self-efficacy, depression, perfectionism, body image satisfaction, dietary restraint and eating, and shape and weight concerns...
December 7, 2016: Diabetes Educator
https://www.readbyqxmd.com/read/27932062/experiencing-neonatal-maternal-separation-increased-pain-sensitivity-in-adult-male-mice-involvement-of-oxytocinergic-system
#2
Hossein Amini-Khoei, Shayan Amiri, Ali Mohammadi-Asl, Sakineh Alijanpour, Simin Poursaman, Arya Haj-Mirzaian, Mojgan Rastegar, Azam Mesdaghinia, Hamid Reza Banafshe, Ehsanollah Sadeghi, Elika Samiei, Shahram Ejtemaie Mehr, Ahmad Reza Dehpour
Early-life stress adversely affects the development of the brain, and alters a variety of behaviors such as pain in later life. In present study, we investigated how early-life stress (maternal separation or MS) can affect the nociceptive response later in life. We particularly focused on the role of oxytocin (OT) in regulating nociception in previously exposed (MS during early postnatal development) mice that were subjected to acute stress (restraint stress or RS). Further, we evaluated whether such modulation of pain sensation in MS mice are regulated by shared mechanisms of the OTergic and opioidergic systems...
November 30, 2016: Neuropeptides
https://www.readbyqxmd.com/read/27927995/the-biomechanics-of-seed-germination
#3
REVIEW
Tina Steinbrecher, Gerhard Leubner-Metzger
From a biomechanical perspective, the completion of seed (and fruit) germination depends on the balance of two opposing forces: the growth potential of the embryonic axis (radicle-hypocotyl growth zone) and the restraint of the seed-covering layers (endosperm, testa, and pericarp). The diverse seed tissues are composite materials which differ in their dynamic properties based on their distinct cell wall composition and water uptake capacities. The biomechanics of embryo cell growth during seed germination depend on irreversible cell wall loosening followed by water uptake due to the decreasing turgor, and this leads to embryo elongation and eventually radicle emergence...
December 7, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27925568/letter
#4
Embashire
The government needs to understand that nurses join agencies to get the salary they deserve. When will they realise continuing pay restraint is a false economy?
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27924184/revealed-opportunism-how-physicians-game-prior-authorization-protocols-until-they-are-rescinded
#5
Natan R Kahan, Dan-Andrei Waitman, David P Chinitz
BACKGROUND: Prior authorization (PA) is a management technique that has been implemented to manage the utilization of expensive drugs and to improve the precision of drug prescribing. PA requirements may incentivize physicians to document adverse effects, sometimes falsely, to meet the eligibility requirements. OBJECTIVES: To identify documentation patterns that may facilitate the quantitative analysis of physician gaming and underreporting behaviors associated with the prescribing of angiotensin-converting enzyme (ACE) inhibitors in a primary care setting, and to evaluate the effect of a PA requirement on the documentation of adverse events as a way to receive approval for more expensive drugs...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27923963/motivators-and-barriers-to-engaging-in-healthy-eating-and-physical-activity-a-cross-sectional-survey-in-young-adult-men
#6
Lee M Ashton, Melinda J Hutchesson, Megan E Rollo, Philip J Morgan, Clare E Collins
Many Australian young men (18-25 years) fail to meet recommendations in national dietary or physical activity (PA) guidelines. However, there is a lack of understanding of their perspectives on PA and diet to inform intervention design. This study examined young men's motivators and barriers to healthy eating and PA, along with differences by demographic and behavioral factors. A cross-sectional online survey was completed by 282 men aged 18 to 25 years in Australia. Results identified the most common motivators for healthy eating included improving health (63...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27923288/toll-like-receptor-4-protects-against-stress-induced-ulcers-via-regulation-of-glucocorticoid-production-in-mice
#7
Liang Wang, Pengfei Luo, Fang Zhang, Yuelu Zhang, Xingtong Wang, Fei Chang, Yuechan Zhang, Hongtai Tang, Zhaofan Xia
Stress-induced gastric ulcer is an important life-threatening condition, while the molecular basis of its development is incompletely understood. Toll-like receptor 4 (TLR4), an innate immune pattern recognition receptor, can induce pro-inflammatory transcription, aggravating a stress ulcer. The present study found that TLR4 played a protective role in a mouse model of water immersion (23 °C) restraint stress. Wild-type (WT) and TLR4(-/-) male mice were respectively divided into five groups (5 per group), and exposed to the stressor for 0, 0...
