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https://www.readbyqxmd.com/read/27906479/knowledge-and-practice-in-cardiovascular-disease-prevention-among-hospital-registered-nurses-a-cross-sectional-study
#1
Shu Ding, Ying Deng, Sai Lu, Karen V Lamb, Ying Zhang, Ying Wu
AIMS AND OBJECTIVES: To investigate the knowledge and clinical practices of cardiovascular disease (CVD) prevention among registered nurses (RNs) who worked on three major clinical units in Beijing hospitals. BACKGROUND: Health education on CVD prevention is an important component of nursing practice, however, Chinese RNs' knowledge and practice patterns have been poorly explored in previous studies. DESIGN: A cross-sectional study. METHODS: A stratified random sample of three hundred RNs was recruited from two tertiary hospitals in Beijing, China...
December 1, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27906397/a-room-temperature-environmentally-friendly-solution-process-to-assemble-silver-nanowire-architectures-for-flexible-transparent-electrodes
#2
Ye Yang, Jin-Long Wang, Lei Liu, Zhi-Hua Wang, Jian-Wei Liu, Shu-Hong Yu
In this study, we present a room-temperature environmentally friendly solution process to optimize the performance of the flexible transparent electrodes by co-assembling Ag nanowires and CaCO3 nanowires, and then etching CaCO3 nanowires away, leaving Ag nanowire networks with controllable optical transparency and electrical conductivity. The obtained Ag nanowire flexible transparent electrodes exhibit an averaged transmittance of up to 90% when the sheet resistance is 70 Ω sq(-1) which shows no degradation even after 2000 cycles of fatigue test, indicating their excellent mechanical flexibility and stability...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27905552/protonation-enhancement-by-dichloromethane-doping-in-low-pressure-photoionization
#3
Jinian Shu, Yao Zou, Ce Xu, Zhen Li, Wanqi Sun, Bo Yang, Haixu Zhang, Peng Zhang, Pengkun Ma
Doping has been used to enhance the ionization efficiency of analytes in atmospheric pressure photoionization, which is based on charge exchange. Compounds with excellent ionization efficiencies are usually chosen as dopants. In this paper, we report a new phenomenon observed in low-pressure photoionization: Protonation enhancement by dichloromethane (CH2Cl2) doping. CH2Cl2 is not a common dopant due to its high ionization energy (11.33 eV). The low-pressure photoionization source was built using a krypton VUV lamp that emits photons with energies of 10...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905049/radiofrequency-ablation-vs-microwave-ablation-for-patients-with-benign-thyroid-nodules-a-propensity-score-matching-study
#4
Wen-Wen Yue, Shu-Rong Wang, Feng Lu, Li-Ping Sun, Le-Hang Guo, Yong-Lin Zhang, Xiao-Long Li, Hui-Xiong Xu
PURPOSE: To compare the efficacy and the safety of radiofrequency ablation and microwave ablation for treatment of benign thyroid nodules using a propensity score matching study design. METHODS: Two hundred and sixty patients with benign thyroid nodules were studied retrospectively, including 102 patients treated with radiofrequency ablation and 158 treated with microwave ablation. To reduce confounding bias due to retrospective assignment, propensity score matching was performed to balance the preablation data of the two groups...
November 30, 2016: Endocrine
https://www.readbyqxmd.com/read/27904655/increased-set1-binding-at-the-promoter-induces-aberrant-epigenetic-alterations-and-up-regulates-cyclic-adenosine-5-monophosphate-response-element-modulator-alpha-in-systemic-lupus-erythematosus
#5
Qing Zhang, Shu Ding, Huilin Zhang, Hai Long, Haijing Wu, Ming Zhao, Vera Chan, Chak-Sing Lau, Qianjin Lu
BACKGROUND: Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). This research aimed to investigate the mechanisms regulating CREMα expression in SLE. RESULTS: From the chromatin immunoprecipitation (ChIP) microarray data, we found a sharply increased H3 lysine 4 trimethylation (H3K4me3) amount at the CREMα promoter in SLE CD4+ T cells compared to controls...
