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https://www.readbyqxmd.com/read/29232702/adipose-tissue-deficiency-of-hormone-sensitive-lipase-causes-fatty-liver-in-mice
#1
Bo Xia, Guo He Cai, Hao Yang, Shu Pei Wang, Grant A Mitchell, Jiang Wei Wu
Fatty liver is a major health problem worldwide. People with hereditary deficiency of hormone-sensitive lipase (HSL) are reported to develop fatty liver. In this study, systemic and tissue-specific HSL-deficient mice were used as models to explore the underlying mechanism of this association. We found that systemic HSL deficient mice developed fatty liver in an age-dependent fashion between 3 and 8 months of age. To further explore the mechanism of fatty liver in HSL deficiency, liver-specific HSL knockout mice were created...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29232612/aliphatic-hydrocarbons-recovered-in-vegetables-from-soils-based-on-their-in-situ-distribution-in-various-soil-humus-fractions-using-a-successive-extraction-method
#2
Juan Zhang, Shu-Kai Fan, Ming-Hua Zhang, Michael L Grieneisen, Jian-Feng Zhang
Aliphatic hydrocarbons (AHs) are major petroleum contaminants in the environment. In this study, the AHs bound to various soil endogenetic humus fractions were separated through successive extraction. Most of the AHs (46.1%) in soils were adsorbed onto/into humic acids (HA) and a small quantity of AHs (9.6%) were organic solvent extractable. AHs in B. chinensis were also analyzed since their potential risks to the residents through ingestion. AHs from C21 to C34, so called high molecular weight AHs (HMWAHs), were dominant AHs in B...
December 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29232309/a-bispecific-antibody-based-on-pertuzumab-fab-has-potent-antitumor-activity
#3
Wentong Deng, Jiayu Liu, Haitao Pan, Li Li, Changhua Zhou, Xiaojuan Wang, Rui Shu, Bin Dong, Donglin Cao, Qing Li, Zhong Wang
Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed and activated in metastatic breast cancers. Monoclonal antibodies targeting Her2, such as trastuzumab and pertuzumab, have become important targeted therapies for patients with HER2-positive breast cancer. Both trastuzumab and pertuzumab can reduce Her2 positive tumor burden by inhibiting Her2 signaling and inducing ADCC activities (antibody dependent cell-mediated cytotoxicity). In this study, we have generated a bispecific antibody, Her2(Per)-S-Fab, by linking the pertuzumab Fab to an anti-CD16 single domain antibody...
January 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29232210/response-percutaneous-vascular-interventions-versus-bypass-surgeries-in-patients-with-critical-limb-ischemia
#4
Chi Shu, Jiarong Wang, Yazhou He, Jichun Zhao
No abstract text is available yet for this article.
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29232101/a-driver-switchover-mechanism-of-influenza-virus-transport-from-microfilaments-to-microtubules
#5
Li-Juan Zhang, Li Xia, Shu-Lin Liu, En-Ze Sun, Qiu-Mei Wu, Li Wen, Zhi-Ling Zhang, Dai-Wen Pang
When infecting host cells, influenza virus must move on microfilaments (MFs) at the cell periphery and then move along microtubules (MTs) through the cytosol to reach the perinuclear region for genome release. But how viruses switch from the actin roadway to the microtubule highway remains obscure. To settle this issue, we systematically dissected the role of related motor proteins in the transport of influenza virus between cytoskeletal filaments in situ and in real-time using quantum dot (QD)-based single-virus tracking (SVT) and multicolor imaging...
