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https://www.readbyqxmd.com/read/29334496/oxygen-in-the-critically-ill-friend-or-foe
#1
Elisa Damiani, Abele Donati, Massimo Girardis
PURPOSE OF REVIEW: To examine the potential harmful effects of hyperoxia and summarize the results of most recent clinical studies evaluating oxygen therapy in critically ill patients. RECENT FINDINGS: Excessive oxygen supplementation may have detrimental pulmonary and systemic effects because of enhanced oxidative stress and inflammation. Hyperoxia-induced lung injury includes altered surfactant protein composition, reduced mucociliary clearance and histological damage, resulting in atelectasis, reduced lung compliance and increased risk of infections...
January 12, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29334398/formation-of-shelf-stable-pickering-high-internal-phase-emulsions-hipe-through-the-inclusion-of-whey-protein-microgels
#2
Somayeh Zamani, Nicholas Malchione, Michael J Selig, Alireza Abbaspourrad
High internal phase emulsions (HIPE) prepared using whey protein microgels (WPMs) as a surfactant were demonstrated to have substantially higher stability than HIPEs prepared using similar loadings of non-gelled whey protein isolate (WPI) or Tween 20. Microgel colloids were prepared from WPI solutions by heat treatment at 85 °C in a narrow pH range (5.8-6.0) to particle sizes of approximately 90, 160 and 350 nm in diameter. ζ-potentials of the WPM increased in negativity with decreasing particle size from -7...
January 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29327416/comparative-proteomics-studies-of-insect-cuticle-by-tandem-mass-spectrometry-application-of-a-novel-proteomics-approach-to-the-pea-aphid-cuticular-proteins
#3
Masson Victor, Arafah Karim, Voisin Sébastien, Bulet Philippe
The exoskeleton of arthropods, called cuticle, is a biological composite material consisting principally of N-acetylglucosamine polymer embedded in cuticular proteins (CPs). The CPs have been studied and characterized by mass spectrometry in several cuticular structures and in many arthropods. Such analyses were usually carried out by protein extraction using SDS detergent followed by electrophoresis, allowing detection and identification of a large number of CPs. To build a repertoire of cuticular structures from Bombyx mori, Apis mellifera and Anopheles gambiae we avoided the use of SDS and electrophoresis...
January 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29327014/design-of-biomimetic-substrates-for-long-term-maintenance-of-alveolar-epithelial-cells
#4
James C H Poon, Zhongfa Liao, Takaya Suzuki, Miranda M Carleton, John P Soleas, J Stewart Aitchison, Golnaz Karoubi, Alison P McGuigan, Thomas K Waddell
There is a need to establish in vitro lung alveolar epithelial culture models to better understand the fundamental biological mechanisms that drive lung diseases. While primary alveolar epithelial cells (AEC) are a useful option to study mature lung biology, they have limited utility in vitro. Cells that survive demonstrate limited proliferative capacity and loss of phenotype over the first 3-5 days in traditional culture conditions. To address this limitation, we generated a novel physiologically relevant cell culture system for enhanced viability and maintenance of phenotype...
January 12, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29325094/functional-rescue-of-misfolding-abca3-mutations-by-small-molecular-correctors
#5
Susanna Kinting, Stefanie Höppner, Ulrike Schindlbeck, Maria E Forstner, Jacqueline Harfst, Thomas Wittmann, Matthias Griese
ABCA3, a phospholipid transporter in lung lamellar bodies (LB), is essential for the assembly of pulmonary surfactant and LB biogenesis. Mutations in the ABCA3 gene are an important genetic cause for respiratory distress syndrome in neonates and interstitial lung disease in children and adults, for which there is currently no cure.The aim of this study was to prove that disease causing misfolding ABCA3 mutations can be corrected in vitro and to investigate available options for correction.We stably expressed HA-tagged wild type ABCA3 or variants p...
