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https://www.readbyqxmd.com/read/28880521/peptide-dendrons-as-thermal-stability-amplifiers-for-igg1-monoclonal-antibody-biotherapeutics
#1
Rohit Bansal, Sameer Dhawan, Soumili Chatterjee, Govind Maurya, V Haridas, Anurag Singh Rathore
Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical industry for treatment of life-threatening chronic diseases such as cancer, skin ailments and immune disorders. Instabilities such as aggregation, fragmentation, oxidation and reduction have resulted in the practice of storing these products at low temperatures (-80ºC to -20ºC). However, reliable storage at these temperatures can be a challenge, particularly in developing and underdeveloped countries and hence lately there has been a renewed interest in creating formulations that would offer stability at higher temperatures (25ºC to 55ºC)...
September 7, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28877748/a-pilot-clinical-trial-of-recombinant-human-angiotensin-converting-enzyme-2-in-acute-respiratory-distress-syndrome
#2
Akram Khan, Cody Benthin, Brian Zeno, Timothy E Albertson, John Boyd, Jason D Christie, Richard Hall, Germain Poirier, Juan J Ronco, Mark Tidswell, Kelly Hardes, William M Powley, Tracey J Wright, Sarah K Siederer, David A Fairman, David A Lipson, Andrew I Bayliffe, Aili L Lazaar
BACKGROUND: Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form of human angiotensin-converting enzyme 2 (rhACE2), could attenuate acute lung injury. METHODS: We conducted a two-part phase II trial comprising an open-label intrapatient dose escalation and a randomized, double-blind, placebo-controlled phase in ten intensive care units in North America...
September 7, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28873558/selective-and-eco-friendly-synthesis-of-lipoaminoacid-based-surfactants-for-food-using-immobilized-lipase-and-protease-biocatalysts
#3
Claudia Bernal, Fanny Guzman, Andres Illanes, Lorena Wilson
Lipoaminoacids, as surfactants, are an excellent option for food industry due to the currently trends in consumption of functional and natural ingredients. Synthesis of lauroyl glycine lipoaminoacid was carried out with a lipase from Pseudomonas stutzeri and a protease from Bacillus subtilis, which were immobilized in octyl-glyoxyl silica and glyoxyl-silica supports, respectively, comparing their catalytic performance. The enzymatic selectivity towards the lipoaminoacid instead of the dipeptide glycylglycine and synthesis yield were evaluated with respect to the characteristics of the immobilized biocatalysts and synthesis conditions...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28872861/an-entropic-anomaly-observed-in-lipid-polymorphisms-induced-by-surfactant-peptide-sp-b-1-25
#4
Nhi Tran, Justin J Kurian, Avni Bhatt, Robert McKenna, Joanna R Long
The N-terminal 25 amino-acid residues of pulmonary surfactant protein B (SP-B1-25) induces unusual lipid polymorphisms in a model lipid system, 4:1 DPPC/POPG, mirroring the lipid composition of native pulmonary surfactant. It is widely suggested that SP-B1-25 induced lipid polymorphisms within the alveolar aqueous subphase provide a structural platform for rapid lipid adsorption to the air-water interface. Here, we characterize in detail the phase behavior of DPPC and POPG in hydrated lipid assemblies containing therapeutic levels of SP-B1-25 using (2)H and (31)P solid state NMR spectroscopy...
September 5, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28845101/synthesis-and-surface-activity-of-cationic-amino-acid-based-surfactants-in-aqueous-solution
#5
Katarzyna E Greber
I studied the possibility of using amino acid-based surfactants as emulsifiers at the same time as preservatives. Fourteen lipopeptides were synthesized employing a solid phase peptide synthesis procedure. All compounds were designed to be positively charged from +1 to +4 and acylated with fatty acid chain-palmitic and miristic. The surface activity of the obtained lipopeptides was tested using a semi-automatic tensiometer to calculate parameters describing the behavior of lipopeptides in the air/water interface...