December 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/29232038/novel-techniques-and-preliminary-results-of-ex-vivo-liver-resection-and-autotransplantation-for-end-stage%C3%A2-hepatic-alveolar-echinococcosis-a-study-of-31-cases
#6
Xianwei Yang, Yiwen Qiu, Bin Huang, Wentao Wang, Shu Shen, Xi Feng, Yonggang Wei, Jianyong Lei, Jichun Zhao, Bo Li, Tianfu Wen, Lunan Yan
Ex vivo liver resection combined with autotransplantation is a recently introduced approach to cure end-stage hepatic alveolar echinococcosis (HAE), which is considered unresectable by conventional radical resection due to echinococcal dissemination into the crucial intrahepatic conduits and adjacent structures. This manuscript aims discuss the manipulation details and propose reasonable indications for this promising technique. All patients successfully underwent liver autotransplantation with no intraoperative mortality...
December 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29231612/-theoretical-origin-and-clinical-application-of-wrist-ankle-acupuncture-therapy
#7
Qiong Wang, Qinghui Zhou
The theory of wrist-ankle acupuncture is consistent with traditional meridian-collateral theory. For example, the body divisions of wrist-ankle acupuncture are corresponding to the distribution of 12 cutaneous regions of meridians, the needling sites of it are to the running courses of 12 meridians; the indications of it are to those of 12 meridians. The needling sites of wrist-ankle acupuncture are relevant with some special acupoints of acupuncture theory. For example, the 12-needling sites of wrist-ankle acupuncture are located similar to those of 12 meridian points and have very similar indications...
May 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231591/-exploration-of-acupoint-combination-and-needling-techniques-in-the-reinforcing-and-reducing-manipulation-at-different-acupoints
#8
Qing Dai, Xiesun Sheng, Feng Chen
The reinforcing and reducing manipulation at different acupoints is a kind of acupuncture manipulations and has satisfactory clinical therapeutic effects, combined with a proper needling techniques. The reinforcing needling method is used in the upper and the reducing one in the lower, the distal acupoints are combined with the nearby acupoints. The local acupoints or adjcant acupoints of the affected area are regarded as the nearby acupoints, e.g. the acupoints in the upper. The distant acupoints and the acupoints on the hand and foot are named as distal acupoints, e...
April 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231505/-relationship-between-the-distribution-of-spinal-nerve-posterior-ramus-and-locations-of-acupoint-in-low-back
#9
Peng Li, Jinsheng Liu, Xiangnan Chen, Lixian Wu, Suming Jiang, Guogang Xu
OBJECTIVE: To explore the relationship between the distributions of posterior ramus of spinal nerve (PRSN) and locations of acupoint in low back through anatomical observation. METHODS: The regional anatomy was performed at five corpses to observe the distribution of erector spinae muscle and PRSN in areas of Jiaji points and back-shu points in low back. RESULTS: The T12, L1, L2, L3 and L4 PRSN distributed on both sides of the spine; the medial branches of PRSN travelled between spinalis thoracis muscle and longissimus thoracis muscle, while the lateral branches of PRSN travelled between longissimus thoracis muscle and iliocostalis lumborum muscle...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231477/-analysis-on-the-acupoint-conception
#10
Jingsheng Zhao
To explore the original connotation of acupoint concept, investigating specifically Neijing (Internal Canon of Medicine) and the excavated medical literature as well as the relevant works, the study was conducted in terms of the three aspects, i.e. the early titling and basic meaning of acupoint, the initial analysis on "shu" and the connotation of acupoint concept. It is believed that the relationship of acupoint with meridian tropism and qi as well as the application and indication reflect the acupoint specialty rather than its substantive characteristics...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231439/-professor-lai-xinsheng-s-clinical-experience-in-the-treatment-of-premature-ovarian-failure-with-tongyuan-acupuncture-technique-and-chinese-herbal-medicine
