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https://www.readbyqxmd.com/read/29889693/lupus-and-vaccinations
#1
Alexis Mathian, Micheline Pha, Zahir Amoura
PURPOSE OF REVIEW: To review the latest data in the field of vaccinations in systemic lupus erythematosus (SLE), focusing on pneumococcal, seasonal influenza, herpes zoster and human papillomavirus infections. RECENT FINDINGS: Less than 40% of patients responded adequately to the 23-valent pneumococcal polysaccharide (PPS23) vaccine. A randomized controlled trial showed that sequential administration of the pneumococcal conjugate vaccine followed by the PPS23 vaccine was well tolerated but was not superior to the PPS23 vaccine alone in terms of immunogenicity...
June 9, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29879320/effect-of-active-immunization-with-il-17a-on-b-cell-function-and-infection-risk-in-pristane-induced-lupus-model
#2
Kusworini Handono, Mirza Zaka Pratama, Dita Kartika Sari, Hanestya Oky Hermawan, Hafishtyawan Maulidyananta Agdana, Keryasta Becik Kawuningan, Nafisah Nur'aini, Dian Hasanah, Handono Kalim
PURPOSE: The aim of this study was to determine the effect of active immunization of interleukin (IL)-17A to inhibit B cell functions and monitor the risk of infection in a pristane-induced lupus mice model. METHODS: Female Balb/c mice were given a single intraperitoneal injection of 0.5 mL pristane. IL-17A was coupled to keyhole limpet hemocyanin (KLH) and given to mice in three different doses: D0 (0 μg/mL), D1 (1 μg/mL), and D2 (10 μg/mL). The vaccine was given three times with 3-week intervals...
June 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29868831/antibody-status-against-measles-in-previously-vaccinated-childhood-systemic-lupus-erythematosus-patients-a-prospective-case-control-study
#3
Despoina N Maritsi, George Vartzelis, John Kopsidas, Nikos Spyridis, Maria N Tsolia
No abstract text is available yet for this article.
June 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29757414/vaccination-coverage-in-systemic-lupus-erythematosus-a-cross-sectional-analysis-of-the-german-long-term-study-lula-cohort
#4
Gamal Chehab, Jutta G Richter, Ralph Brinks, Rebecca Fischer-Betz, Borgi Winkler-Rohlfing, Matthias Schneider
Objectives: Vaccinations are an important measure to prevent infections in immunocompromised patients. The knowledge of vaccination coverage and reasons for non-vaccination in patients with SLE is scarce. The aim of this study was to assess coverage rates of selected vaccinations in a representative sample of SLE patients and to identify predictors for non-vaccination. Methods: In 2013, information on selected vaccinations (coverage, application and reservations) and on demographics, clinical parameters and health beliefs was assessed by means of a self-reported questionnaire among a representative sample of SLE patients in Germany (LuLa cohort)...
May 10, 2018: Rheumatology
https://www.readbyqxmd.com/read/29741129/decreased-antibodies-against-rubella-in-previously-vaccinated-treatment-na%C3%A3-ve-childhood-systemic-lupus-erythematous-patients-a-prospective-case-control-study
#5
D N Maritsi, S Coffin, M Onoufriou, N Spyridis, M N Tsolia
No abstract text is available yet for this article.
May 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29735288/clinical-practice-guidelines-for-the-treatment-of-systemic-lupus-erythematosus-by-the-mexican-college-of-rheumatology
#6
Daniel Xibillé-Friedmann, Marcela Pérez-Rodríguez, Sandra Carrillo-Vázquez, Everardo Álvarez-Hernández, Francisco Javier Aceves, Mario C Ocampo-Torres, Conrado García-García, José Luis García-Figueroa, Javier Merayo-Chalico, Ana Barrera-Vargas, Margarita Portela-Hernández, Sandra Sicsik, Lilia Andrade-Ortega, Víctor Manuel Rosales-Don Pablo, Aline Martínez, Pilar Prieto-Seyffert, Mario Pérez-Cristóbal, Miguel Ángel Saavedra, Zully Castro-Colín, Azucena Ramos, Gabriela Huerta-Sil, María Fernanda Hernández-Cabrera, Luis Javier Jara, Leonardo Limón-Camacho, Lizbet Tinajero-Nieto, Leonor A Barile-Fabris
There are national and international clinical practice guidelines for systemic lupus erythematosus treatment. Nonetheless, most of them are not designed for the Mexican population or are devoted only to the treatment of certain disease manifestations, like lupus nephritis, or are designed for some physiological state like pregnancy. The Mexican College of Rheumatology aimed to create clinical practice guidelines that included the majority of the manifestations of systemic lupus erythematosus, and also incorporated guidelines in controversial situations like vaccination and the perioperative period...
