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https://www.readbyqxmd.com/read/29334553/post-treatment-controllers-after-treatment-interruption-in-chronically-hiv-infected-patients
#1
Franco Maggiolo, Elisa Di Filippo, Laura Comi, Annapaola Callegaro
OBJECTIVE: Control HIV replication requires continuous combined antiretroviral therapy (cART) as discontinuation of cART results in a rapid viral rebound. However, a few individuals exist who took cART for several years and did not show the expected viral rebound after treatment cessation. Most post-treatment controllers (PTCs) are early treated individuals. We report three cases who started cART during chronic infection. DESIGN: Patients were treated and monitored according to Italian guidelines...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334551/rapid-decline-of-hiv-1-dna-and-rna-in-infants-starting-very-early-art-may-pose-a-diagnostic-challenge
#2
Kirsten A Veldsman, Jean Maritz, Shahieda Isaacs, Mary Grace Katusiime, Anita Janse Van Rensburg, Barbara Laughton, John W Mellors, Mark F Cotton, Gert U van Zyl
OBJECTIVE: Birth diagnosis of HIV-1 infection offers an ideal opportunity for early antiretroviral treatment (ART) to limit HIV-1 reservoir size and limit disease progression. Although data on cellular HIV-1 DNA decay exist for children commencing treatment from 2-3 months of age, data is lacking for starting shortly after birth. DESIGN: We studied infants who initiated ART within 8 days after birth to assess HIV-1 DNA levels longitudinally. METHODS: Children were recruited from public health clinics in Cape Town where birth diagnosis of HIV-1 coupled with early ART initiation occurred...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334550/chronic-hepatitis-c-virus-infection-and-subsequent-hiv-viral-load-among-women-with-hiv-initiating-antiretroviral-therapy
#3
Sarah J Willis, Stephen R Cole, Daniel Westreich, Andrew Edmonds, Christopher B Hurt, Svenja Albrecht, Kathryn Anastos, Michael Augenbraun, Margaret Fischl, Audrey L French, Aley G Kalapila, Roksana Karim, Marion G Peters, Michael Plankey, Eric C Seaberg, Phyllis C Tien, Adaora A Adimora
OBJECTIVE(S): One in four persons living with HIV is coinfected with HCV. Biological and behavioral mechanisms may increase HIV viral load among coinfected persons. Therefore, we estimated the longitudinal effect of chronic HCV on HIV suppression after ART initiation among women with HIV (WWH). DESIGN: HIV RNA was measured every six months among 441 WWH in the Women's Interagency HIV Study who initiated ART from 2000-2015. METHODS: Log-binomial regression models were used to compare the proportion of study visits with detectable HIV RNA between women with and without chronic HCV...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334547/quality-of-life-improvement-in-resource-limited-settings-after-one-year-of-second-line-antiretroviral-therapy-use-among-adult-men-and-women
#4
Thiago S Torres, Linda J Harrison, Alberto M La Rosa, Sandra W Cardoso, Lu Zheng, McNeil Ngongondo, Fatma Some, Umesh G Lalloo, Thando Mwelase, Ann C Collier, Michael D Hughes
OBJECTIVE: We evaluated improvement of quality of life (QoL) after one year of second-line antiretroviral therapy (ART) use in resource-limited settings (RLS) among adult men and women, comparing two randomized treatment arms. DESIGN: ACTG A5273 was a randomized clinical trial of second-line ART comparing lopinavir/ritonavir (LPV/r) + raltegravir (RAL) with LPV/r + nucleos(t)ide reverse transcriptase inhibitors (NRTIs) in participants failing a non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimen at 15 sites in 9 RLS...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334546/impact-of-early-antiretroviral-therapy-eligibility-on-hiv-acquisition-household-level-evidence-from-rural-south-africa
#5
Catherine E Oldenburg, Jacob Bor, Guy Harling, Frank Tanser, Tinofa Mutevedzi, Maryam Shahmanesh, George R Seage, Victor De Gruttola, Matthew J Mimiaga, Kenneth H Mayer, Deenan Pillay, Till Bärnighausen
OBJECTIVES: We investigate the effect of immediate ART eligibility on HIV incidence among HIV-uninfected household members. DESIGN: Regression discontinuity study arising from a population-based cohort. METHODS: Household members of patients seeking care at the Hlabisa HIV Treatment and Care Programme in rural KwaZulu-Natal South Africa between January 2007 and August 2011 with CD4 counts up to 350 cells/μl were eligible for inclusion if they had at least two HIV tests and were HIV-uninfected at the time the index patient linked to care (N = 4,115)...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29334197/increased-non-aids-mortality-among-persons-with-aids-defining-events-after-antiretroviral-therapy-initiation
