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Granulosa theca cell

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https://www.readbyqxmd.com/read/29772405/a-transcriptomic-comparison-of-theca-and-granulosa-cells-in-chicken-and-cattle-follicles-reveals-esr2-as-a-potential-regulator-of-cyp19a1-expression-in-the-theca-cells-of-chicken-follicles
#1
Ruoxi Jing, Lantao Gu, Jinqiu Li, Yanzhang Gong
Previous studies have shown that theca and granulosa cell layers in follicles do not play the same roles in mammals and birds, especially regarding the synthesis of estrogen. The functions of these two cell types have been well characterized in cattle, but they remain unclear in chickens. To clarify this issue, a comparison of small yellow follicles (SYFs) in chickens and cattle at different follicular development stages was done by weighted gene co-expression network analysis (WGCNA). The modules obtained from WGCNA were used for further identification of the key genes associated with CYP19A1 expression...
April 28, 2018: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/29771299/at-the-crossroads-of-fate-somatic-cell-lineage-specification-in-the-fetal-gonad
#2
Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao
The reproductive endocrine systems are vastly different between male and female. This sexual dimorphism of endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. The majority of gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the gonadal somatic cells initiate sex-specific differentiation during gonadal sex determination with the specification of the supporting cell lineages: Sertoli cells in the testis vs...
May 15, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29723542/effects-of-fibroblast-growth-factors-and-the-transcription-factor-early-growth-response-1-on-bovine-theca-cells
#3
Peng Han, Hilda Guerrero-Netro, Anthony Estienne, Christopher A Price
The theca cell layer of the ovarian follicle secretes growth factors that impact the function of granulosa cells. One such factor is fibroblast growth factor 18 (FGF18) that causes apoptosis of granulosa cells, however it is not known if FGF18 induces apoptosis also in theca cells. Addition of recombinant FGF18 to bovine theca cells in vitro inhibited steroidogenesis but, in contrast to previous data in granulosa cells, decreased the incidence of apoptosis. FGF18 activated typical FGF signaling pathways in theca cells, which was not previously observed in granulosa cells...
April 30, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29706614/coherent-apoptotic-and-autophagic-activities-involved-in-regression-of-chicken-postovulatory-follicles
#4
Xin Lin, Xingting Liu, Yanfen Ma, Yuling Mi, Weidong Zeng, Jian Li, Caiqiao Zhang
After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P4 ) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. The function and regression mechanisms of avian POFs remain poorly understood. Here we investigated the changes in apoptotic and autophagic activities that were involved during POF degradation...
April 29, 2018: Aging
https://www.readbyqxmd.com/read/29684814/transcriptional-and-translational-abundance-of-bone-morphogenetic-protein-bmp-2-4-6-7-and-their-receptors-bmpr1a-1b-and-bmpr2-in-buffalo-ovarian-follicle-and-the-role-of-bmp4-and-bmp7-on-estrogen-production-and-survival-of-cultured-granulosa-cells
#5
G Rajesh, S R Mishra, A Paul, M Punetha, G M Vidyalakshmi, K Narayanan, S Bag, S K Bhure, V Singh Chouhan, V P Maurya, G Singh, Mihir Sarkar
BMPs and their receptors modulate the granulosa cell (GC) function in the follicle of domestic animals. Since little is known on BMPs in the buffalo, the present study was aimed to investigate the expression of BMP2, 4, 6, 7 and their receptors BMPR1A, BMPR1B, BMPR2 in the GC and theca cells (TC) of ovarian follicles and the role of BMP4 and BMP7 on buffalo GC. Follicles were classified into four groups based on size and E2 level in the follicular fluid as follows: (i) Group1(4-6 mm; <0.5 ng/mL) (ii) Group 2 (7-9 mm; 0...
April 16, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29679326/synthetic-peg-hydrogel-for-engineering-the-environment-of-ovarian-follicles
#6
Uziel Mendez, Hong Zhou, Ariella Shikanov
The functional unit within the ovary is the ovarian follicle, which is also a morphological unit composed of three basic cell types: the oocyte, granulosa, and theca cells. Similar to human ovarian follicles, mouse follicles can be isolated from their ovarian environment and cultured in vitro to study folliculogenesis, or follicle development for days or weeks. Over the course of the last decade, follicle culture in a three-dimensional (3D) environment exponentially improved the outcomes of in vitro folliculogenesis...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29668890/luteinizing-hormone-facilitates-antral-follicular-maturation-and-survival-via-thecal-paracrine-signaling-in-cattle
#7
Katsushige Hattori, Makoto Orisaka, Shin Fukuda, Kimihisa Tajima, Yukiko Yamazaki, Tetsuya Mizutani, Yoshio Yoshida
The use of LH supplementation in assisted reproductive technology (ART) cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral follicles, we used an in vitro two-cell system that involved co-culturing bovine granulosa cells (GC) and theca cells (TC) on a collagen membrane. Treatment of TC with LH stimulated androgen production in TC by inducing the expression of androgenic factors, subsequently increasing estrogen biosynthesis in GC by providing androgen substrates and inducing aromatase expression...
