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https://www.readbyqxmd.com/read/28230370/coarse-grained-prediction-of-peptide-binding-to-g-protein-coupled-receptors
#1
Bartholomé Delort, Pedro Renault, Landry Charlier, Florent Raussin, Jean Martinez, Nicolas Floquet
In this study, we used the Martini Coarse-Grained model with no applied restraints to predict the binding mode of some peptides to G-Protein Coupled Receptors (GPCRs). Both the Neurotensin-1 and the chemokine CXCR4 receptors were used as test cases. Their ligands, NTS8-13 and CVX15 peptides, respectively, were initially positioned in the surrounding water box. Using a protocol based on Replica Exchange Molecular Dynamics (REMD), both opening of the receptors and entry of the peptides into their dedicated pockets were observed on the μs time-scale...
February 23, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28229540/introduction-to-special-issue-self-regulation-of-appetite-it-s-complicated
#2
Deborah Young-Hyman
OBJECTIVE: A meeting of multidisciplinary biobehavioral scientists and National Institutes of Health (NIH) program staff was convened by the Office of Behavioral and Social Sciences Research, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH to examine mechanisms associated with humans' ability to self-regulate appetite and appetitive behavior. METHODS: Based upon prior discussions of the NIH Obesity Research Task Force Behavioral Phenotyping Work Group, the premise was adopted that, in modern society, multiple factors on multiple levels interact to create circumstances wherein self-control of appetite is difficult, leading to overconsumption of unhealthy foods versus healthy eating patterns, contributing to our current levels of obesity...
March 2017: Obesity
https://www.readbyqxmd.com/read/28227701/heart-rate-reactivity-associated-to-positive-and-negative-food-and-non-food-visual-stimuli
#3
Pekka Kuoppa, Mika P Tarvainen, Leila Karhunen, Johanna Narvainen, Pekka Kuoppa, Mika P Tarvainen, Leila Karhunen, Johanna Narvainen, Leila Karhunen, Mika P Tarvainen, Pekka Kuoppa, Johanna Narvainen
Using food as a stimuli is known to cause multiple psychophysiological reactions. Heart rate variability (HRV) is common tool for assessing physiological reactions in autonomic nervous system. However, the findings in HRV related to food stimuli have not been consistent. In this paper the quick changes in HRV related to positive and negative food and non-food visual stimuli are investigated. Electrocardiogram (ECG) was measured from 18 healthy females while being stimulated with the pictures. Subjects also filled Three-Factor Eating Questionnaire to determine their eating behavior...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226253/modeling-single-vehicle-run-off-road-crash-severity-in-rural-areas-accounting-for-unobserved-heterogeneity-and-age-difference
#4
Linfeng Gong, Wei David Fan
This study investigates factors that significantly contribute to the severity of driver injuries resulting from single-vehicle run-off-road (SV ROR) crashes. A mixed logit model approach is employed to explore the potential unobserved heterogeneous effects associated with each age group: young (ages 16-24), middle-aged (ages 25-65), and older drivers (ages over 65). Likelihood ratio tests indicated that the development of separate injury severity models for each age group is statistically superior to estimating a single model using all data...
February 19, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28225463/doctors-without-borders
#5
Val Wass, Lesley Southgate
The unprecedented demands of patient and population priorities created by globalization and escalating health and social inequities will not be met unless medical education changes. Educators have failed to move fast enough to create an education framework that meets current population needs. A new common set of professional values around global social accountability is necessary. Education borders must be broken down at three levels-societal-institutional, interpersonal, and individual.At a societal-institutional level, global health must be embraced as part of a philosophy of population needs, human rights, equity, and justice...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224866/the-governing-body-nurse-as-a-clinical-commissioning-group-nurse-leader
#6
Angela Dempsey, Virginia Minogue
Aim The aim of this study was to understand governing body nurses' perspective of their effect on, and leadership of, clinical commissioning groups (CCGs). Method Semi-structured face-to-face and telephone interviews were conducted with a sample of governing body nurses, CCG chairs and regional chief nurses. A total of 23 individuals were interviewed. Findings Governing body nurses were overwhelmingly positive about their role and believed they had a positive effect on the CCG governing body. Specifically, they provided leadership for the quality agenda and compassionate practice...
