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https://www.readbyqxmd.com/read/28944846/hedyotis-diffusa-willd-suppresses-metastasis-in-5%C3%A2-fluorouracil%C3%A2-resistant-colorectal-cancer-cells-by-regulating-the-tgf%C3%A2-%C3%AE-signaling-pathway
#1
Zijun Lai, Zhaokun Yan, Wujin Chen, Jun Peng, Jianyu Feng, Qiongyu Li, Yiyi Jin, Jiumao Lin
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract, and threatens the survival and health of patients with CRC. Chemotherapy remains one of the main therapeutic approaches for patients with CRC; however, drug resistance limits the long‑term use. CRC cells with multi‑drug resistance (MDR) exhibit increased survival times and metastatic potential, which may lead to the recurrence and metastasis of CRC. In addition, MDR is one of the major causes of chemotherapy failure in clinical treatment...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944765/folate-receptor-targeted-nir-sensitive-polydopamine-nanoparticles-for-chemo-photothermal-cancer-therapy
#2
Hao Li, Zhen Jin, Sunghoon Cho, Mi Jeong Jeon, Van Du Nguyen, Jong-Oh Park, Sukho Park
We propose the use of folate-receptor-targeted, near-infrared-sensitive polydopamine nanoparticles (NPs) for chemo-photothermal cancer therapy as an enhanced type of drug-delivery system which can be synthesized by in situ polymerization and conjugation with folic acid. The NPs consist of a Fe3O4/Au core, coated polydopamine, conjugated folic acid, and loaded anti-cancer drug (doxorubicin). The proposed multifunctional NPs show many advantages for therapeutic applications such as good biocompatibility and easy bioconjugation...
September 25, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28944654/ovarian-cancer-therapy-by-vsvmp-gene-mediated-by-a-paclitaxel-enhanced-nanoparticle
#3
Jianlin Long, Yuping Yang, Tianyi Kang, Wei Zhao, Hao Cheng, Yujiao Wu, Ting Du, Beibei Liu, Yang Li, Feng Luo, Maling Gou
Nanoparticles have great promise for gene delivery. However, the transfection efficiency of nanoparticle-based gene delivery systems is always unsatisfied to meet the requirement of effective gene therapy. Herein, we used low dosage paclitaxel to enhance a nanoscaled gene delivery system that was self-assembled from DOTAP and MPEG-PLA(DPP), creating a paclitaxel-encapsulated DPP nanoparticle (P-DPP). The encapsulated low-dosage paclitaxel significantly improved the gene delivery efficiency of the DPP nanoparticles against multiple cancer cells, in some of which the transfection efficiency is as high as 92%...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944496/the-unidirectional-hypoxia-activated-prodrug-oct1002-inhibits-growth-and-vascular-development-in-castrate-resistant-prostate-tumors
#4
Heather Nesbitt, Jenny Worthington, Rachel J Errington, Laurence H Patterson, Paul J Smith, Stephanie R McKeown, Declan J McKenna
BACKGROUND: OCT1002 is a unidirectional hypoxia-activated prodrug (uHAP) OCT1002 that can target hypoxic tumor cells. Hypoxia is a common feature in prostate tumors and is known to drive disease progression and metastasis. It is, therefore, a rational therapeutic strategy to directly target hypoxic tumor cells in an attempt to improve treatment for this disease. Here we tested OCT1002 alone and in combination with standard-of-care agents in hypoxic models of castrate-resistant prostate cancer (CRPC)...
September 24, 2017: Prostate
https://www.readbyqxmd.com/read/28944452/nano-pulse-stimulation-induces-potent-immune-responses-eradicating-local-breast-cancer-while-reducing-distant-metastases
#5
Siqi Guo, Yu Jing, Niculina I Burcus, Brittany P Lassiter, Royena Tanaz, Richard Heller, Stephen J Beebe
Nano-Pulse Stimulation (NPS) as a developing technology has been studied for minimally invasive, non-thermal local cancer elimination for more than a decade. Here we show that a single NPS treatment results in complete regression of the poorly immunogenic, metastatic 4T1-Luc mouse mammary carcinoma. Impressively, spontaneous distant organ metastases were largely prevented, even in those animals with incomplete tumor regression. All tumor-free mice were protected from secondary tumor cell challenge, demonstrating a vaccine-like effect...