April 13, 2018: Endocrinology
https://www.readbyqxmd.com/read/29558965/regulation-by-fsh-of-the-dynamic-expression-of-retinol-binding-protein-4-in-the-mouse-ovary
#8
Yanwen Jiang, Yun Zhao, Shuxiong Chen, Lu Chen, Chunjin Li, Xu Zhou
BACKGROUND: Ovarian retinoid homeostasis plays an important role in the physiological function of the ovary. Retinol-binding protein 4 (RBP4) acts as the mediator for the systemic and intercellular transport of retinol and is heavily involved in cellular retinol influx, efflux, and exchange. However, the expression patterns and regulatory mechanisms of Rbp4 in the ovary remain unclear. METHODS: The expression pattern of ovarian Rbp4 was examined in immature mice during different developmental stages and in adult mice during different stages of the estrous cycle...
March 20, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29544640/from-follicular-development-and-ovulation-to-ovarian-cancers-an-unexpected-journey
#9
JoAnne S Richards
Follicular development and ovulation are complex development processes that are regulated by multiple, interacting pathways and cell types. The oocyte, cumulus cells, granulosa cells, and theca cells communicate to impact follicular development and ovulation. Many hormones and cytokines control intracellular regulatory networks and transcription factors, some of which are cell type specific. Molecular biology approaches and mutant mouse models have contributed immensely to our knowledge of what genes and signaling cascades impact each stage of follicular development and ovulation, and how the alteration of gene expression profiles and the activation of specific signaling pathways can impact ovarian cancer development in ovarian surface epithelial cells as well as granulosa cells...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29544629/the-effect-of-steroid-hormones-on-ovarian-follicle-development
#10
Chia-Hong Chou, Mei-Jou Chen
Ovarian follicular cell undergoes extensive proliferation and differentiation during the period that the follicle evolved from the primordial state to its ovulatory phase and then corpus luteum status. During this process, different and various levels of steroid hormones in follicular fluid, or obtained from circulation and adjacent cells as granulosa and theca cells, or from environment and diet will all affect the process of follicular growth and development. Differential steroid hormones might have differential effects on ovarian folliculogenesis via the effect on granulosa cell growth and follicular fluid formation that involves cell proliferation, apoptosis, and angiogenesis within the follicle...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29536385/histone-demethylase-kdm4a-and-kdm4b-expression-in-granulosa-cells-from-women-undergoing-in-vitro-fertilization
#11
Adam J Krieg, Sarah R Mullinax, Frances Grimstad, Kaitlin Marquis, Elizabeth Constance, Yan Hong, Sacha A Krieg, Katherine F Roby
PURPOSE: To assess expression of the histone demethylases KDM4A and KDM4B in granulosa collected from women undergoing oocyte retrieval and to determine if expression was related to pregnancy outcome. METHODS: Cumulus and mural granulosa cells were obtained from women undergoing oocyte retrieval. KDM4A and KDM4B mRNA expression was determined by qRT-PCR. KDM4A and KDM4B proteins were immunohistochemically localized in ovarian tissue sections obtained from archival specimens...
March 14, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29527916/the-influence-of-testosterone-on-the-expression-and-function-of-vitamin-d3-receptor-vdr-protein-in-the-porcine-ovarian-follicle
#12
M Herian, M R Luck, M Grzesiak
Recently it has been shown that vitamin D(3) acting via its cognate receptor (VDR) regulates the growth, differentiation and function of female reproductive tissues including ovary. The aim of the study was to examine the effect of testosterone (T) and its antagonist 2-hydroxyflutamide (HF) on VDR protein expression and function in porcine ovarian follicles. Medium size antral follicles expressing great amount of androgen receptors and represent high steroidogenic activity were used in this research. After 6 h incubation of whole follicles with T, HF or T+HF, immunohistochemical analysis of VDR revealed its nuclear localization in granulosa and theca interna cells in control and experimental groups...
March 12, 2018: Physiological Research
https://www.readbyqxmd.com/read/29482665/study-on-the-relationship-between-expression-patterns-of-cocaine-and-amphetamine-regulated-transcript-and-hormones-secretion-in-porcine-ovarian-follicles
#13
Pengfei Li, Jinzhu Meng, Jiongjie Jing, Qingling Hao, Zhiwei Zhu, Jianbo Yao, Lihua Lyu
BACKGROUND: Cocaine-and amphetamine regulated transcript (CART) is an endogenous neuropeptide, which is widespread in animals, plays a key role in regulation of follicular atresia in cattle and sheep. Among animal ovaries, CART mRNA was firstly found in the cattle ovaries. CART was localized in the antral follicles oocytes, granulosa and cumulus cells by immunohistochemistry and in situ hybridization. Further research found that secretion of E2 was inhibited in granulosa cells with a certain dose of CART, the effect depends on the stage of cell differentiation, suggesting that CART could play a crucial role in regulating follicle atresia...