2017: Journal of Surfactants and Detergents
https://www.readbyqxmd.com/read/28828368/inhalation-therapies-in-acute-respiratory-distress-syndrome
#6
REVIEW
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A Matthay
The defining features of acute respiratory distress syndrome (ARDS) are an excessive inflammatory respiratory response associated with high morbidity and mortality. Treatment consists mainly of measures to avoid worsening lung injury and cannot reverse the underlying pathophysiological process. New pharmacological agents have shown promising results in preclinical studies; however, they have not been successfully translated to patients with ARDS. The lack of effective therapeutic interventions has resulted in a recent interest in strategies to prevent ARDS with treatments delivering medications directly to the lungs by inhalation and nebulization, hopefully minimizing systemic adverse events...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28828358/biomarkers-for-the-acute-respiratory-distress-syndrome-how-to-make-the-diagnosis-more-precise
#7
REVIEW
M Isabel García-Laorden, José A Lorente, Carlos Flores, Arthur S Slutsky, Jesús Villar
The acute respiratory distress syndrome (ARDS) is an acute inflammatory process of the lung caused by a direct or indirect insult to the alveolar-capillary membrane. Currently, ARDS is diagnosed based on a combination of clinical and physiological variables. The lack of a specific biomarker for ARDS is arguably one of the most important obstacles to progress in developing novel treatments for ARDS. In this article, we will review the current understanding of some appealing biomarkers that have been measured in human blood, bronchoalveolar lavage fluid (BALF) or exhaled gas that could be used for identifying patients with ARDS, for enrolling ARDS patients into clinical trials, or for better monitoring of patient's management...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28795574/molecularly-imprinted-porous-monolithic-materials-from-melamine-formaldehyde-for-selective-trapping-of-phosphopeptides
#8
Mingquan Liu, Tri Minh Tran, Ahmed Awad Abbas Elhaj, Silje Bøen Torsetnes, Ole N Jensen, Börje Sellergren, Knut Irgum
Thirty-five melamine-formaldehyde (MF) monolithic materials with bimodal pore distributions were synthesized in fused silica capillaries by catalyst-free polycondensation, starting with an aqueous MF precondensate, using acetonitrile as the macroporogen and a variety of aliphatic polyethers and triblock copolymeric surfactants as porogens and mesoporogens, respectively. By varying the prepolymer composition and the type and molecular weight of the polymeric porogen components, a library of porous monolithic materials was produced, covering a range of meso- and macroporous properties...
September 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28793908/transcriptomic-analysis-comparing-mouse-strains-with-extreme-total-lung-capacities-identifies-novel-candidate-genes-for-pulmonary-function
#9
Leema George, Ankita Mitra, Tania A Thimraj, Martin Irmler, Sangeetha Vishweswaraiah, Lars Lunding, Dorothea Hühn, Alicia Madurga, Johannes Beckers, Heinz Fehrenbach, Swapna Upadhyay, Holger Schulz, George D Leikauf, Koustav Ganguly
BACKGROUND: Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice. We identified seven lung function quantitative trait loci (QTL: Lfnq1-Lfnq7) in backcross/intercross mice derived from these inbred strains. We further demonstrated, superoxide dismutase 3, extracellular (Sod3), Kit oncogene (Kit) and secreted phosphoprotein 1 (Spp1) located on these Lfnqs as lung function determinants...
August 9, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28792261/ph-sensitive-phlip-%C3%A2-coated-niosomes
#10
Mohan C Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A Andreev, Yana K Reshetnyak
Nanomedicine is becoming very popular over conventional methods due to the ability to tune physico-chemical properties of nano vectors, which are used for encapsulation of therapeutic and diagnostic agents. However, the success of nanomedicine primarily relies on how specifically and efficiently nanocarriers can target pathological sites to minimize undesirable side effects and enhance therapeutic efficacy. Here, we introduce a novel class of targeted nano drug delivery system, which can be used as an effective nano-theranostic for cancer...
