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https://www.readbyqxmd.com/read/28918223/an-ecological-model-to-factors-associated-with-booster-seat-use-a-population-based-study
#1
Sarit Shimony Kanat, Rosa Gofin
Belt-positioning booster seat use (BPB) is an effective technology to prevent severe child injury in cases of car crash. However, in many countries, age-appropriate car restraint use for children aged 4-7 years old remains the lowest among all age groups. The aim of this study was to identify the main determinants of BPB use through a comprehensive approach. An ecological model was used to analyze individual, parent-child relationships, and neighborhood characteristics. Parents of children enrolled in the first and second grades completed a self-reported questionnaire (n=745)...
September 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28918093/topological-structure-determination-of-rna-using-small-angle-x-ray-scattering
#2
Yuba R Bhandari, Linxin Fan, Xianyang Fang, George Zaki, Eric A Stahlberg, Wei Jiang, Charles D Schwieters, Jason R Stagno, Yun-Xing Wang
Knowledge of RNA three-dimensional topological structures provides important insight into the relationship between RNA structural components and function. It is often likely that near complete sets of biochemical and biophysical data containing structural restraints are not available but one still wants to obtain knowledge about approximate topological folding of RNA. In this regard, general methods for determining such topological structures with minimum readily available restraints are lacking. Naked RNAs are difficult to crystallize and NMR spectroscopy is generally limited to small RNA fragments...
September 13, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28916246/pre-clinical-toxicology-considerations-for-vaccine-development
#3
REVIEW
Nabil Al-Humadi
Vaccine development requires pre-clinical toxicology studies, following good laboratory practice (GLP), before first in human (phase I) use. Many factors are critical in the final outcome of any pre-clinical toxicology study. The study design is one of these critical factors and should be carefully planned to avoid any false negative and/or false positive results. Preparation is another most critical factor in a successful study. Major changes in any procedure during the course of study should be avoided by all means...
September 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28915909/differential-signal-sensitivities-can-contribute-to-the-stability-of-multispecies-bacterial-communities
#4
János Juhász, Dóra Bihary, Attila Jády, Sándor Pongor, Balázs Ligeti
BACKGROUND: Bacterial species present in multispecies microbial communities often react to the same chemical signal but at vastly different concentrations. The existence of different response thresholds with respect to the same signal molecule has been well documented in quorum sensing which is one of the best studied inter-cellular signalling mechanisms in bacteria. The biological significance of this phenomenon is still poorly understood, and cannot be easily studied in nature or in laboratory models...
September 15, 2017: Biology Direct
https://www.readbyqxmd.com/read/28914290/reducing-routine-labs-teaching-residents-restraint
#5
Michael I Ellenbogen, Kevin J O'Leary
No abstract text is available yet for this article.
September 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28913833/symptom-trajectories-throughout-two-family-therapy-treatments-for-adolescent-anorexia-nervosa
#6
Stuart B Murray, Eva Pila, Daniel Le Grange, Susan M Sawyer, Elizabeth K Hughes
OBJECTIVE: This study aimed to examine the trajectory of symptom remission and affective functioning throughout the course of two family-based treatments for adolescent anorexia nervosa (AN): conjoint family-based treatment (FBT) and parent-focused treatment (PFT). METHOD: Participants were 107 adolescents (Mage  = 15.5 years, SD = 1.5) with a primary diagnosis of AN who participated in a randomized clinical trial comparing FBT (N = 55) and PFT (N = 51)...
September 15, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28913321/mixed-tumor-in-deep-lobe-and-versatility-of-acellular-dermal-matrix
#7
Jin Hwan Byun, Jung Soo Lim, Hye Kyung Lee
Frey's syndrome and infra-auricular depressed deformities are the ones of the most common complications that can occur after total parotidectomy. We report 1 case of pleomorphic adenoma occurred in the deep lobe that obtained good results from using acellular dermal matrix (ADM) after total parotidectomy. A 24-year-old man visited the hospital with oval shape mass in right mandibular angle which of 4 cm in size was found in the deep lobe of right parotid gland from Magnetic resonance imaging scanning and a pleomorphic adenoma was suspected...