February 26, 2018: Biological Research
https://www.readbyqxmd.com/read/29435926/how-to-explore-the-function-and-importance-of-micrornas-micrornas-expression-profile-and-their-target-pathway-prediction-in-bovine-ovarian-cells
#14
Anna E Zielak-Steciwko, John A Browne
Micro RNAs (miRNA) are integral components of genetic regulatory networks and act by binding to the transcripts of their corresponding target genes, leading to a decrease in protein production levels either by mRNA degradation or by translational repression. While the role of miRNAs is ubiquitous, they have a particular importance with regard to cell differentiation. The miRNA-target mRNA interaction has a significant impact on many signaling pathways and the cross-talk between them; playing a regulatory role in a variety of different physiological processes within the cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29413902/transcriptome-profiling-of-bovine-ovarian-theca-cells-treated-with-fibroblast-growth-factor-9
#15
L F Schütz, R E Hurst, N B Schreiber, L J Spicer
We reported previously that fibroblast growth factor 9 (FGF9) acts as an antidifferentiation factor, stimulating proliferation of granulosa cells (GCs) and theca cells (TCs) while suppressing hormone-induced steroidogenesis of these cells. How FGF9 acts to simultaneously suppress steroidogenesis and stimulate proliferation remains to be fully elucidated. Thus, this study was undertaken to clarify the effects of FGF9 on the TC transcriptome. Ovaries were obtained from beef heifers at a local abattoir, TCs were isolated from large antral follicles, and cultured with or without 30 ng/mL of FGF9 for 24 h in the presence of LH and IGF-1...
April 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29409020/follicular-localization-of-growth-differentiation-factor-8-and-its-receptors-in-normal-and-polycystic-ovary-syndrome-ovaries
#16
Ting-Ting Lin, Hsun-Ming Chang, Xiao-Ling Hu, Peter C K Leung, Yi-Min Zhu
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and its etiology has not been characterized. Growth differentiation factor 8 (GDF8) is a member of the transforming growth factor-β superfamily that plays a critical role in the regulation of ovarian functions. However, the expression pattern of GDF8 in the human ovary is not yet clear. This study examined the cellular distribution of GDF8 and its putative cellular receptors (ACVR2A, ACVR2B, and ALK5) in a series of normal (n = 34) and PCOS ovaries (n = 14)...
May 1, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29385487/microrna-221-expression-in-theca-and-granulosa-cells-hormonal-regulation-and-function
#17
Cheyenne L Robinson, Lingna Zhang, Luis F Schütz, Morgan L Totty, Leon J Spicer
Small noncoding RNA molecules (miRNA) regulate protein levels in a post-transcriptional manner by partial base pairing to the 3'-UTR of target genes thus mediating degradation or translational repression. Previous studies indicate that numerous miRNA regulate the biosynthesis of intraovarian hormones, and emerging evidence indicates that one of these, miRNA-221 (MIR221), may be a modulator of ovarian function. However, the hormonal control of ovarian MIR221 is not known. The objectives of this study were to investigate the developmental and hormonal regulation of MIR221 expression in granulosa (GC) and theca cell (TC) and its possible role in regulating follicular function...
March 6, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29374087/food-restriction-but-not-fish-oil-increases-fertility-in-hens-role-of-rarres2
#18
Namya Mellouk, Christelle Ramé, Joël Delaveau, Christophe Rat, Maxime Marchand, Frédéric Mercerand, Angélique Travel, Aurélien Brionne, Pascal Chartrin, Linlin Ma, Pascal Froment, Joëlle Dupont
Overfed hens selected for their rapid growth become fatter and develop reproductive disorders. Herein, we aimed to demonstrate that food restriction leading to a weight reduction and/or a supplementation with fish oil may be effective in preventing reproductive disorders through the regulation of adipokine expression in broiler hens. This study included four groups of food restricted (Rt) or ad libitum hens (Ad, feeding at a rate 1.7 times greater than Rt hens) supplemented or unsupplemented with fish oil (1%)...
April 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29374086/the-role-of-tight-junction-proteins-in-ovarian-follicular-development-and-ovarian-cancer
#19
REVIEW
Lingna Zhang, Tao Feng, Leon J Spicer
Tight junctions (TJ) are protein structures that control the transport of water, ions and macromolecules across cell layers. Functions of the transmembrane TJ protein, occluding (OCLN) and the cytoplasmic TJ proteins, tight junction protein 1 (TJP1; also known as zona occludens protein-1), cingulin (CGN) and claudins (CLDN) are reviewed, and current evidence of their role in the ovarian function is reviewed. Abundance of OCLN , CLDNs and TJP1 mRNA changed during follicular growth. In vitro treatment with various growth factors known to affect ovarian folliculogenesis indicated that CGN , OCLN and TJP1 are hormonally regulated...
April 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29371816/expression-of-the-gonadotropin-receptors-during-follicular-development
#20
REVIEW
Hiroshi Kishi, Yoshikazu Kitahara, Fumiharu Imai, Kohshiro Nakao, Hiroto Suwa
Background: Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying these phenomena. Methods: The literature was reviewed, including that published by the authors. Main findings Results: Follicle-stimulating hormone receptor expression in the granulosa cells was induced by androgens that were derived from growth differentiation factor-9-stimulated theca cells...
January 2018: Reproductive Medicine and Biology
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