December 6, 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27917740/delirium-superimposed-on-dementia-phenomenological-differences-between-patients-with-and-without-behavioral-and-psychological-symptoms-of-dementia-in-a-specialized-delirium-unit
#8
Jennifer Abengaña, Mei Sian Chong, Laura Tay
BACKGROUND: Overlap between neuropsychiatric symptoms of dementia and delirium complicates diagnosis of delirium superimposed on dementia (DSD). This study sought to examine differences in delirium presentation and outcomes between DSD patients with and without pre-existing behavioral and psychological symptoms of dementia (BPSD). METHODS: This was a prospective cohort study of older adults with DSD admitted to a specialized delirium unit (December 2010-August 2012)...
December 5, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27916189/editorial-commentary-lateral-extra-articular-reconstructions-with-anterior-cruciate-ligament-surgery-are-these-operative-procedures-supported-by-in%C3%A2-vitro-biomechanical-studies
#9
EDITORIAL
Frank R Noyes
There remains controversy on the role of a concurrent lateral extra-articular procedure with anterior cruciate ligament (ACL) reconstruction. Previous biomechanical studies often are historical and inconclusive. Studies show the anterolateral ligament and iliotibial band are secondary restraints and, when injured in conjunction with the ACL, produce gross (Grade 3) pivot-shift subluxations. Recent robotic studies show a well-placed bone-patellar tendon-bone reconstruction does restore time-zero kinematics with a negative pivot-shift...
December 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27914750/-medical-prescription-and-informed-consent-for-the-use-of-physical-restraints-in-nursing-homes-in-the-canary-islands-spain
#10
Gabriel J Estévez-Guerra, Emilio Fariña-López, Eva Penelo
OBJECTIVE: To identify the frequency of completion of informed consent and medical prescription in the clinical records of older patients subject to physical restraint, and to analyse the association between patient characteristics and the absence of such documentation. METHODS: A cross-sectional and descriptive multicentre study with direct observation and review of clinical records was conducted in nine public nursing homes, comprising 1,058 beds. RESULTS: 274 residents were physically restrained...
November 30, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#11
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27913525/checkpoint-inhibition-in-myeloma
#12
Don M Benson
Historically, attempts at cancer immunotherapy have emphasized strategies designed to stimulate or augment the immune system into action. In the past decade, a complementary approach has developed, that of releasing immune cells from inhibitory restraint. Discoveries in the fundamental biology of how immunity is regulated, how the immune system interfaces with malignancy, and how cancer cells may exploit these processes to evade detection have all been translated into the rapidly growing field of therapeutic immune checkpoint inhibition for cancer...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27911715/the-control-of-inflammation-via-the-phosphorylation-and-dephosphorylation-of-tristetraprolin-a-tale-of-two-phosphatases
#13
REVIEW
Andrew R Clark, Jonathan L E Dean
Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted the fundamental role of TTP in the restraint of inflammation. Since then, work from several groups has generated a detailed picture of the expression and function of TTP. It is a sequence-specific RNA-binding protein that orchestrates the deadenylation and degradation of several mRNAs encoding inflammatory mediators. It is very extensively post-translationally modified, with more than 30 phosphorylations that are supported by at least two independent lines of evidence...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27910948/improved-in-cell-structure-determination-of-proteins-at-near-physiological-concentration
#14
Teppei Ikeya, Tomomi Hanashima, Saori Hosoya, Manato Shimazaki, Shiro Ikeda, Masaki Mishima, Peter Güntert, Yutaka Ito
Investigating three-dimensional (3D) structures of proteins in living cells by in-cell nuclear magnetic resonance (NMR) spectroscopy opens an avenue towards understanding the structural basis of their functions and physical properties under physiological conditions inside cells. In-cell NMR provides data at atomic resolution non-invasively, and has been used to detect protein-protein interactions, thermodynamics of protein stability, the behavior of intrinsically disordered proteins, etc. in cells. However, so far only a single de novo 3D protein structure could be determined based on data derived only from in-cell NMR...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910254/identification-and-analysis-of-factors-contributing-to-the-reduction-in-seclusion-and-restraint-for-a-population-with-intellectual-disability
#15
Caroline Larue, Marie-Hélène Goulet, Marie-Josée Prevost, Alexandre Dumais, Jacques Bellavance
BACKGROUND: A cohort of 11 patients with an intellectual disability and a psychiatric diagnosis present severe behavioural disorders in psychiatric hospital of Quebec in 2009. Control-measure use for this clientele has now been reduced. How do management personnel, families and care teams explain the changes? What clinical interventions did management and care providers implement that contributed to the reduction? METHOD: A retrospective case study was conducted...