August 9, 2017: Molecular Membrane Biology
https://www.readbyqxmd.com/read/28759721/microchip-circulation-drastically-accelerates-amyloid-aggregation-of-1-42-%C3%AE-amyloid-peptide-from-felis-catus
#11
Witold Gospodarczyk, Maciej Kozak
Amyloid aggregation process of amyloid beta 1-42 peptide is responsible for Alzheimer disease, concerning millions of elderly people worldwide. Although there has a great deal of attention made to tackle this disease, there still has not been found any medicine for this fatal disorder. In order to come against this challenge, it is vital to thoroughly understand the molecular mechanism underlying peptide amyloid aggregation process, as well as seek for substances which could hamper this aggregation. In order to shed light on mechanisms leading to amyloidogenesis, we employed a microfluidic system to determine the possible influence of in vivo-like flow in microchip channel itself on peptide amyloidogenesis...
July 31, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28755992/microgels-of-silylated-hpmc-as-a-multimodal-system-for-drug-co-encapsulation
#12
Mohamed Zayed, Corine Tourne-Peteilh, Michel Ramonda, Gildas Rethore, Pierre Weiss, Jean Martinez, Gilles Subra, Ahmad Mehdi, Jean-Marie Devoisselle, Philippe Legrand
Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles. Silylated hydrogels are alkoxysilane hybrid polymers that can be engaged in a sol-gel process, providing chemical cross linking in physiological conditions, and functionalized biocompatible hybrid materials. In the present work, microgels were prepared with silylated (hydroxypropyl)methyl cellulose (Si-HPMC) that was chemically cross linked in soft conditions of pH and temperature...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28733934/draft-genome-sequence-of-the-deep-sea-bacterium-moritella-sp-jt01-and-identification-of-biotechnologically-relevant-genes
#13
Robert Cardoso de Freitas, Estácio Jussie Odisi, Chiaki Kato, Marcus Adonai Castro da Silva, André Oliveira de Souza Lima
Deep-sea bacteria can produce various biotechnologically relevant enzymes due to their adaptations to high pressures and low temperatures. To identify such enzymes, we have sequenced the genome of the polycaprolactone-degrading bacterium Moritella sp. JT01, isolated from sediment samples from Japan Trench (6957 m depth), using a Illumina HiSeq2000 sequencer (12.1 million paired-end reads) and CLC Genomics Workbench (version 6.5.1) for the assembly, resulting in a 4.83-Mb genome (42 scaffolds). The genome was annotated using Rapid Annotation using Subsystem Technology (RAST), Protein Homology/analogY Recognition Engine V 2...
July 22, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28732169/design-of-modular-peptide-surfactants-and-their-surface-activity
#14
Hao-Fei Wang, David Wibowo, Zhengzhong Shao, Anton P J Middelberg, Chun-Xia Zhao
Designed peptide surfactants offer a number of advanced properties over conventional petrochemical surfactants, including biocompatibility, sustainability, and tailorability of the chemical and physical properties through peptide design. Their biocompatibility and degradability make them attractive for various applications, particularly for food and pharmaceutical applications. In this work, two new peptide surfactants derived from an amphiphilic peptide surfactant (AM1) were designed (AM-S and C8-AM) to better understand links between structure, interfacial activity, and emulsification...
August 4, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28720540/formulations-and-toxicologic-in-vivo-studies-of-aqueous-cyclosporin-a-eye-drops-with-cyclodextrin-nanoparticles
#15
Sunna Jóhannsdóttir, Johannes K Kristinsson, Zoltán Fülöp, Gudrún Ásgrímsdóttir, Einar Stefánsson, Thorsteinn Loftsson
Cyclosporin A (CyA) is an immunosuppressive drug used topically to treat ocular inflammatory disorder such as dry eye disease (DES). It is a lipophilic cyclic peptide with molecular weight of 1202.6Da. The aim of this study was to develop surfactant free aqueous 0.2% (w/v) CyA eye drops where the drug is present in an aqueous vehicle containing CyA/cyclodextrin (CyA/CD) nanoparticles and then do three-month toxicological testing in rabbits. Five formulations of different CD concentrations were studied, all of them contained 12...
