keyword
MENU ▼
Read by QxMD icon Read
search

Prospective

keyword
https://www.readbyqxmd.com/read/29475205/the-pituitary-thyroid-axis-and-prolactin-secretion-in-hemodialysis-patients-in-two-endemic-regions-of-eastern-germany
#1
Franz Maximilian Rasche, Ronny Rettig, Thomas Frese, Wilma Gertrud Rasche, Filip Barinka, Guenter Roesl, Frieder Keller, Tom H Lindner, Jochen G Schneider, Joachim Beige, Thomas Ebert, Stephan Schiekofer
INTRODUCTION: Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. PATIENTS AND METHODS: 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study...
February 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29475164/thiazolidinediones-as-antidiabetic-agents-a-critical-review
#2
REVIEW
M J Nanjan, Manal Mohammed, B R Prashantha Kumar, M J N Chandrasekar
Thiazolidinediones (TZDs) or Glitazones are an important class of insulin sensitizers used in the treatment of Type 2 diabetes mellitus (T2DM). TZDs were reported for their antidiabetic effect through antihyperglycemic, hypoglycemic and hypolipidemic agents. In time, these drugs were known to act by increasing the transactivation activity of Peroxisome Proliferators Activated Receptors (PPARs). The clinically used TZDs that suffered from several serious side effects and hence withdrawn/updated later, were full agonists of PPAR-γ and potent insulin sensitizers...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29475130/the-influence-of-winter-and-summer-seasons-on-physical-fitness-in-aged-population
#3
P Bezerra, Luis P Rodrigues, C Ayan, J M Cancela
Epidemiological studies have described the association between physical fitness and health. Few have reported the impact of seasonal variation on fitness determinants, in elderly. We investigated the effects of summer and winter environmental conditions on physical fitness, in both exercise and non-exercise elders. 371 non-institutionalized older adults (74.1% female; 78.4 ± 5.3 years) randomly recruited from a total sample of 1338 subjects from north of Portugal, were prospectively followed during 1 year and 3 assessments were performed - April (baseline), October (summer season) and April (winter season)...
February 15, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29475110/pathological-fracture-risk-assessment-in-patients-with-femoral-metastases-using-ct-based-finite-element-methods-a-retrospective-clinical-study
#4
Amir Sternheim, Ornit Giladi, Yair Gortzak, MIchael Drexler, Moshe Salai, Nir Trabelsi, Charles Milgrom, Zohar Yosibash
Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery. CT-based finite element analyses (CTFEA) have been shown to accurately predict strength in femurs with metastatic tumors in an ex-vivo study. In order to assess the utility of CTFEA as a clinical tool to determine the need for fixation of patients with MBD of the femur, an ad hoc CTFEA was performed on a retrospective cohort of fifty patients...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475096/phenotypic-and-functional-profile-of-th17-and-treg-cells-in-allergic-fungal-sinusitis
#5
Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Neelima Gupta, Sonal Sharma, Naseem Akhter, Vishnampettai G Ramachandran, Shafiul Haque, Sajad Ahmad Dar
Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29475092/the-impact-of-donor-characteristics-on-the-invariant-natural-killer-t-cells-of-granulocyte-colony-stimulating-factor-mobilized-marrow-grafts-and-peripheral-blood-grafts
#6
Hong Yan, Zhao Xiangyu, Yu Xingxing, Bian Zhilei, Chang Yingjun, Yu Wang, Zhang Xiaohui, Xu Lanping, Huang Xiaojun, Zhao Xiaosu
INTRODUCTION: Invariant natural killer T cells (iNKTs) are a rare but vital subset of immunomodulatory T cells and play an important role in allogeneic hematopoietic stem cell trans-plantation (HSCT). The association of donor characteristics with the number and frequency of the iNKTs subsets in allografts remains poorly understood. In this paper, we prospectively investigate the association of donor characteristics with iNKTs dose and frequency in granulocyte-colony-stimulating factor (G-CSF) mobilized marrow and peripheral blood harvests...
February 20, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29474997/footwear-generated-dynamic-biomechanical-manipulation-and-perturbation-training-for-chronic-nonspecific-low-back-pain
#7
Se Won Lee, Ratnakar Veeramachaneni, Ibrahim Abou Saleh, Karen Morice, Timothy Tiu, Yungtai Lo, Kevin Frison, Matthew Bartels
BACKGROUND: Home-based therapy optimizing biomechanics and neuromuscular control is increasingly recognized as a treatment option for chronic nonspecific low back pain (CNSLBP). However, its impact on pain, function and gait is limited among patients in a metropolitan area. OBJECTIVE: To evaluate the change of pain, function and gait parameters with home-based therapy using footwear generated biomechanical manipulation and perturbation training (FGBMPT) in a population with CNSLBP in a metropolitan area...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474994/the-association-between-ambulatory-activity-body-composition-and-hip-or-knee-joint-replacement-due-to-osteoarthritis-a-prospective-cohort-study
#8
I P Munugoda, K Wills, F Cicuttini, S E Graves, M Lorimer, G Jones, M L Callisaya, D Aitken
OBJECTIVE: To examine the association between ambulatory activity (AA), body composition measures and hip or knee joint replacement (JR) due to osteoarthritis. DESIGN: At baseline, 1082 community-dwelling older-adults aged 50 - 80 years were studied. AA was measured objectively using pedometer and body composition by dual-energy x-ray absorptiometry. The incidence of primary (first-time) JR was determined by data linkage to the Australian Orthopaedic Association National Joint Replacement Registry...
