keyword
MENU ▼
Read by QxMD icon Read
search

SHU

keyword
https://www.readbyqxmd.com/read/28239993/maternal-betaine-supplementation-in-rats-induces-intergenerational-changes-in-hepatic-igf-1-expression-and-dna-methylation
#1
Nannan Zhao, Shu Yang, Yun Hu, Haibo Dong, Ruqian Zhao
SCOPE: Betaine is widely used in animal nutrition to promote growth. Here we aimed to investigate whether maternal betaine supplementation during pregnancy can exert multigenerational effects on growth across two generations and the possible epigenetic modifications associated to such effects. METHODS AND RESULTS: In this study, 3-month-old female Sprague-Dawley rats were fed diet supplemented with 1% betaine throughout the pregnancy and lactation. Betaine-supplemented dams produced bigger litter but smaller F1 pups at birth and weaning...
February 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#2
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28239455/the-underlying-mechanism-of-prodromal-pd-insights-from-the-parasympathetic-nervous-system-and-the-olfactory-system
#3
REVIEW
Shu-Ying Liu, Piu Chan, A Jon Stoessl
Neurodegeneration of Parkinson's disease (PD) starts in an insidious manner, 30-50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, during which the disease pathology has started but is insufficient to result in clinical manifestations, offers a valuable window for disease-modifying therapies. The most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of neurons...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28239327/polypoid-lesions-at-the-anal-canal-what-do-they-hint
#4
Shu Chen Wei, Been Ren Lin, Chia Tung Shun, Jau Min Wong
No abstract text is available yet for this article.
January 2017: Intestinal Research
https://www.readbyqxmd.com/read/28239059/contact-and-repellant-activities-of-zerumbone-and-its-analogues-from-the-essential-oil-of-zingiber-zerumbet-l-smith-against-lasioderma-serricorne
#5
Yan Wu, Shan-Shan Guo, Dong-Ye Huang, Cheng-Fang Wang, Jian-Yu Wei, Zhi-Hua Li, Jian-Sheng Sun, Jia-Feng Bai, Zhao-Fu Tian, Ping-Juan Wang, Shu-Shan Du
The contact toxicity and repellent activities of the essential oil extracted from the rhizomes of Zingiber zerumbet (L.) Smith (Zingiberaceae) was evaluated against cigarette beetles (Lasioderma serricorne). The essential oil obtained by hydrodistillation was investigated by GC-FID and GC-MS. The main constituents of the essential oil were zerumbone (40.2%), α-caryophyllene (8.6%), humulene epoxide II (7.3%), camphene (5.9%) and fenchene (4.7%). Zerumbone and its analogues totally are accounting for 60.3% of the essential oil...
February 24, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28238968/changes-in-macroautophagy-chaperone-mediated-autophagy-and-mitochondrial-metabolism-in-murine-skeletal-and-cardiac-muscle-during-aging
#6
Jin Zhou, Shu Yun Chong, Andrea Lim, Brijesh K Singh, Rohit A Sinha, Adam B Salmon, Paul M Yen
Aging causes a general decline in cellular metabolic activity, and function in different tissues and whole body homeostasis. However, the understanding about the metabolomic and autophagy changes in skeletal muscle and heart during aging is still limited. We thus examined markers for macroautophagy, chaperone-mediated autophagy (CMA), mitochondrial quality control, as well as cellular metabolites in skeletal and cardiac muscle from young (5 months old) and aged (27 months old) mice. We found decreased autophagic degradation of p62 and increased ubiquitinated proteins in both tissues from aged mice, suggesting a decline in macroautophagy during aging...
February 26, 2017: Aging
https://www.readbyqxmd.com/read/28238888/decrease-in-regulatory-t-cell-function-in-chronic-hepatitis-c-patients-receiving-pegylated-interferon-plus-ribavirin
#7
Kuo-Chih Tseng, Yun-Che Ho, Chi-Wei Tseng, Ling-Huei Tseng, Yu-Hsi Hsieh, Ting-Tsung Chang, Shu-Fen Wu
OBJECTIVES: Regulatory T cells (Tregs) play an important role in the pathogenesis of chronic hepatitis C (CHC) infection. Pegylated interferon is the standard therapy for CHC patients in Asian countries. This study aims to evaluate the frequency and function of Tregs in CHC patients receiving combination therapy. METHODS: CHC patients (n=30) who had elevated alanine aminotransferase and underwent combination therapy were included. Clinical data and Tregs function were checked at baseline, 12 weeks after treatment, end of treatment, and at the end of a 24-week follow-up...
February 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28238753/glucocorticoid-induced-leucine-zipper-overexpression-inhibits-lipopolysaccharide-induced-retinal-inflammation-in-rats
#8
Ruiping Gu, Boya Lei, Qinmeng Shu, Gang Li, Gezhi Xu
Glucocorticoid-induced leucine zipper (GILZ) mediates several effects of glucocorticoids and has important anti-inflammatory properties. Here, we explored the role of GILZ in inhibiting retinal inflammation. Endotoxin-induced uveitis (EIU) was established in rats by intravitreal injection of lipopolysaccharide (LPS). GILZ levels decreased in the EIU retina at 4 h after LPS injection and slowly recovered within 24 h. Retinal GILZ was downregulated by recombinant lentivirus-delivered short-hairpin RNA targeting GILZ (shRNA-GILZ-rLV) and upregulated by recombinant lentivirus-mediated GILZ overexpression (Oe-GILZ-rLV)...