#11
Xiaozhe Li, Sujuan Zhang
In the treatment of premature ovarian failure (POF), professor LAI Xinsheng focuses on the determination of syndrome to seek for etiology, associating with the differentiation of meridian and collateral and that of zangfu organs. Professor LAI believes that POF is mainly manifested as amenorrhea and infertility, localized in the kidney, with the dysfunction of liver, spleen and heart. It is impacted by many pathological factors, such as cold blockage, qi stagnation, blood stagnation, blood deficiency, yin deficiency, etc...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231346/-discussion-on-locating-of-back-shu-points
#12
Bingyan Cao, Shipeng Zhu, Tong Liu
Back-shu points were firstly discussed in Lingshu (the Miraculous Pivot), and various location methods of back-shu points had been proposed by acupuncturists until conclusive method was made in Song dynasty. In this paper, the different location methods of back-shu points were reviewed; based on this, the reasons of divergences among each theory on location methods were discussed, and the theoretical background and reference of the original establishment of back-shu points were further explored. Therefore, it was proposed that the standardized location of back-shu points should be just considered as the center of possible distribution range, and adjustment should be made during clinical application according to the variability of individual combined with finger pressing...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231318/-differences-of-acupuncture-and-moxibustion-on-heart-rate-variability-in-qi-deficiency-syndrome-a-randomized-controlled-trial
#13
Qing Shu, Danhong Sun, Hua Wang, Fengxia Liang, Litscher Gerhard, Litscher Daniela, Gaischek Ingrid, Li Chen, Wenjuan He, Yayuan Wang
OBJECTIVE: To observe the improvement of acupuncture and moxibustion on symptoms of qi-deficiency syndrome as well as their differences on the parameters of heart rate variability (HRV). METHODS: Thirty patients with qi-deficiency syndrome and 15 healthy volunteers were recruited. Thirty patients with qi-deficiency syndrome were randomly assigned into an acupuncture group and a moxibustion group, 15 cases in each one. Fifteen healthy volunteers were allocated as a healthy control group...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231035/an-asymmetric-dehydrogenative-diels-alder-reaction-for-the-synthesis-of-chiral-tetrahydrocarbazole-derivatives
#14
Xiang Wu, Hai-Jie Zhu, Shi-Bao Zhao, Shu-Sen Chen, Yun-Fei Luo, You-Gui Li
An asymmetric dehydrogenative Diels-Alder reaction of 2-methyl-3-phenylmethylindoles and α,β-unsaturated aldehydes has been established. The successful in situ generation of the indole ortho-quinodimethane intermediate and the iminium activation of enals are the keys to success, providing various tetrahydrocarbazole derivatives with up to >99% ee.
December 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/29230663/advantages-with-prophylactic-peg-rhg-csf-versus-rhg-csf-in-breast-cancer-patients-receiving-multiple-cycles-of-myelosuppressive-chemotherapy-an-open-label-randomized-multicenter-phase-iii-study
#15
Jie Xie, Jun Cao, Jing-Fen Wang, Bai-Hong Zhang, Xiao-Hua Zeng, Hong Zheng, Yang Zhang, Li Cai, Yu-Dong Wu, Qiang Yao, Xiao-Chun Zhao, Wei-Dong Mao, Ai-Mei Jiang, Shao-Shui Chen, Shun-E Yang, Shu-Sen Wang, Jian-Hong Wang, Yue-Yin Pan, Bi-Yong Ren, Yan-Ju Chen, Li-Zhi Ouyang, Kai-Jian Lei, Jing-Hua Gao, Wen-He Huang, Zhan Huang, Tao Shou, Yan-Ling He, Jing Cheng, Yang Sun, Wei-Ming Li, Shu-de Cui, Xin Wang, Zhi-Guo Rao, Hu Ma, Wei Liu, Xue-Yong Wu, Wei-Xi Shen, Fei-Lin Cao, Ze-Min Xiao, Biao Wu, Shu-Yan Tian, Dong Meng, Peng Shen, Bi-Yun Wang, Zhonghua Wang, Jian Zhang, Leiping Wang, Xi-Chun Hu