September 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28944214/oncolytic-viruses-interaction-of-virus-and-tumor-cells-in-the-battle-to-eliminate-cancer
#6
REVIEW
Anwen Howells, Giulia Marelli, Nicholas R Lemoine, Yaohe Wang
Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have recently been the focus of extensive research aiming to develop their therapeutic potential. The ultimate aim is to design a virus which can effectively replicate within the host, specifically target and lyse tumor cells and induce robust, long lasting tumor-specific immunity. There are a number of viruses which are either naturally tumor-selective or can be modified to specifically target and eliminate tumor cells. This means they are able to infect only tumor cells and healthy tissue remains unharmed...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28943944/andrographolide-suppresses-proliferation-of-human-colon-cancer-sw620-cells-through-the-tlr4-nf-%C3%AE%C2%BAb-mmp-9-signaling-pathway
#7
Rui Zhang, Jian Zhao, Jian Xu, De-Xin Jiao, Jian Wang, Zhi-Qiang Gong, Jian-Hui Jia
Modern pharmacological research has revealed that andrographolide has various functions, including anti-bacterial, anti-inflammatory and anti-viral effects, immunoregulation, treating cardiovascular and cerebrovascular diseases, and prevention and treatment of alcoholic liver injury. The present study investigated whether andrographolide suppresses the proliferation of human colon cancer cell through the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB/matrix metalloproteinase-9 (MMP-9) signaling pathway...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943931/a-missing-link-between-ron-expression-and-oncological-outcomes-in-resected-left-sided-pancreatic-cancer
#8
Dai Hoon Han, Chang Moo Kang, Sung Whan Lee, Ho Kyoung Hwang, Woo Jung Lee
Alteration and activation of recepteur d'origine nantais (RON) expression is known to be associated with cancer progression and decreased survival in various types of human cancer, including pancreatic cancer. Therefore, in the present study, RON expression levels were determined in resected left-sided pancreatic cancer to evaluate the potential oncological role of RON in the clinical setting of distal pancreatic cancer. From January 2005 to December 2011, a total of 57 patients underwent radical distal pancreatectomy for left-sided pancreatic cancer...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943529/quisqualis-indica-improves-benign-prostatic-hyperplasia-by-regulating-prostate-cell-proliferation-and-apoptosis
#9
Charith Ub Wijerathne, Hee-Seon Park, Hye-Yun Jeong, Ji-Won Song, Og-Sung Moon, Young-Won Seo, Young-Suk Won, Hwa-Young Son, Jong-Hwan Lim, Sung-Hum Yeon, Hyo-Jung Kwun
Quisqualis indica (QI) has been used for treating disorders such as stomach pain, constipation, and digestion problem. This study was aimed to evaluate the therapeutic efficacy of QI extract on treating benign prostatic hyperplasia (BPH) in LNCaP human prostate cancer cell line and a testosterone-induced BPH rat model. LNCaP cells were treated with QI plus testosterone propionate (TP), and androgen receptor (AR) and prostate specific antigen (PSA) expression levels were assessed by Western blotting. To induce BPH, the rats were subjected to a daily subcutaneous injection of TP (3 mg/kg) for 4 wk...
September 22, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28943391/cytogenetic-effects-of-jacareubin-from-calophyllum-brasiliense-on-human-peripheral-blood-mononucleated-cells-in-vitro-and-on-mouse-polychromatic-erythrocytes-in-vivo
#10
W R García-Niño, E Estrada-Muñiz, M Valverde, R Reyes-Chilpa, L Vega
Jacareubin is a xanthone isolated from the heartwood of Calophyllum brasiliense with antibacterial and gastroprotective properties and the intention for clinical use as an anti-cancer treatment (due to the similar chemical structure to other anti-neoplastic drugs) requires an investigation of whether this compound can generate adverse effects on non-transformed cells. Jacareubin (0.5-1000μM in DMSO) was more cytotoxic on phytohemagglutinin (PHA)-stimulated normal human peripheral blood mononuclear cells (PBMCs; IC50 at 72h by MTT: 85...
