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https://www.readbyqxmd.com/read/28549271/the-association-between-the-early-motor-repertoire-and-language-development-in-term-children-born-after-normal-pregnancy
#1
Sahar Salavati, Christa Einspieler, Giulia Vagelli, Dajie Zhang, Jasmin Pansy, Johannes G M Burgerhof, Peter B Marschik, Arend F Bos
BACKGROUND: The assessment of the early motor repertoire is a widely used method for assessing the infant's neurological status. AIM: To determine the association between the early motor repertoire and language development. STUDY DESIGN: Prospective cohort study. SUBJECTS: 22 term children born after normal pregnancy; video recorded for the assessment of the early motor repertoire including their motor optimality score (MOS), according to Prechtl, at 3 and 5months post term...
May 23, 2017: Early Human Development
https://www.readbyqxmd.com/read/28549269/high-hair-cortisol-concentrations-predict-worse-cognitive-outcome-after-stroke-results-from-the-tabasco-prospective-cohort-study
#2
E Ben Assayag, O Tene, A D Korczyn, L Shopin, E Auriel, J Molad, H Hallevi, C Kirschbaum, N M Bornstein, S Shenhar-Tsarfaty, E Kliper, T Stalder
BACKGROUND AND PURPOSE: The role of stress-related endocrine dysregulation in the development of cognitive changes following a stroke needs further elucidation. We explored this issue in a longitudinal study on stroke survivors using hair cortisol concentrations (HCC), a measure of integrated long-term cortisol levels. METHODS: Participants were consecutive cognitively intact first-ever mild-moderate ischemic stroke/transient ischemic attack (TIA) survivors from the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study...
May 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28549248/metastatic-chromophobe-renal-cell-carcinoma-treated-with-targeted-therapies-a-renal-cross-channel-group%C3%A2-study
#3
Emeline Colomba, Gwénaël Le Teuff, Tim Eisen, Grant D Stewart, Kate Fife, James Larkin, Andrea Biondo, Lisa Pickering, Anandagopal Srinivasan, Helen Boyle, Lisa Derosa, Cora N Sternberg, Federica Recine, Christy Ralph, Carolina Saldana, Philippe Barthélémy, Jean Christophe Bernhard, Howard Gurney, Gregory Verhoest, Elodie Vauleon, Pierre Bigot, Julien Berger, Christian Pfister, Gwenaelle Gravis, Jean-Michel Rodier, Stéphane Culine, Armelle Caty, Frederic Rolland, Franck Priou, Bernard Escudier, Laurence Albiges
BACKGROUND: Treatment of non-clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC. METHODS: We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era...
May 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28549144/video-assisted-thoracoscopic-surgery-approach-for-transmyocardial-laser-revascularization
#4
Mohammad A Bashir, Brandon C Lyle, Ali S Nasr, Kalpaj Parekh
Transmyocardial laser revascularization is an established therapy for refractory coronary artery disease. However, utilization of the technology is not as widespread as expected. This is despite the fact that the efficacy of the technology has been established in multiple prospective randomized trials. Furthermore, only about 5% of transmyocardial laser revascularization cases annually are performed in a minimally invasive fashion. We report a case of a female patient treated in a minimally invasive thoracoscopic fashion...
May 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28549087/thalamic-alterations-remote-to-infarct-appear-as-focal-iron-accumulation-and-impact-clinical-outcome
#5
Grégory Kuchcinski, Fanny Munsch, Renaud Lopes, Antoine Bigourdan, Jason Su, Sharmila Sagnier, Pauline Renou, Jean-Pierre Pruvo, Brian K Rutt, Vincent Dousset, Igor Sibon, Thomas Tourdias
Thalamic alterations have been observed in infarcts initially sparing the thalamus but interrupting thalamo-cortical or cortico-thalamic projections. We aimed at extending this knowledge by demonstrating with in vivo imaging sensitive to iron accumulation, one marker of neurodegeneration, that (i) secondary thalamic alterations are focally located in specific thalamic nuclei depending on the initial infarct location; and (ii) such secondary alterations can contribute independently to the long-term outcome. To tackle this issue, 172 patients with an infarct initially sparing the thalamus were prospectively evaluated clinically and with magnetic resonance imaging to quantify iron through R2* map at 24-72 h and at 1-year follow-up...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28549077/clinical-criteria-for-subtyping-parkinson-s-disease-biomarkers-and-longitudinal-progression
#6
Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Alain Dagher, Ronald B Postuma
Parkinson's disease varies widely in clinical manifestations, course of progression and biomarker profiles from person to person. Identification of distinct Parkinson's disease subtypes is of great priority to illuminate underlying pathophysiology, predict progression and develop more efficient personalized care approaches. There is currently no clear way to define and divide subtypes in Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative, we aimed to identify distinct subgroups via cluster analysis of a comprehensive dataset at baseline (i...