June 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28913137/intra-cesarean-insertion-and-fixation-of-frameless-intrauterine-devices
#8
REVIEW
Ateş Karateke, Abdulkadir Turgut, Özkan Özdamar, Dirk Wildemeersch
Various contraceptive methods are available to postpartum women including hormonal and nonhormonal barriers, as well as injectable forms. Of all the available birth control methods, intrauterine devices (IUD) are felt by many to be the near-ideal form of contraception, and are recommended by advocacy groups, physicians, and gynecological organizations worldwide. Immediate postpartum IUD insertion deserves greater attention because it can provide immediate contraception, prevents repeat unintended pregnancies, and may serve to reduce the incidence or need for secondary cesarean delivery; however, insertion of conventional T-shape IUDs immediately post placenta delivery is limited by their high expulsion and displacement rates...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912247/mir-212-mediates-counter-regulation-on-crh-expression-and-hpa-axis-activity-in-male-mice
#9
Yuxiao Tang, Xingjian Cai, Hongwei Zhang, Hui Shen, Wanyin Wang, Zhilei Shen, Wei Gu, Changquan Ling, Min Li
The mechanisms of hypothalamic-pituitary-adrenal (HPA) axis regulation have been studied persistently but still are not elucidated. Considering the emerging roles of microRNA in stress response, we conducted a microRNA microarray in mice hypothalamus to identify the potential role of microRNAs in regulating the HPA axis. In total, 41 microRNAs changed during heat stress, in which we found that miR-212 contains binding sequence with corticotropin-releasing hormone (CRH) 3'UTR according to sequence analysis. We observed that miR-212 expression in the hypothalamus was escalated by repeated heat and restraint stress...
September 14, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28911273/memory-enhancement-of-fresh-ginseng-on-deficits-induced-by-chronic-restraint-stress-in-mice
#10
Liming Dong, Yi Wang, Jingwei Lv, Hongxia Zhang, Ning Jiang, Cong Lu, Pan Xu, Xinmin Liu
OBJECTIVES: Chronic stress exposure can disrupt the balance of organisms, result in learning and memory impairments and induce oxidative stress. However, there is a lack of safe and effective long-term therapeutic agents for stress-related injuries. Fresh ginseng (FG), an unprocessed raw root of ginseng, has antioxidant and neuroprotective activities and has been used as functional health food in Asian countries for many years. The aim of this study was to verify the protective effects of FG on chronic restraint stress (CRS)-induced learning and memory impairments as well as oxidative stress damage in mice...
September 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28910377/parametric-analysis-of-occupant-ankle-and-tibia-injuries-in-frontal-impact
#11
Fuhao Mo, Xiaoqing Jiang, Shuyong Duan, Zhi Xiao, Sen Xiao, Wei Shi
OBJECTIVE: Non-fatal tibia and ankle injuries without proper protection from the restraint system has gotten wide attention from researchers. This study aimed to investigate occupant tibia and ankle injuries under realistic frontal impact environment that is rarely considered in previous experimental and simulant studies. METHODS: An integrated occupant-vehicle model was established by coupling an isolated car cab model and a hybrid occupant model with a biofidelic pelvis-lower limb model, while its loading conditions were extracted from the realistic full-frontal impact test...
2017: PloS One
https://www.readbyqxmd.com/read/28903543/biosimilars-in-rheumatology-a-review-of-the-evidence-and-their-place-in-the-treatment-algorithm
#12
Hendrik Schulze-Koops, Alla Skapenko
Determining biosimilarity involves a comprehensive exercise with a focus on determining the comparability of the molecular characteristics and preclinical profile of the biosimilar and reference product, such that there is less need for extensive clinical testing to assure comparability of clinical outcomes. Three anti-TNF biosimilar agents are approved for patients with rheumatic diseases in the European Union. The infliximab (Remicade®) biosimilars CT-P13 (Remsima® and Inflectra®) and SB2 (Flixabi®) and the etanercept (Enbrel®) biosimilar SB4 (Benepali®) have shown close comparability to their reference medicinal products, having undergone extensive evaluations...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28903330/inhibition-of-hsf1-suppresses-the-growth-of-hepatocarcinoma-cell-lines-in-vitro-and-akt-driven-hepatocarcinogenesis-in-mice
#13
Antonio Cigliano, Chunmei Wang, Maria G Pilo, Marta Szydlowska, Stefania Brozzetti, Gavinella Latte, Giovanni M Pes, Rosa M Pascale, Maria A Seddaiu, Gianpaolo Vidili, Silvia Ribback, Frank Dombrowski, Matthias Evert, Xin Chen, Diego F Calvisi
Upregulation of the heat shock transcription factor 1 (HSF1) has been described as a frequent event in many cancer types, but its oncogenic role in hepatocellular carcinoma (HCC) remains poorly delineated. In the present study, we assessed the function(s) of HSF1 in hepatocarcinogenesis via in vitro and in vivo approaches. In particular, we determined the importance of HSF1 on v-Akt murine thymoma viral oncogene homolog (AKT)-induced liver cancer development in mice. We found that knockdown of HSF1 activity via specific siRNA triggered growth restraint by suppressing cell proliferation and inducing massive cell apoptosis in human HCC cell lines...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902557/will-automated-driving-technologies-make-today-s-effective-restraint-systems-obsolete
#14
Damien Subit, Philippe Vézin, Sébastien Laporte, Baptiste Sandoz
No abstract text is available yet for this article.