January 9, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29324568/effects-of-pressure-support-ventilation-on-ventilator-induced-lung-injury-in-mild-acute-respiratory-distress-syndrome-depend-on-level-of-positive-end-expiratory-pressure
#6
Paulo A F Magalhães, Gisele de A Padilha, Lillian Moraes, Cíntia L Santos, Ligia de A Maia, Cassia L Braga, Maria do Carmo M B Duarte, Lívia B Andrade, Alberto Schanaider, Vera L Capellozzi, Robert Huhle, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva
BACKGROUND: Harmful effects of spontaneous breathing have been shown in experimental severe acute respiratory distress syndrome (ARDS). However, in the clinical setting, spontaneous respiration has been indicated only in mild ARDS. To date, no study has compared the effects of spontaneous assisted breathing with those of fully controlled mechanical ventilation at different levels of positive end-expiratory pressure (PEEP) on lung injury in ARDS. OBJECTIVE: To compare the effects of assisted pressure support ventilation (PSV) with pressure-controlled ventilation (PCV) on lung function, histology and biological markers at two different PEEP levels in mild ARDS in rats...
January 10, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29323902/maillard-conjugation-of-sodium-alginate-to-whey-protein-for-enhanced-resistance-to-surfactant-induced-competitive-displacement-from-air-water-interfaces
#7
Bingqing Cai, Anna Saito, Shinya Ikeda
Whey protein adsorbed to an interface forms a viscoelastic interfacial film but is displaced competitively from the interface by a small-molecule surfactant added afterward. The present study evaluated the impact of the covalent conjugation of high- or low-molecular-weight sodium alginate (HA or LA) to whey protein isolate (WPI) via the Maillard reaction on the ability of whey protein to resist surfactant-induced competitive displacement from the air-water interface. Surfactant added after the pre-adsorption of conjugate to the interface increased surface pressure...
January 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29311495/fluorescent-imaging-analysis-for-distribution-of-fluorescent-dye-labeled-or-encapsulated-liposome-in-monocrotaline-induced-pulmonary-hypertension-model-rat
#8
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured...
January 6, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29304723/adsorption-of-polypropylene-oxide-polyethylene-oxide-type-surfactants-at-surfaces-of-pharmaceutical-relevant-materials-effect-of-surface-energetics-and-surfactant-structures
#9
Jinjiang Li, Sneha Rudraraju, Songyan Zheng, Archana Jaiswal
Protein therapeutics are exposed to various surfaces during product development, where their adsorption possibly causes unfolding, denaturation, and aggregation. In this paper, we aim to characterize four types of typical surfaces used in the development of biologics: polycarbonate, polyethersulfone, borosilicate glass, and cellulose. Contact angles of these surfaces were measured using three probing liquids: water, formamide, and diidomethane, from which acid/base (AB) and Lifshitz-van der Waals (LW) interaction components were derived...
January 5, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29282698/elevated-surfactant-protein-levels-and-increased-flow-of-cerebrospinal-fluid-in-cranial-magnetic-resonance-imaging
#10
Stefan Schob, Alexander Weiß, Alexey Surov, Julia Dieckow, Cindy Richter, Mandy Pirlich, Diana Horvath-Rizea, Wolfgang Härtig, Karl-Titus Hoffmann, Matthias Krause, Ulf Quäschling
Surfactant proteins (SPs) are a multifunctional group of proteins, responsible for the regulation of rheological properties of body fluids, host defense, and cellular waste clearance. Their concentrations are changed in cerebrospinal fluid (CSF) of patients suffering from communicating hydrocephalus. Hydrocephalic conditions are accompanied by altered CSF flow dynamics; however, the association of CSF-SP concentrations and CSF flow has not yet been investigated. Hence, the aim of this study was to evaluate the association between SP concentrations in the CSF and marked CSF flow phenomena at different anatomical landmarks of CSF spaces...
December 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29281616/influence-of-type-of-congenital-heart-defects-on-epithelial-lining-fluid-composition-in-infants-undergoing-cardiac-surgery-with-cardiopulmonary-bypass
#11
Manuela Simonato, Aldo Baritussio, Virgilio P Carnielli, Luca Vedovelli, Gianclaudio Falasco, Michele Salvagno, Massimo Padalino, Paola Cogo
BACKGROUND: In children with congenital heart disease (CHD), altered pulmonary circulation compromises gas exchange. Moreover, pulmonary dysfunction is a complication of cardiac surgery with cardiopulmonary bypass (CPB). No data are available on the effect of different CHDs on lung injury. The aim of this study was to analyze epithelial lining fluid (ELF) surfactant composition in children with CHD. METHODS: Tracheal aspirates (TAs) from 72 CHD children [age 2.9 (0...
