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https://www.readbyqxmd.com/read/29036927/chinese-olive-canarium-album-l-fruit-extract-attenuates-metabolic-dysfunction-in-diabetic-rats
#1
Yu-Te Yeh, An-Na Chiang, Shu-Chen Hsieh
Hyperglycemia and dysregulation of lipid metabolism play a crucial role in metabolic dysfunction. The aims of present study were to evaluate the ameliorative effect of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. CO-EtOAc, rich in gallic acid and ellagic acid, could markedly decreased the body weight and epididymal adipose mass. In addition, CO-EtOAc increased serum HDL-C levels, hepatic GSH levels, and antioxidant enzyme activities; lowered blood glucose, serum levels of total cholesterol (TC), triglycerides (TG), bile acid, and tumor necrosis factor alpha (TNFα); and reduced TC and TG in liver...
October 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#2
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036729/reversal-of-lung-fibrosis-an-unexpected-finding-in-survivor-of-acute-respiratory-distress-syndrome
#3
Chih-Hao Chang, Yu-Hsiang Juan, Han-Chung Hu, Kuo-Chin Kao, Chung-Shu Lee
No abstract text is available yet for this article.
October 3, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29036672/convergence-and-divergence-of-brain-network-dysfunction-in-deficit-and-non-deficit-schizophrenia
#4
Miao Yu, Zhengjia Dai, Xiaowei Tang, Xiang Wang, Xiaobin Zhang, Weiwei Sha, Shuqiao Yao, Ni Shu, Xindi Wang, Jiaying Yang, Xiangyang Zhang, Xiangrong Zhang, Yong He, Zhijun Zhang
Deficit schizophrenia (DS), characterized by primary and enduring negative symptoms, has been considered as a pathophysiologically distinct schizophrenic subgroup. Neuroimaging characteristics of DS, especially functional brain network architecture, remain largely unknown. Resting-state functional magnetic resonance imaging and graph theory approaches were employed to investigate the topological organization of whole-brain functional networks of 114 male participants including 33 DS, 41 non-deficit schizophrenia (NDS) and 40 healthy controls (HCs)...
July 20, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036535/ploc-manimal-predict-subcellular-localization-of-animal-proteins-with-both-single-and-multiple-sites
#5
Xiang Cheng, Shu-Guang Zhao, Wei-Zhong Lin, Xuan Xiao, Kuo-Chen Chou
Motivation: Cells are deemed the basic unit of life. However, many important functions of cells as well as their growth and reproduction are performed via the protein molecules located at their different organelles or locations. Facing explosive growth of protein sequences, we are challenged to develop fast and effective method to annotate their subcellular localization. However, this is by no means an easy task. Particularly, mounting evidences have indicated proteins have multi-label feature meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites...
July 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036227/evolution-of-hepatitis-a-virus-seroprevalence-among-hiv-positive-adults-in-taiwan
#6
Yu-Lin Lee, Kuan-Yin Lin, Chien-Yu Cheng, Chia-Wen Li, Chia-Jui Yang, Mao-Song Tsai, Hung-Jen Tang, Te-Yu Lin, Ning-Chi Wang, Yi-Chien Lee, Shih-Ping Lin, Yu-Shan Huang, Hsin-Yun Sun, Jun-Yu Zhang, Wen-Chien Ko, Shu-Hsing Cheng, Yuan-Ti Lee, Chun-Eng Liu, Chien-Ching Hung
OBJECTIVES: The study aimed to describe the seroprevalence of hepatitis A virus (HAV) in HIV-positive adult patients in Taiwan between 2012 and 2016 and to examine the evolution of HAV seroprevalence between 2004-2007 and 2012-2016. METHODS: Clinical information and data of anti-HAV antibody results were collected from 2,860 antiretroviral-naïve HIV-positive Taiwanese aged 18 years or older who initiated combination antiretroviral therapy at 11 hospitals around Taiwan between 2012 and 2016 (2012-2016 cohort)...