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28901702/eating-attitudes-and-behaviours-of-students-enrolled-in-undergraduate-nutrition-and-dietetics-degrees
#15
Tetyana Rocks, Fiona Pelly, Gary Slater, Lisa A Martin
AIM: The prevalence of disordered eating has been frequently reported in university students; however, the prevalence amongst Australian undergraduate students studying degrees with a focus on nutrition is uncertain. The aims of this study were to: (i) assess eating attitudes and behaviours of students enrolled in nutrition and dietetics, (ii) compare those to students enrolled in another health degree of occupational therapy (OT) and (iii) explore possible relationships between eating attitudes and behaviours and other characteristics of both cohorts...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28898077/simulation-of-reversible-protein-protein-binding-and-calculation-of-binding-free-energies-using-perturbed-distance-restraints
#16
Jan Walther Perthold, Chris Oostenbrink
Virtually all biological processes depend on the interaction between proteins at some point. The correct prediction of biomolecular binding free-energies has many interesting applications in both basic and applied pharmaceutical research. While recent advances in the field of molecular dynamics (MD) simulations have proven the feasibility of the calculation of protein-protein binding free energies, the large conformational freedom of proteins and complex free energy landscapes of binding processes make such calculations a difficult task...
September 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28895763/relationship-of-eating-behaviors-with-age-anthropometric-measurements-and-body-composition-parameters-among-professional-indian-women
#17
Aatma Singh, Kiran Bains, Harpreet Kaur
One hundred volunteer female college teachers were selected from Jalandhar, Punjab, India. General obesity was found in 56.6%, 76.9%, and 76.2%, abdominal obesity in 56.6%, 57.7%, and 81.0%, of 30- to 39-year-old (Group I), 40- to 49-year-old, (Group II) and 50- to 59-year-old (Group III) participants, respectively. A significantly (p ≤ .05) lower mean value of uncontrolled eating domain was observed in the participants belonging to Group I in comparison to Groups II and III. The cognitive restraint was less in Group III (13...
September 12, 2017: Ecology of Food and Nutrition
https://www.readbyqxmd.com/read/28891707/-experiences-with-the-three-factor-eating-questionnaire-r21-in-young-men
#18
Edit Czeglédi
INTRODUCTION: Eating behaviours play a crucial role in the development of obesity. AIMS: To conduct a psychometric analysis of the Three-Factor Eating Questionnaire-R21 and to investigate the correlates of obesogenic eating behaviours among males. METHOD: Participants of the cross-sectional questionnaire-based study were male university students (n = 239, mean of age: 20.3 years, SD = 2.78 years). MEASURES: self-reported body weight and body height, Three-Factor Eating Questionnaire-R21, Trait Anxiety Scale of the State-Trait Anxiety Inventory...
September 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28891701/sedative-effects-of-intranasal-midazolam-administration-in-wild-caught-blue-fronted-amazon-amazona-aestiva-and-orange-winged-amazon-amazona-amazonica-parrots
#19
Débora P H Schaffer, Nayone L L C de Araújo, Ana Cláudia S Raposo, Emanoel F Martins Filho, João Victor R Vieira, Arianne P Oriá
Safe and effective sedation protocols are important for chemical restraint of birds in clinical and diagnostic procedures, such as clinical evaluations, radiographic positioning, and blood collection. These protocols may reduce stress and ease the management of wild-caught birds, which are susceptible to injury or death when exposed to stressful situations. We compare the sedative effect of intranasal midazolam in wild-caught blue-fronted (Amazona aestiva) and orange-winged (Amazona amazonica) Amazon parrots...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28891689/multimodal-drug-therapy-and-physical-rehabilitation-in-the-successful-treatment-of-capture-myopathy-in-a-lesser-flamingo-phoeniconaias-minor
#20
Michael Stephen McEntire, Carlos R Sanchez
A wild-caught lesser flamingo (Phoeniconaias minor) from the Fort Worth Zoo (Fort Worth, TX, USA) presented with moderate lameness that progressed to the inability to stand 2 days after restraint and handling. Results of blood tests showed severely elevated creatine phosphokinase (CPK) and aspartate aminotransferase (AST) activities, confirming suspected capture myopathy. Intensive supportive therapy, consisting of intravenous fluids and muscle relaxants, along with physical rehabilitation therapy, nutritional support, and anxiolytics, were instituted to aid in relaxation and muscle regeneration...
September 2017: Journal of Avian Medicine and Surgery
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