2016: Clinical Epigenetics
https://www.readbyqxmd.com/read/27903967/new-differentially-expressed-genes-and-differential-dna-methylation-underlying-refractory-epilepsy
#6
Xi Liu, Shu Ou, Tao Xu, Shiyong Liu, Jinxian Yuan, Hao Huang, Lu Qin, Hui Yang, Lifen Chen, Xinjie Tan, Yangmei Chen
Epigenetics underlying refractory epilepsy is poorly understood, especially in patients without distinctive genetic alterations. DNA methylation may affect gene expression in epilepsy without affecting DNA sequences. Herein, we analyzed genome-wide DNA methylation and gene expression in brain tissues of 10 patients with refractory epilepsy using methylated DNA immunoprecipitation linked with sequencing and mRNA Sequencing. Diverse distribution of differentially methylated genes was found in X chromosome, while differentially methylated genes appeared rarely in Y chromosome...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903300/inhaled-nitric-oxide-and-the-risk-of-renal-dysfunction-in-patients-with-acute-respiratory-distress-syndrome-a-propensity-matched-cohort-study
#7
Sheng-Yuan Ruan, Hon-Yen Wu, Hsien-Ho Lin, Huey-Dong Wu, Chong-Jen Yu, Mei-Shu Lai
BACKGROUND: Inhaled nitric oxide (iNO) is a rescue therapy for severe hypoxemia in patients with acute respiratory distress syndrome (ARDS). Pooled data from clinical trials have signaled a renal safety warning for iNO therapy, but the significance of these findings in daily clinical practice is unclear. We used primary data to evaluate the risk of iNO-associated renal dysfunction in patients with ARDS. METHODS: We conducted a cohort study using data from a tertiary teaching hospital to evaluate the risk of incident renal replacement therapy (RRT) in iNO users compared with that of non-users...
November 30, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27903094/effects-of-self-complementarity-codon-optimization-transgene-and-dose-on-liver-transduction-with-aav8
#8
Peter Bell, Lili Wang, Shu-Jen Chen, Hongwei Yu, Yanqing Zhu, Mohamad Nayal, Zhenning He, John White, Deborah Lebel-Hagan, James M Wilson
Numerous methods of vector design and delivery have been employed in an attempt to increase transgene expression following AAV-based gene therapy. Here, we conducted a gene transfer study in mice to compare the effects of vector self-complementarity (double- or single-stranded DNA), codon optimization of the transgene, and vector dose on transgene expression levels in liver. Two different reporter genes were used: human ornithine transcarbamylase (hOTC) detected by immunofluorescence, and enhanced green fluorescent protein (EGFP) detected by direct fluorescence...
November 30, 2016: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/27902621/total-laparoscopic-right-hemicolectomy-with-3-step-stapled-intracorporeal-isoperistaltic-ileocolic-anastomosis-for-colon-cancer-an-evaluation-of-short-term-outcomes
#9
Tu Jian-Cheng, Wang Shu-Sheng, Zhang Bo, Fang Jian, Zhou Liang
Laparoscopic right hemicolectomy with extracorporeal anastomosis is a widely used procedure; several authors have published their approach to intracorporeal anastomosis. In this paper, we present an approach developed by us and compare short-term outcomes with those of extracorporeal anastomosis in colon cancer patients.Retrospective review of colon cancer patients treated with laparoscopic right hemicolectomy either with intracorporeal anastomosis (TLG group) or extracorporeal anastomosis (LG group) at the Zhangjiagang Hospital Affiliated to Soochow University between January 2011 and October 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27902495/methodological-evaluation-of-the-noninvasive-estimation-of-central-systolic-blood-pressure-in-nontreated-patients-the-bogalusa-heart-study
#10
Camilo Fernandez, Robert Hsu, Gary Sander, Azad Hussain, Rupert Barshop, Shengxu Li, Tian Shu, Tao Zhang, Patrycja Galazka, Wei Chen, Lydia Bazzano, Thomas D Giles
OBJECTIVES: This study sought to compare the estimation of central systolic blood pressure (cSBP) obtained by two different noninvasive devices, in addition to its comparisons with measured peripheral systolic blood pressure (pSBP), in a biracial (Black/White) community-based cohort. PARTICIPANTS AND METHODS: Estimations of cSBP by applanation tonometry were obtained in 586 participants of the Bogalusa Heart Study (mean age: 43.5 years; 69% White, 54% women) using two different commonly used instruments: Omron HEM-9000AI and SphygmoCor CPV...
