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wegener's radiation therapy

Sören Dahlke, Diana Steinmann, Hans Christiansen, Martin Durisin, Andre Eckardt, Gerd Wegener, Michael Bremer, Andreas Meyer
AIM: To evaluate treatment-related factors such as overall treatment time (OTT) and radiation treatment time (RTT) in head-and-neck cancer. PATIENTS AND METHODS: A total of 216 patients with locoregionally advanced inoperable head and neck cancer were treated with definitive radio(chemo)therapy. Mean follow-up was 37 months. RESULTS: Median time from diagnosis to start of radiotherapy (total waiting time) was 34 days, and comprised of referral waiting time and time for preparatory work...
September 2017: In Vivo
Franziska Geiser, Katharina Zajackowski, Rupert Conrad, Katrin Imbierowicz, Ingo Wegener, Kaye A Herth, Anne Sarah Urbach
BACKGROUND: The importance of hope is evident in clinical oncological care. Hope is associated with psychological and also physical functioning. However, there is still a dearth of empirical research on hope as a multidimensional concept. The Herth Hope Index is a reliable and valid instrument for the measurement of hope and is available in many languages. Until now no authorized German translation has been published and validated. METHODS: After translation, the questionnaire was completed by 192 patients with different tumor entities in radiation therapy...
2015: Oncology Research and Treatment
Andrzej Wygoda, Tomasz Rutkowski, Krzysztof Składowski, Beata Hejduk
Wegener's granulomatosis is a rare disease (10 per 1 000 000 new cases per year), etiologically connected with necrotizing vasculitis of small to medium-size vessels. The disease occurs predominantly in the upper respiratory tract, lungs and kidneys, but any organ may be affected during the course of the illness. It may be difficult to diagnose, especially when c-ACNA antibodies (serologic symptom of Wegener's granulomatosis) are undetectable and chest X-ray is normal. Early diagnosis is crucial for treatment results...
2013: Contemporary Oncology Współczesna Onkologia
Allyson J Ocean, Kenneth L Pennington, Michael J Guarino, Arif Sheikh, Tanios Bekaii-Saab, Aldo N Serafini, Daniel Lee, Max W Sung, Seza A Gulec, Stanley J Goldsmith, Timothy Manzone, Michael Holt, Bert H O'Neil, Nathan Hall, Alberto J Montero, John Kauh, David V Gold, Heather Horne, William A Wegener, David M Goldenberg
BACKGROUND: It has been demonstrated that the humanized clivatuzumab tetraxetan (hPAM4) antibody targets pancreatic ductal carcinoma selectively. After a trial of radioimmunotherapy that determined the maximum tolerated dose of single-dose yttrium-90-labeled hPAM4 ((90) Y-hPAM4) and produced objective responses in patients with advanced pancreatic ductal carcinoma, the authors studied fractionated radioimmunotherapy combined with low-dose gemcitabine in this disease. METHODS: Thirty-eight previously untreated patients (33 patients with stage IV disease and 5 patients with stage III disease) received gemcitabine 200 mg/m(2) weekly for 4 weeks with (90) Y-hPAM4 given weekly in Weeks 2, 3, and 4 (cycle 1), and the same cycle was repeated in 13 patients (cycles 2-4)...
November 15, 2012: Cancer
M C B Godoy, C Viswanathan, E Marchiori, M T Truong, M F Benveniste, S Rossi, E M Marom
The reversed halo sign is characterised by a central ground-glass opacity surrounded by denser air-space consolidation in the shape of a crescent or a ring. It was first described on high-resolution CT as being specific for cryptogenic organising pneumonia. Since then, the reversed halo sign has been reported in association with a wide range of pulmonary diseases, including invasive pulmonary fungal infections, paracoccidioidomycosis, pneumocystis pneumonia, tuberculosis, community-acquired pneumonia, lymphomatoid granulomatosis, Wegener granulomatosis, lipoid pneumonia and sarcoidosis...
September 2012: British Journal of Radiology
Seza A Gulec, Steven J Cohen, Kenneth L Pennington, Lionel S Zuckier, Ralph J Hauke, Heather Horne, William A Wegener, Nick Teoh, David V Gold, Robert M Sharkey, David M Goldenberg
PURPOSE: Humanized antibody hPAM4 specifically binds a mucin glycoprotein expressed in pancreatic adenocarcinomas. This phase I study evaluated a single dose of (90)Y-clivatuzumab tetraxetan ((90)Y-labeled hPAM4) in patients with advanced pancreatic cancer. EXPERIMENTAL DESIGN: Twenty-one patients (4 stage III; 17 stage IV) received (111)In-hPAM4 for imaging and serum sampling before (90)Y-hPAM4. Study procedures evaluated adverse events, safety laboratories, computed tomography (CT) scans, biomarkers, pharmacokinetics, radiation dosimetry, and immunogenicity (HAHA)...
