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Granulosa theca cell

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https://www.readbyqxmd.com/read/29334661/altered-expression-of-il-1%C3%AE-il-1ri-il-1rii-il-1ra-and-il-4-could-contribute-to-anovulation-and-follicular-persistence-in-cattle
#1
A F Stassi, M E Baravalle, E M Belotti, A N Amweg, E Angeli, M M L Velázquez, F Rey, N R Salvetti, H H Ortega
Cystic ovarian disease (COD) is an important cause of infertility in dairy cattle. The main signs of this infertility are ovulation failure and follicular persistence. The aim of this study was to examine the expression of the cytokines IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 in ovarian follicular structures at different times of persistence in a model of follicular persistence induced by prolonged administration of progesterone in dairy cows. Protein expression of IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 was evaluated by immunohistochemistry...
January 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29330967/the-impact-of-bisphenol-s-on-bovine-granulosa-and-theca-cells
#2
K A Campen, M Lavallee, Cmh Combelles
Bisphenol S (BPS) is an endocrine-disrupting chemical with multiple potential mechanisms of action, including as an oestrogen receptor agonist. BPS is increasingly used in plastics and thermal receipts as a substitute for bisphenol A, which has been phased out due to concerns about human health implications. The ability of BPS to alter female reproductive function in mammals has not been widely studied, despite the importance of normal hormone signalling for female reproduction. The aim of this study was to investigate how BPS (in a wide range of doses, including very low doses) affects granulosa cell and theca cell steroid hormone production and cell viability in the bovine...
January 12, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29312650/nanoparticles-and-female-reproductive-system-how-do-nanoparticles-affect-oogenesis-and-embryonic-development
#3
REVIEW
Cong-Cong Hou, Jun-Quan Zhu
Along with the increasing application of nanoparticles (NPs) in many walks of life, environmental exposure to NPs has raised considerable health concerns. When NPs enter a pregnant woman's body through inhalation, venous injection, ingestion or skin permeation, maternal toxic stress reactions such as reactive oxygen species (ROS), inflammation, apoptosis and endocrine dyscrasia are induced in different organs, particularly in the reproductive organs. Recent studies have shown that NPs disturb the developing oocyte by invading the protective barrier of theca cells, granulosa cell layers and zona pellucida...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297778/chronic-cholestasis-is-associated-with-hypogonadism-and-premature-ovarian-failure-in-adult-rats-cholestasis-causes-ovarian-hypogonadism
#4
Yomna I Mahmoud
Hypogonadism is a well-known complication in males with chronic liver diseases. However, the consequences of chronic hepatopathies on female reproductive capacities have received relatively little attention. The present study evaluates the effect of chronic obstructive jaundice on the ovary of adult cycling rats. Estrous cyclicity was monitored to check the functional status of the hypothalamic-pituitary-ovarian axis. Ovarian changes were assessed using histomorphometric, immunohistochemical, and ultrastructural techniques...
January 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29275192/detection-of-aristaless-related-homeobox-protein-in-ovarian-sex-cord-stromal-tumors
#5
Tamara Knific, Snježana Frković Grazio, Tea Lanišnik Rižner
OBJECTIVE: To examine the potential of ARX as a novel biomarker of ovarian endometriosis and other ovarian pathologies. METHODS: The mRNA level of ARX in ovarian endometriosis and normal endometrium samples was determined by real-time PCR, while the protein level was determined by Western blotting and immunohistochemical staining. Immunohistochemical analysis was performed on nearly 200 tissue samples of different ovarian pathologies. GraphPad Prism was used for statistical analysis...
December 21, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29227911/inhibin-a-and-inhibin-b-in-cyclic-and-pregnant-mares-and-mares-with-granulosa-theca-cell-tumors-physiological-and-diagnostic-implications
#6
A J Conley, E L Scholtz, G Dujovne, R F Cotterman, E L Legacki, R C Uliani, M A Alvarenga, B A Ball, B Kalra, G V Savjani, A Kumar
Studies in mares have examined serum inhibin concentrations using immuno-assays unable to distinguish dimeric inhibin-A from inhibin-B isoforms. Inhibin-A and inhibin-B immuno-assays were used to investigate concentrations in cyclic mares, young and old (6 vs 19 years old, respectively) mares following hemi-ovariectomy, mares during pregnancy and in mares with confirmed granulosa cell tumors (GCTs). Mares with inter-ovulatory intervals of 26 days had ovulatory peaks of inhibin-A averaging 80 pg/mL with a mid-cycle nadir of 5 pg/mL...