2017: PloS One
https://www.readbyqxmd.com/read/29035786/comparative-transcriptome-analysis-reveals-networks-of-genes-activated-in-the-whitefly-bemisia-tabaci-when-fed-on-tomato-plants-infected-with-tomato-yellow-leaf-curl-virus
#7
Daniel K Hasegawa, Wenbo Chen, Yi Zheng, Navneet Kaur, William M Wintermantel, Alvin M Simmons, Zhangjun Fei, Kai-Shu Ling
The whitefly Bemisia tabaci can transmit hundreds of viruses to numerous agricultural crops in the world. Five genera of viruses, including Begomovirus and Crinivirus, are transmitted by B. tabaci. There is little knowledge about the genes involved in virus acquisition and transmission by whiteflies. Using a comparative transcriptomics approach, we evaluated the gene expression profiles of whiteflies (B. tabaci MEAM1) after feeding on tomato infected by a begomovirus, Tomato yellow leaf curl virus (TYLCV), in comparison to a recent study, in which whiteflies were fed on tomato infected by the crinivirus, Tomato chlorosis virus (ToCV)...
October 13, 2017: Virology
https://www.readbyqxmd.com/read/29035465/enhanced-specificity-of-braf-v600e-genotyping-using-wild-type-blocker-coupled-with-internal-competitive-reference-in-a-single-tube
#8
Jia Peng, Kun Wei, Shu Yu, Xiang Yang, Xiang Zhao, Yu Liu, Xiao-Yan Zhu, Na Zhao, Qing Huang, Wei-Ling Fu
BACKGROUND: Mutations in the BRAF gene have been strongly associated with failure in cancer treatment using epidermal growth factor receptor (EGFR) antibodies. To better diagnose and assess the prognosis of cancer patients, mutation screening of the BRAFV600E gene should be performed prior to clinical anti-tumor drug therapy to avoid ineffective treatment. METHODS: In our previous study, we developed a real-time wild-type blocking PCR (WTB-PCR), which can amplify the mutant allele at high efficiency while simultaneously inhibiting the amplification of wild-type alleles...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035335/selectivity-enhancement-in-electronic-nose-based-on-an-optimized-dqn
#9
Yu Wang, Jianguo Xing, Shu Qian
In order to enhance the selectivity of metal oxide gas sensors, we use a flow modulation method to exploit transient sensor information. The method is based on modulating the flow of the carrier gas that brings the species to be measured into the sensor chamber. We present an active perception strategy by using a DQN which can optimize the flow modulation online. The advantage of DQN is not only that the classification accuracy is higher than traditional methods such as PCA, but also that it has a good adaptability under small samples and labeled data...
October 16, 2017: Sensors
https://www.readbyqxmd.com/read/29034980/geometric-design-of-scalable-forward-scatterers-for-optimally-efficient-solar-transformers
#10
Hye-Na Kim, Sanaz Vahidinia, Amanda L Holt, Alison M Sweeney, Shu Yang
It will be ideal to deliver equal, optimally efficient "doses" of sunlight to all cells in a photobioreactor system, while simultaneously utilizing the entire solar resource. Backed by the numerical scattering simulation and optimization, here, the design, synthesis, and characterization of the synthetic iridocytes that recapitulated the salient forward-scattering behavior of the Tridacnid clam system are reported, which presents the first geometric solution to allow narrow, precise forward redistribution of flux, utilizing the solar resource at the maximum quantum efficiency possible in living cells...
October 16, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29034931/spontaneous-symmetry-breaking-induced-unidirectional-rotation-of-a-chain-grafted-colloidal-particle-in-the-active-bath
#11
Hui-Shu Li, Chao Wang, Wen-de Tian, Yu-Qiang Ma, Cheng Xu, Ning Zheng, Kang Chen
Exploiting the energy of randomly moving active agents such as bacteria is a fascinating way to power a microdevice. Here we show, by simulations, that a chain-grafted disk-like colloidal particle can rotate unidirectionally and hence output work when immersed in a thin film of active particle suspension. The collective spontaneous symmetry breaking of chain configurations is the origin of the unidirectional rotation. Long persistence time, large propelling force and/or small rotating friction are keys to sustaining the collective broken symmetry and realizing the rotation...