July 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28705615/transcutaneous-immunotherapy-of-pollinosis-using-solid-in-oil-nanodispersions-loaded-with-t-cell-epitope-peptides
#16
Qingliang Kong, Momoko Kitaoka, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto
Pollinosis, a typical seasonal allergy, is a serious public health problem. Limited numbers of patients receive curative immunotherapy instead of symptomatic therapy; however, there are still some concerns about the inconvenience and side effects of subcutaneous injections and sublingual administration caused by immunotherapy. Here, we propose a simple and safe transcutaneous immunotherapy using solid-in-oil (S/O) nanodispersions loaded with vaccine T cell epitope peptides derived from pollen allergen. S/O nanodispersions are oil-based dispersions of antigens coated with hydrophobic surfactants...
July 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28684364/polyarginine-nanocapsules-a-versatile-nanocarrier-with-potential-in-transmucosal-drug-delivery
#17
Ana Gonzalez-Paredes, Dolores Torres, María José Alonso
The objective of this work was to investigate the potential utility of nanocapsules composed of an oily core decorated with a single polyarginine (PARG), or double PARG/polyacrylic acid (PAA) layer as oral peptide delivery carrier. A step-by-step formulation optimization process was designed, which involved the study of the influence of the surfactants, oils and polymer shells (PARG of different molecular weight and PAA) on the nanocapsules physicochemical properties, peptide loading efficiency, stability in simulated intestinal fluids (SIF) and capacity to enhance the permeability of the intestinal epithelium...
July 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28643235/design-and-evaluation-of-rgd-modified-gemini-surfactant-based-lipoplexes-for-targeted-gene-therapy-in-melanoma-model
#18
Waleed Mohammed-Saeid, Jackson Chitanda, Mays Al-Dulaymi, Ronald Verrall, Ildiko Badea
PURPOSE: We have developed and evaluated novel peptide-targeted gemini surfactant-based lipoplexes designed for melanoma gene therapy. METHODS: Integrin receptor targeting peptide, cyclic-arginylglycylaspartic acid (cRGD), was either chemically coupled to a gemini surfactant backbone or physically co-formulated with lipoplexes. Several formulations and transfection techniques were developed. Transfection efficiency and cellular toxicity of the lipoplexes were evaluated in an in vitro human melanoma model...
September 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28623702/adsorption-of-ionic-surfactants-at-microscopic-air-water-interfaces-using-the-micropipette-interfacial-area-expansion-method-measurement-of-the-diffusion-coefficient-and-renormalization-of-the-mean-ionic-activity-for-sds
#19
Koji Kinoshita, Elisa Parra, David Needham
The dynamic adsorption of ionic surfactants at air-water interfaces have been less-well studied than that of the simpler non-ionics since experimental limitations on dynamic surface tension (DST) measurements create inconsistencies in their kinetic analysis. Using our newly designed "Micropipette interfacial area-expansion method", we have measured and evaluated both equilibrium and dynamic adsorption of a well-known anionic surfactant, sodium dodecyl sulphate (SDS), in the absence or presence of 100mM NaCl...
May 25, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28605904/kalata-b1-and-kalata-b2-have-a-surfactant-like-activity-in-phosphatidylethanolomine-containing-lipid-membranes
#20
Charles G Cranfield, Sónia Troeira Henriques, Boris Martinac, Paul Duckworth, David J Craik, Bruce Cornell
Cyclotides are cyclic disulfide-rich peptides that are chemically and thermally stable and possess pharmaceutical and insecticidal properties. The activities reported for cyclotides correlate with their ability to target phosphatidylethanolamine (PE)-phospholipids and disrupt cell membranes. However, the mechanism by which this disruption occurs remains unclear. In the current study we examine the effect of the prototypic cyclotides, kalata B1 (kB1) and kalata B2 (kB2), on tethered lipid bilayer membranes (tBLMs) using swept frequency electrical impedance spectroscopy...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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