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https://www.readbyqxmd.com/read/27910867/effects-of-annual-influenza-vaccination-on-morbidity-and-mortality-in-patients-with-systemic-lupus-erythematosus-a-nationwide-cohort-study
#1
Chi-Ching Chang, Yu-Sheng Chang, Wei-Sheng Chen, Yi-Hsuan Chen, Jin-Hua Chen
Studies on the clinical efficacy of influenza vaccination on patients with systemic lupus erythematosus (SLE) are scant. The present study compared the incidence of hospitalization, morbidity, and mortality in patients with SLE between cohorts with and without influenza vaccination. We used the Taiwan's insurance claims data between 2001 and 2012 for identifying annual adult patients with SLE with (N = 1765) and without (N = 8360) influenza vaccination. The incidence rate ratio and hazard ratio (HR) for morbidities and mortality were measured for the vaccine and nonvaccine cohorts...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893866/ecology-and-demography-of-free-roaming-domestic-dogs-in-rural-villages-near-serengeti-national-park-in-tanzania
#2
Anna M Czupryna, Joel S Brown, Machunde A Bigambo, Christopher J Whelan, Supriya D Mehta, Rachel M Santymire, Felix J Lankester, Lisa J Faust
Free-roaming dogs (Canis lupus familiaris) are of public health and conservation concern because of their potential to transmit diseases, such as rabies, to both people and wildlife. Understanding domestic dog population dynamics and how they could potentially be impacted by interventions, such as rabies vaccination, is vital for such disease control efforts. For four years, we measured demographic data on 2,649 free-roaming domestic dogs in four rural villages in Tanzania: two villages with and two without a rabies vaccination campaign...
2016: PloS One
https://www.readbyqxmd.com/read/27799438/risk-of-high-grade-cervical-dysplasia-and-cervical-cancer-in-women-with-systemic-lupus-erythematosus-receiving-immunosuppressive-drugs
#3
C H Feldman, J Liu, S Feldman, D H Solomon, S C Kim
OBJECTIVE: Prior studies suggest an increased risk of cervical cancer among women with systemic lupus erythematosus. However, the relationship with immunosuppressive drugs is not well studied in US nationwide cohorts. We compared the risk of high-grade cervical dysplasia and cervical cancer among women with systemic lupus erythematosus who started immunosuppressive drugs versus hydroxychloroquine. METHODS: We identified systemic lupus erythematosus patients initiating immunosuppressive drugs or hydroxychloroquine using claims data from two US commercial health plans and Medicaid (2000-2012)...
October 31, 2016: Lupus
https://www.readbyqxmd.com/read/27753574/anthrax-vaccine-and-the-risk-of-rheumatoid-arthritis-and-systemic-lupus-erythematosus-in-the-u-s-military-a-case-control-study
#4
Barbara H Bardenheier, Jonathan Duffy, Susan K Duderstadt, Jay B Higgs, Michael P Keith, Patricia J Papadopoulos, William R Gilliland, Michael M McNeil
U.S. military personnel assigned to areas deemed to be at high risk for anthrax attack receive Anthrax Vaccine Adsorbed (AVA). Few cases of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have been reported in persons who received AVA. Using a matched case-control study design, we assessed the relationship of RA and SLE with AVA vaccination using the Defense Medical Surveillance System. We identified potential cases using International Classification of Diseases, 9th Revision, Clinical Modification codes and confirmed cases with medical record review and rheumatologist adjudication...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27748652/severe-thrombocytopenic-purpura-after-meningococcal-c-vaccination-in-a-woman-affected-by-systemic-lupus-erythematosus
#5
Francesca Angelotti, Antonio Tavoni
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September 7, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27739111/estimating-the-size-of-the-u-s-population-at-risk-of-severe-adverse-events-from-replicating-smallpox-vaccine
#6
Ellen P Carlin, Nichole Giller, Rebecca Katz
OBJECTIVE: To quantify the population at risk of serious adverse reactions to replicating smallpox vaccine. DESIGN AND SAMPLE: Conditions known or suspected to carry risk were identified via Centers for Disease Control and Prevention planning documents, other federal publications, and peer-reviewed literature. Conditions identified were categorized as historically recognized risks or more recently recognized immunocompromised states that may pose risk. Major historical risk factors were as follows: eczema/atopic dermatitis, pregnancy, HIV, and primary immunodeficiency...
October 13, 2016: Public Health Nursing
https://www.readbyqxmd.com/read/27682966/human-papillomavirus-infection-and-cervical-lesions-in-rheumatic-diseases-a-systematic-review
#7
Ana Raposo, Chiara Tani, José Costa, Marta Mosca
An association between immune-mediated diseases and cervical pre-malignant and malignant lesions is described, having the human papillomavirus (HPV) infection a causal role. Related studies have been generally focused on systemic lupus erythematosus (SLE) patients, but relatively to other diseases, such as rheumatoid arthritis (RA), Sjögren's syndrome (SS) and systemic sclerosis (SSc), data has not been systematically evaluated. We conducted a systematic review analysis of the literature in PubMed, including articles published until March of 2015, in patients with RA, SS, SLE and SSc, to evaluate the frequency of HPV infection, cervical dysplasia and cervical cancer, and associated factors, with particular interest on the role of glucocorticoids and immunosuppressive treatment...