#6
April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling
INTRODUCTION: HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS: We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART from 1996 to 2014. Causes of death were assigned using the Coding Causes of Death in HIV (CoDe) protocol...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29331972/cohort-profile-the-comparative-outcomes-and-service-utilization-trends-coast-study-among-people-living-with-and-without-hiv-in-british-columbia-canada
#7
Oghenowede Eyawo, Mark W Hull, Kate Salters, Hasina Samji, Angela Cescon, Paul Sereda, Viviane D Lima, Bohdan Nosyk, David G T Whitehurst, Scott A Lear, Julio S G Montaner, Robert S Hogg
PURPOSE: The Comparative Outcomes And Service Utilization Trends (COAST) Study in British Columbia (BC), Canada, was designed to evaluate the determinants of health outcomes and health care services use among people living with HIV (PLHIV) as they age in the period following the introduction of combination antiretroviral therapy (cART). The study also assesses how age-associated comorbidities and health care use among PLHIV may differ from those observed in the general population. PARTICIPANTS: COAST was established through a data linkage between two provincial data sources: The BC Centre for Excellence in HIV/AIDS Drug Treatment Program, which centrally manages cART dispensation across BC and contains prospectively collected data on demographic, immunological, virological, cART use and other clinical information for all known PLHIV in BC; and Population Data BC, a provincial data repository that holds individual event-level, longitudinal data for all 4...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29330308/survival-outcomes-of-primary-cutaneous-t-cell-lymphoma-in-hiv-infected-patients-a-national-population-based-study
#8
Jianhong Wang, Rong Liang, Caixia Hao, Xiangxiang Liu, Na Zhang, Xiaohui Duan, Hongjuan Dong, Baoxia Dong, Hongtao Gu, Guangxun Gao, Tao Zhang, Qingxian Bai, Xiequn Chen
This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected and non-HIV-infected patients. All data were from the Surveillance, Epidemiology, and End Results program, 1973-2013, of the U.S. National Cancer Institute. Data of 318 HIV-infected patients and 1272 non-HIV-infected patients with primary CTCL were analyzed. Endpoints were overall survival and cancer-specific mortality. Independent variables included demographics, pre-existing malignancy, treatments, and environmental factors...
January 12, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29330173/seasonal-variations-in-tuberculosis-diagnosis-among-hiv-positive-individuals-in-southern-africa-analysis-of-cohort-studies-at-antiretroviral-treatment-programmes
#9
Marie Ballif, Kathrin Zürcher, Stewart E Reid, Andrew Boulle, Matthew P Fox, Hans W Prozesky, Cleophas Chimbetete, Marcel Zwahlen, Matthias Egger, Lukas Fenner
OBJECTIVES: Seasonal variations in tuberculosis diagnoses have been attributed to seasonal climatic changes and indoor crowding during colder winter months. We investigated trends in pulmonary tuberculosis (PTB) diagnosis at antiretroviral therapy (ART) programmes in Southern Africa. SETTING: Five ART programmes participating in the International Epidemiology Database to Evaluate AIDS in South Africa, Zambia and Zimbabwe. PARTICIPANTS: We analysed data of 331 634 HIV-positive adults (>15 years), who initiated ART between January 2004 and December 2014...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29329940/cardiovascular-risk-reduction-in-persons-living-with-hiv-treatment-development-feasibility-and-preliminary-results
#10
Patricia A Cioe, Kate M Guthrie, Matthew S Freiberg, David M Williams, Christopher W Kahler
Persons living with HIV (PLWH) have elevated risks for cardiovascular disease (CVD). Our goal was to develop and pilot test a tailored intervention to improve CVD risk perception and the adoption of heart-healthy behaviors. In-depth qualitative interviews were conducted with 30 PLWH participants to examine learning needs and preferences. An intervention manual was developed and tested in an open pilot with eight participants. Participants were stable on antiretroviral therapy and were recruited from two urban HIV clinics in the northeastern United States...