May 4, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29708835/the-effect-of-history-of-abnormal-pap-smear-or-preceding-hpv-infection-on-the-humoral-immune-response-to-quadrivalent-human-papilloma-virus-qhpv-vaccine-in-women-with-systemic-lupus-erythematosus
#7
J Patricia Dhar, Lynnette Essenmacher, Renee Dhar, Ardella Magee, Joel Ager, Robert J Sokol
OBJECTIVE: To determine if natural human papillomavirus (HPV) infection would induce an anamnestic response to quadrivalent (qHPV) vaccine in women with Systemic Lupus Erythematosus (SLE). METHODS: Thirty four women (19-50 years) with mild to moderate and minimally active or inactive SLE received standard qHPV vaccine. Neutralizing antibody titers to HPV 6, 11, 16 and18 were evaluated pre- and post- vaccine using HPV competitive Luminex Immunoassay. For each HPV type, logistic regressions were performed to explore the relationship between a positive titer at baseline with their final geometric mean titer and with the rise in titer...
April 30, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29706295/recent-advances-in-the-development-of-vaccines-for-chronic-inflammatory-autoimmune-diseases
#8
REVIEW
Naru Zhang, Kutty Selva Nandakumar
Chronic inflammatory autoimmune diseases leading to target tissue destruction and disability are not only causing increase in patients' suffering but also contribute to huge economic burden for the society. General increase in life expectancy and high prevalence of these diseases both in elderly and younger population emphasize the importance of developing safe and effective vaccines. In this review, at first the possible mechanisms and risk factors associated with chronic inflammatory autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes (T1D) are discussed...
April 26, 2018: Vaccine
https://www.readbyqxmd.com/read/29699792/long-term-immunogenicity-of-a-quadrivalent-human-papillomavirus-vaccine-in-systemic-lupus-erythematosus
#9
C C Mok, L Y Ho, C H To
OBJECTIVES: To evaluate the 5-year immunogenicity of a quadrivalent human papillomavirus (HPV) vaccine (GARDASIL) in patients with systemic lupus erythematosus (SLE). METHODS: Female SLE patients and controls, aged 18-35 years, who received GARDASIL in 2011 and sero-converted 12 months post-vaccination were followed for persistence of immunogenicity. Antibody measurement to HPV serotypes 6, 11, 16, 18 was repeated at 5 years. The rate of sero-reversion was compared between patients and controls, and factors associated with sero-reversion of the anti-HPV antibodies were studied...
April 23, 2018: Vaccine
https://www.readbyqxmd.com/read/29619588/autoimmune-inflammatory-syndrome-induced-by-mineral-oil-a-health-problem
#10
Olga Vera-Lastra, Gabriela Medina, María Pilar Cruz-Domínguez, Gabriel Medrano Ramírez, Raymundo Benjamin Priego Blancas, Ana Lilia Peralta Amaro, Anabel Villanueva Martínez, Jesús Sepúlveda Delgado, Luis J Jara
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) includes the following conditions: siliconosis, Gulf War syndrome, macrophagic myofasciitis syndrome, and post-vaccination phenomena. Afterward, other syndromes have been recognized, such as in ASIA by mineral oil (ASIA-MO). These conditions are triggered by adjuvants and they are the result of the interplay of genetic and environmental factors. ASIA-MO is defined as the infiltration of oily type modeling substances for cosmetic purposes. It has been reported in many countries and used surreptitiously...
June 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29609210/does-sle-care-provided-in-a-lupus-clinic-result-in-higher-quality-of-care-than-general-rheumatology-clinic
#11
Shilpa Arora, Ailda Nika, Laura Trupin, Hrudya Abraham, Joel Block, Winston Sequeira, Jinoos Yazdany, Meenakshi Jolly
PURPOSE: We compared the quality of care received by SLE patients in two settings within the same academic institution (Lupus Clinic, LC and General Rheumatology Clinic, GRC) using validated SLE quality measures (QM). METHODS: 150 consenting, consecutive SLE patients receiving longitudinal care at Rush University GRC (73) and subspecialty LC (77) were recruited. An updated QM survey and retrospective medical chart review was used for evaluation of each QM. The overall and individual (20) QM performance was calculated and compared between two groups...
April 2, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29490770/-in-vitro-induction-of-t-regulatory-cells-by-a-methylated-cpg-dna-sequence-in-humans-potential-therapeutic-applications-in-allergic-and-autoimmune-diseases
#12
Oliver J Lawless, Joseph A Bellanti, Milton L Brown, Kathryn Sandberg, Jason G Umans, Li Zhou, Weiqian Chen, Julie Wang, Kan Wang, Song Guo Zheng
BACKGROUND: Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative effort to find ways of increasing Tregs as a method of therapy for these conditions. One such line of investigation includes the study of how ligation of Toll-like receptors (TLRs) by CpG oligonucleotides (ODN) results in an immunostimulatory cascade that leads to induction of T-helper (Th) type 1 and Treg-type immune responses...