October 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29034635/-structural-regulation-by-calcium-ion-in-preparing-cross-linked-enzyme-aggregates
#12
Xiaoqi Han, Shu Bai, Qinghong Shi
We studied the effect of calcium ion on particle size and pore structure of cross-linked enzyme aggregates (CLEAs) of glucose oxidase, with activity and stability of the enzyme as evaluation criteria. With calcium ion to prepare CLEA significantly decreased particle sizes of CLEAs whilst the pore structures of CLEAs gradually disappeared with the increase of calcium concentration. When glucose oxidase was precipitated at 0.1 mmol/L Ca²⁺, glucose oxidase in CLEA showed the definitive pore structure. Moreover, glucose oxidase activity in CLEA with Ca²⁺ was 1...
December 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29034434/genomic-analyses-reveal-low-mitochondrial-and-high-nuclear-diversity-in-the-cyclosporin-producing-fungus-tolypocladium-inflatum
#13
Yong-Jie Zhang, Xiao-Qing Yang, Shu Zhang, Richard A Humber, Jianping Xu
Mitochondrial DNA is generally regarded to evolve faster than nuclear DNA in animals, whereas if this is also true in fungi remains unclear. Herein, we annotate the first complete mitochondrial genome (mitogenome) of the cyclosporin-producing fungus Tolypocladium inflatum and report the genome-wide sequence variations among five isolates originating from distantly separated localities. We found that T. inflatum has among the most compact of fungal mitogenomes; its 25 kb DNA molecule encodes all standard fungal mitochondrial genes and harbors only one intron...
October 15, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29033953/development-and-characterization-of-transgenic-sugarcane-with-insect-resistance-and-herbicide-tolerance
#14
Wen Zhi Wang, Ben Peng Yang, Xiao Yan Feng, Zheng Ying Cao, Cui Lian Feng, Jun Gang Wang, Guo Ru Xiong, Lin Bo Shen, Jun Zeng, Ting Ting Zhao, Shu Zhen Zhang
Genetically modified crops which had been commercial applied extensively majorly are the insect resistance and herbicide tolerance events. In this study, the Bt insecticidal gene Cry1Ab, the glyphosate-tolerant gene EPSPS, and the selection marker gene PMI were combined into a single transferred DNA fragment and introduced into sugarcane by Agrobacterium-mediated transformation. Thirty-three resistant plantlets were obtained after selection using a PMI/mannose selection system. Thirty of these resistant plantlets were PCR positive for the three target genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29033377/proposed-treatment-paradigm-for-intracranial-chondrosarcomas-based-on-multidisciplinary-coordination
#15
Da Li, Jian-Cong Weng, Gui-Jun Zhang, Shu-Yu Hao, Jie Tang, Li-Wei Zhang, Liang Wang, Zhen Wu, Wang Jia, Jun-Ting Zhang
OBJECTIVES: There was no consensus regarding the treatment of intracranial chondrosarcoma (CSA). The study aimed to evaluate the adverse factors for progression-free survival (PFS) and overall survival (OS), and propose a treatment strategy for CSA. METHODS: The clinical chart and radiographic data of 106 consecutive cases (mesenchymal and conventional CSA in 18 and 88 patients, respectively) of surgically treated CSAs were retrospectively reviewed. RESULTS: Gross total resection was achieved in 43 patients (40...