May 25, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28549070/the-atherogenic-index-of-plasma-and-the-risk-of-mortality-in-incident-dialysis-patients-results-from-a-nationwide-prospective-cohort-in-korea
#7
Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Hyung Jong Kim, Tae-Hyun Yoo
BACKGROUND: The atherogenic index of plasma (AIP), which is the logarithmic ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), had a linear relationship with clinical outcomes in the general population. However, the association of each lipid profile, TG and HDL-C, with survival was not straightforward in dialysis patients. This non-linear association led us to further investigate the prognostic impact of the AIP in these patients. METHODS: From a nationwide prospective cohort, 1,174 incident dialysis patients were included...
2017: PloS One
https://www.readbyqxmd.com/read/28549045/effect-of-preoperative-molding-helmet-in-patients-with-sagittal-synostosis
#8
Asra Hashmi, Neena I Marupudi, Sandeep Sood, Arlene Rozzelle
BACKGROUND: In our practice, the authors found that molding helmet used for plagiocephaly preoperatively, in patients with sagittal synostosis, decreased bathrocephaly, forehead bossing, and improved posterior vertex, as well as Cephalic Index (CI). This prompted us to investigate the impact of preoperative molding helmet in patients with sagittal synostosis. METHODS: A prospective study was performed on patients undergoing surgical correction of sagittal synostosis, over a 5-year period...
May 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28549041/value-of-osteoblast-derived-exosomes-in-bone-diseases
#9
Min Ge, Yingzhi Wu, Ronghu Ke, Tianyi Cai, Junyi Yang, Xiongzheng Mu
PURPOSE: The authors' purpose is to reveal the value of osteoblast-derived exosomes in bone diseases. METHODS: Microvesicles from supernatants of mouse Mc3t3 were isolated by ultracentrifugation and then the authors presented the protein profile by proteomics analysis. RESULTS: The authors detected a total number of 1536 proteins by mass spectrometry and found 172 proteins overlap with bone database. The Ingenuity Pathway Analysis shows network of "Skeletal and Muscular System Development and Function, Developmental Disorder, Hereditary Disorder" and pathway about osteogenesis...
May 25, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28549023/technical-feasibility-of-a-combined-noncontrast-magnetic-resonance-protocol-for-preoperative-transcatheter-aortic-valve-replacement-evaluation
#10
Paola M Cannaò, Giuseppe Muscogiuri, U Joseph Schoepf, Carlo N De Cecco, Pal Suranyi, Virginia W Lesslie, Davide Piccini, Shivraman Giri, Akos Varga-Szemes
PURPOSE: The aim of this study was to prospectively evaluate the technical feasibility of a noncontrast magnetic resonance angiography (MRA) protocol using investigational prototype self-navigated 3D (SN3D) radial whole-heart and quiescent-interval single-shot (QISS) pulse sequences regarding their potential in planning transcatheter aortic valve replacement (TAVR). MATERIALS AND METHODS: Five patients (76±7 y) with severe aortic valve stenosis and prior computed tomographic angiography (CTA) for TAVR planning and 10 healthy volunteers (28±6 y) underwent noncontrast MRA on a 1...