November 29, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27902478/a-retrospective-clinical-study-of-comparing-paclitaxel-plus-s-1-versus-paclitaxel-plus-cisplatin-as-the-first-line-treatment-for-patients-with-advanced-esophageal-squamous-cell-carcinoma
#11
Hai-Ying Wang, Zhi-Hua Yao, Hong Tang, Yan Zhao, Shui-Ling Jin, Wen-Ping Zhou, Shu-Na Yao, Shu-Jun Yang, Yan-Yan Liu, Su-Xia Luo
BACKGROUND: In advanced esophageal squamous cell carcinoma (ESCC), paclitaxel plus cisplatin are considered as active and tolerable. The current clinical study was conducted to retrospectively compare the efficacy and safety of first-line paclitaxel/S-1(PS) and paclitaxel/cisplatin(TP) regimens in advanced ESCC. RESULTS: The overall response rate of PS was slightly, but not significantly, higher (25 patients, 46%) than that of TP (23 patients, 39%, P = 0.432). Median overall survival (OS) was similar for PS and TP (11...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27902477/astragalus-polysaccharide-restores-autophagic-flux-and-improves-cardiomyocyte-function-in-doxorubicin-induced-cardiotoxicity
#12
Yuan Cao, Tao Shen, Xiuqing Huang, Yajun Lin, Beidong Chen, Jing Pang, Guoping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li
Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. However, whether APS could mitigate chemotherapy-induced cardiotoxicity is unclear thus far. We used a doxorubicin-induced neonatal rat cardiomyocyte injury model and a mouse heart failure model to explore the function of APS...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901498/targeting-the-vegf-c-vegfr3-axis-suppresses-slug-mediated-cancer-metastasis-and-stemness-via-inhibition-of-kras-yap1-signaling
#13
REVIEW
Yu-Wen Yeh, Ching-Chia Cheng, Shu-Ting Yang, Chi-Feng Tseng, Ting-Yu Chang, Sin-Ying Tsai, Earl Fu, Chien-Ping Chiang, Li-Chuan Liao, Pei-Wen Tsai, Yung-Luen Yu, Jen-Liang Su
Vascular endothelial growth factor-C (VEGF-C) has been implicated in epithelial-mesenchymal transition (EMT) processes and various human cancers, including skin cancer. Skin cancer is an aggressive human malignancy with increasing incidence worldwide; however, the underlying mechanisms involved in VEGF-C-induced skin cancer stemness and metastasis remain unclear. Here, we report that VEGF-C enhances skin cancer migration, invasion and stemness through Slug up-regulation. Oncomine database analysis indicated that the KRAS/MAPK (mitogen-activated protein kinases) pathway and YAP1 (yes-associated protein 1) expression are positively correlated with metastatic skin cancer...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901095/analgesic-effect-and-safety-of-single-dose-intra-articular-magnesium-after-arthroscopic-surgery-a-systematic-review-and-meta-analysis
#14
Chao Zeng, Yu-Sheng Li, Jie Wei, Dong-Xing Xie, Xi Xie, Liang-Jun Li, Shu-Guang Gao, Wei Luo, Yi-Lin Xiong, Wen-Feng Xiao, Guang-Hua Lei
To examine the analgesic effect and safety of single-dose intra-articular (IA) magnesium (Mg) after arthroscopic surgery. Pubmed, Embase and Cochrane library were searched through in January 2016. Eight RCTs and eight experimental studies were included. The IA Mg exhibited a significantly lower pain score when compared with placebo (MD, -0.41, 95% CI, -0.78 to -0.05, p = 0.03). There was no significant difference between Mg and bupivacaine in terms of pain relief and the time to first analgesic request...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901076/prevalence-of-metabolic-syndrome-and-its-risk-factors-among-rural-adults-in-nantong-china
#15
Jing Xiao, Chuan-Li Wu, Yue-Xia Gao, Shu-Lan Wang, Lei Wang, Qing-Yun Lu, Xiao-Jian Wang, Tian-Qi Hua, Huan Shen, Hui Cai