December 5, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29329553/inhibitors-of-the-integrase-transportin-sr2-interaction-block-hiv-nuclear-import
#11
Jonas Demeulemeester, Jolien Blokken, Stéphanie De Houwer, Lieve Dirix, Hugo Klaassen, Arnaud Marchand, Patrick Chaltin, Frauke Christ, Zeger Debyser
BACKGROUND: Combination antiretroviral therapy efficiently suppresses HIV replication in infected patients, transforming HIV/AIDS into a chronic disease. Viral resistance does develop however, especially under suboptimal treatment conditions such as poor adherence. As a consequence, continued exploration of novel targets is paramount to identify novel antivirals that do not suffer from cross-resistance with existing drugs. One new promising class of targets are HIV protein-cofactor interactions...
January 12, 2018: Retrovirology
https://www.readbyqxmd.com/read/29329396/patient-level-benefits-associated-with-decentralization-of-antiretroviral-therapy-services-to-primary-health-facilities-in-malawi-and-uganda
#12
George Abongomera, Levison Chiwaula, Paul Revill, Travor Mabugu, Edward Tumwesige, Misheck Nkhata, Fabian Cataldo, J van Oosterhout, Robert Colebunders, Adrienne K Chan, Cissy Kityo, Charles Gilks, James Hakim, Janet Seeley, Diana M Gibb, Deborah Ford
Background: The Lablite project captured information on access to antiretroviral therapy (ART) at larger health facilities ('hubs') and lower-level health facilities ('spokes') in Phalombe district, Malawi and in Kalungu district, Uganda. Methods: We conducted a cross-sectional survey among patients who had transferred to a spoke after treatment initiation (Malawi, n=54; Uganda, n=33), patients who initiated treatment at a spoke (Malawi, n=50; Uganda, n=44) and patients receiving treatment at a hub (Malawi, n=44; Uganda, n=46)...
January 10, 2018: International Health
https://www.readbyqxmd.com/read/29329301/estimated-mortality-on-hiv-treatment-among-active-patients-and-patients-lost-to-follow-up-in-4-provinces-of-zambia-findings-from-a-multistage-sampling-based-survey
#13
Charles B Holmes, Izukanji Sikazwe, Kombatende Sikombe, Ingrid Eshun-Wilson, Nancy Czaicki, Laura K Beres, Njekwa Mukamba, Sandra Simbeza, Carolyn Bolton Moore, Cardinal Hantuba, Peter Mwaba, Caroline Phiri, Nancy Padian, David V Glidden, Elvin Geng
BACKGROUND: Survival represents the single most important indicator of successful HIV treatment. Routine monitoring fails to capture most deaths. As a result, both regional assessments of the impact of HIV services and identification of hotspots for improvement efforts are limited. We sought to assess true mortality on treatment, characterize the extent under-reporting of mortality in routine health information systems in Zambia, and identify drivers of mortality across sites and over time using a multistage, regionally representative sampling approach...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29329280/status-of-hiv-epidemic-control-among-adolescent-girls-and-young-women-aged-15-24-years-seven-african-countries-2015-2017