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28224788/coarse-grained-molecular-modeling-of-solution-structure-ensemble-of-dengue-virus-non-structural-protein-5-with-small-angle-x-ray-scattering-intensity
#7
Guanhua Zhu, Wuan Geok Saw, Anjaiah Nalaparaju, Gerhard Grüber, Lanyuan Lu
An ensemble modeling scheme incorporating coarse-grained simulations with experimental small-angle X-ray scattering (SAXS) data is applied to the dengue virus 2 (DENV2) non-structural protein 5 (NS5). NS5 serves a key role in viral replication through its two domains that are connected by a ten-residue polypeptide segment. A set of representative structures are generated from a simulated structure pool using SAXS data fitting by the non-negativity least squares (NNLS) or the standard Ensemble Optimization Method (EOM) based on a genetic algorithm (GA)...
February 22, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28221058/concurrent-and-prognostic-utility-of-subtyping-anorexia-nervosa-along-dietary-and-negative-affect-dimensions
#8
Kelsie T Forbush, Kelsey E Hagan, Rachel H Salk, Jennifer E Wildes
: Bulimia nervosa can be reliably classified into subtypes based on dimensions of dietary restraint and negative affect. Community and clinical studies have shown that dietary-negative affect subtypes have greater test-retest reliability and concurrent and predictive validity compared to subtypes based on the Diagnostic and Statistical Manual of Mental Disorders (DSM). Although dietary-negative affect subtypes have shown utility for characterizing eating disorders that involve binge eating, this framework may have broader implications for understanding restrictive eating disorders...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28217649/effects-of-the-schema-therapy-and-mindfulness-on-the-maladaptive-schemas-hold-by-the-psoriasis-patients-with-the-psychopathology-symptoms
#9
Parvin Jamali Gojani, Mohsen Masjedi, Shahnaz Khaleghipour, Ehsan Behzadi
BACKGROUND: This study aimed to compare the effects of the schema along with mindfulness-based therapies in the psoriasis patients. MATERIALS AND METHODS: This semi-experimental study with post- and pre-tests was conducted on the psoriasis patients in the Dermatology Clinic of the Isfahan Alzahra Hospital, Iran using the convenience sampling in 2014. The patients had a low general health score. The experimental groups included two treatment groups of schema-based (n = 8) and mindfulness (n = 8)...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28217451/erectile-dysfunction-masculinity-and-psychosocial-outcomes-a-review-of-the-experiences-of-men-after-prostate-cancer-treatment
#10
REVIEW
Suzanne K Chambers, Eric Chung, Gary Wittert, Melissa K Hyde
Prostate cancer (PC) treatment side-effects such as erectile dysfunction (ED) can impact men's quality of life (QoL), psychosocial and psycho-sexual adjustment. Masculinity (i.e., men's identity or sense of themselves as being a man) may also be linked to how men respond to PC treatment and ED however the exact nature of this link is unclear. This review aims to provide a snapshot of the current state of evidence regarding ED, masculinity and psychosocial impacts after PC treatment. Three databases (Medline/PsycINFO, CINHAL, and EMBASE) were searched January 1st 1980 to January 31st 2016...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28216042/protein-structure-determination-by-assembling-super-secondary-structure-motifs-using-pseudocontact-shifts
#11
Kala Bharath Pilla, Gottfried Otting, Thomas Huber
Computational and nuclear magnetic resonance hybrid approaches provide efficient tools for 3D structure determination of small proteins, but currently available algorithms struggle to perform with larger proteins. Here we demonstrate a new computational algorithm that assembles the 3D structure of a protein from its constituent super-secondary structural motifs (Smotifs) with the help of pseudocontact shift (PCS) restraints for backbone amide protons, where the PCSs are produced from different metal centers...
February 16, 2017: Structure
https://www.readbyqxmd.com/read/28214906/-evaluating-the-quality-of-care-in-nursing-homes-comparison-of-three-international-models
#12
Alessandro Rubino, Fabrizio Leigheb, Carmela Rinaldi, Angelo Di Dio, Sanita Knesse, Chiara Donnarumma, Massimiliano Panella
The aim of this observational descriptive study was to identify the main international models evaluating the quality of nursing homes for non self-sufficient elderly persons, and to apply them in the Italian health system. Firstly, a bibliographic search of institutional websites and Pubmed-Medline was performed to identify the main international models. Secondly, three variables were chosen to evaluate the level of implementability of the models: (1) frequency of use of quality indicators in the international models; (2) degree of constructability of the models in two Italian nursing homes; (3) perceived relevance of the indicators used by the chosen models, by nursing home workers...
