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Granulosa theca cell

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https://www.readbyqxmd.com/read/29132723/ovarian-sex-cord-stromal-tumours-and-their-mimics
#1
REVIEW
Robert H Young
Sex cord-stromal tumours of the ovary include many of the most morphologically intriguing ovarian neoplasms and albeit many of them are rare, they factor into the differential diagnosis more often than their frequency might suggest. The most common malignant form, the adult granulosa cell tumour, may grossly simulate various surface epithelial neoplasms. Microscopically, confusion with endometrioid carcinoma may occur because the cords and microfollicles of the granulosa cell tumour may be mimicked by endometrioid carcinoma and the latter may have pale nuclei with nuclear grooves...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29130964/changes-in-the-proliferation-apoptosis-balance-in-the-bovine-ovary-a-key-early-event-in-follicular-persistence
#2
E Matías Belotti, Antonela F Stassi, Melisa M L Velázquez, Pablo U Díaz, Belkis E Marelli, Florencia Rey, Ulises S Notaro, Hugo H Ortega, Natalia R Salvetti
The objective of this work was to evaluate proliferation and apoptosis in the bovine ovary in a model of follicular persistence induced by low levels of progesterone to detect incipient changes during cystic ovarian disease development on the expected day of ovulation (day 0) and after 5, 10, and 15 days of follicular persistence. We analyzed cell proliferation by evaluating the expression of Ki-67 and apoptosis by evaluating caspase-3, BAX, and BCL2 expression. Proliferation was similar in the granulosa and theca cells of antral follicles in the P0 group (treated with progesterone up to the expected day of ovulation) and in the control group...
November 3, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29097063/expression-and-localization-of-polypeptide-n-acetylgalactosaminyltransferase-like-protein-5-in-the-reproductive-organs-and-sperm-of-hu-sheep
#3
Xiaolei Yao, M A Ei-Samahy, Xu Feng, Tinging Zhang, Fengzhe Li, Guomin Zhang, Jing Pang, Haitao Nie, Feng Wang
The polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5) is involved in male fertility; however, its involvement in the reproduction and fertility of females remains unclear. Therefore, the present study aimed to examine the presence of GALNTL5 in the reproductive organs of ewes during the estrus period and to investigate its expression in cauda epididymal and ejaculated sperm. Results showed that GALNTL5 mRNA and protein were present in some reproductive organs of ewes during the estrus period...
October 27, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29095972/placental-growth-factor-is-required-for-ovulation-luteinization-and-angiogenesis-in-primate-ovulatory-follicles
#4
Hannah R Bender, Heidi A Trau, Diane M Duffy
Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine if PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Ovarian biopsies and whole ovaries were collected before (0h) and up to 36h after hCG administration to span the ovulatory interval. PGF and VEGFA were expressed by both granulosa cells and theca cells...
October 30, 2017: Endocrinology
https://www.readbyqxmd.com/read/29093602/fertility-preservation-in-female-patients-with-breast-cancer-a-current-overview
#5
Veronika Guenther, Ibrahim Alkatout, Wiebe Junkers, Dirk Bauerschlag, Nicolai Maass, Soeren von Otte
Many premenopausal patients who develop breast cancer have not yet completed their family planning, so measures of fertility protection to preserve their fertile potential would be beneficial. Polychemotherapy causes irreversible damage to the ovarian follicles - irrespective of whether in a neoadjuvant or adjuvant setting - and this can sometimes result in permanent infertility. Depending on which cytostatic agents are used and on the age-related ovarian reserve of the woman, gonadotoxic risk must be classified as low, moderate or high...