April 16, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27671512/immunogenicity-of-23-valent-pneumococcal-vaccine-in-children-with-systemic-lupus-erythematosus
#8
Soheila Alyasin, Marzieh Adab, Asieh Hosseinpour, Reza Amin, Maryam Babaei
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. OBJECTIVE: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27670650/-management-of-systemic-lupus-erythematosus
#9
M Aringer, M Schneider
In the last few decades a number of small, often largely unrecognized steps have fundamentally changed the management of systemic lupus erythematosus (SLE). The current goal is to stop all disease activity without long-term use of more than 5 mg prednisolone per day. Remission, i.e. absence of activity in the SLE activity score of choice, is the defined target in the treat to target approach. The essential basic measures include life-long hydroxychloroquine as well as protection from sunlight (UV) and vitamin D substitution...
September 26, 2016: Der Internist
https://www.readbyqxmd.com/read/27666813/mercury-as-an-environmental-stimulus-in-the-development-of-autoimmunity-a-systematic-review
#10
William Crowe, Philip J Allsopp, Gene E Watson, Pamela J Magee, J J Strain, David J Armstrong, Elizabeth Ball, Emeir M McSorley
Autoimmune diseases result from an interplay of genetic predisposition and factors which stimulate the onset of disease. Mercury (Hg), a well-established toxicant, is an environmental factor reported to be linked with autoimmunity. Hg exists in several chemical forms and is encountered by humans in dental amalgams, certain vaccines, occupational exposure, atmospheric pollution and seafood. Several studies have investigated the effect of the various forms of Hg, including elemental (Hg(0)), inorganic (iHg) and organic mercury (oHg) and their association with autoimmunity...
September 23, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27636738/high-resolution-analysis-of-antibodies-to-post-translational-modifications-using-peptide-nanosensor-microarrays
#11
Jung-Rok Lee, D James Haddon, Nidhi Gupta, Jordan V Price, Grace M Credo, Vivian K Diep, Kyunglok Kim, Drew A Hall, Emily C Baechler, Michelle Petri, Madoo Varma, Paul J Utz, Shan X Wang
Autoantibodies are a hallmark of autoimmune diseases such as lupus and have the potential to be used as biomarkers for diverse diseases, including immunodeficiency, infectious disease, and cancer. More precise detection of antibodies to specific targets is needed to improve diagnosis of such diseases. Here, we report the development of reusable peptide microarrays, based on giant magnetoresistive (GMR) nanosensors optimized for sensitively detecting magnetic nanoparticle labels, for the detection of antibodies with a resolution of a single post-translationally modified amino acid...
September 20, 2016: ACS Nano
https://www.readbyqxmd.com/read/27586799/the-importance-of-the-type-i-interferon-system-in-autoimmunity
#12
REVIEW
Lars Rönnblom
The type I interferon (IFN) system is our main defense against viral infections and consists of a large number of sensors of nucleic acid that can trigger the production of more than 15 different proteins with antiviral and immunostimulatory capacity. There are several observations suggesting an important role for this system in the etiopathogenesis of systemic lupus erythematosus (SLE) and other autoimmune diseases. Among these are the development of autoimmune diseases during IFN-α treatment, a prominent increase in the expression of type I IFN regulated genes (an IFN signature) in a number of rheumatic diseases, the existence of endogenous IFN inducers in SLE patients and a genetic association between autoimmune diseases and gene variants within the type I IFN signalling pathway...
July 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27562062/germinal-centers-and-autoimmune-disease-in-humans-and-mice
#13
Anthony L DeFranco
Antibodies are involved in the pathogenesis of many autoimmune diseases. Although the mechanisms underlying the antibody response to infection or vaccination are reasonably well understood, we still have a poor understanding of the nature of autoimmune antibody responses. The most well studied are the anti-nuclear antibody responses characteristic of systemic lupus erythematosus and studies over the past decade or so have demonstrated a critical role for signaling by TLR7 and/or TLR9 in B cells to promote these responses...
October 11, 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/27435706/autoimmune-reaction-after-anti-tetanus-vaccination-description-of-four-cases-and-review-of-the-literature
#14
N Ruhrman-Shahar, J Torres-Ruiz, P Rotman-Pikielny, Y Levy
Autoimmune reaction after vaccination is sporadically reported in the medical literature. Vaccinations are generally safe and have an important role in eradicating endemic diseases worldwide. Nevertheless, the question arises as to whether there is a possibility of post-vaccination autoimmune phenomena. The anti-tetanus vaccine is being used since 1924, and it is part of the recommended immunization schedules for children. There are few reports of autoimmune diseases, such as rheumatoid arthritis and anti-phospholipid syndrome after anti-tetanus vaccination...