February 24, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28238747/role-of-c-ebp-homologous-protein-chop-and-endoplasmic-reticulum-in-asthma-exacerbation-by-regulating-the-il-4-stat6-tfec-il-4r%C3%AE-positive-feedback-loop-in-m2-macrophages
#9
Yi Wang, Jianghui Zhu, Lei Zhang, Zhijun Zhang, Long He, Yong Mou, Yanhan Deng, Yong Cao, Ping Yang, Yunchao Su, Jianping Zhao, Shu Zhang, Qilin Yu, Jifa Hu, Zhishui Chen, Qin Ning, Xudong Xiang, Yongjian Xu, Cong-Yi Wang, Weining Xiong
BACKGROUND: C/EBP homologous protein (CHOP), a marker of endoplasmic reticulum (ER) stress, exhibits aberrant expression patterns during the development of asthma. However, its exact role in asthma pathogenesis is not fully understood. OBJECTIVES: We aimed to determine the function and mechanism of CHOP in the pathogenesis of allergic asthma in patients and animals. METHODS: Studies were conducted in asthmatic patients and CHOP(-/-) mice to dissect the role of CHOP and ER stress in asthma pathogenesis...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238438/arid2-modulates-dna-damage-response-in-human-hepatocellular-carcinoma-cells
#10
Atsushi Oba, Shu Shimada, Yoshimitsu Akiyama, Taketo Nishikawaji, Kaoru Mogushi, Hiromitsu Ito, Satoshi Matsumura, Arihiro Aihara, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Hiroshi Asahara, Atsushi Kaida, Masahiko Miura, Minoru Tanabe, Shinji Tanaka
BACKGROUND & AIMS: Recent genomic studies have identified frequent mutations of AT-rich interactive domain 2 (ARID2) in hepatocellular carcinoma (HCC), but it is not still understood how ARID2 exhibits tumor suppressor activities. METHODS: We established the ARID2 knockout human HCC cell lines by using CRISPR/Cas9 system, and investigated the gene expression profiles and biological functions. RESULTS: Bioinformatic analysis indicated that UV-response genes were negatively regulated in the ARID2 knockout cells, and they were sensitized to UV irradiation...
February 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28238349/long-term-outcome-of-catheter-ablation-for-left-posterior-fascicular-ventricular-tachycardia-with-the-development-of-left-posterior-fascicular-block-and-characteristics-of-repeat-procedures
#11
Bin Luo, Gongbu Zhou, Xiaogang Guo, Xu Liu, Jiandu Yang, Qi Sun, Jian Ma, Shu Zhang
OBJECTIVE: The present study aimed to retrospectively investigate long-term clinical outcomes of patients undergoing catheter ablation of left posterior fascicular ventricular tachycardia (LPF-VT) with the development of left posterior fascicular block (LPF block) and characteristics of repeat procedures. METHODS AND RESULTS: A total of 195 patients (mean age 29.76±1.03years, 16.4% females) who underwent catheter ablation for LPF-VT were consecutively enrolled...
February 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28238064/hepatic-inflammation-fibrosis-cancer-axis-in-the-rat-hepatocellular-carcinoma-induced-by-diethylnitrosamine
#12
Yong-Fang Ding, Zhen-Hui Wu, Ying-Jie Wei, Luan Shu, Yun-Ru Peng
PURPOSE: Hepatocellular carcinoma (HCC) cases are closely associated with chronic inflammation and fibrosis which is known as hepatic inflammation-fibrosis-cancer (IFC) axis. The aim of this study is to elucidate the development characteristics of the rat HCC model based on IFC axis. METHODS: The diethylnitrosamine (DEN)-induced rat HCC, which presents a stepwise histopathological progression that is similar to human HCC, was used to analyze the features of the different stages (inflammation, fibrosis, cancer)...
February 25, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28238045/estimation-of-the-cumulative-incidence-function-under-multiple-dependent-and-independent-censoring-mechanisms
#13
Judith J Lok, Shu Yang, Brian Sharkey, Michael D Hughes
Competing risks occur in a time-to-event analysis in which a patient can experience one of several types of events. Traditional methods for handling competing risks data presuppose one censoring process, which is assumed to be independent. In a controlled clinical trial, censoring can occur for several reasons: some independent, others dependent. We propose an estimator of the cumulative incidence function in the presence of both independent and dependent censoring mechanisms. We rely on semi-parametric theory to derive an augmented inverse probability of censoring weighted (AIPCW) estimator...