BACKGROUND: PEG-rhG-CSF reduces neutropenia and improves chemotherapy safety. In China's registration trial (CFDA: 2006L01305), we assessed its efficacy and safety against rhG-CSF, and prospectively explored its value over multiple cycles of chemotherapy. METHODS: In this open-label, randomized, multicenter phase 3 study, breast cancer patients (n = 569) were randomized to receive PEG-rhG-CSF 100 µg/kg, PEG-rhG-CSF 6 mg, or rhG-CSF 5 µg/kg/d after chemotherapy...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230660/dietary-intake-of-soy-and-cruciferous-vegetables-and-treatment-related-symptoms-in-chinese-american-and-non-hispanic-white-breast-cancer-survivors
#16
Sarah J O Nomura, Yi-Ting Hwang, Scarlett Lin Gomez, Teresa T Fung, Shu-Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun-Ling Zheng, Judy Huei-Yu Wang
PURPOSE: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. METHODS: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0-III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230541/theoretical-and-experimental-investigation-into-a-eutectic-system-of-3-4-dinitropyrazole-and-1-methyl-3-4-5-trinitropyrazole
#17
Shuang-Fei Zhu, Shu-Hai Zhang, Rui-Jun Gou, Fu-de Ren
Eutectic mixtures of 3,4-dinitropyrazole (DNP) and 1-methyl-3,4,5-trinitropyrazole (MTNP) were investigated by theoretical and experimental methods. The mass ratio of DNP and MTNP ranged from 0:100 to 100:0. Melting points of the mixtures were predicted through observing the inflection point of a specific volume vs. temperature in molecular dynamics (MD) simulation. The results are in good agreement with experimental results obtained from the differential scanning calorimeter (DSC) study. The binding energy of a 50/50 DNP/MTNP eutectic mixture is lower than those of other mixtures, in accordance with the common sense that the melting point of materials is linked to the strength of intermolecular interactions...
December 11, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29230371/mass-marking-of-juvenile-schizothorax-wangchiachii-fang-with-alizarin-red-s-and-evaluation-of-stock-enhancement-in-the-jinping-area-of-the-yalong-river
#18
Kun Yang, Shu Li, Xiaoshuai Liu, Weixiong Gan, Longjun Deng, Yezhong Tang, Zhaobin Song
Schizothorax wangchiachii is a key fish species in the stock enhancement program of the Yalong River hydropower project, China. Alizarin red S (ARS) was used to mark large numbers of juvenile S. wangchiachii in the Jinping Hatchery and later used to evaluate stock enhancement in the Jinping area of the Yalong River. In a small-scale pilot study, 7,000 juveniles of the 2014 cohort were successfully marked by immersion in ARS solution, and no mortality was recorded during the marking process. The ARS mark in the fish otoliths remained visible 20 months later...
2017: PeerJ
https://www.readbyqxmd.com/read/29230255/control-of-cell-proliferation-by-a-porous-chitosan-scaffold-with-multiple-releasing-capabilities
#19
Shu-Jyun Cai, Ching-Wen Li, Daphne Weihs, Gou-Jen Wang
The aim of this study was to develop a porous chitosan scaffold with long-acting drug release as an artificial dressing to promote skin wound healing. The dressing was fabricated by pre-freezing at different temperatures (-20 and -80 °C) for different periods of time, followed by freeze-drying to form porous chitosan scaffolds with different pore sizes. The chitosan scaffolds were then used to investigate the effect of the controlled release of fibroblast growth factor-basic (bFGF) and transforming growth factor-β1 (TGFβ1) on mouse fibroblast cells (L929) and bovine carotid endothelial cells (BEC)...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/29230240/utility-of-endoscopic-examination-in-the-diagnosis-of-acute-graft-versus-host-disease-in-the-lower-gastrointestinal-tract
#20
Kosuke Nomura, Toshiro Iizuka, Daisuke Kaji, Hisashi Yamamoto, Yasutaka Kuribayashi, Masami Tanaka, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Yasunori Ota, Shuichi Taniguchi, Shu Hoteya
Background and Aims: We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods: Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014, 186 of whom underwent colonoscopy and biopsy and had no cytomegalovirus infection. The endoscopic findings and histologic diagnosis from these 186 patients were retrospectively analyzed...
2017: Gastroenterology Research and Practice
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