#14
Kristin Brown, Daniel B Williams, Steve Kinchen, Suzue Saito, Elizabeth Radin, Hetal Patel, Andrea Low, Stephen Delgado, Owen Mugurungi, Godfrey Musuka, Beth A Tippett Barr, E Amaka Nwankwo-Igomu, Leala Ruangtragool, Avi J Hakim, Thokozani Kalua, Rose Nyirenda, Gertrude Chipungu, Andrew Auld, Evelyn Kim, Danielle Payne, Nellie Wadonda-Kabondo, Christine West, Elizabeth Brennan, Beth Deutsch, Anteneh Worku, Sasi Jonnalagadda, Lloyd B Mulenga, Kumbutso Dzekedzeke, Danielle T Barradas, Haotian Cai, Sundeep Gupta, Stanley Kamocha, Margaret A Riggs, Karampreet Sachathep, Wilford Kirungi, Joshua Musinguzi, Alex Opio, Sam Biraro, Elizabeth Bancroft, Jennifer Galbraith, Herbert Kiyingi, Mansoor Farahani, Wolfgang Hladik, Edith Nyangoma, Choice Ginindza, Zandile Masangane, Fortune Mhlanga, Zandile Mnisi, Pasipamire Munyaradzi, Amos Zwane, Sean Burke, Felix B Kayigamba, Harriet Nuwagaba-Biribonwoha, Ruben Sahabo, Trong T Ao, Chiara Draghi, Caroline Ryan, Neena M Philip, Fausta Mosha, Aroldia Mulokozi, Phausta Ntigiti, Angela A Ramadhani, Geoffrey R Somi, Cecilia Makafu, Veronicah Mugisha, Julius Zelothe, Kayla Lavilla, David W Lowrance, Rennatus Mdodo, Elizabeth Gummerson, Paul Stupp, Kyaw Thin, Koen Frederix, Stefania Davia, Amee M Schwitters, Stephen D McCracken, Yen T Duong, David Hoos, Bharat Parekh, Jessica E Justman, Andrew C Voetsch
In 2016, an estimated 1.5 million females aged 15-24 years were living with human immunodeficiency virus (HIV) infection in Eastern and Southern Africa, where the prevalence of HIV infection among adolescent girls and young women (3.4%) is more than double that for males in the same age range (1.6%) (1). Progress was assessed toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2020 targets for adolescent girls and young women in sub-Saharan Africa (90% of those with HIV infection aware of their status, 90% of HIV-infected persons aware of their status on antiretroviral treatment [ART], and 90% of those on treatment virally suppressed [HIV viral load <1,000 HIV RNA copies/mL]) (2) using data from recent Population-based HIV Impact Assessment (PHIA) surveys in seven countries...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29327783/nonsurgical-management-of-human-immunodeficiency-virus-associated-parotid-cysts-a-systematic-review-and-meta-analysis
#15
Akash N Naik, William B Clinkscales, Masanari G Kato, Shaun A Nguyen, M Boyd Gillespie
BACKGROUND: The purpose of this clinical review was to analyze the effectiveness of nonsurgical management options for human immunodeficiency virus (HIV)-associated parotid cysts. METHODS: We conducted systematic and meta-analysis reviews. Primary outcomes were complete or partial responses. RESULTS: Systematic review identified 12 relevant studies. The average rates of complete response for antiretroviral therapy (ART), sclerotherapy, and fine-needle aspiration (FNA) were 52...