December 27, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29278744/quantification-of-surfactant-proteins-in-tears-of-patients-suffering-from-dry-eye-disease-compared-to-healthy-subjects
#12
Andreas Posa, Friedrich Paulsen, Richard Dietz, Fabian Garreis, Ralph Sander, Martin Schicht, Saadettin Sel, Michael Scholz, Christian M Hammer, Lars Bräuer
PURPOSE: To quantify and compare the amounts of surfactant proteins SP-A, SP-B, SP-C and SP-D in the tear fluid collected from patients with dry eye syndrome and from individuals with a healthy ocular surface. METHODS: Schirmer strips were used to collect tear fluid from both eyes of 241 volunteers (99 men, 142 women; age range: 18-87 years). Dry eye syndrome was diagnosed by ophthalmologists in 125 patients, whereas the healthy control group comprised 116 individuals...
December 24, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29276339/frog-foams-and-natural-protein-surfactants
#13
Alan Cooper, Steven J Vance, Brian O Smith, Malcolm W Kennedy
Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam nests of tropical frogs and other unusual sources. These proteins, and their associated foams, are relatively stable and bio-compatible, but with intriguing molecular structures that reveal a new class of surfactant activity. Here we review the structures and functional mechanisms of some of these proteins as revealed by experiments involving a range of biophysical and biochemical techniques, with additional mechanistic support coming from more recent site-directed mutagenesis studies...
December 5, 2017: Colloids and Surfaces. A, Physicochemical and Engineering Aspects
https://www.readbyqxmd.com/read/29274832/extremely-preterm-fetal-sheep-lung-responses-to-antenatal-steroids-and-inflammation
#14
Kevin Visconti, Paranthaman Senthamaraikannan, Matthew W Kemp, Masatoshi Saito, Boris W Kramer, John P Newnham, Alan H Jobe, Suhas G Kallapur
BACKGROUND: The efficacy of antenatal steroids for fetal lung maturation in the peri-viable period is not fully understood. OBJECTIVE(S): To determine the lung maturational effects of ANS and inflammation in early gestation sheep fetuses, similar to the peri-viable period in humans. STUDY DESIGN: Date-mated ewes with singleton fetuses were randomly assigned to one of 4 treatment groups (n=8/group): 1) maternal intramuscular injection (IM) of betamethasone (Beta), 2) intra-amniotic lipopolysaccharide (IA) (LPS), 3) Beta+LPS, 4) IA+IM Saline (controls)...
December 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29262357/myoglobin-and-%C3%AE-lactalbumin-form-smaller-complexes-with-the-biosurfactant-rhamnolipid-than-with-sds
#15
Henriette Gavlshøj Mortensen, Jens Kvist Madsen, Kell K Andersen, Thomas Vosegaard, G Roshan Deen, Daniel E Otzen, Jan Skov Pedersen
Biosurfactants (BSs) attract increasing attention as sustainable alternatives to petroleum-derived surfactants. This necessitates structural insight into how BSs interact with proteins encountered by current chemical surfactants. Thus, small-angle x-ray scattering (SAXS) has been used for studying the structures of complexes made of the proteins α-Lactalbumin (αLA) and myoglobin (Mb) with the biosurfactant rhamnolipid (RL). For comparison, complexes between αLA and the chemical surfactant sodium dodecyl sulfate (SDS) were also investigated...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29251807/proteomic-diversity-of-high-density-lipoprotein-explains-its-association-with-clinical-outcome-in-patients-with-heart-failure
#16
Johanna Elisabeth Emmens, Donald J L Jones, Thong H Cao, Daniel C S Chan, Simon P R Romaine, Paulene A Quinn, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Hans L Hillege, Chim C Lang, Piotr Ponikowski, Nilesh J Samani, Dirk J van Veldhuisen, Faiz Zannad, Aeilko H Zwinderman, Marco Metra, Rudolf A de Boer, Adrian A Voors, Leong L Ng
AIMS: Previously, low high-density lipoprotein (HDL) cholesterol was found to be one of the strongest predictors of mortality and/or heart failure (HF) hospitalisation in patients with HF. We therefore performed in-depth investigation of the multifunctional HDL proteome to reveal underlying pathophysiological mechanisms explaining the association between HDL and clinical outcome. METHODS AND RESULTS: We selected a cohort of 90 HF patients with 1:1 cardiovascular death/survivor ratio from BIOSTAT-CHF...