February 25, 2017: Lifetime Data Analysis
https://www.readbyqxmd.com/read/28237906/an-extensive-analysis-of-various-texture-feature-extractors-to-detect-diabetes-mellitus-using-facial-specific-regions
#14
Ting Shu, Bob Zhang, Yuan Yan Tang
INTRODUCTION: Researchers have recently discovered that Diabetes Mellitus can be detected through non-invasive computerized method. However, the focus has been on facial block color features. In this paper, we extensively study the effects of texture features extracted from facial specific regions at detecting Diabetes Mellitus using eight texture extractors. MATERIALS AND METHODS: The eight methods are from four texture feature families: (1) statistical texture feature family: Image Gray-scale Histogram, Gray-level Co-occurance Matrix, and Local Binary Pattern, (2) structural texture feature family: Voronoi Tessellation, (3) signal processing based texture feature family: Gaussian, Steerable, and Gabor filters, and (4) model based texture feature family: Markov Random Field...
February 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28237304/stack-and-fugitive-emissions-of-major-air-pollutants-from-typical-brick-kilns-in-china
#15
Yuanchen Chen, Wei Du, Shaojie Zhuo, Weijian Liu, Yuanlong Liu, Guofeng Shen, Shuiping Wu, Jianjun Li, Bianhong Zhou, Gehui Wang, Eddy Y Zeng, Hefa Cheng, Wenxin Liu, Shu Tao
Little information exists on emission factors (EFs, quantities of pollutants emitted per unit of fuel consumed) for brick kilns in China, although brick kilns are important emission sources of many air pollutants, and 45% of the world's bricks are produced in China. In this study, EFs of carbon dioxide (CO2), carbon monoxide (CO), sulfur dioxide (SO2), nitrogen oxides (NOx), particulate matters (PMs), black carbon (BC), organic carbon (OC), and polycyclic aromatic hydrocarbons (PAHs) for brick kilns were derived based on field measurements of a total of 18 brick kilns of major types in China...
February 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28237296/frontal-subcortical-circuitry-in-social-attachment-and-relationships-a-cross-sectional-fmri-ale-meta-analysis
#16
Shu-Hui Lee, Zachary M Walker, James B Hale, S H Annabel Chen
Researchers have explored the concept of attachment in multiple ways, from animal studies examining imprinting to abnormal attachment in psychopathology. However, until recently, few have considered how neural circuitry develops the effective social bonds that are subsequently replicated in relationships across the lifespan. This current cross-sectional study undertook a fMRI Activation Likelihood Estimation (ALE) meta-analyses to examine the neurocircuitry that governs emotional and behavioural functions critical for building effective social relationships in children and adults...
February 22, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28237163/fibrovascular-corneal-mass-a-rare-initial-sign-of-rheumatoid-arthritis
#17
Darren Shu Jeng Ting, Seema Anand
No abstract text is available yet for this article.
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28237028/association-between-slc11a1-nramp1-polymorphisms-and-susceptibility-to-tuberculosis-in-chinese-holstein-cattle
#18
Kaihua Liu, Bin Zhang, Zhaochun Teng, Youtao Wang, Guodong Dong, Cong Xu, Bo Qin, Chunlian Song, Jun Chai, Yang Li, Xianwei Shi, Xianghua Shu, Yifang Zhang
We investigated the associations between SLC11A1 polymorphisms and susceptibility to tuberculosis (TB) in Chinese Holstein cattle, using a case-control study of 136 animals that had positive reactions to TB tests and showed symptoms and 96 animals that had negative reactions to tests and showed no symptoms. Polymerase chain reaction (PCR) sequencing and the restriction fragment length polymorphism (RFLP) technique were used to detect and determine SLC11A1 polymorphisms. Association analysis identified significant correlations between SLC11A1 polymorphisms and susceptibility/resistance to TB, and two genetic markers for SLC11A1 were established using PCR-RFLP...
March 2017: Tuberculosis
https://www.readbyqxmd.com/read/28236929/the-effect-of-gender-on-outcomes-after-lower-extremity-revascularization
#19
REVIEW
Jiarong Wang, Yazhou He, Chi Shu, Jichun Zhao, Luc Dubois
OBJECTIVE: The effect of gender on outcomes after lower extremity revascularization is controversial. The aim of our systemic review and meta-analysis was to evaluate the gender-related outcomes after peripheral vascular interventions. METHODS: We systematically searched MEDLINE, Embase, Cochrane Database, and Scopus to identify studies comparing outcomes after revascularization according to gender. A random-effects model was used to pool outcomes. Time-to-event data were reported using hazard ratios (HRs) and dichotomous data were presented using odds ratios (ORs)...
March 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28236860/effect-of-equipotent-doses-of-bupivacaine-and-ropivacaine-in-high-fat-diet-fed-neonatal-rodent-model
#20
Ying-Dong Lian, Zong-Xiang Chen, Kang-Ru Zhu, Shu-Yin Sun, Li-Ping Zhu
OBJECTIVES: The increase in the prevalence of obesity presents a significant health and economic problem. Obesity has been reported to be a major contributor to variety of chronic diseases. Childhood obesity has been rising over the past decades leading to various complications in health. Millions of infants and children undergo surgery every year on various health grounds. The present investigation was undertaken to evaluate the effect of spinal anesthesia of equipotent doses of ropivacaine and bupivacaine on over-weight neonatal rats...
March 2017: Brazilian Journal of Anesthesiology
keyword
keyword
40082
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"