January 12, 2018: Head & Neck
https://www.readbyqxmd.com/read/29327520/risk-factors-of-clinical-and-immunological-failure-in-south-indian-cohort-on-generic-antiretroviral-therapy
#16
Mucheli Shravan Sadashiv, Priscilla Rupali, Abi Manesh, Rajesh Kannangai, Ooriapadickal Cherian Abraham, Susanne A Pulimood, Rajiv Karthik, S Rajkumar, Kurien Thomas
Background: Since the time of NACO Antiretroviral (ART) roll-out, generic ART has been the mainstay of therapy. There are many studies documenting the efficacy of generic ART but with the passage of time, failure of therapy is on the rise. As institution of second line ART has significant financial implications both for a program and for an individual it is imperative that we determine factors which contribute towards treatment failure in a cohort of patients on generic antiretroviral therapy...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29327419/treatment-interruption-in-hiv-positive-patients-followed-up-in-cameroon-s-antiretroviral-treatment-program-individual-and-healthcare-supply-related-factors-anrs-12288-evolcam-survey
#17
Christelle Tong, Marie Suzan-Monti, Luis Sagaon-Teyssier, Mohamed Mimi, Christian Laurent, Gwenaëlle Maradan, Marie-Thérèse Mengue, Bruno Spire, Christopher Kuaban, Laurent Vidal, Sylvie Boyer
INTRODUCTION: Decreasing international financial resources for HIV and increasing numbers of antiretroviral treatment (ART) treated patients may jeopardize treatment continuity in low income settings. Using data from the EVOLCam ANRS-12288 survey, this study aimed to document the prevalence of unplanned treatment interruption for more than 2 consecutive days (TI>2d) and investigate associated individual and healthcare supply-related factors within the Cameroonian ART Program. METHODS: A cross-sectional mixed methods survey was carried out between April and December 2014 in 19 HIV services of the Center and Littoral regions...
January 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29327397/translating-international-hiv-treatment-guidelines-into-local-priorities-in-indonesia
#18
Noor Tromp, Rozar Prawiranegara, Adiatma Siregar, Rudi Wisaksana, Lucas Pinxten, Juul Pinxten, Arry Lesmana Putra, Deni Sunjaya Lesmana, Maarten Jansen, Jan Hontelez, Scott Maurits, Febrina Maharani, Leon Bijlmakers, Rob Baltussen
OBJECTIVE: International guidelines recommend countries to expand Antiretroviral therapy (ART) to all HIV-infected individuals and establish local-level priorities in relation to other treatment, prevention and mitigation interventions through fair processes. However, no practical guidance is provided for such priority setting processes. Evidence-informed deliberative processes (EDPs) fill this gap and combine stakeholder deliberation to incorporate relevant social values with rational decision-making informed by evidence on these values...
January 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29325435/early-stages-of-hiv-treatment-cascade-in-people-living-with-hiv-in-saint-petersburg-russia
#19
M V Vetrova, O V Aleksandrova, A E Paschenko, S E Toropov, V V Rassokhin, R A Abyshev, O S Levina, L M Niccolai, R Heimer
The proportion of people living with HIV (PLWH) in need of antiretroviral therapy (ART) is growing rapidly in Russia. Successful treatment outcomes reduces disease progression and contributes to HIV epidemic control. We conducted a pilot study following 100 PLWH newly found eligible for ART in St. Petersburg, Russia. We determined the proportion of PLWH who initiated ART, remained in treatment, and achieved an undetectable VL during 6-month follow up. Semi-structured interviews were conducted prior the initiation of ART and progress along the cascade was assessed through medical chart review...
January 11, 2018: AIDS Care
https://www.readbyqxmd.com/read/29324842/effect-of-analytical-treatment-interruption-and-reinitiation-of-antiretroviral-therapy-on-hiv-reservoirs-and-immunologic-parameters-in-infected-individuals
#20
Katherine E Clarridge, Jana Blazkova, Kevin Einkauf, Mary Petrone, Eric W Refsland, J Shawn Justement, Victoria Shi, Erin D Huiting, Catherine A Seamon, Guinevere Q Lee, Xu G Yu, Susan Moir, Michael C Sneller, Mathias Lichterfeld, Tae-Wook Chun
Therapeutic strategies aimed at achieving antiretroviral therapy (ART)-free HIV remission in infected individuals are under active investigation. Considering the vast majority of HIV-infected individuals experience plasma viral rebound upon cessation of therapy, clinical trials evaluating the efficacy of curative strategies would likely require inclusion of ART interruption. However, it is unclear what impact short-term analytical treatment interruption (ATI) and subsequent reinitiation of ART have on immunologic and virologic parameters of HIV-infected individuals...
January 2018: PLoS Pathogens
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