Jensen Doucet, Lauren Kiri, Kathleen O'Connell, Sharon Kehoe, Robert J Lewandowski, David M Liu, Robert J Abraham, Daniel Boyd
Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization...
January 26, 2018: Journal of Functional Biomaterials