June 15, 2011: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Lasse Wegener Lund, Kjeld Schmiegelow, Catherine Rechnitzer, Christoffer Johansen
High survival rates after childhood cancer raise attention to possible psychosocial late effects. We focus on predictors of psychosocial outcomes based on diagnosis, treatment, demography, somatic disease, and methodological problems. Overall, survivors evaluate their health-related quality of life to be normal or even better than controls, although virtually all diagnostic subgroups report psychosocial impairment. Central nervous system tumor survivors have significant psychosocial problems. Negative outcomes were associated with cranial radiation therapy, female gender, and young age at diagnosis...
April 2011: Pediatric Blood & Cancer
J Finsterer
Vasculitis affecting the peripheral nerves predominantly manifests as subacute, progressive, asymmetric sensorimotor polyneuropathy or mononeuritis multiplex, and more rarely as painful mononeuropathy, pure sensory neuropathy, neuropathy of the cranial nerves, plexopathy, or as autonomic neuropathy. Vasculitic neuropathy may occur isolated or non-isolated (systemic) together with involvement of other organs. Systemic vasculitis with involvement of the peripheral nerves is further subdivided into primary (Takayasu syndrome, giant cell arteritis, classical panarteritis nodosa, thrombangitis obliterans, Kawasaki disease, Churg-Strauss syndrome, Wegener granulomatosis, cryoglobulinemic vasculitis, Behcet disease, microscopic polyangitis, Schoenlein Henoch purpura) or secondary systemic vasculitis (autoimmune connective tissue diseases, vasculitis from infection, sarcoidosis, malignancy, drugs, radiation, or diabetes)...
June 2009: Acta Neurologica Belgica
M O Klein, K A Grötz, C Walter, J Wegener, W Wagner, B Al-Nawas
AIM: The aim of this retrospective study was to investigate prognostic parameters for the rehabilitation of mandibular continuity defects with free autologous bone and dental implants for patients after intraoral squamous cell carcinoma. METHODS: Following potential prognostic factors for implant survival were analyzed: bony bed (local bone versus augmented iliac crest bone), radiation dose (no radiation, <50 Gy, >or=50 Gy) and implant dimensions. Kaplan-Meier survival estimates of the inserted implants were performed...
2009: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
A Eckardt, G Wegener, J H Karstens
PURPOSE: The purpose of simultaneous chemoradiotherapy is to increase local tumor control and to decrease the incidence of distant metastases. Platinum-based chemotherapy regimens are widely accepted as standard treatment in advanced head and neck cancer. Due to their remarkable activity as well as radiosensitizing effects, taxanes play in increasing role in multimodality treatment concepts of solid tumors. MATERIAL AND METHODS: Since 1989 a total of 85 patients with advanced squamous cell carcinoma of the oral cavity and oropharynx were recruited to participate in two different prospective clinical trials of preoperative chemoradiation...
January 2006: Mund-, Kiefer- und Gesichtschirurgie: MKG
Torsten Liersch, Johannes Meller, Bettina Kulle, Thomas M Behr, Peter Markus, Claus Langer, B Michael Ghadimi, William A Wegener, Jacqueline Kovacs, Ivan D Horak, Heinz Becker, David M Goldenberg
PURPOSE: Although complete resection (R0) of liver metastases (LM) remains the treatment of choice for colorectal cancer (CRC) patients amenable to curative therapy, only approximately one third survive for 5 years. The objective of this phase II study was to evaluate the safety and efficacy of radioimmunotherapy (RAIT) after salvage resection of LM. PATIENTS AND METHODS: Twenty-three patients who underwent surgery for LM of CRC received a dose of 40 to 60 mCi/m2 of 131I-labetuzumab, which is a humanized monoclonal antibody against carcinoembryonic antigen...
September 20, 2005: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
H Feldmann
SUMMARY: A diary and an extensive correspondence of Heinrich Hertz and his family provide a meticulous documentation of his life, made available by Albrecht Folsing in 1997 through a carefully investigated biography, which permit the conclusion that H. Hertz died of Wegener's granulomatosis, 45 years before this disease had been explored. WEGENER'S GRANULOMATOSIS: The symptoms of the granulomatosis, that was first described by Friedrich Wegener in 1936 and 1939 are presented in short with literal quotations of the author: It begins with a refractory cold that will last until the end, then follow involvement of the paranasal sinuses, ears, mucous lining of mouth and pharynx, slight fever, weakness, in the final phase dissemination with nephritis, septic fever, arthritis, myalgia, paralyses leading to total immobility, exitus...