October 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29045588/the-mycotoxin-metabolite-deepoxy-deoxynivalenol-increases-apoptosis-and-decreases-steroidogenesis-in-bovine-ovarian-theca-cells
#6
Hilda M Guerrero-Netro, Anthony Estienne, Younès Chorfi, Christopher A Price
The mycotoxin deoxynivalenol (DON) has been shown to inhibit ovarian granulosa cell function in cattle in vitro, but it is not known whether DON or its metabolite deepoxy-DON (DOM-1) affect theca cell function. The objectives of the present study were to determine the effects of DON and of DOM-1 on theca cell steroidogenesis and apoptosis, and to determine the main pathways through which they act. Bovine theca cells were cultured in a non-luteinizing serum-free culture system, and challenged with DON or DOM-1 for 4 d to measure steroidogenesis and apoptosis, for 1-8 h to measure immediate-early genes, and for 5-60 min to measure phosphorylation of intracellular signaling proteins...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28982594/endocrine-disruptor-effect-of-perfluorooctane-sulfonic-acid-pfos-and-perfluorooctanoic-acid-pfoa-on-porcine-ovarian-cell-steroidogenesis
#7
Andrea Chaparro-Ortega, Miguel Betancourt, Patricia Rosas, Francisco G Vázquez-Cuevas, Roberto Chavira, Edmundo Bonilla, Eduardo Casas, Yvonne Ducolomb
Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate that they act as endocrine disruptors, in addition to inducing alterations and damaging reproductive health; however, the biological mechanisms by which these disorders are produced are not yet understood. The aim of this study was to analyze the effect of PFOS and PFOA on in vitro steroidogenic secretion in porcine theca and granulosa cells, with or without gonadotropic stimulation. Granulosa and theca cells were isolated and cultured...
October 2, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28972875/effect-of-melatonin-on-bovine-theca-cells-in-vitro
#8
T Feng, L F Schutz, B C Morrell, M C Perego, L J Spicer
Melatonin affects granulosa cell function in several species but its function in theca cells is less clear, particularly in monotocous animals. Thus, the objectives of this study were to determine the effects of melatonin on theca cell steroidogenesis, gene expression and cell proliferation in a monotocous species, namely cattle. Ovaries were collected from a local bovine abattoir, from which theca cells were isolated from large (8-22mm) follicles and treated with various hormones in serum-free medium for 24h or 48h...
October 4, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28965601/the-role-of-lysosomes-in-the-phenomenon-of-concentration-of-aluminum-and-indium-in-the-female-reproductive-system-an-ultrastructural-study
#9
REVIEW
Mhamdi Marwa, Florea Adrian, Badri Nedra, Maghraoui Samira, Matei Horea, Tekaia Walid-Habib, Rym Baati, Tekaya Leila
The female reproductive system is one of the most complex systems in the body taking into account the hormonal fluctuations associated with ovarian and uterine menstrual cycles. The purpose of this work was to study the impact of aluminum nitrate and indium sulfate on the uterus and the ovary of a pregnant rat. The experiment was performed on adult female rats of Wistar strain weighing approximately 250g. The Transmission Electron Microscopy (TEM) showed the presence of electron-dense material in lysosomes of both uterine cells (myometrium and endometrium cells) and in the cells of the ovary (internal theca and granulosa cells)...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28940132/formation-of-multiple-oocyte-follicles-in-culture
#10
Alice P Christensen, Emeline Peyrache, Heidy Kaune, Suzannah A Williams
Basement membranes are found in every organ of the body. They provide structure and a selective filter for molecules. The ovary is no different with the follicular basal lamina (FBL) separating the granulosa and theca cells, facilitating regulation of the changing follicular environment providing appropriate conditions for the developing oocyte. The FBL is modified in C1galt1 Mutant mice (C1galt1 (FF):ZP3Cre) resulting from oocyte-specific deletion of C1galt1. Changes in the FBL lead to follicles joining to generate multiple-oocyte follicles (MOFs); where two or more oocytes are contained within a single follicle...