March 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29382052/exploring-the-gaps-in-practical-ethical-guidance-for-animal-welfare-considerations-of-field-interventions-and-innovations-targeting-dogs-and-cats
#13
Louisa Tasker, Susan F Getty, Joyce R Briggs, Valerie A W Benka
Domestic dogs ( Canis lupus familiaris ) and cats ( Felis silvestris catus ) are common species targeted by nongovernmental or intergovernmental organizations, veterinarians and government agencies worldwide, for field interventions (e.g., population management, rabies vaccination programs) or innovations (e.g., development of technologies or pharmaceuticals to improve animal welfare). We have a moral responsibility to ensure that the conduct of this work is humane for dogs or cats, and to consider the human communities in which the animals live...
January 27, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29336179/belimumab-and-antipneumococcal-vaccination-in-patients-with-systemic-lupus-erythematosus
#14
Tudor Azoicai, Sabina Antoniu, Irina Draga Caruntu, Doina Azoicai, Ileana Antohe, Cristina Gavrilovici
In systemic lupus erythematosus (SLE), flares can be caused by infections. In particular, Streptococcus pneumoniae infection can be severe or even potentially lethal in absence of previous immunization or in case of 'aggressive' systemic antibiotic therapy. Immunization efficacy, however, can be reduced in such patients with the use of the various immunosuppressive therapeutic regimens. In particular, the use of novel monoclonal antibodies against B lymphocytes raises concerns over the potential interference with antipneumococcal vaccination...
March 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29236153/insufficient-vaccination-rates-in-patients-with-systemic-lupus-erythematosus-in-a-german-outpatient-clinic
#15
M Krasselt, C Baerwald, O Seifert
BACKGROUND: Patients with systemic lupus erythematosus (SLE) are at an increased risk of acquiring infections due to the disease itself and the immunosuppressive therapy. Furthermore, infections largely contribute to overall SLE mortality. Vaccinations against preventable diseases are therefore of particular importance for these patients. AIMS: To estimate vaccination frequencies among patients with SLE, we studied patients in a survey and calculated vaccination rates based on their vaccination documents...
December 13, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29224679/a-review-on-sle-and-malignancy
#16
REVIEW
May Y Choi, Kelsey Flood, Sasha Bernatsky, Rosalind Ramsey-Goldman, Ann E Clarke
Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition. It predominantly affects young and middle-aged women. While improvements in the diagnosis and treatment of SLE have altered prognosis, morbidity and mortality rates remain higher than the general population. In addition to renal injury, cardiovascular disease, and infection, malignancy is known to be a significant cause of death in this population...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29224673/understanding-the-role-of-environmental-factors-in-the-development-of-systemic-lupus-erythematosus
#17
REVIEW
Christine G Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H Costenbader
Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for increased risk of SLE associated with exposure to crystalline silica, current cigarette smoking, use of oral contraceptives, and postmenopausal hormone replacement therapy, while there is an inverse association with alcohol use...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29202939/risk-factors-for-herpes-zoster-a-systematic-review-and-meta-analysis
#18
REVIEW
Kosuke Kawai, Barbara P Yawn
OBJECTIVE: To systematically review studies examining risk factors for herpes zoster (HZ). METHODS: We performed a literature search using PubMed, EMBASE, and Web of Science for articles published from January 1, 2003, to February 1, 2017. A random-effects model was used to summarize the risk ratio (RR) or odds ratio (OR) and 95% CI. RESULTS: Of the 3450 studies screened, we included 84 studies in the systematic review and conducted meta-analysis in 62 studies...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#19
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
February 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29031481/systemic-lupus-erythematosus-following-meningococcal-vaccination
#20
Alexandria D Holmes, Osman Z Abbasi, Jeanne L Jacoby
Systemic erythematosus lupus (SLE) affects multiple organs and involves complex immune dysfunction. Because vaccinations are inherently designed to stimulate the immune response, they have been linked with increased risk for flare of SLE and other autoimmune disorders, and their association with new-onset autoimmune disease has been postulated in several case reports. To our knowledge, this is the first reported case of the meningococcal vaccine precipitating SLE in a previously undiagnosed patient. We present a case of a previously healthy, 17 year old Asian female who presented to the ED with 14 days of fever and fatigue after administration of the meningococcal vaccine, as well as 5 days of facial rash...
January 2018: American Journal of Emergency Medicine
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