December 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29208899/in-vivo-transplantation-of-3d-encapsulated-ovarian-constructs-in-rats-corrects-abnormalities-of-ovarian-failure
#7
Sivanandane Sittadjody, Justin M Saul, John P McQuilling, Sunyoung Joo, Thomas C Register, James J Yoo, Anthony Atala, Emmanuel C Opara
Safe clinical hormone replacement (HR) will likely become increasingly important in the growing populations of aged women and cancer patients undergoing treatments that ablate the ovaries. Cell-based HRT (cHRT) is an alternative approach that may allow certain physiological outcomes to be achieved with lower circulating hormone levels than pharmacological means due to participation of cells in the hypothalamus-pituitary-ovary feedback control loop. Here we describe the in vivo performance of 3D bioengineered ovarian constructs that recapitulate native cell-cell interactions between ovarian granulosa and theca cells as an approach to cHRT...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29205453/localization-of-thrombospondin-1-and-its-receptor-cd36-in-the-ovary-of-the-ostrich-struthio-camelus
#8
D Rodler, F Sinowatz
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a decisive role for the rapid growth of avian follicles. Compared to mammals, few data on the angiogenesis in the avian ovary are available. However, whereas several pro-angiogenic factors in the avian ovary have been recently studied in detail, little information is available on the localization of anti-angiogenic factors. The aim of this study was to determine the localization and possible function of the anti-angiogenic factor thrombospondin-1 (TSP-1) and its receptor CD36 in the ovary of the ostrich using immunohistochemistry and to correlate the results with ultrastructural data...
December 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29196492/high-fat-diet-exposure-from-pre-pubertal-age-induces-pcos-in-rats
#9
Roshni S Patel, Gaurang B Shah
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts with menarche in adolescents. Presently available animal models focuses on ovarian but not metabolic features of PCOS. Therefore, we hypothesized that high fat diet feeding to pre-pubertal female rats results in both reproductive and metabolic features of PCOS. Pre-pubertal female rats were divided into two groups: group I received normal pellet diet and group II received high fat diet (HFD)...
December 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29192811/effects-of-vitamin-d-on-ovary-in-dhea-treated-pcos-rat-model-a-light-and-electron-microscopic-study
#10
Latife Seyran Çelik, Yurdun Kuyucu, Ebru Dündar Yenilmez, Abdullah Tuli, Kenan Dağlıoğlu, Ufuk Özgü Mete
AIM: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques. METHODS: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. In DHEA group, the PCOS rat model was developed by 6mg/kg/day dehydroepiandrosterone administration as subcutaneously injections. In DHEA+Vit.D group, 6 mg/kg/day DHEA and 120ng/100g/week 1,25(OH)2D3 was performed simultaneously...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29154873/medaka-igf1-identifies-somatic-cells-and-meiotic-germ-cells-of-both-sexes
#11
Cancan Yuan, Kerang Chen, Yefei Zhu, Yongming Yuan, Mingyou Li
Insulin-like growth factors (IGFs) play significant roles in regulating cell proliferation, differentiation and reproduction in diverse organisms. Here, we report the identification of medaka igf1 and the expression pattern of igf1 RNA in adult medaka gonads. Using RT-PCR, igf1 RNA was easily detected in several somatic organs and adult gonads of both sexes. Using chromogenic in situ hybridization, igf1 RNA in the ovary was found in stage I-IV oocytes and in the somatic cells throughout oogenesis. In the testis, igf1 RNA was present in meiotic products and the somatic cells surrounding male germ cells throughout spermatogenesis...
November 14, 2017: Gene
https://www.readbyqxmd.com/read/29132723/ovarian-sex-cord-stromal-tumours-and-their-mimics
#12
REVIEW
Robert H Young
Sex cord-stromal tumours of the ovary include many of the most morphologically intriguing ovarian neoplasms and albeit many of them are rare, they factor into the differential diagnosis more often than their frequency might suggest. The most common malignant form, the adult granulosa cell tumour, may grossly simulate various surface epithelial neoplasms. Microscopically, confusion with endometrioid carcinoma may occur because the cords and microfollicles of the granulosa cell tumour may be mimicked by endometrioid carcinoma and the latter may have pale nuclei with nuclear grooves...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29130964/changes-in-the-proliferation-apoptosis-balance-in-the-bovine-ovary-a-key-early-event-in-follicular-persistence
#13
E Matías Belotti, Antonela F Stassi, Melisa M L Velázquez, Pablo U Díaz, Belkis E Marelli, Florencia Rey, Ulises S Notaro, Hugo H Ortega, Natalia R Salvetti
The objective of this work was to evaluate proliferation and apoptosis in the bovine ovary in a model of follicular persistence induced by low levels of progesterone to detect incipient changes during cystic ovarian disease development on the expected day of ovulation (day 0) and after 5, 10, and 15 days of follicular persistence. We analyzed cell proliferation by evaluating the expression of Ki-67 and apoptosis by evaluating caspase-3, BAX, and BCL2 expression. Proliferation was similar in the granulosa and theca cells of antral follicles in the P0 group (treated with progesterone up to the expected day of ovulation) and in the control group...