May 25, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28549014/robot-assisted-versus-laparoscopic-surgery-for-rectal-cancer-a-phase-ii-open-label-prospective-randomized-controlled-trial
#11
Min Jung Kim, Sung Chan Park, Ji Won Park, Hee Jin Chang, Dae Yong Kim, Byung-Ho Nam, Dae Kyung Sohn, Jae Hwan Oh
OBJECTIVE: The phase II randomized controlled trial aimed to compare the outcomes of robot-assisted surgery with those of laparoscopic surgery in the patients with rectal cancer. BACKGROUND: The feasibility of robot-assisted surgery over laparoscopic surgery for rectal cancer has not been established yet. METHODS: Between February 21, 2012 and March 11, 2015, patients with rectal cancer (cT1-3NxM0) were enrolled. Patients were randomized 1:1 to either robot-assisted or laparoscopic surgery, and stratified per sex and administration of preoperative chemoradiotherapy...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28549010/a-clinical-feasibility-trial-for-identification-of-exceptional-responders-in-whom-breast-cancer-surgery-can-be-eliminated-following-neoadjuvant-systemic-therapy
#12
Henry M Kuerer, Gaiane M Rauch, Savitri Krishnamurthy, Beatriz E Adrada, Abigail S Caudle, Sarah M DeSnyder, Dalliah M Black, Lumarie Santiago, Brian P Hobbs, Anthony Lucci, Michael Gilcrease, Rosa F Hwang, Rosalind P Candelaria, Mariana Chavez-MacGregor, Benjamin D Smith, Elsa Arribas, Tanya Moseley, Mediget Teshome, Makesha V Miggins, Vicente Valero, Kelly K Hunt, Wei T Yang
OBJECTIVE: To determine the accuracy of fine-needle aspiration (FNA) and vacuum-assisted core biopsy (VACB) in assessing the presence of residual cancer in the breast after neoadjuvant systemic therapy (NST). SUMMARY BACKGROUND DATA: Pathologic complete response (pCR) rates after NST have improved dramatically, suggesting that surgery might be avoided in some patients. Safe avoidance of surgery would require accurate confirmation of no residual invasive/in situ carcinoma...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28548988/toward-precision-medicine-tailoring-interventional-strategies-based-on-noninvasive-brain-stimulation-for-motor-recovery-after-stroke
#13
Philipp J Koch, Friedhelm C Hummel
PURPOSE OF REVIEW: To support the recovery of disability and the reduced functional capacity influencing the independence of daily life after focal brain lesions like stroke, the application of noninvasive brain stimulation (NIBS) by repetitive transcranial magnetic stimulation or transcranial electric stimulation has been found useful in the last decades. Still, a positive influence on the recovery seems to be restricted to specific subgroups of patients. Therefore, a closer look on individual parameters influencing the recovery course and the effect of NIBS is needed...
May 25, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28548967/detection-of-activating-and-acquired-resistant-mutation-in-plasma-from-egfr-mutated-nsclc-patients-by-peptide-nucleic-acid-pna-clamping-assisted-fluorescence-melting-curve-analysis
#14
Chang Gon Kim, Hyo Sup Shim, Min Hee Hong, Yoon Jin Cha, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Jin Gu Lee, Chang Young Lee, Byoung Chul Cho, Hye Ryun Kim
This study was designed to prospectively examine whether peptide nucleic acid clamping-assisted fluorescence melting curve analysis (PANAMutyper™) is feasible for the detection of activating and acquired resistant epidermal growth factor receptor (EGFR) mutation in plasma. Patients with non-small cell lung cancer harboring activating EGFR mutations who were scheduled to undergo EGFR-tyrosine kinase inhibitors (EGFR-TKIs) were enrolled between September 2011 and March 2015. A total of 102 patients with EGFR-mutated lung cancer were enrolled, 53 had available plasma samples at disease progression, and 28 underwent serial plasma sampling during EGFR-TKI treatment...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548962/prognostic-implication-of-leucocyte-subpopulations-in-diffuse-large-b-cell-lymphoma
#15
Xiao Han, Jing Ruan, Wei Zhang, Daobin Zhou, Dongsheng Xu, Qiang Pei, Mingqi Ouyang, Mengxuan Zuo
BACKGROUND: Recent studies have suggested that variables related to host adaptive immunity and the tumor microenvironment may predict the outcome in patients with non-Hodgkin's lymphoma. This study was undertaken to determine the prognostic value of peripheral blood leucocyte subpopulations in diffuse large-B-cell lymphoma patients. METHODS: We prospectively analyzed the 16 leukocyte subpopulations using Cytodiff flow cytometric technique in a cohort of 45 diffuse large-B-cell lymphoma patients at a single institution between February and December 2014...