October 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28938399/gonadotropin-dependent-neuregulin-1-signaling-regulates-female-rat-ovarian-granulosa-cell-survival
#11
Indrajit Chowdhury, Alicia Branch, Sharifeh Mehrabi, Byron D Ford, Winston E Thompson
Mammalian ovarian follicular development and maturation of an oocyte competent to be fertilized and develop into an embryo depends on tightly regulated, spatiotemporally orchestrated crosstalk among cell death, survival, and differentiation signals through extra- and intraovarian signals, as well as on a permissive ovarian follicular microenvironment. Neuregulin-1 (NRG1) is a member of the epidermal growth factor-like factor family that mediates its effects by binding to a member of the erythroblastoma (ErbB) family...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28903889/gdf9-and-bmp15-expressions-and-fine-structure-changes-during-folliculogenesis-in-polycystic-ovary-syndrome
#12
Meryem İlkay Karagül, Savaş Aktaş, Banu Coşkun Yılmaz, Mustafa Yılmaz, Gülhan Örekiçi Temel
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is the most frequently seen endocrine disorder in women of the reproductive age with the prevalence of about 10%. AIMS: To investigate the efficiency of the growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during folliculogenesis in a dehydroepiandrosterone (DHEA)-induced mouse PCOS model. STUDY DESIGN: Animal experimentation. METHODS: Mice were divided into three groups; control, vehicle and PCOS group...
September 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28901488/the-role-of-fructose%C3%A2-1-6%C3%A2-bisphosphatase-1-in-abnormal-development-of-ovarian-follicles-caused-by-high-testosterone-concentration
#13
Tao Liu, Han Zhao, Jianfeng Wang, Xin Shu, Yuan Gao, Xiaoli Mu, Fei Gao, Hongbin Liu
The present study aimed to identify the molecular mechanisms underlying the effects of the fructose‑1,6‑bisphosphatase 1 (FBP1) signaling pathway within normal follicle development and in hyperandrogenism‑induced abnormal follicle growth. To achieve this, murine primary follicles, granulosa cells (GCs) and theca‑interstitial cells (TICs) were isolated, cultured in vitro and treated with a high concentration of androgens. A concentration of 1x10‑5 mol/l testosterone was considerable to induce hyperandrogenism by MTT assay...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28870888/cell-secreted-vesicles-containing-micrornas-as-regulators-of-gamete-maturation
#14
Juliano C da Silveira, Ana Clara F C M de Avila, Hannah L Garrett, Jason Bruemmer, Quinton Winger, Gerrit Bouma
Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa cells, cumulus cells and the oocyte all secrete factors throughout follicle growth and maturation that are critical for ovulation of a high quality oocyte with the competence to develop into an embryo. Similarly, maturation of sperm occurs as it transits the epididymis during which epididymal epithelium and sperm exchange secretory factors that are required for sperm to gain motility and fertility...
September 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28854741/zona-pellucida-protein-b2-messenger-ribonucleic-acid-expression-varies-with-follicular-development-and-granulosa-cell-location
#15
A P Benson, M N Malloy, J R Steed, V L Christensen, B D Fairchild, A J Davis
The freshly ovulated ovum in avian species is surrounded by a protein layer called the inner perivitelline layer (IPVL). The IPVL contains zona pellucida proteins and 6 distinct zona pellucida genes have been identified (ZPA, ZPB1, ZPB2, ZPC, ZPD and ZPX1) in the chicken. In the present research, the expression of the mRNA for ZPA, ZPB2, and ZPX1 was investigated in 2 lines of turkey hens selected for either increased egg production (E line) or increased body weight (F line). Theca and granulosa cell expression of the mRNA for ZPA and ZPB2 was also investigated in hierarchical and prehierarchical follicles from broiler breeder hens...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28843075/expression-of-adiponectin-and-its-receptors-adipor1-and-adipor2-in-goat-ovary-and-its-effect-on-oocyte-nuclear-maturation-in%C3%A2-vitro
#16
Bruna S P Oliveira, Joana A S Costa, Elizabete T Gomes, Diogo M F Silva, Sandra M Torres, Pedro L J Monteiro, Antônio S Santos Filho, Maria Madalena P Guerra, Gustavo F Carneiro, Aurea Wischral, André M Batista
Adiponectin is an adipokine secreted primarily by adipocytes and is involved in the control of male and female reproductive functions. Circulating levels of adiponectin are inversely correlated with body fat mass, and its biological effects are predominantly mediated through two receptors, AdipoR1 and AdipoR2. The aim of the present study was to verify the expression of the adiponectin system (adiponectin and its receptors, AdipoR1 and AdipoR2) in goat ovary using qPCR and immunohistochemistry analyses and further investigate the in vitro effects of recombinant adiponectin (5 μg/mL and 10 μg/mL) on goat oocyte nuclear maturation...