The prevalence of metabolic syndrome (MS) varies worldwide due to genetic and environmental factors. A population-based cross-sectional study, with 37,582 participants recruited in Nantong, China in 2007-2008 (stage I) and 2013 (stage II). Socio-demographic, lifestyle factors, disease history and fasting blood sample were collected. The prevalence of MS was much higher in 2013 (42.6%) than that in 2007-2008 (21.6%), which was significantly higher in older people in both stages. Participants with two or more familial history of diseases were associated with a higher MS prevalence compared to those who didn't have familial history of diseases...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901049/glucocorticoid-receptor-and-histone-deacetylase-6-mediate-the-differential-effect-of-dexamethasone-during-osteogenesis-of-mesenchymal-stromal-cells-mscs
#16
Marilyn G Rimando, Hao-Hsiang Wu, Yu-An Liu, Chien-Wei Lee, Shu-Wen Kuo, Yin-Ping Lo, Kuo-Fung Tseng, Yi-Shiuan Liu, Oscar Kuang-Sheng Lee
Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced by a potent synthetic form of glucocorticoid (GC), dexamethasone (Dex). Paradoxically, when used chronically in patients, GCs exert negative effects on bone, a phenomenon known as glucocorticoid-induced osteoporosis in clinical practice. The mechanism on how GC differentially affects bone precursor cells to become mature osteoblasts during osteogenesis remains elusive. In this study, the dose and temporal regulation of Dex on MSC differentiation into osteoblasts were investigated...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27901005/characteristics-of-electroencephalogram-arousals-of-sleep-disordered-breathing-children-at-different-sleep-stages
#17
Da-Bo Liu, Yu-Jing Yao, Zhen-Yun Huang, Jian-Wen Zhong, Jia-Jian Xu, Shu-Yao Qiu, Shao-Feng Liu, Xin-Hua Yi
No abstract text is available yet for this article.
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27901003/fibroblast-growth-factor-receptor-1-gene-amplification-in-nonsmall-cell-lung-cancer
#18
REVIEW
Jian-Long Miao, Rui-Juan Liu, Jin-Hua Zhou, Shu-Hua Meng
OBJECTIVE: To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 (FGFR1) amplification and to establish an association between FGFR1 amplification and the clinical characteristics of nonsmall cell lung cancer (NSCLC). DATA SOURCES: We searched PubMed for English-language studies published between January 2010 and May 2016. STUDY SELECTION: We included all relevant articles, with no limitation of study design...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27900750/-the-management-of-itching-in-burn-patients-during-the-rehabilitation-stage
#19
Shu-Fen Lo, Li-Jung Chang, Ting-Yuan Shiue, Ching-Yi Pan, Hui-Chuan Wu
Pruritus, a distressing symptom that affects burn patients, not only interferes with activities of daily living but also causes disturbed sleep, which has been associated with anxiety, depression, and other types of negative moods. Furthermore, the uncontrolled scratching that often accompanies pruritus causes tissue damage and may damage or destroy the skin graft. In this paper, the authors first describe the definition and mechanism of pruritus and next use itching-assessment tools to identify the triggering factors...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27900677/downregulation-of-the-long-non-coding-rna-meg3-promotes-angiogenesis-after-ischemic-brain-injury-by-activating-notch-signaling
#20
Juan Liu, Qing Li, Kun-Shan Zhang, Bin Hu, Xin Niu, Shu-Min Zhou, Si-Guang Li, Yu-Ping Luo, Yang Wang, Zhi-Feng Deng
Angiogenesis after ischemic brain injury contributes to the restoration of blood supply in the ischemic zone. Strategies to improve angiogenesis may facilitate the function recovery after stroke. Recent researches have demonstrated that dysfunction of long non-coding RNAs are associated with angiogenesis. We have previously reported that long non-coding RNAs (lncRNAs) are aberrantly expressed in ischemic stroke. However, little is known about long non-coding RNAs and theirs role in angiogenesis after stroke...
November 29, 2016: Molecular Neurobiology
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