Nathalie R A Beets, Floris S Verheij, Hannah Williams, Dana M Omer, Sabrina T Lin, Li-Xuan Qin, Geerard L Beets, Regina G H Beets-Tan, Iris H Wei, Maria Widmar, Emmanouil P Pappou, Martin R Weiser, Garrett M Nash, J Joshua Smith, Philip B Paty, Joao Miranda, Tae-Hyung Kim, Marc J Gollub, Julio Garcia-Aguilar
OBJECTIVE: Assess the significance of enlarged lateral lymph nodes (LLN) for disease recurrence, metastasis, and organ preservation in patients with rectal cancer. BACKGROUND: Optimal treatment of rectal adenocarcinoma involving LLN is subject to debate. METHODS: A post hoc analysis of the OPRA trial, a multicenter study of patients with rectal cancer treated with total neoadjuvant therapy (TNT) followed by total mesorectal excision or watch-and-wait management...
April 22, 2024: Annals of Surgery