February 20, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29474992/anatomical-total-shoulder-arthroplasty-used-for-glenohumeral-osteoarthritis-has-higher-survival-rates-than-hemiarthroplasty-a-nordic-registry-based-study
#9
Jeppe V Rasmussen, Randi Hole, Trygve Metlie, Stig Brorson, Ville Äärimaa, Yilmaz Demir, Björn Salomonsson, Steen L Jensen
OBJECTIVE: To report the10-year survival rates of different shoulder arthroplasty types used for glenohumeral osteoarthritis. DESIGN: Data from 2004-2013 was prospectively collected by the national shoulder arthroplasty registers in Denmark, Norway and Sweden and merged into a harmonized dataset under the umbrella of the Nordic Arthroplasty Register Association. The common dataset included data that all three registers could deliver and where consensus regarding definitions could be made...
February 20, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29474989/proportion-of-adult-community-acquired-pneumonia-cases-attributable-to-streptococcus-pneumoniae-among-hajj-pilgrims-in-2016
#10
Ali AlBarrak, Badriah Alotaibi, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Yassein Seedahmed, Mohamed Alshaer, Abdulaziz Altaweel, Husameddin Elshiekh, Abdulhafiz Turkistani, Tanaz Petigara, John Grabenstein, Saber Yezli
BACKGROUND: The Hajj mass gathering is a risk for pneumococcal disease. We evaluated the proportion of adult community-acquired pneumonia (CAP) cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016. To add sensitivity to etiologic attribution, we used a urine-antigen test, in addition to culture-based methods METHODS: Adults hospitalized with x-ray confirmed CAP were prospectively enrolled from all general hospitals designated to treat Hajj pilgrims in the holy cities of Mecca and Medina...
February 20, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29474983/an-in-depth-evaluation-of-the-validity-and-logistics-surrounding-the-testing-of-ar-v7-mrna-expression-in-circulating-tumor-cells
#11
Anieta M Sieuwerts, Bianca Mostert, Michelle van der Vlugt-Daane, Jaco Kraan, Corine Beaufort, Mai Van, Wendy J C Prager, Bram De Laere, Nick Beije, Paul Hamberg, Hans M Westgeest, Metin Tascilar, Luc Y Dirix, Wendy Onstenk, Ronald de Wit, Martijn P Lolkema, Ron H J Mathijssen, John W M Martens, Stefan Sleijfer
Recent reports have emphasized the clinical relevance of detecting the androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to measure AR-V7 by RT-qPCR in RNA isolated from CellSearch-enriched CTCs to provide an AR-V7 positive/negative score in a clinically acceptable time range. CellSearch-enirched CTCs from metastatic castration-resistant prostate cancer patients were characterized by RT-qPCR. After optimization it was prospectively tested whether it was possible to report the AR-V7 status within 11 days (PRELUDE study)...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29474971/pre-diagnosis-use-of-statins-associates-with-increased-survival-times-of-patients-with-pancreatic-cancer
#12
Tsuyoshi Hamada, Natalia Khalaf, Chen Yuan, Vicente Morales-Oyarvide, Ana Babic, Jonathan A Nowak, Zhi Rong Qian, Kimmie Ng, Douglas A Rubinson, Peter Kraft, Edward L Giovannucci, Meir J Stampfer, Charles S Fuchs, Shuji Ogino, Brian M Wolpin
BACKGROUND & AIMS: Statin medications, most commonly prescribed to reduce lipid levels and prevent cardiovascular disease, may be associated with longer survival times of patients with cancer. However, the association of statins with outcomes of patients with pancreatic adenocarcinoma is not clear. METHODS: We analyzed the association of statin use before a diagnosis of pancreatic cancer with survival times of 648 participants in the Nurses' Health Study and Health Professionals Follow-up Study who were diagnosed with pancreatic adenocarcinoma from 2000 through 2013...
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29474887/genome-writing-current-progress-and-related-applications
#13
Yueqiang Wang, Yue Shen, Ying Gu, Shida Zhu, Ye Yin
The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field...
February 20, 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29474886/patient-reported-outcomes-in-prospective-cohort-study-of-electrochemotherapy
#14
N Al-Hadithy, Alexandra Dehnel, Alexander George, Robert Kisiel, Craig Lunt, Christopher Stone
Metastatic spread of malignant tumours to skin is a well described phenomenon with incidence of approximately 0.7-9% of all metastases depending on histological type of primary cancer. Electrochemotherapy (ECT) is an efficient local tumour ablation modality that has proven clinical efficacy in the treatment of various types of tumours metastasis to skin. Aims of this study are to evaluate the activity, toxicity, and feasibility of treating patients with electrochemotherapy (ECT); their clinical outcomes and patient report outcome measures...