December 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29250453/pulmonary-neuroendocrine-cell-hyperplasia-associated-with-surfactant-protein-c-gene-mutation
#17
Norlalak Jiramethee, David Erasmus, Lawrence Nogee, Andras Khoor
Familial interstitial lung disease (ILD) is defined as presence of ILD in 2 or more family members. Surfactant protein C (SFTPC) gene mutations are rare, but well-known cause of familial ILD. We reported a 20-year-old male, who was referred for lung transplantation. He was symptomatic at age 3 and underwent surgical lung biopsy at age 6, which revealed a nonspecific interstitial pneumonia (NSIP) pattern. Genetic workup revealed a novel SFTPC mutation in the first intron with a C to A transversion. At age 21, he underwent bilateral lung transplantation...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/29246663/secretory-lipase-from-the-human-pathogen-leishmania-major-heterologous-expression-in-the-yeast-pichia-pastoris-and-biochemical-characterization
#18
Saoussen Ben Ayed, Madiha Bou Ali, Aymen Bali, Youssef Gargouri, Dhafer Laouini, Yassine Ben Ali
Leishmaniasis is a parasitic reticuloendotheliosis whose pathogen is a zooflagellate belonging to the genus Leishmania transmitted by the bite of an infected phlebotome. Recently, a unique secretory lipase from the human pathogen Leishmania donovani Ldlip3 has been identified and characterized. This lipase has a high identity with a putative triacylglycerol lipase of Leishmania major (Lmlip2). In the present study, Lmlip2 was expressed in the eukaryotic heterologous expression system Pichia pastoris as tagged enzyme of 308 amino acids...
December 12, 2017: Biochimie
https://www.readbyqxmd.com/read/29246207/plasma-surfactant-protein-d-as-a-diagnostic-biomarker-for-acute-respiratory-distress-syndrome-validation-in-us-and-korean-cohorts
#19
Jinkyeong Park, Maria Pabon, Augustine M K Choi, Ilias I Siempos, Laura E Fredenburgh, Rebecca M Baron, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Chi-Min Park, Gee Young Suh
BACKGROUND: Acute respiratory distress syndrome (ARDS) is potentially underrecognized by clinicians. Early recognition and subsequent optimal treatment of patients with ARDS may be facilitated by usage of biomarkers. Surfactant protein D (SP-D), a marker of alveolar epithelial injury, has been proposed as a potentially useful biomarker for diagnosis of ARDS in a few studies. We tried to validate the performance of plasma SP-D levels for diagnosis of ARDS. METHODS: We conducted a retrospective analysis using data from three (two in USA and one in Korea) prospective biobank cohorts involving 407 critically ill patients admitted to medical intensive care unit (ICU)...
December 15, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29233681/studies-on-the-development-of-antibodies-for-the-highly-hydrophobic-plasticizers-dinch-and-deht
#20
Stefanie Baldofski, Carsten Jörg Canitz, Leif-Alexander Garbe, Rudolf J Schneider
Diisononylcyclohexane-1,2-dicarboxylate (DINCH) and di-2-ethylhexyl terephthalate (DEHT), two of the most important substitutes for phthalate plasticizers, are used for a wide range of applications. Consequently, an increasing occurrence in urine and environmental samples is reported. Reliable and fast analytical methods for the quantification of these plasticizers are needed. So far, mainly GC-MS or LC-MS methods are used. We aimed to develop the first antibodies and immunoassays allowing for high-throughput analysis of samples...
December 9, 2017: Analytical Biochemistry
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