September 21, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28943206/kaolinite-in-pharmaceutics-and-biomedicine
#11
REVIEW
Mahmoud E Awad, Alberto López-Galindo, Massimo Setti, Mahmoud M El-Rahmany, César Viseras Iborra
Kaolinite Al2Si2O5(OH)4 is an abundant and inexpensive geomaterial regarded as one of the most common clay minerals in the earth's crust and the most widespread phase among the other kaolin polymorphs (halloysite, dickite and nacrite). Structurally, it is a hydrous aluminum phyllosilicate member belonging to the dioctahedral 1:1 kaolin mineral group. The particle size of the pseudohexagonal kaolinite platelets is normally <2μm (if compared to a human red blood cell of a typical diameter 6.2-8.2μm or to a virus particle of about 50nm diameter)...
September 21, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28943195/diels-alder-mediated-release-of-gemcitabine-from-hybrid-nanoparticles-for-enhanced-pancreatic-cancer-therapy
#12
Adeolu Oluwasanmi, Wejdan Al-Shakarchi, Ayesha Manzur, Mohammed H Aldebasi, Rayan S Elsini, Malek K Albusair, Katherine J Haxton, Anthony D M Curtis, Clare Hoskins
Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was developed by introducing a linker between HNPs and gemcitabine. Whereby, heat generation resulting from laser irradiation of the HNPs promoted linker breakdown resulting in prodrug liberation. In vitro evaluation in pancreatic adenocarcinoma cells, showed the prodrug was 4...
September 21, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28942721/assessment-of-venous-thromboembolism-treatment-in-patients-with-cancer-on-low-molecular-weight-heparin-warfarin-and-the-direct-oral-anticoagulants
#13
Ellen M Uppuluri, Kelly R Burke, Christina Mactal Haaf, Nancy L Shapiro
Background Direct oral anticoagulants (DOACs) are not recommended for venous thromboembolism (VTE) treatment in patients with cancer because their safety and efficacy have not been compared to low molecular weight heparin (LMWH) in large trials. Routine anti-Xa monitoring in cancer patients on LMWH is also not recommended due to limited data correlating anti-Xa levels and outcomes. Objective Compare the safety and efficacy of DOACs to LMWH and warfarin and assess the relationship of anti-Xa monitoring and outcomes in patients with cancer taking LMWH in an urban university setting...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28942553/clinacanthus-nutans-mitigates-neuronal-apoptosis-and-ischemic-brain-damage-through-augmenting-the-c-ebp%C3%AE-driven-ppar-%C3%AE-transcription
#14
Jui-Sheng Wu, Mei-Han Kao, Hsin-Da Tsai, Wai-Mui Cheung, Jin-Jer Chen, Wei-Yi Ong, Grace Y Sun, Teng-Nan Lin
Clinacanthus nutans Lindau (C. nutans) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies including snake and insect bites, skin rashes, viral infections, and cancer. However, the underlying molecular mechanisms for its action and whether C. nutans can offer protection on stroke damage in brain remain largely unknown. In the present study, we demonstrated protective effects of C. nutans extract to ameliorate neuronal apoptotic death in the oxygen-glucose deprivation model and to reduce infarction and mitigate functional deficits in the middle cerebral artery occlusion model, either administered before or after hypoxic/ischemic insult...
September 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28942432/the-application-and-mechanism-of-pd-pathway-blockade-for-cancer-therapy
#15
REVIEW
Xing Wang, Shan Huang, Ya Zhang, Lin Zhu, Xiaoliang Wu
Research in cancer therapeutics has achieved major progress in the understanding of the tumour-immunity cycle, which controls the delicate balance between the immune system and tumour. Identification of cancer cell T-cell inhibitory signals, including PD-L1, has generated novel insight into how to reinvigorate the patients' immune cells to respond to a variety of tumour types. PD-1 and PD-L1 (PD) inhibitory pathway blockade appears to a highly promising therapy and could accomplish durable anti-tumour responses with a reasonable toxicity profile...
September 23, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28942285/amentoflavone-suppresses-tumor-growth-in-ovarian-cancer-by-modulating-skp2
#16
Honggai Liu, Qingfen Yue, Shehong He
AIM: Ovarian cancer is one of most common malignancies in women and is associated with high reoccurrence rate and poor prognosis. This study is designed to investigate the anti-tumor effects of amentoflavone (AF), one of the major active ingredients of S. tamariscina, against ovarian cancer. MATERIALS AND METHODS: Human ovarian cancer cell lines SKOV3 and OVCAR-3 were used in this study. The effect of AF on cell viability was examined by CCK-8 assay. Cell apoptosis and cell cycle distribution was determined by flow cytometry...