February 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29474847/serum-mirna-predicts-viable-disease-post-chemotherapy-in-testicular-non-seminoma-germ-cell-tumor-patients
#15
Ricardo Leão, Ton van Agthoven, Arnaldo Figueiredo, Michael A S Jewett, Kamel Fadaak, Joan Sweet, Ardalan E Ahmad, Lynn Anson-Cartwright, Peter Chung, Aaron Hansen, Padraig Warde, Pedro Castelo-Branco, Martin O'Malley, Philippe L Bedard, Leendert H J Looijenga, Robert J Hamilton
PURPOSE: Retroperitoneal lymph node dissection (RPLND) is recommended for residual masses >1cm post-chemotherapy (pc) in nonseminoma germ cell tumors (NSGCT). Currently, there is no reliable predictor for pcRPLND histology and up to 50% will harbour necrosis/fibrosis only, thus rendering a potentially morbid surgery to be of limited therapeutic value. In this study we aimed to evaluate the ability of defined serum microRNAs (miRNA) to predict residual viable NSGCT after chemotherapy...
February 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29474844/cardiac-output-in-pre-eclampsia-is-associated-with-the-presence-of-fetal-growth-restriction-not-gestation-at-onset-a-prospective-cohort-study
#16
Jasmine Tay, Lin Foo, Giulia Masini, Phillip R Bennett, Carmel M Mceniery, Ian B Wilkinson, Christoph C Lees
BACKGROUND AND OBJECTIVES: Pre-eclampsia (PE) and fetal growth restriction (FGR) are considered to be placentally-mediated disorders. The clinical manifestations are widely held to relate to gestation age at onset with early- and late-onset PE considered to be phenotypically distinct. Recent studies have reported conflicting findings in relation to cardiovascular function, and in particular cardiac output, in PE and FGR. STUDY DESIGN: We investigated maternal cardiovascular function in relation to clinical subtype in 45 pathological pregnancies (14 'PE only', 16 'FGR only', 15 'PE and FGR') and compared these with 107 healthy person observations...
February 20, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#17
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29474748/changes-in-prostate-orientation-due-to-removal-of-a-foley-catheter
#18
Dale W Litzenberg, Daniel G Muenz, Paul G Archer, William C Jackson, Daniel A Hamstra, Jason W Hearn, Matthew J Schipper, Daniel E Spratt
PURPOSE: Investigate the impact on prostate orientation caused by use and removal of a Foley catheter, and the dosimetric impact on men prospectively treated with prostate stereotactic body radiotherapy (SBRT). METHODS: Twenty-two men underwent a CT simulation with a Foley in place (FCT), followed immediately by a second treatment planning simulation without the Foley (TPCT). The change in prostate orientation was determined by rigid registration of three implanted transponders between FCT and TPCT and compared to measured orientation changes during treatment...
February 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29474699/rationale-and-design-of-the-eacvi-afib-echo-europe-registry-for-assessing-relationships-of-echocardiographic-parameters-with-clinical-thrombo-embolic-and-bleeding-risk-profile-in-non-valvular-atrial-fibrillation
#19
Maurizio Galderisi, Erwan Donal, Julien Magne, Francesco Lo Iudice, Eustachio Agricola, Leyla Elif Sade, Matteo Cameli, Ehud Schwammenthal, Nuno Cardim, Bernard Cosyns, Andreas Hagendorff, Alexandar N Neskovic, Josè Luis Zamorano, Patrizio Lancellotti, Gilbert Habib, Thor Edvardsen, Bogdan A Popescu
The European Society of Cardiology (ESC) guidelines for management of atrial fibrillation (AF) recommend the use of CHA2DS2VASc risk score for assessment of thromboembolic (TE) risk, whereas the stratification of bleeding risk should be obtained by HAS-Bleed to balance the most appropriate anticoagulation (OAC) therapy. However, men with CHA2DS2VASc score = 1 and women with CHA2DS2VASc = 2, who are at intermediate TE risk, represent a grey zone where guidelines do not provide a definite OAC indication...
March 1, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29474682/a-multisite-longitudinal-study-of-risk-factors-for-incarceration-and-impact-on-mental-health-and-substance-use-among-young-transgender-women-in-the-usa
#20
Jaclyn M White Hughto, Sari L Reisner, Trace S Kershaw, Fredrick L Altice, Katie B Biello, Matthew J Mimiaga, Robert Garofalo, Lisa M Kuhns, John E Pachankis
Background: Transgender women are disproportionately incarcerated in the US relative to the general population. A dearth of research has explored the factors that predict incarceration among transgender women or the longitudinal impact of incarceration on the health of this population. Methods: Between 2012 and 2015, 221 transgender women ages 16-29 from Boston, MA and Chicago, IL were prospectively assessed at baseline, 4, 8 and 12 months. Mixed effects models were used to identify risk factors for incarceration and examine whether incarceration predicts somatic, anxiety and depressive symptoms, illicit drug use, and binge drinking over time, controlling for baseline psychiatric and substance use disorders...
February 21, 2018: Journal of Public Health
keyword
keyword
4008
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"