November 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28214871/restraint-stress-during-pregnancy-rapidly-raises-kynurenic-acid-levels-in-mouse-placenta-and-fetal-brain
#13
Francesca M Notarangelo, Robert Schwarcz
Stressful events during pregnancy adversely affect brain development and may increase the risk of psychiatric disorders later in life. Early changes in the kynurenine (KYN) pathway (KP) of tryptophan (TRP) degradation, which contains several neuroactive metabolites, including kynurenic acid (KYNA), 3-hydroxykynurenine (3-HK), and quinolinic acid (QUIN), may constitute a molecular link between prenatal stress and delayed pathological consequences. To begin testing this hypothesis experimentally, we examined the effects of a 2-h restraint stress on KP metabolism in pregnant FVB/N mice on gestational day 17...
February 18, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28214452/calorie-counting-and-fitness-tracking-technology-associations-with-eating-disorder-symptomatology
#14
Courtney C Simpson, Suzanne E Mazzeo
The use of online calorie tracking applications and activity monitors is increasing exponentially. Anecdotal reports document the potential for these trackers to trigger, maintain, or exacerbate eating disorder symptomatology. Yet, research has not examined the relation between use of these devices and eating disorder-related attitudes and behaviors. This study explored associations between the use of calorie counting and fitness tracking devices and eating disorder symptomatology. Participants (N=493) were college students who reported their use of tracking technology and completed measures of eating disorder symptomatology...
February 9, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28212499/validation-of-the-french-version-of-the-dsm-5-yale-food-addiction-scale-in-a-nonclinical-sample
#15
Paul Brunault, Robert Courtois, Ashley N Gearhardt, Philippe Gaillard, Kevin Journiac, Sarah Cathelain, Christian Réveillère, Nicolas Ballon
OBJECTIVE: The Yale Food Addiction Scale (YFAS) is the only questionnaire that assesses food addiction (FA) based on substance dependence criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM), Fourth Edition, Text Revision. Following recent updating of addiction criteria, a new DSM-5 version (YFAS 2.0) has been developed. Our study tested the psychometric properties of the French YFAS 2.0 in a nonclinical population. METHOD: We assessed 330 nonclinical participants for FA (French YFAS 2...
March 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28208298/surface-accessibility-and-dynamics-of-macromolecular-assemblies-probed-by-covalent-labeling-mass-spectrometry-and-integrative-modeling
#16
Carla Schmidt, Jamie A Macpherson, Andy M Lau, Ken Wei Tan, Franca Fraternali, Argyris Politis
Mass spectrometry (MS) has become an indispensable tool for investigating the architectures and dynamics of macromolecular assemblies. Here we show that covalent labeling of solvent accessible residues followed by their MS-based identification yields modeling restraints that allow mapping the location and orientation of subunits within protein assemblies. Together with complementary restraints derived from cross-linking and native MS, we built native-like models of four heterocomplexes with known subunit structures and compared them with available X-ray crystal structures...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207811/accelerated-flexible-protein-ligand-docking-using-hamiltonian-replica-exchange-with-a-repulsive-biasing-potential
#17
Katja Ostermeir, Martin Zacharias
A molecular dynamics replica exchange based method has been developed that allows rapid identification of putative ligand binding sites on the surface of biomolecules. The approach employs a set of ambiguity restraints in replica simulations between receptor and ligand that allow close contacts in the reference replica but promotes transient dissociation in higher replicas. This avoids long-lived trapping of the ligand or partner proteins at nonspecific, sticky, sites on the receptor molecule and results in accelerated exploration of the possible binding regions...
2017: PloS One
https://www.readbyqxmd.com/read/28204980/interfaith-spiritual-care-a-systematic-review
#18
Anke I Liefbroer, Erik Olsman, R Ruard Ganzevoort, Faridi S van Etten-Jamaludin
Although knowledge on spiritual care provision in an interfaith context is essential for addressing the diversity of patients' religious and spiritual needs, an overview of the literature is lacking. Therefore, this article reviews the empirical literature on interfaith spiritual care (ISC) in professional caring relationships. A systematic search in electronic databases was conducted to identify empirical studies published after 2000. Twenty-two studies were included. The quality of the included studies was assessed, and their results were thematically analyzed...
February 15, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28200010/physical-restraints-and-nursing-home-residents-dying-to-be-safe
#19
Shaun T O'Keeffe
No abstract text is available yet for this article.
February 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28198320/new-approach-to-restraint
#20
Elaine Cole
RCN head of education Stephanie Aiken is full of praise for the work of the mental health nurse team at Black Country Partnership NHS Trust. 'They have incredible passion that really stands out,' she says. 'The plans start with the patient and work for them, and you can see that this is what the team is passionate about.'
February 15, 2017: Nursing Standard
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