June 2005: Laryngo- Rhino- Otologie
Cristiano Beck Neviani, Heloisa de Andrade Carvalho, Cláudio Hossamu, Salim Aisen, Wladimir Nadalin
No abstract text is available yet for this article.
February 2002: Otolaryngology—Head and Neck Surgery
P Mathur, S K Gupta, A R Wegener, W Breipohl, M H Ahrend, Y D Sharma, Y K Gupta, R B Vajpayee
PURPOSE: To compare effects of calpain inhibitors on in vitro light-scattering in rat lens soluble protein and calcium-ionophore (A23187)-induced cataract formation in cultured rat lenses. METHODS: Rat lens soluble protein was hydrolyzed for 24 hours by activation of endogenous lens calpain. Ten calpain inhibitors were tested in this model at 10 and 25 microM concentration. As an index of protein precipitation, light scattering was measured daily at 405 nm for 8 days...
December 2000: Current Eye Research
K A Grötz, U W Wahlmann, F Krummenauer, J Wegener, B al-Nawas, H D Kuffner, W Wagner
In comparison to tumor patients not receiving radiotherapy, the rehabilitation of masticatory function after head and neck irradiation is limited due to radiation-induced caries, radioxerostomia, and the risk of osteoradionecrosis. This study focused on implants in the irradiated jaw and on the evaluation of the prognosis and the effect of potential factors on the prognosis. The retrospective study covered 197 implants (47 patients) from 1988 to 1997. The implant prognosis was determined by implant survival statistics (Kaplan-Meier)...
May 1999: Mund-, Kiefer- und Gesichtschirurgie: MKG
R G Graper, H H Orenstein, R J Rohrich, H S Byrd, B K Rich
Midline granuloma is a mutilating process produced by a number of diseases that progressively destroy the nose, paranasal sinuses, and palate. Infectious, neoplastic, and idiopathic forms of this disease have been described. The specific diagnoses must be ascertained, as the treatment is different depending on the etiology of the disease. Radiation therapy is the treatment of choice for idiopathic midline destructive disease, while cytoxan is appropriate for Wegener's granulomatosis, polymorphic reticulosis, and primary nasal lymphomas...
November 1996: Annals of Plastic Surgery
R Pauzner, H Mayan, E Hershko, M Alcalay, Z Farfel
Wegener's granulomatosis (WG) is a rare multisystem disease of unknown etiology. We describe a woman with WG who relapsed twice during 2 pregnancies with appearance of tracheal stenosis. During the first pregnancy which ended with a delivery of a healthy baby, the subglottic stenosis responded to laser radiation and glucocorticosteroid therapy. An uneventful therapeutic abortion was performed during the 2nd pregnancy. Our case brings to 15 the number of pregnancies which were recorded in 10 women with WG. Diagnosis of WG was done during pregnancy in 4 cases, and at the postpartum period in 3 cases...
June 1994: Journal of Rheumatology
U M Rothacher, J A Rump, E W Herbst, U Blum, W Maier, H H Peter
The lethal midline granuloma and limited Wegener's granulomatosis show clinical similarity, although they are of different etiology. The following case of a 53-year-old woman shows how difficult it is to establish the precise diagnosis of lethal midline granuloma. The diagnosis depends on the pathological finding of a lymphoma. The lymphoma can be differentiated in a T- or a B-cell lymphoma by immunostaining. However, the diagnostic yield of biopsies from the nose is not perfect. It would be, therefore, important to find other diagnostic criteria...
August 1994: Immunität und Infektion
R A DeRemee, L H Weiland, T J McDonald
Respiratory vasculitis is characterized by granulomatous changes pathologically. Both upper and lower respiratory tracts may be involved. It is convenient to separate three entities: (1) Wegener's granulomatosis, (2) allergic granulomatosis and angiitis, or Churg-Strauss syndrome, and (3) polymorphic reticulosis/lymphomatoid granulomatosis complex. Churg-Strauss syndrome responds well to glucocorticoids. Cytotoxic drugs appear necessary for ultimate control of Wegener's granulomatosis. Radiation therapy is effective in controlling polymorphic reticulosis/lymphomatoid granulomatosis when it is localized to one site...
August 1980: Mayo Clinic Proceedings
J R Casuccio, E Yanagisawa
Three distinct diseases of undetermined etiology have been presented: sarcoidosis, Wegener's granulomatosis, and midline (nonhealing) granuloma, all of which have similar clinical presentations in the midface. The correct diagnosis is essential because the treatment of each disease is different. Sarcoidosis responds best to corticosteroids, Wegener's granulomatosis to cyclophosphamide, and midline granuloma to radiation therapy. The otolaryngologist should be familiar with these diseases, since their important clinical manifestations are most frequently found in the nose, sinuses, and related structures...
May 1981: Otolaryngologic Clinics of North America
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