July 19, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27428889/environmental-exposures-and-the-development-of-systemic-lupus-erythematosus
#15
Medha Barbhaiya, Karen H Costenbader
PURPOSE OF REVIEW: This review examines evidence relating environmental factors to the development of systemic lupus erythematosus (SLE). RECENT FINDINGS: The strongest epidemiologic evidence exists for the associations of silica, cigarette smoking, oral contraceptives, postmenopausal hormone therapy and endometriosis, with SLE incidence. Recent studies have also provided robust evidence of the association between alcohol consumption and decreased SLE risk. There are preliminary, conflicting or unsubstantiated data that other factors, including air pollution, ultraviolet light, infections, vaccinations, solvents, pesticides and heavy metals such as mercury, are related to SLE risk...
September 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27418024/coexisting-bacillus-calmette-gu%C3%A3-rin-induced-lupus-vulgaris-involving-the-vaccination-site-and-lichen-scrofulosorum-in-an-immunocompetent-boy
#16
Gnaneshwar Rao Angoori
The coexistence of Bacillus Calmette-Guérin (BCG)-induced lupus vulgaris involving the site of vaccination with lichen scrofulosorum is rare. Herein we report a 3-year-old boy who presented with lupus vulgaris at the vaccination site 3 weeks after neonatal BCG vaccination followed by the development of lichen scrofulosorum approximately 2.5 years later. Characteristic clinical morphology, typical histopathology, and positive DNA polymerase chain reaction for Mycobacterium bovis confirmed the clinical diagnosis...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27417999/adjuvants-and-vaccines-induced-autoimmunity-animal-models
#17
Jiram Torres Ruiz, Luis Luján, Miri Blank, Yehuda Shoenfeld
The emergence of autoimmunity after vaccination has been described in many case reports and series. Everyday there is more evidence that this relationship is more than casual. In humans, adjuvants can induce non-specific constitutional, musculoskeletal or neurological clinical manifestations and in certain cases can lead to the appearance or acceleration of an autoimmune disease in a subject with genetic susceptibility. The fact that vaccines and adjuvants can trigger a pathogenic autoimmune response is corroborated by animal models...
July 14, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27406735/quadrivalent-human-papillomavirus-vaccine-and-autoimmune-adverse-events-a-case-control-assessment-of-the-vaccine-adverse-event-reporting-system-vaers-database
#18
David A Geier, Mark R Geier
Gardasil is a quadrivalent human papillomavirus (HPV4) vaccine that was approved for use by the US Food and Drug Administration in June 2006. HPV4 vaccine is routinely recommended for administration to women in the USA who are 11-12 years old by the Advisory Committee on Immunization Practices. Previous studies suggest HPV4 vaccine administration was associated with autoimmune diseases. As a consequence, an epidemiological assessment of the vaccine adverse event reporting system database was undertaken for adverse event reports associated with vaccines administered from 2006 to 2014 to 6-39 year-old recipients with a listed US residence and a specified female gender...
July 13, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27267647/miliary-tuberculosis-a-severe-opportunistic-infection-in-juvenile-systemic-lupus-erythematosus-patients
#19
Priscilla S Freire, João D Montoni, Aline S M Ribeiro, Heloísa H Marques, Thais Mauad, Clovis A Silva
INTRODUCTION: One of the main issues in juvenile systemic lupus erythematosus (JSLE) patients is infection, such as tuberculosis (TB). Of note, SLE patients are susceptible to pulmonary and extrapulmonary TB. However, to our knowledge, this contagious disease was rarely reported in pediatric lupus population, particularly diffuse or miliary TB. Therefore, from January 1983 to December 2011, 5,635 patients were followed-up at our Pediatric Rheumatology Unit and 285 (5%) of them met the American College of Rheumatology classification criteria for SLE...
May 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27235612/pharmacologic-therapies-for-rheumatologic-and-autoimmune-conditions
#20
REVIEW
Alison M Bays, Gregory Gardner
Disease-modifying antirheumatic drugs (DMARDs) are commonly prescribed by rheumatologists to reduce disease activity and induce remission in autoimmune conditions such as systemic lupus erythematosus and rheumatoid arthritis. Steroids are sometimes used in combination with DMARD therapy and should be used at the lowest effective dose for the least amount of time. There are many biologic agents available for use for inflammatory arthritis and other autoimmune conditions. Care should be taken when prescribing and managing DMARDS, steroids and biologic agents medications with a careful eye towards screening for infectious disease, vaccination, bone heath and lab monitoring...
July 2016: Medical Clinics of North America
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