November 3, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29097063/expression-and-localization-of-polypeptide-n-acetylgalactosaminyltransferase-like-protein-5-in-the-reproductive-organs-and-sperm-of-hu-sheep
#14
Xiaolei Yao, M A Ei-Samahy, Xu Feng, Tinging Zhang, Fengzhe Li, Guomin Zhang, Jing Pang, Haitao Nie, Feng Wang
The polypeptide N-acetylgalactosaminyltransferase-like protein 5 (GALNTL5) is involved in male fertility; however, its involvement in the reproduction and fertility of females remains unclear. Therefore, the present study aimed to examine the presence of GALNTL5 in the reproductive organs of ewes during the estrus period and to investigate its expression in cauda epididymal and ejaculated sperm. Results showed that GALNTL5 mRNA and protein were present in some reproductive organs of ewes during the estrus period...
October 27, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29095972/placental-growth-factor-is-required-for-ovulation-luteinization-and-angiogenesis-in-primate-ovulatory-follicles
#15
Hannah R Bender, Heidi A Trau, Diane M Duffy
Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine if PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Ovarian biopsies and whole ovaries were collected before (0h) and up to 36h after hCG administration to span the ovulatory interval. PGF and VEGFA were expressed by both granulosa cells and theca cells...
October 30, 2017: Endocrinology
https://www.readbyqxmd.com/read/29093602/fertility-preservation-in-female-patients-with-breast-cancer-a-current-overview
#16
Veronika Guenther, Ibrahim Alkatout, Wiebe Junkers, Dirk Bauerschlag, Nicolai Maass, Soeren von Otte
Many premenopausal patients who develop breast cancer have not yet completed their family planning, so measures of fertility protection to preserve their fertile potential would be beneficial. Polychemotherapy causes irreversible damage to the ovarian follicles - irrespective of whether in a neoadjuvant or adjuvant setting - and this can sometimes result in permanent infertility. Depending on which cytostatic agents are used and on the age-related ovarian reserve of the woman, gonadotoxic risk must be classified as low, moderate or high...
October 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29045588/the-mycotoxin-metabolite-deepoxy-deoxynivalenol-increases-apoptosis-and-decreases-steroidogenesis-in-bovine-ovarian-theca-cells
#17
Hilda M Guerrero-Netro, Anthony Estienne, Younès Chorfi, Christopher A Price
The mycotoxin deoxynivalenol (DON) has been shown to inhibit ovarian granulosa cell function in cattle in vitro, but it is not known whether DON or its metabolite deepoxy-DON (DOM-1) affect theca cell function. The objectives of the present study were to determine the effects of DON and of DOM-1 on theca cell steroidogenesis and apoptosis, and to determine the main pathways through which they act. Bovine theca cells were cultured in a non-luteinizing serum-free culture system, and challenged with DON or DOM-1 for 4 d to measure steroidogenesis and apoptosis, for 1-8 h to measure immediate-early genes, and for 5-60 min to measure phosphorylation of intracellular signaling proteins...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28982594/endocrine-disruptor-effect-of-perfluorooctane-sulfonic-acid-pfos-and-perfluorooctanoic-acid-pfoa-on-porcine-ovarian-cell-steroidogenesis
#18
Andrea Chaparro-Ortega, Miguel Betancourt, Patricia Rosas, Francisco G Vázquez-Cuevas, Roberto Chavira, Edmundo Bonilla, Eduardo Casas, Yvonne Ducolomb
Previous studies with perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) indicate that they act as endocrine disruptors, in addition to inducing alterations and damaging reproductive health; however, the biological mechanisms by which these disorders are produced are not yet understood. The aim of this study was to analyze the effect of PFOS and PFOA on in vitro steroidogenic secretion in porcine theca and granulosa cells, with or without gonadotropic stimulation. Granulosa and theca cells were isolated and cultured...
October 2, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28972875/effect-of-melatonin-on-bovine-theca-cells-in-vitro
#19
T Feng, L F Schutz, B C Morrell, M C Perego, L J Spicer
Melatonin affects granulosa cell function in several species but its function in theca cells is less clear, particularly in monotocous animals. Thus, the objectives of this study were to determine the effects of melatonin on theca cell steroidogenesis, gene expression and cell proliferation in a monotocous species, namely cattle. Ovaries were collected from a local bovine abattoir, from which theca cells were isolated from large (8-22mm) follicles and treated with various hormones in serum-free medium for 24h or 48h...
October 4, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28965601/the-role-of-lysosomes-in-the-phenomenon-of-concentration-of-aluminum-and-indium-in-the-female-reproductive-system-an-ultrastructural-study
#20
REVIEW
Mhamdi Marwa, Florea Adrian, Badri Nedra, Maghraoui Samira, Matei Horea, Tekaia Walid-Habib, Rym Baati, Tekaya Leila
The female reproductive system is one of the most complex systems in the body taking into account the hormonal fluctuations associated with ovarian and uterine menstrual cycles. The purpose of this work was to study the impact of aluminum nitrate and indium sulfate on the uterus and the ovary of a pregnant rat. The experiment was performed on adult female rats of Wistar strain weighing approximately 250g. The Transmission Electron Microscopy (TEM) showed the presence of electron-dense material in lysosomes of both uterine cells (myometrium and endometrium cells) and in the cells of the ovary (internal theca and granulosa cells)...
December 2017: Journal of Trace Elements in Medicine and Biology
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