October 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29032716/prediction-of-coronary-plaque-progression-using-biomechanical-factors-and-vascular-characteristics-based-on-computed-tomography-angiography
#16
Xiujian Liu, Guanghui Wu, Chuangye Xu, Yuna He, Lixia Shu, Yuyang Liu, Nan Zhang, Changyan Lin
OBJECTIVES: Coronary atherosclerotic plaques progress in a highly individual manner. Accurately predicting plaque progression will promote clinical management of atherosclerosis. The purpose of this study was to investigate the role of local biomechanics factors and vascular characteristics in coronary plaque progression and arterial remodeling. METHODS: Computed tomography angiography-based three-dimensional reconstruction of the native right coronary artery was performed in vivo in twelve patients with acute coronary syndrome at baseline and 12-month follow-up...
October 16, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29032686/3-hydroxypterostilbene-suppresses-colitis-associated-tumorigenesis-by-inhibition-of-il-6-stat3-signaling-in-mice
#17
Ching-Shu Lai, Guliangyang Yang, Shiming Li, Pei-Sheng Lee, Bini Wang, Min-Ching Chung, Kalyanam Nagabhushanam, Min-Hsiung Pan, Chi-Tang Ho
3'-Hydroxypterostilbene (trans-3,5-dimethoxy-3',4'-hydroxystilbene) presents in Sphaerophysa salsula, Pterocarpus marsupium, and Honey Bee propolis and has been reported to exhibit several biological activities. Herein, we aimed to explore the chemopreventive effects of dietary 3'-hydroxypterostilbene and underlying molecular mechanisms on colitis-associated cancer using the azoxymethane (AOM)/dextran sodium sulfate (DSS) model. 3'-Hydroxypterostilbene administration effectively ameliorated the colon shortening and number of tumors in AOM/DSS-treated mice (3...
October 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29032191/aging-and-a-genetic-kibra-polymorphism-interactively-affect-feedback-and-observation-based-probabilistic-classification-learning
#18
Nicolas W Schuck, Jessica R Petok, Martijn Meeter, Brit-Maren M Schjeide, Julia Schröder, Lars Bertram, Mark A Gluck, Shu-Chen Li
Probabilistic category learning involves complex interactions between the hippocampus and striatum that may depend on whether acquisition occurs via feedback or observation. Little is known about how healthy aging affects these processes. We tested whether age-related behavioral differences in probabilistic category learning from feedback or observation depend on a genetic factor known to influence individual differences in hippocampal function, the KIBRA gene (single nucleotide polymorphism rs17070145). Results showed comparable age-related performance impairments in observational as well as feedback-based learning...
September 5, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29032168/ineffectiveness-of-the-tobacco-hazards-prevention-act-in-patients-with-severe-and-persistent-mental-illness
#19
B-C Shu, F-W Lung, S-E Guo, K-C Chen, S-Y Fang, A-L Wang
OBJECTIVES: The effect of the Tobacco Hazards Prevention Act (THPA) on the reduction of tobacco use in the general population in Taiwan is understood. However, there has been little research on how these policies affect people with severe and persistent mental illness (SPMI). Hence, the influence of the THPA on daily cigarette use by patients with SPMI was investigated in a 3-year follow-up. The risk and protective factors in smoking behavior and cessation were investigated. STUDY DESIGN: This is an observational study...
October 12, 2017: Public Health
https://www.readbyqxmd.com/read/29032021/clinical-characteristics-and-survival-outcomes-of-terminally-ill-patients-undergoing-withdrawal-of-mechanical-ventilation
#20
Yu-Shin Hung, Shu-Hui Lee, Chia-Yen Hung, Chao-Hui Wang, Chen-Yi Kao, Hung-Ming Wang, Wen-Chi Chou
BACKGROUND: Withdrawal of mechanical ventilation is an important, but rarely explored issue in Asia during end-of-life care. This study aimed to describe the clinical characteristics and survival outcomes of terminally ill patients undergoing withdrawal of mechanical ventilation in Taiwan. METHODS: One-hundred-thirty-five terminally ill patients who had mechanical ventilation withdrawn between 2013 and 2016, from a medical center in Taiwan, were enrolled. Patients' clinical characteristics and survival outcomes after withdrawal of mechanical ventilation were analyzed...
October 11, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
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