Wanying Yang, Wujian Li, Wujie Zhou, Shen Wang, Weiqi Wang, Zhenshan Wang, Na Feng, Tiecheng Wang, Ying Xie, Yongkun Zhao, Feihu Yan, Xianzhu Xia
The Ebola virus (EBOV) is a member of the Orthoebolavirus genus, Filoviridae family, which causes severe hemorrhagic diseases in humans and non-human primates (NHPs), with a case fatality rate of up to 90%. The development of countermeasures against EBOV has been hindered by the lack of ideal animal models, as EBOV requires handling in biosafety level (BSL)-4 facilities. Therefore, accessible and convenient animal models are urgently needed to promote prophylactic and therapeutic approaches against EBOV. In this study, a recombinant vesicular stomatitis virus expressing Ebola virus glycoprotein (VSV-EBOV/GP) was constructed and applied as a surrogate virus, establishing a lethal infection in hamsters...
March 29, 2024: Virologica Sinica