August 18, 2017: Theriogenology
https://www.readbyqxmd.com/read/28840465/gold-and-female-reproductive-organs-an-ultrastructural-study
#17
Nedra Badri, Maroua Mhamdi, Ridha Ben Ali, Horea Matei, Walid-Habib Tekaya, Adrian Florea, Samira Maghraoui, Leila Tekaya
Gold, a heavy yellow-colored metal, is usually found in nature as a metallic element or as salts. This noble metal historically had a reputation as an anti-inflammatory medicine for rheumatoid arthritis, a nervine, and a remedy for nervous disorders, as well as a potential anticancer agent. It has also been used as component in dental restorations and in implant materials. The present study was undertaken to point out histological and ultrastructural effects of gold, administered by intraperitoneal route, in pregnant female reproductive organs (ovary and uterus), in order to clarify its side effects on the reproductive function...
August 24, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28827713/diethylstilbestrol-administration-inhibits-theca-cell-androgen-and-granulosa-cell-estrogen-production-in-immature-rat-ovary
#18
Yoshitaka Imamichi, Toshio Sekiguchi, Takeshi Kitano, Takashi Kajitani, Reiko Okada, Yoshihiko Inaoka, Kaoru Miyamoto, Junsuke Uwada, Satoru Takahashi, Takahiro Nemoto, Asuka Mano, Md Rafiqul Islam Khan, Md Tariqul Islam, Koh-Ichi Yuhki, Hitoshi Kashiwagi, Fumitaka Ushikubi, Nobuo Suzuki, Takanobu Taniguchi, Takashi Yazawa
Diethylstilbestrol (DES), a strong estrogenic compound, is well-known to affect the reproductive system. In this study, we investigated the effects of DES administration on gonadotropin levels and ovarian steroidogenesis in prepubertal rats. DES treatment acutely reduced serum LH levels, followed by a reduction in the expression of various steroidogenesis-related genes in theca cells. Serum FSH levels were almost unaffected by DES-treatment, even though Cyp19a1 expression was markedly reduced. Serum progesterone, testosterone and estradiol levels were also declined at this time...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723674/nanoparticles-and-female-reproductive-system-how-do-nanoparticles-affect-oogenesis-and-embryonic-development
#19
REVIEW
Cong-Cong Hou, Jun-Quan Zhu
Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman's body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28633436/membrane-androgen-receptor-zip9-induces-croaker-ovarian-cell-apoptosis-via-stimulatory-g-protein-alpha-subunit-and-map-kinase-signaling
#20
Aubrey Converse, Chenan Zhang, Peter Thomas
Recent studies show that androgen-induced apoptosis in Atlantic croaker primary granulosa and theca (G/T) cells and in human breast and prostate cancer cell lines is mediated by the membrane androgen receptor ZIP9, which belongs to the SLC39A zinc transporter family. However, the apoptotic signaling pathways remain unclear because ZIP9 activates an inhibitory G protein in human cancer cells, whereas recombinant croaker ZIP9 activates a stimulatory G protein (Gs) in transfected cancer cells. We investigated androgen-dependent apoptotic pathways to identify the signaling pathways regulated through wild-type croaker ZIP9 in ovarian follicle cells...
September 1, 2017: Endocrinology
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