May 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548938/nkp30-expression-is-a-prognostic-immune-biomarker-for-stratification-of-patients-with-intermediate-risk-acute-myeloid-leukemia
#16
Anne-Sophie Chretien, Cyril Fauriat, Florence Orlanducci, Jerome Rey, Gaelle Bouvier Borg, Emmanuel Gautherot, Samuel Granjeaud, Clemence Demerle, Jean-François Hamel, Adelheid Cerwenka, Elke Pogge von Strandmann, Norbert Ifrah, Catherine Lacombe, Pascale Cornillet-Lefebvre, Jacques Delaunay, Antoine Toubert, Christine Arnoulet, Norbert Vey, Daniel Olive
Cytogenetics and European Leukemia Net (ELN) genetic classification predict patients at increased risk of relapse in acute myeloid leukemia (AML) except in the intermediate risk group for which further prognostic determinants are required. We have previously shown that Natural Killer (NK) cell defects in AML are predictors of poor overall survival (OS). This study aimins at validating NKp30, a receptor that mediates NK activation, as a prognostic biomarker for AML patients with intermediate prognosis.NKp30 expression was prospectively assessed at diagnosis on NK cells from peripheral blood by flow cytometry (N = 201 patients)...
May 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28548907/evaluation-of-thermal-optical-analysis-method-of-elemental-carbon-for-marine-fuel-exhaust
#17
Maija K Lappi, Jyrki P Ristimäki
The awareness of black carbon (BC) as the second largest anthropogenic contributor in global warming and an ice melting enhancer has increased. Due to prospected increase in shipping especially in the Arctic reliability of BC emissions and their invented amounts from ships is gaining more attention. The International Maritime Organisation (IMO) is actively working towards estimation of quantities and effects of BC especially in the Arctic. IMO has launched work towards constituting a definition for BC and agreeing appropriate methods for its determination from shipping emission sources...
May 26, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28548875/overweight-obesity-and-height-as-risk-factors-for-meningioma-glioma-pituitary-adenoma-and-nerve-sheath-tumor-a-large-population-based-prospective-cohort-study
#18
Markus K H Wiedmann, Cathrine Brunborg, Antonio Di Ieva, Kristina Lindemann, Tom B Johannesen, Lars Vatten, Eirik Helseth, John A Zwart
BACKGROUND: In 2016, the International Agency for Research on Cancer (IARC) has announced that avoiding body fatness (i.e. overweight and obesity) contributes to prevent meningioma occurrence, but considered the available evidence for glioma inadequate. The association of body fatness with other CNS tumor subgroups is largely unknown. OBJECTIVES: To assess whether body fatness or body height are associated with risk for meningioma, glioma, pituitary adenoma (PA) or nerve sheath tumor (NST) in a large population-based Norwegian cohort...
May 26, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28548822/iron-containing-metal-organic-frameworks-structure-synthesis-and-applications-in-environmental-remediation
#19
Xiaocheng Liu, Yaoyu Zhou, Jiachao Zhang, Lin Tang, Lin Luo, Guangming Zeng
Metal-organic Frameworks (MOFs) with Fe content are gradually developing into an independent branch in environmental remediation, requiring economical, effective, low toxic strategies to the complete procedure. In this review, the recent advancements in the structure, synthesis and environmental application focusing on the mechanism are presented. The unique structure of novel design proposed specific characteristics of different iron containing MOFs with potential innovation. Synthesis of typical MILs, NH2-MILs and MILs based materials reveal the basis and defect of the current method, indicating the optimal means for the actual requirements...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28548821/turning-nonspecific-interference-into-signal-amplification-covalent-biosensing-nanoassembly-enabled-by-metal-catalyzed-cross-coupling
#20
Hao Li, Fang Wang, Shenguang Ge, Haiyun Liu, Mei Yan, Jinghua Yu
In this work, a new method of protein detection in complicated samples is proposed. This method employs probe-target recognition to induce cross-linking among the probe, the target, and the nonspecific proteins in the complicated sample as a means to convert interference into effective signal amplification. This also eliminates the necessity of multistep signal amplification in a separate solution system. On the basis of this strategy, a simple and robust assay for the activity of serum cathepsin B is established...
May 26, 2017: Analytical Chemistry
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