December 2, 2016: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/27910133/physical-restraints-and-associations-with-neuropsychiatric-symptoms-and-personal-characteristics-in-residential-care-a-cross-sectional-study
#16
Marja Kuronen, Hannu Kautiainen, Pertti Karppi, Sirpa Hartikainen, Hannu Koponen
BACKGROUND: Physical restraints are widely used in residential care. The objective was to investigate restraint use and its associations with neuropsychiatric symptoms and personal characteristics in residential care. METHODS: Data were collected in the South Savo Hospital District from 66 of 68 public or private institutions providing long-term residential care. Nurses assessed the use of physical restraints and neuropsychiatric symptoms (NPS) included in the symptom list of the Neuropsychiatric Inventory (NPI)...
December 2, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27906732/safety-profile-of-children-in-an-enclosure-bed
#17
Eileen Sherburne, Julia A Snethen, Sheryl Kelber
PURPOSE: Pediatric nurses care for many children in the hospital setting whose behavioral challenges can impact safety. One intervention utilized to prevent injury and improve safety when caring for this population of children has been the enclosure bed. Scant information was found in the literature that discusses the use of the enclosure bed in the pediatric setting. The purpose of this article is to examine the use of the enclosure bed in the pediatric setting. A secondary aim is to identify the population of children where an enclosure bed was implemented and the safety factors associated with use of the enclosure bed...
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27904790/current-concepts-in-the-treatment-of-gross-patellofemoral-instability
#18
Grant Buchanan, LeeAnne Torres, Brian Czarkowski, Charles E Giangarra
: Patellofemoral instability is a painful and commonly recurring condition, which often must be managed surgically. Diagnosis can be aided by the use of a variety of physical exam signs, such as the Q angle, Beighton hypermobility score, glide test, J sign, patellar tilt test, and apprehension test. Imaging modalities including x-ray, CT, and MRI guide both diagnosis and management by revealing trochlear dysplasia, bony malalignment, and ligamentous injury that contribute to instability...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27901467/structural-basis-for-the-disaggregase-activity-and-regulation-of-hsp104
#19
Alexander Heuck, Sonja Schitter-Sollner, Marcin Józef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
The Hsp104 disaggregase is a two-ring ATPase machine that rescues various forms of non-native proteins including the highly resistant amyloid fibers. The structural-mechanistic underpinnings of how the recovery of toxic protein aggregates is promoted and how this potent unfolding activity is prevented from doing collateral damage to cellular proteins are not well understood. Here, we present structural and biochemical data revealing the organization of Hsp104 from Chaetomium thermophilum at 3.7 Å resolution...
November 30, 2016: ELife
https://www.readbyqxmd.com/read/27899641/3d-genome-structure-modeling-by-lorentzian-objective-function
#20
Tuan Trieu, Jianlin Cheng
The 3D structure of the genome plays a vital role in biological processes such as gene interaction, gene regulation, DNA replication and genome methylation. Advanced chromosomal conformation capture techniques, such as Hi-C and tethered conformation capture, can generate chromosomal contact data that can be used to computationally reconstruct 3D structures of the genome. We developed a novel restraint-based method that is capable of reconstructing 3D genome structures utilizing both intra-and inter-chromosomal contact data...
November 29, 2016: Nucleic Acids Research
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