September 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28942113/novel-serms-based-on-3-aryl-4-aryloxy-2h-chromen-2-one-skeleton-a-possible-way-to-dual-er%C3%AE-vegfr-2-ligands-for-treatment-of-breast-cancer
#17
Guoshun Luo, Xinyu Li, Guoqing Zhang, Chengzhe Wu, Zhengpu Tang, Linyi Liu, Qidong You, Hua Xiang
There is considerable interest in developing new SERMs as multifunctional agents in women's health. Development of dual selective estrogen receptor modulators/VEGFR-2 inhibitors (SERMs/V-2I) has been an attractive strategy for the discovery of new breast cancer therapeutic agents. Our previous efforts led to the preparation of a series of 3-aryl-4-anilino-2H-chromen-2-ones endowed with potent estrogen receptor binding affinity and anti-proliferative efficacy. In this study, various structurally related 3-aryl-4-anilino/aryloxy-2H-chromen-2-one analogues were rationally designed, synthesized and evaluated as a new chemo-type of dual ERα and VEGFR-2 inhibitors...
September 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28942036/polysaccharides-isolated-from-hedyotis-diffusa-inhibits-the-aggressive-phenotypes-of-laryngeal-squamous-carcinoma-cells-via-inhibition-of-bcl-2-mmp-2-and-%C3%AE-pa
#18
Caiqin Wu, Huanan Luo, Weijun Ma, Xiaoyong Ren, Chuangxin Lu, Ni Li, Zhenghui Wang
Hedyotis diffusa, a traditional Chinese herbal medicine, possesses anti-cancer, anti-oxidative, and anti-inflammatory effects. The aim of this study is to explore the anti-tumor potential of Hedyotis diffusa polysaccharides (HDP) in human larynx squamous carcinoma. High performance size-exclusion chromatography analysis indicated the homogeneous nature of HDP. Total carbohydrate content in HDP was 97.3%, without contamination of protein and nucleic acid. HDP suppressed the proliferation of Hep2 human larynx squamous carcinoma cells in a time- and dose-dependent manner...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28940860/nanoparticles-prepared-from-porcine-cells-support-the-healing-of-cutaneous-inflammation-in-mice-and-wound-re-epithelialization-in-human-skin
#19
Natalia Kunz, Eva Hauenschild, Sebastian Maass, Kai-Uwe Kalies, Matthias Klinger, Melanie Barra, Lars Hecht, Franz Helbig, Stefan Soellner, Charles C Caldwell, Ralf J Ludwig, Jürgen Westermann, Kathrin Kalies
Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these observations, we asked whether CDNPs would improve inflammatory skin disorders. To address this, we utilized two distinct mouse models of cutaneous inflammation: the autoimmune skin blistering disease epidermolysis bullosa acquisita (EBA) as an example of an autoantibody-induced cutaneous inflammation, and Leishmania major (L...
September 23, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28940667/drugs-for-metabolic-conditions-and-prostate-cancer-death-in-men-on-gnrh-agonists
#20
Cecilia Bosco, Chloe Wong, Hans Garmo, Danielle Crawley, Lars Holmberg, Niklas Hammar, Jan Adolfsson, Pär Stattin, Mieke Van Hemelrijck
BACKGROUND: It is unclear whether metabolic syndrome and its related drugs is affecting treatment response in men with prostate cancer (PCa) on Gonadotropin releasing Hormone (GnRH) agonists. We aimed to evaluate whether drugs for metabolic conditions influence PCa-specific mortality in men starting GnRH agonists. METHODS: We selected all men receiving GnRH agonists as primary treatment in PCBaSe Sweden (n=9,267). Use of drugs for metabolic conditions (i.e. anti-diabetes, anti-dyslipidaemia, and anti-hypertension) in relation to all cause, cardiovascular disease (CVD), and PCa-specific death was studied using multivariate Cox proportional hazard and Fine and Gray competing regression models...
September 20, 2017: BJU International
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